2,3,7,8-tetrachlorodibenzo-P-dioxin induces cytochrome P450IA1 enzyme activity by activating transcription of the corresponding gene

Amy E. Lusska; Keith W. Jones; Cornelis J. Elferink; Lena Wu; Emily S. Shen; Long Ping Wen; James P. Whitlock

doi:10.1016/0065-2571(91)90019-I

2,3,7,8-tetrachlorodibenzo-P-dioxin induces cytochrome P450IA1 enzyme activity by activating transcription of the corresponding gene

Amy E. Lusska
, Keith W. Jones
, Cornelis J. Elferink
, Lena Wu
, Emily S. Shen
, Long Ping Wen
, James P. Whitlock

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

We have reviewed the transcriptional regulation of the CYP1A1 gene, which encodes the cytochrome P450IA1 enzyme. TCDD induces CYP1A1 transcription via a receptor- and enhancer-dependent mechanism that involves multiple protein-DNA interactions. The system provides an example of enzyme regulation at the level of gene transcription.

Original language	English (US)
Pages (from-to)	307-317
Number of pages	11
Journal	Advances in Enzyme Regulation
Volume	31
Issue number	C
DOIs	https://doi.org/10.1016/0065-2571(91)90019-I
State	Published - 1991
Externally published	Yes

ASJC Scopus subject areas

Molecular Medicine
Molecular Biology
Genetics
Cancer Research

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10.1016/0065-2571(91)90019-I

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title = "2,3,7,8-tetrachlorodibenzo-P-dioxin induces cytochrome P450IA1 enzyme activity by activating transcription of the corresponding gene",

abstract = "We have reviewed the transcriptional regulation of the CYP1A1 gene, which encodes the cytochrome P450IA1 enzyme. TCDD induces CYP1A1 transcription via a receptor- and enhancer-dependent mechanism that involves multiple protein-DNA interactions. The system provides an example of enzyme regulation at the level of gene transcription.",

author = "Lusska, \{Amy E.\} and Jones, \{Keith W.\} and Elferink, \{Cornelis J.\} and Lena Wu and Shen, \{Emily S.\} and Wen, \{Long Ping\} and Whitlock, \{James P.\}",

note = "Funding Information: Supported by research grants from the American Cancer Society, the National Cancer Institute, and the National Institute of Environmental Health Sciences.",

year = "1991",

doi = "10.1016/0065-2571(91)90019-I",

language = "English (US)",

volume = "31",

pages = "307--317",

journal = "Advances in Enzyme Regulation",

issn = "0065-2571",

publisher = "Elsevier Ltd",

number = "C",

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TY - JOUR

T1 - 2,3,7,8-tetrachlorodibenzo-P-dioxin induces cytochrome P450IA1 enzyme activity by activating transcription of the corresponding gene

AU - Lusska, Amy E.

AU - Jones, Keith W.

AU - Elferink, Cornelis J.

AU - Wu, Lena

AU - Shen, Emily S.

AU - Wen, Long Ping

AU - Whitlock, James P.

N1 - Funding Information: Supported by research grants from the American Cancer Society, the National Cancer Institute, and the National Institute of Environmental Health Sciences.

PY - 1991

Y1 - 1991

N2 - We have reviewed the transcriptional regulation of the CYP1A1 gene, which encodes the cytochrome P450IA1 enzyme. TCDD induces CYP1A1 transcription via a receptor- and enhancer-dependent mechanism that involves multiple protein-DNA interactions. The system provides an example of enzyme regulation at the level of gene transcription.

AB - We have reviewed the transcriptional regulation of the CYP1A1 gene, which encodes the cytochrome P450IA1 enzyme. TCDD induces CYP1A1 transcription via a receptor- and enhancer-dependent mechanism that involves multiple protein-DNA interactions. The system provides an example of enzyme regulation at the level of gene transcription.

UR - https://www.scopus.com/pages/publications/0026038699

UR - https://www.scopus.com/pages/publications/0026038699#tab=citedBy

U2 - 10.1016/0065-2571(91)90019-I

DO - 10.1016/0065-2571(91)90019-I

M3 - Article

C2 - 1652189

AN - SCOPUS:0026038699

SN - 0065-2571

VL - 31

SP - 307

EP - 317

JO - Advances in Enzyme Regulation

JF - Advances in Enzyme Regulation

IS - C

ER -

2,3,7,8-tetrachlorodibenzo-P-dioxin induces cytochrome P450IA1 enzyme activity by activating transcription of the corresponding gene

Abstract

ASJC Scopus subject areas

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