2'-5'-Oligoadenylate synthetase, neopterin and β2-microglobulin in asymptomatic HIV-infected individuals

P. L. Witt, G. T. Spear, M. J. Lindstrom, H. A. Kessler, E. C. Borden, J. Phair, A. L. Landay

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


This study examined 2',5'-oligoadenylate (2,5A) synthetase activity in 26 individuals during the asymptomatic phase of HIV infection and its correlation with neopterin or β2-microglobulin. In HIV-antibody-positive (HIV-Ab+) asymptomatic people, both neopterin and β2-microglobulin levels in sera were significantly elevated; in contrast, 2,5A-synthetase activity in peripheral blood mononuclear cells was not significantly higher than in HIV-antibody-negative controls. The 2,5A-synthetase levels in symptomatic people (AIDS-related complex and AIDS) were significantly higher than in either asymptomatic or control individuals. However, within the group of HIV-infected asymptomatic individuals, all three markers were positively correlated. In this group, neopterin values were negatively correlated with the number of CD4+ lymphocytes while a positive correlation was found between 2,5A-synthetase and the number of CD8+ lymphocytes. Asymptomatic people with detectable serum HIV p24 antigen had significantly higher 2,5A-synthetase, neopterin, β2-microglobulin and number of CD8+ lymphocytes. This study suggests that elevated 2,5A-synthetase activity may reflect a different aspect of host response to HIV infection than do elevated neopterin or β2-microglobulin.

Original languageEnglish (US)
Pages (from-to)289-293
Number of pages5
Issue number3
StatePublished - 1991
Externally publishedYes


  • 2',5'-oligoadenylate synthetase
  • AIDS
  • asymptomatic
  • CD4+ lymphocytes
  • neopterin
  • β-microglobulin

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases


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