7,N,N trimethyltryptamine: A selective inhibitor of synaptosomal serotonin uptake

R. A. Glennon, B. Martin, K. M. Johnson, D. End

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

7,N,N-Trimethyltryptamine (TMT) was synthesized and evaluated as an inhibitor of synaptosomal biogenic amine uptake in rat forebrain homogenates. In addition to inhibiting 3H-serotonin uptake (IC50=0.4 μm). TMT appears to be quite selective and is much less potent in blocking either 3H-norepinephrine or 3H-dopamine uptake (IC50=180 μM and 61 μM, respectively).

Original languageEnglish (US)
Pages (from-to)161-164
Number of pages4
JournalResearch Communications in Chemical Pathology and Pharmacology
Volume19
Issue number1
StatePublished - 1978

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Toxicology
  • Pharmacology
  • Pharmacology, Toxicology and Pharmaceutics(all)

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