Abstract
Introduction: 5-aminolevulinic acid induced protoporphyrin IX (5-ALA-PpIX) fluorescence guidance has emerged as a valuable surgical adjunct for resection of intracranial tumors. Methods: Here we present a focused review on 5-ALA-PpIX fluorescence guidance for meningiomas. Results: We discuss the clinical studies and specific applications to date as well as the two main intraoperative fluorescence technologies applied to meningiomas. Conclusions: The use of 5-ALA-PpIX in meningiomas holds promising potential so neurosurgeons can improve surgical outcomes for patients with meningiomas as well as be pioneers in developing improved fluorescence imaging technologies.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 555-565 |
| Number of pages | 11 |
| Journal | Journal of Neuro-Oncology |
| Volume | 141 |
| Issue number | 3 |
| DOIs | |
| State | Published - Feb 15 2019 |
| Externally published | Yes |
Keywords
- 5-Aminolevulinic acid
- Fluorescence-guided surgery
- Meningioma
- Protoporphyrin IX
- Quantitative fluorescence
- Spectroscopy
ASJC Scopus subject areas
- Oncology
- Neurology
- Clinical Neurology
- Cancer Research