2,3,7,8-tetrachlorodibenzo-P-dioxin induces cytochrome P450IA1 enzyme activity by activating transcription of the corresponding gene

Amy E. Lusska, Keith W. Jones, Cornelis J. Elferink, Lena Wu, Emily S. Shen, Long Ping Wen, James P. Whitlock

Research output: Contribution to journalArticle

4 Scopus citations


We have reviewed the transcriptional regulation of the CYP1A1 gene, which encodes the cytochrome P450IA1 enzyme. TCDD induces CYP1A1 transcription via a receptor- and enhancer-dependent mechanism that involves multiple protein-DNA interactions. The system provides an example of enzyme regulation at the level of gene transcription.

Original languageEnglish (US)
Pages (from-to)307-317
Number of pages11
JournalAdvances in Enzyme Regulation
Issue numberC
StatePublished - 1991
Externally publishedYes


ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Cancer Research

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