1H, 13C and 15N NMR assignments of RNA recognizing motifs 1 and 2 of BRUNOL-3 protein from human involved in myotonic dystrophy

Harshesh Bhatt, Kashyap Maruthi, Neel Sarovar Bhavesh

Research output: Contribution to journalArticle

Abstract

BRUNOL-3 protein, an alternate splicing factor, has been known for playing a major role in myotonic dystrophy. It binds to the cTNT m-RNA and prevents splicing of exon-5 region, leading to translation of troponin protein having differential affinity for Ca2+. Here, we report sequence-specific 1H, 13C, and 15N resonance assignments for RNA recognition motifs 1 and 2 of BRUNOL-3 protein.

Original languageEnglish (US)
Pages (from-to)143-145
Number of pages3
JournalBiomolecular NMR Assignments
Volume4
Issue number2
DOIs
StatePublished - Oct 1 2010
Externally publishedYes

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Keywords

  • Alternate splicing factor
  • BRUNOL-3
  • Cardiac troponin T
  • Myotonic dystrophy

ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry

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