Abstract
Metastable aldehydes produced by lipid peroxidation act as 'toxic second messengers' that extend the injurious potential of free radicals. 4-Hydroxy 2-nonenal (HNE), a highly toxic and most abundant stable end product of lipid peroxidation, has been implicated in the tissue damage, dysfunction, injury associated with aging and other pathological states such as cancer, Alzheimer, diabetes, cardiovascular and inflammatory complications. Further, HNE has been considered as an oxidative stress marker and a secondary signaling molecule to regulate a number of cell signaling pathways. Biological activity of HNE depends on its intracellular concentration, which can differentially modulate cell death, growth and differentiation. Therefore, the mechanisms responsible for maintaining the intracellular levels of HNE are most important, not only in the defense against oxidative stress but also in the pathophysiology of a number of disease processes. In this review, we discuss the significance of HNE in mediating various disease processes and how regulation of its metabolism could be therapeutically effective.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 230-237 |
| Number of pages | 8 |
| Journal | Current Medicinal Chemistry |
| Volume | 21 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jan 2014 |
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Keywords
- 4-Hydroxy 2-nonenal
- Alzheimer
- Cancer
- Cataract
- Oxidative stress
ASJC Scopus subject areas
- Molecular Medicine
- Pharmacology
- Medicine(all)
Cite this
4-hydroxynonenal in the pathogenesis and progression of human diseases. / Shoeb, Mohammad; Ansari, Naseem; Srivastava, Satish; Ramana, Kota.
In: Current Medicinal Chemistry, Vol. 21, No. 2, 01.2014, p. 230-237.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - 4-hydroxynonenal in the pathogenesis and progression of human diseases
AU - Shoeb, Mohammad
AU - Ansari, Naseem
AU - Srivastava, Satish
AU - Ramana, Kota
PY - 2014/1
Y1 - 2014/1
N2 - Metastable aldehydes produced by lipid peroxidation act as 'toxic second messengers' that extend the injurious potential of free radicals. 4-Hydroxy 2-nonenal (HNE), a highly toxic and most abundant stable end product of lipid peroxidation, has been implicated in the tissue damage, dysfunction, injury associated with aging and other pathological states such as cancer, Alzheimer, diabetes, cardiovascular and inflammatory complications. Further, HNE has been considered as an oxidative stress marker and a secondary signaling molecule to regulate a number of cell signaling pathways. Biological activity of HNE depends on its intracellular concentration, which can differentially modulate cell death, growth and differentiation. Therefore, the mechanisms responsible for maintaining the intracellular levels of HNE are most important, not only in the defense against oxidative stress but also in the pathophysiology of a number of disease processes. In this review, we discuss the significance of HNE in mediating various disease processes and how regulation of its metabolism could be therapeutically effective.
AB - Metastable aldehydes produced by lipid peroxidation act as 'toxic second messengers' that extend the injurious potential of free radicals. 4-Hydroxy 2-nonenal (HNE), a highly toxic and most abundant stable end product of lipid peroxidation, has been implicated in the tissue damage, dysfunction, injury associated with aging and other pathological states such as cancer, Alzheimer, diabetes, cardiovascular and inflammatory complications. Further, HNE has been considered as an oxidative stress marker and a secondary signaling molecule to regulate a number of cell signaling pathways. Biological activity of HNE depends on its intracellular concentration, which can differentially modulate cell death, growth and differentiation. Therefore, the mechanisms responsible for maintaining the intracellular levels of HNE are most important, not only in the defense against oxidative stress but also in the pathophysiology of a number of disease processes. In this review, we discuss the significance of HNE in mediating various disease processes and how regulation of its metabolism could be therapeutically effective.
KW - 4-Hydroxy 2-nonenal
KW - Alzheimer
KW - Cancer
KW - Cataract
KW - Oxidative stress
UR - http://www.scopus.com/inward/record.url?scp=84893273332&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84893273332&partnerID=8YFLogxK
U2 - 10.2174/09298673113209990181
DO - 10.2174/09298673113209990181
M3 - Article
VL - 21
SP - 230
EP - 237
JO - Current Medicinal Chemistry
JF - Current Medicinal Chemistry
SN - 0929-8673
IS - 2
ER -