In rodents the effect of 17α estradiol upon collagen is identical to that of 17β estradiol, but the 17α estradiol effect upon uterine lining is 1/1000 that of 17β estradiol. Both steroids reverse the effect of D penicillamine on rodent skin collagen. Five human beings with the skin collagen changes associated with D penicillamine were treated with 17α estradiol for three to six weeks. 17α estradiol caused no detectable changes in blood pressure, breast development, menstrual periods, serum liver enzymes, serum proteins, plasma growth hormone, insulin, serum clotting factors, serum triglycerides, serum copper or serum ceruloplasma. In contrast, 17α estradiol increased skin prolyl hydroxylase activity, increased soluble collagen content in the skin and increased urinary hydroxyproline excretion. These studies with 17α estradiol, point out a specificity difference between the various sites of estrogen action in human beings.
|Original language||English (US)|
|Number of pages||11|
|Journal||Research Communications in Chemical Pathology and Pharmacology|
|State||Published - 1976|
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