5-ALA induced PpIX fluorescence spectroscopy in neurosurgery: a review

A. Gautheron; J. D. Bernstock; T. Picart; J. Guyotat; P. A. Valdés; B. Montcel

doi:10.3389/fnins.2024.1310282

5-ALA induced PpIX fluorescence spectroscopy in neurosurgery: a review

A. Gautheron, J. D. Bernstock, T. Picart, J. Guyotat, P. A. Valdés, B. Montcel

Neurosurgery

Research output: Contribution to journal › Review article › peer-review

8 Scopus citations

Abstract

The review begins with an overview of the fundamental principles/physics underlying light, fluorescence, and other light-matter interactions in biological tissues. It then focuses on 5-aminolevulinic acid (5-ALA)-induced protoporphyrin IX (PpIX) fluorescence spectroscopy methods used in neurosurgery (e.g., intensity, time-resolved) and in so doing, describe their specific features (e.g., hardware requirements, main processing methods) as well as their strengths and limitations. Finally, we review current clinical applications and future directions of 5-ALA-induced protoporphyrin IX (PpIX) fluorescence spectroscopy in neurosurgery.

Original language	English (US)
Article number	1310282
Pages (from-to)	1310282
Journal	Frontiers in Neuroscience
Volume	18
DOIs	https://doi.org/10.3389/fnins.2024.1310282
State	Published - 2024

Keywords

5-aminolevulinic acid (5-ALA)
brain tumors
fluorescence guided surgery
fluorescence spectroscopy
image guidance
neurooncology
neurosurgery
protoporphyrin IX (PpIX)

ASJC Scopus subject areas

General Neuroscience

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10.3389/fnins.2024.1310282

Cite this

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title = "5-ALA induced PpIX fluorescence spectroscopy in neurosurgery: a review",

abstract = "The review begins with an overview of the fundamental principles/physics underlying light, fluorescence, and other light-matter interactions in biological tissues. It then focuses on 5-aminolevulinic acid (5-ALA)-induced protoporphyrin IX (PpIX) fluorescence spectroscopy methods used in neurosurgery (e.g., intensity, time-resolved) and in so doing, describe their specific features (e.g., hardware requirements, main processing methods) as well as their strengths and limitations. Finally, we review current clinical applications and future directions of 5-ALA-induced protoporphyrin IX (PpIX) fluorescence spectroscopy in neurosurgery.",

keywords = "5-aminolevulinic acid (5-ALA), brain tumors, fluorescence guided surgery, fluorescence spectroscopy, image guidance, neurooncology, neurosurgery, protoporphyrin IX (PpIX)",

author = "A. Gautheron and Bernstock, {J. D.} and T. Picart and J. Guyotat and Vald{\'e}s, {P. A.} and B. Montcel",

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year = "2024",

doi = "10.3389/fnins.2024.1310282",

language = "English (US)",

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T1 - 5-ALA induced PpIX fluorescence spectroscopy in neurosurgery

T2 - a review

AU - Gautheron, A.

AU - Bernstock, J. D.

AU - Picart, T.

AU - Guyotat, J.

AU - Valdés, P. A.

AU - Montcel, B.

PY - 2024

Y1 - 2024

N2 - The review begins with an overview of the fundamental principles/physics underlying light, fluorescence, and other light-matter interactions in biological tissues. It then focuses on 5-aminolevulinic acid (5-ALA)-induced protoporphyrin IX (PpIX) fluorescence spectroscopy methods used in neurosurgery (e.g., intensity, time-resolved) and in so doing, describe their specific features (e.g., hardware requirements, main processing methods) as well as their strengths and limitations. Finally, we review current clinical applications and future directions of 5-ALA-induced protoporphyrin IX (PpIX) fluorescence spectroscopy in neurosurgery.

AB - The review begins with an overview of the fundamental principles/physics underlying light, fluorescence, and other light-matter interactions in biological tissues. It then focuses on 5-aminolevulinic acid (5-ALA)-induced protoporphyrin IX (PpIX) fluorescence spectroscopy methods used in neurosurgery (e.g., intensity, time-resolved) and in so doing, describe their specific features (e.g., hardware requirements, main processing methods) as well as their strengths and limitations. Finally, we review current clinical applications and future directions of 5-ALA-induced protoporphyrin IX (PpIX) fluorescence spectroscopy in neurosurgery.

KW - 5-aminolevulinic acid (5-ALA)

KW - brain tumors

KW - fluorescence guided surgery

KW - fluorescence spectroscopy

KW - image guidance

KW - neurooncology

KW - neurosurgery

KW - protoporphyrin IX (PpIX)

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5-ALA induced PpIX fluorescence spectroscopy in neurosurgery: a review

Abstract

Keywords

ASJC Scopus subject areas

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Hyperspectral, Quantitative Intraoperative Fluorescence Image Guided Brain Surgery

Cite this

5-ALA induced PpIX fluorescence spectroscopy in neurosurgery: a review

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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Fingerprint

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Hyperspectral, Quantitative Intraoperative Fluorescence Image Guided Brain Surgery

Cite this