Abstract
Vitamin (vit) D deficiency and preterm birth (PTB) are more prevalent among African American (AA) women compared to caucasian (Cau) women. Because vit D is important in regulating cell-mediated immune responses, vit D insufficiency or deficiency during pregnancy may enhance inflammation in pregnant women and increase the risk of PTB. In this study, circulatory levels of 25-hydroxy (OH) and 1,25-dihydroxy (OH)2 vit D were measured using chemiluminescence and radioimmunoassay techniques, respectively, in AA (n = 108) and Cau (n = 84) women who delivered at term and preterm. The results from this study suggest that the serum levels of the 25-(OH) vit D concentrations tend to decrease (P =.06) in the Cau women who delivered at preterm compared to those delivering at term. However, the 25-(OH) vit D levels in Cau and AA between term and preterm deliveries were not significantly different. The serum levels of 1,25-(OH)2 vit D were found to be significantly lower in AA women compared to Cau women (P <.02) at term, and in the Cau (P <.01) and AA (P <.04) women delivering at preterm compared to those delivering at term. One-way analysis of variance demonstrated that 1,25-(OH)2 vit D levels were significantly lower in participants delivering at preterm (<34 weeks and between 34 and 37 weeks) compared to those delivering at term (>37 weeks).These results suggest that low levels of serum 1,25-(OH)2 vit D are associated with PTB, and vit D can potentially be used as a novel diagnostic marker in the detection of PTB.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 244-250 |
| Number of pages | 7 |
| Journal | Reproductive Sciences |
| Volume | 21 |
| Issue number | 2 |
| DOIs | |
| State | Published - 2014 |
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Keywords
- 1,25-(OH)2 vitamin D
- 25-(OH) vitamin D
- African Americans
- Caucasians
- preterm birth
- serum levels
ASJC Scopus subject areas
- Obstetrics and Gynecology
Cite this
1,25-Dihydroxyvitamin D deficiency is associated with preterm birth in African American and Caucasian women. / Thota, Chandrasekhar; Menon, Ramkumar; Fortunato, Stephen J.; Brou, Lina; Lee, Jae Eun; Al-Hendy, Ayman.
In: Reproductive Sciences, Vol. 21, No. 2, 2014, p. 244-250.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - 1,25-Dihydroxyvitamin D deficiency is associated with preterm birth in African American and Caucasian women
AU - Thota, Chandrasekhar
AU - Menon, Ramkumar
AU - Fortunato, Stephen J.
AU - Brou, Lina
AU - Lee, Jae Eun
AU - Al-Hendy, Ayman
PY - 2014
Y1 - 2014
N2 - Vitamin (vit) D deficiency and preterm birth (PTB) are more prevalent among African American (AA) women compared to caucasian (Cau) women. Because vit D is important in regulating cell-mediated immune responses, vit D insufficiency or deficiency during pregnancy may enhance inflammation in pregnant women and increase the risk of PTB. In this study, circulatory levels of 25-hydroxy (OH) and 1,25-dihydroxy (OH)2 vit D were measured using chemiluminescence and radioimmunoassay techniques, respectively, in AA (n = 108) and Cau (n = 84) women who delivered at term and preterm. The results from this study suggest that the serum levels of the 25-(OH) vit D concentrations tend to decrease (P =.06) in the Cau women who delivered at preterm compared to those delivering at term. However, the 25-(OH) vit D levels in Cau and AA between term and preterm deliveries were not significantly different. The serum levels of 1,25-(OH)2 vit D were found to be significantly lower in AA women compared to Cau women (P <.02) at term, and in the Cau (P <.01) and AA (P <.04) women delivering at preterm compared to those delivering at term. One-way analysis of variance demonstrated that 1,25-(OH)2 vit D levels were significantly lower in participants delivering at preterm (<34 weeks and between 34 and 37 weeks) compared to those delivering at term (>37 weeks).These results suggest that low levels of serum 1,25-(OH)2 vit D are associated with PTB, and vit D can potentially be used as a novel diagnostic marker in the detection of PTB.
AB - Vitamin (vit) D deficiency and preterm birth (PTB) are more prevalent among African American (AA) women compared to caucasian (Cau) women. Because vit D is important in regulating cell-mediated immune responses, vit D insufficiency or deficiency during pregnancy may enhance inflammation in pregnant women and increase the risk of PTB. In this study, circulatory levels of 25-hydroxy (OH) and 1,25-dihydroxy (OH)2 vit D were measured using chemiluminescence and radioimmunoassay techniques, respectively, in AA (n = 108) and Cau (n = 84) women who delivered at term and preterm. The results from this study suggest that the serum levels of the 25-(OH) vit D concentrations tend to decrease (P =.06) in the Cau women who delivered at preterm compared to those delivering at term. However, the 25-(OH) vit D levels in Cau and AA between term and preterm deliveries were not significantly different. The serum levels of 1,25-(OH)2 vit D were found to be significantly lower in AA women compared to Cau women (P <.02) at term, and in the Cau (P <.01) and AA (P <.04) women delivering at preterm compared to those delivering at term. One-way analysis of variance demonstrated that 1,25-(OH)2 vit D levels were significantly lower in participants delivering at preterm (<34 weeks and between 34 and 37 weeks) compared to those delivering at term (>37 weeks).These results suggest that low levels of serum 1,25-(OH)2 vit D are associated with PTB, and vit D can potentially be used as a novel diagnostic marker in the detection of PTB.
KW - 1,25-(OH)2 vitamin D
KW - 25-(OH) vitamin D
KW - African Americans
KW - Caucasians
KW - preterm birth
KW - serum levels
UR - http://www.scopus.com/inward/record.url?scp=84901777685&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84901777685&partnerID=8YFLogxK
U2 - 10.1177/1933719113493513
DO - 10.1177/1933719113493513
M3 - Article
VL - 21
SP - 244
EP - 250
JO - Reproductive Sciences
JF - Reproductive Sciences
SN - 1933-7191
IS - 2
ER -