γδ T cells in infection and autoimmunity

Lifei Hou, Tian Wang, Jiaren Sun

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Standing at the interface of innate and adaptive immune, γδ T cells play important pathophysiologic roles in infection, autoimmunity, and tumorigenesis. Recent studies indicate that γδ T cells could be categorized into IFN-γ+ and IL-17+ subsets, both of which possess select TCR usages, bear unique surface markers and require different cytokine signaling to maintain the homeostasis. In addition, as the major innate IL-17 producers, γδ T cells are increasingly appreciated for their involvement in various acute infections and injuries. This review will summarize the characteristics of IFN-γ+ (γδ T-IFN-γ) and IL-17+ γδ T cells (γδT17) and discuss their distinct pathogenic functions in different disease models.

Original languageEnglish (US)
JournalInternational Immunopharmacology
DOIs
StateAccepted/In press - Feb 17 2015

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Keywords

  • Autoimmunity
  • IFN-γ
  • IL-17
  • Infection
  • γδ T cells

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Pharmacology

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