7,N,N trimethyltryptamine: A selective inhibitor of synaptosomal serotonin uptake

R. A. Glennon; B. Martin; K. M. Johnson; D. End

7,N,N trimethyltryptamine: A selective inhibitor of synaptosomal serotonin uptake

R. A. Glennon
, B. Martin
, K. M. Johnson
, D. End

Research output: Contribution to journal › Article › peer-review

Abstract

7,N,N-Trimethyltryptamine (TMT) was synthesized and evaluated as an inhibitor of synaptosomal biogenic amine uptake in rat forebrain homogenates. In addition to inhibiting ³H-serotonin uptake (IC₅₀=0.4 μm). TMT appears to be quite selective and is much less potent in blocking either ³H-norepinephrine or ³H-dopamine uptake (IC₅₀=180 μM and 61 μM, respectively).

Original language	English (US)
Pages (from-to)	161-164
Number of pages	4
Journal	Research Communications in Chemical Pathology and Pharmacology
Volume	19
Issue number	1
State	Published - 1978
Externally published	Yes

ASJC Scopus subject areas

General Pharmacology, Toxicology and Pharmaceutics
Pathology and Forensic Medicine
Toxicology
Pharmacology

Cite this

@article{9718131a0f0a4a1395da1fd093f60e7c,

title = "7,N,N trimethyltryptamine: A selective inhibitor of synaptosomal serotonin uptake",

abstract = "7,N,N-Trimethyltryptamine (TMT) was synthesized and evaluated as an inhibitor of synaptosomal biogenic amine uptake in rat forebrain homogenates. In addition to inhibiting 3H-serotonin uptake (IC50=0.4 μm). TMT appears to be quite selective and is much less potent in blocking either 3H-norepinephrine or 3H-dopamine uptake (IC50=180 μM and 61 μM, respectively).",

author = "Glennon, \{R. A.\} and B. Martin and Johnson, \{K. M.\} and D. End",

year = "1978",

language = "English (US)",

volume = "19",

pages = "161--164",

journal = "Research Communications in Chemical Pathology and Pharmacology",

issn = "0034-5164",

publisher = "PJD Publications Ltd",

number = "1",

}

TY - JOUR

T1 - 7,N,N trimethyltryptamine

T2 - A selective inhibitor of synaptosomal serotonin uptake

AU - Glennon, R. A.

AU - Martin, B.

AU - Johnson, K. M.

AU - End, D.

PY - 1978

Y1 - 1978

N2 - 7,N,N-Trimethyltryptamine (TMT) was synthesized and evaluated as an inhibitor of synaptosomal biogenic amine uptake in rat forebrain homogenates. In addition to inhibiting 3H-serotonin uptake (IC50=0.4 μm). TMT appears to be quite selective and is much less potent in blocking either 3H-norepinephrine or 3H-dopamine uptake (IC50=180 μM and 61 μM, respectively).

AB - 7,N,N-Trimethyltryptamine (TMT) was synthesized and evaluated as an inhibitor of synaptosomal biogenic amine uptake in rat forebrain homogenates. In addition to inhibiting 3H-serotonin uptake (IC50=0.4 μm). TMT appears to be quite selective and is much less potent in blocking either 3H-norepinephrine or 3H-dopamine uptake (IC50=180 μM and 61 μM, respectively).

UR - https://www.scopus.com/pages/publications/0017804907

UR - https://www.scopus.com/pages/publications/0017804907#tab=citedBy

M3 - Article

C2 - 625585

AN - SCOPUS:0017804907

SN - 0034-5164

VL - 19

SP - 161

EP - 164

JO - Research Communications in Chemical Pathology and Pharmacology

JF - Research Communications in Chemical Pathology and Pharmacology

IS - 1

ER -

7,N,N trimethyltryptamine: A selective inhibitor of synaptosomal serotonin uptake

Abstract

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this