4-Hydroxyhexenal: A lipid peroxidation product derived from oxidized docosahexaenoic acid

Frederik J.G.M. Van Kuijk; Laura L. Holte; Edward A. Dratz

doi:10.1016/0005-2760(90)90118-H

4-Hydroxyhexenal: A lipid peroxidation product derived from oxidized docosahexaenoic acid

Frederik J.G.M. Van Kuijk
, Laura L. Holte
, Edward A. Dratz

Research output: Contribution to journal › Article › peer-review

118 Scopus citations

Abstract

4-Hydroxynonenal and 4-hydroxyhexenal are cytotoxic aldehydic products of lipid peroxidation with high biological activity. Peroxidation of n-6 fatty acids produces 4-hydroxynonenal, but the origin of 4-hydroxyhexenal has been uncertain. We now present evidence that 4-hydroxyhexenal is generated by oxidation of docosahexaenoic acid, the most abundant n-3 fatty acid in tissues.

Original language	English (US)
Pages (from-to)	116-118
Number of pages	3
Journal	Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism
Volume	1043
Issue number	1
DOIs	https://doi.org/10.1016/0005-2760(90)90118-H
State	Published - Mar 12 1990
Externally published	Yes

Keywords

4-Hydroxyhexenal
4-Hydroxynonenal
Docosahexaenoic acid
Lipid peroxidation

ASJC Scopus subject areas

Biophysics
Biochemistry
Endocrinology

Access to Document

10.1016/0005-2760(90)90118-H

Cite this

@article{f5cf04de4d834d40b3d262b64856183f,

title = "4-Hydroxyhexenal: A lipid peroxidation product derived from oxidized docosahexaenoic acid",

abstract = "4-Hydroxynonenal and 4-hydroxyhexenal are cytotoxic aldehydic products of lipid peroxidation with high biological activity. Peroxidation of n-6 fatty acids produces 4-hydroxynonenal, but the origin of 4-hydroxyhexenal has been uncertain. We now present evidence that 4-hydroxyhexenal is generated by oxidation of docosahexaenoic acid, the most abundant n-3 fatty acid in tissues.",

keywords = "4-Hydroxyhexenal, 4-Hydroxynonenal, Docosahexaenoic acid, Lipid peroxidation",

author = "\{Van Kuijk\}, \{Frederik J.G.M.\} and Holte, \{Laura L.\} and Dratz, \{Edward A.\}",

year = "1990",

month = mar,

day = "12",

doi = "10.1016/0005-2760(90)90118-H",

language = "English (US)",

volume = "1043",

pages = "116--118",

journal = "Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism",

issn = "0005-2760",

publisher = "Elsevier BV",

number = "1",

}

TY - JOUR

T1 - 4-Hydroxyhexenal

T2 - A lipid peroxidation product derived from oxidized docosahexaenoic acid

AU - Van Kuijk, Frederik J.G.M.

AU - Holte, Laura L.

AU - Dratz, Edward A.

PY - 1990/3/12

Y1 - 1990/3/12

N2 - 4-Hydroxynonenal and 4-hydroxyhexenal are cytotoxic aldehydic products of lipid peroxidation with high biological activity. Peroxidation of n-6 fatty acids produces 4-hydroxynonenal, but the origin of 4-hydroxyhexenal has been uncertain. We now present evidence that 4-hydroxyhexenal is generated by oxidation of docosahexaenoic acid, the most abundant n-3 fatty acid in tissues.

AB - 4-Hydroxynonenal and 4-hydroxyhexenal are cytotoxic aldehydic products of lipid peroxidation with high biological activity. Peroxidation of n-6 fatty acids produces 4-hydroxynonenal, but the origin of 4-hydroxyhexenal has been uncertain. We now present evidence that 4-hydroxyhexenal is generated by oxidation of docosahexaenoic acid, the most abundant n-3 fatty acid in tissues.

KW - 4-Hydroxyhexenal

KW - 4-Hydroxynonenal

KW - Docosahexaenoic acid

KW - Lipid peroxidation

UR - https://www.scopus.com/pages/publications/0025099678

UR - https://www.scopus.com/pages/publications/0025099678#tab=citedBy

U2 - 10.1016/0005-2760(90)90118-H

DO - 10.1016/0005-2760(90)90118-H

M3 - Article

C2 - 2138035

AN - SCOPUS:0025099678

SN - 0005-2760

VL - 1043

SP - 116

EP - 118

JO - Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism

JF - Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism

IS - 1

ER -

4-Hydroxyhexenal: A lipid peroxidation product derived from oxidized docosahexaenoic acid

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this