7,N,N trimethyltryptamine: A selective inhibitor of synaptosomal serotonin uptake

R. A. Glennon, B. Martin, K. M. Johnson, D. End

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

7,N,N-Trimethyltryptamine (TMT) was synthesized and evaluated as an inhibitor of synaptosomal biogenic amine uptake in rat forebrain homogenates. In addition to inhibiting 3H-serotonin uptake (IC50=0.4 μm). TMT appears to be quite selective and is much less potent in blocking either 3H-norepinephrine or 3H-dopamine uptake (IC50=180 μM and 61 μM, respectively).

Original languageEnglish (US)
Pages (from-to)161-164
Number of pages4
JournalResearch Communications in Chemical Pathology and Pharmacology
Volume19
Issue number1
StatePublished - 1978
Externally publishedYes

Fingerprint

Biogenic Amines
Serotonin Uptake Inhibitors
Inhibitory Concentration 50
Rats
Dopamine
Serotonin
Norepinephrine
Prosencephalon

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

Cite this

7,N,N trimethyltryptamine : A selective inhibitor of synaptosomal serotonin uptake. / Glennon, R. A.; Martin, B.; Johnson, K. M.; End, D.

In: Research Communications in Chemical Pathology and Pharmacology, Vol. 19, No. 1, 1978, p. 161-164.

Research output: Contribution to journalArticle

Glennon, R. A. ; Martin, B. ; Johnson, K. M. ; End, D. / 7,N,N trimethyltryptamine : A selective inhibitor of synaptosomal serotonin uptake. In: Research Communications in Chemical Pathology and Pharmacology. 1978 ; Vol. 19, No. 1. pp. 161-164.
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