[18F]Fluorodeoxyglucose positron emission tomography-computerized tomography and lung cancer

A significant referral bias exists

Ikenna Okereke, Sidhu P. Gangadharan, Michael S. Kent, Saila P. Nicotera, Malcolm M. DeCamp

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objective: [18F]Fluorodeoxyglucose positron emission tomography-computerized tomography (PET-CT) scan is a tool widely used in the diagnosis and staging of lung cancer. Referral bias is present when the results of a diagnostic study affect the decision to proceed with definitive testing. This bias artificially increases the sensitivity and decreases the specificity, and may inappropriately alter the decision to undergo definitive testing. The accuracy of PET-CT scan in suspected lung cancer and the role of referral bias were investigated. Methods: From January 2005 through June 2007, 584 consecutive patients undergoing PET-CT scan for suspected lung cancer were studied. Endpoints measured included qualitative and quantitative results of PET-CT scans and pathologic results from patients, who underwent invasive procedures for diagnosis, staging and/or therapy. A positive PET scan was defined as one in which the standard uptake value (SUV) was greater than 2.5. A standard mathematical model, based on overall results of PET-CT scan in all patients, was used to create adjustments to account for the effect of referral bias. Results: A total of 414 (71%) of PET-CT scans were reported as positive, while 170 (29%) were negative. Attempt at tissue diagnosis occurred in 417 patients (71%); surgical intervention was performed in 246 (42%). Whereas 86% (355/414) of patients with a positive PET-CT scan underwent tissue sampling, only 36% (62/170) with a negative PET-CT scan had an attempt (p

Original languageEnglish (US)
Pages (from-to)560-564
Number of pages5
JournalEuropean Journal of Cardio-thoracic Surgery
Volume39
Issue number4
DOIs
StatePublished - Apr 2011
Externally publishedYes

Fingerprint

Fluorodeoxyglucose F18
Positron-Emission Tomography
Lung Neoplasms
Referral and Consultation
Tomography
Theoretical Models
Sensitivity and Specificity

Keywords

  • Diagnostic accuracy
  • Lung cancer
  • Oncology

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery
  • Pulmonary and Respiratory Medicine
  • Medicine(all)

Cite this

[18F]Fluorodeoxyglucose positron emission tomography-computerized tomography and lung cancer : A significant referral bias exists. / Okereke, Ikenna; Gangadharan, Sidhu P.; Kent, Michael S.; Nicotera, Saila P.; DeCamp, Malcolm M.

In: European Journal of Cardio-thoracic Surgery, Vol. 39, No. 4, 04.2011, p. 560-564.

Research output: Contribution to journalArticle

Okereke, Ikenna ; Gangadharan, Sidhu P. ; Kent, Michael S. ; Nicotera, Saila P. ; DeCamp, Malcolm M. / [18F]Fluorodeoxyglucose positron emission tomography-computerized tomography and lung cancer : A significant referral bias exists. In: European Journal of Cardio-thoracic Surgery. 2011 ; Vol. 39, No. 4. pp. 560-564.
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