17β-Estradiol reappropriates mass lost to the hypermetabolic state in thermally injured rats

Kareem R. Abdelfattah, Joshua W. Gatson, David L. Maass, Steven Wolf, Joseph P. Minei, Jane G. Wigginton

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: The hypermetabolic response to severe thermal injury is unlike any physiologic response seen in medicine. While some parallels can be drawn to shock and sepsis states, this response is typified by its intensity and duration. Our group has been interested in the myriad effects of estrogens after injury, specifically the ability of estrogens to reduce inflammatory responses. Given this, and the known link between severe inflammation and the hypermetabolic response, we examined the effects of a single dose of 17β estradiol administered after a severe thermal injury in rats. Methods: Twelve male Sprague-Dawley rats were subject to either a sham burn or a 40% total body surface area burn, followed by fluid resuscitation. Burned animals were divided into a vehicle and treatment group, with injections given 15 min after the injury. Animals were monitored for a period of 45 d, with markers of hypermetabolism (weight, fecal output, food intake, and serum insulin and glucose) measured daily. Results: We identified a significant difference in daily measured weights between the burned groups. We observed a sparing of body mass during the acute phase lasting 2 wk after the injury and an improved recovery phase during the remainder of the study. Glucose and insulin levels during the first week of the study did not differ between the treatment groups. Conclusion: Estrogen may have a role in preserving body mass after severe thermal injury. Further studies are required to determine if this spared body mass composition.

Original languageEnglish (US)
Pages (from-to)136-141
Number of pages6
JournalJournal of Surgical Research
Volume181
Issue number1
DOIs
StatePublished - May 1 2013
Externally publishedYes

Fingerprint

Estradiol
Wounds and Injuries
Estrogens
Hot Temperature
Insulin
Weights and Measures
Glucose
Body Surface Area
Body Composition
Resuscitation
Sprague Dawley Rats
Shock
Sepsis
Eating
Medicine
Inflammation
Injections
Therapeutics
Serum

Keywords

  • Burns
  • Estrogen
  • Inflammation
  • Rodents
  • Weight loss

ASJC Scopus subject areas

  • Surgery

Cite this

17β-Estradiol reappropriates mass lost to the hypermetabolic state in thermally injured rats. / Abdelfattah, Kareem R.; Gatson, Joshua W.; Maass, David L.; Wolf, Steven; Minei, Joseph P.; Wigginton, Jane G.

In: Journal of Surgical Research, Vol. 181, No. 1, 01.05.2013, p. 136-141.

Research output: Contribution to journalArticle

Abdelfattah, Kareem R. ; Gatson, Joshua W. ; Maass, David L. ; Wolf, Steven ; Minei, Joseph P. ; Wigginton, Jane G. / 17β-Estradiol reappropriates mass lost to the hypermetabolic state in thermally injured rats. In: Journal of Surgical Research. 2013 ; Vol. 181, No. 1. pp. 136-141.
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