5-aminolevulinic acid induced protoporphyrin IX (ALA-PpIX) fluorescence guidance in meningioma surgery

Pablo A. Valdes, Matthias Millesi, Georg Widhalm, David W. Roberts

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations

Abstract

Introduction: 5-aminolevulinic acid induced protoporphyrin IX (5-ALA-PpIX) fluorescence guidance has emerged as a valuable surgical adjunct for resection of intracranial tumors. Methods: Here we present a focused review on 5-ALA-PpIX fluorescence guidance for meningiomas. Results: We discuss the clinical studies and specific applications to date as well as the two main intraoperative fluorescence technologies applied to meningiomas. Conclusions: The use of 5-ALA-PpIX in meningiomas holds promising potential so neurosurgeons can improve surgical outcomes for patients with meningiomas as well as be pioneers in developing improved fluorescence imaging technologies.

Original languageEnglish (US)
Pages (from-to)555-565
Number of pages11
JournalJournal of Neuro-Oncology
Volume141
Issue number3
DOIs
StatePublished - Feb 15 2019
Externally publishedYes

Keywords

  • 5-Aminolevulinic acid
  • Fluorescence-guided surgery
  • Meningioma
  • Protoporphyrin IX
  • Quantitative fluorescence
  • Spectroscopy

ASJC Scopus subject areas

  • Oncology
  • Neurology
  • Clinical Neurology
  • Cancer Research

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