4-hydroxynonenal in the pathogenesis and progression of human diseases

Mohammad Shoeb, Naseem H. Ansari, Satish K. Srivastava, Kota V. Ramana

Research output: Contribution to journalArticlepeer-review

69 Scopus citations

Abstract

Metastable aldehydes produced by lipid peroxidation act as 'toxic second messengers' that extend the injurious potential of free radicals. 4-Hydroxy 2-nonenal (HNE), a highly toxic and most abundant stable end product of lipid peroxidation, has been implicated in the tissue damage, dysfunction, injury associated with aging and other pathological states such as cancer, Alzheimer, diabetes, cardiovascular and inflammatory complications. Further, HNE has been considered as an oxidative stress marker and a secondary signaling molecule to regulate a number of cell signaling pathways. Biological activity of HNE depends on its intracellular concentration, which can differentially modulate cell death, growth and differentiation. Therefore, the mechanisms responsible for maintaining the intracellular levels of HNE are most important, not only in the defense against oxidative stress but also in the pathophysiology of a number of disease processes. In this review, we discuss the significance of HNE in mediating various disease processes and how regulation of its metabolism could be therapeutically effective.

Original languageEnglish (US)
Pages (from-to)230-237
Number of pages8
JournalCurrent Medicinal Chemistry
Volume21
Issue number2
DOIs
StatePublished - Jan 2014

Keywords

  • 4-Hydroxy 2-nonenal
  • Alzheimer
  • Cancer
  • Cataract
  • Oxidative stress

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

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