(1S,3R)-1-Aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD) induces burst firing via an inositol-1,4,5-triphosphate-independent pathway at rat dorsolateral septal nucleus

F. Zheng, G. Lonart, K. M. Johnson, J. P. Gallagher

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

We have previously reported that a l-2-amino-3-phosphonopropionate (L-AP3)-sensitive metabotropic glutamate receptor was required for the induction of long-term potentiation (LTP) in rat dorsolateral septal nucleus neurons. (1S,3R)-1-Aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD), a selective agonist for metabotropic glutamate receptors, also causes burst firing of dorsolateral septal nucleus (DLSN) neurons. In this study, we investigated whether this response was mediated by a phospholipase C-(PLC) coupled metabotropic glutamate receptor. The threshold concentration of 1S,3R-ACPD for the induction of burst firing was about 5 μM, while 10 μM 1S,3R-ACPD produced a maximal effect. L-AP3 (50 μM) reduced the burst firing induced by 1S,3R-ACPD (5 μM). Although 1S,3R-ACPD stimulated the formation of inositol-1,4,5-triphosphate [Ins(1,4,5)P3] suggesting the presence of PLC-coupled metabotropic glutamate receptors, it was only effective in a higher (30-100 μM) concentration range. In addition, the 1S,3R-ACPD-stimulated formation of Ins(1,4,5)P3 level was not affected by L-AP3. These observations suggest that the 1S,3R-ACPD induced burst firing is not mediated by PLC-coupled metabotropic glutamate receptors.

Original languageEnglish (US)
Pages (from-to)97-102
Number of pages6
JournalNeuropharmacology
Volume33
Issue number1
DOIs
StatePublished - Jan 1994

Keywords

  • 1S
  • 3R-ACPD
  • Metabotropic glutamate receptors
  • burst firing
  • phospholipase C
  • septum

ASJC Scopus subject areas

  • Pharmacology
  • Cellular and Molecular Neuroscience

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