2,3,7,8-tetrachlorodibenzo-P-dioxin induces cytochrome P450IA1 enzyme activity by activating transcription of the corresponding gene

Amy E. Lusska, Keith W. Jones, Cornelis Elferink, Lena Wu, Emily S. Shen, Long Ping Wen, James P. Whitlock

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We have reviewed the transcriptional regulation of the CYP1A1 gene, which encodes the cytochrome P450IA1 enzyme. TCDD induces CYP1A1 transcription via a receptor- and enhancer-dependent mechanism that involves multiple protein-DNA interactions. The system provides an example of enzyme regulation at the level of gene transcription.

Original languageEnglish (US)
Pages (from-to)307-317
Number of pages11
JournalAdvances in Enzyme Regulation
Volume31
Issue numberC
DOIs
StatePublished - 1991
Externally publishedYes

Fingerprint

Cytochrome P-450 CYP1A1
Dioxins
Enzyme activity
Transcription
Cytochromes
Genes
Enzymes
DNA
Proteins
Polychlorinated Dibenzodioxins

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

Cite this

2,3,7,8-tetrachlorodibenzo-P-dioxin induces cytochrome P450IA1 enzyme activity by activating transcription of the corresponding gene. / Lusska, Amy E.; Jones, Keith W.; Elferink, Cornelis; Wu, Lena; Shen, Emily S.; Wen, Long Ping; Whitlock, James P.

In: Advances in Enzyme Regulation, Vol. 31, No. C, 1991, p. 307-317.

Research output: Contribution to journalArticle

Lusska, Amy E. ; Jones, Keith W. ; Elferink, Cornelis ; Wu, Lena ; Shen, Emily S. ; Wen, Long Ping ; Whitlock, James P. / 2,3,7,8-tetrachlorodibenzo-P-dioxin induces cytochrome P450IA1 enzyme activity by activating transcription of the corresponding gene. In: Advances in Enzyme Regulation. 1991 ; Vol. 31, No. C. pp. 307-317.
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