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  • Pei-Yong Shi
2011

Keratinocytes are cell targets of west nile virus in vivo

Lim, P. Y., Behr, M. J., Chadwick, C. M., Shi, P. Y. & Bernard, K. A., May 1 2011, In : Journal of virology. 85, 10, p. 5197-5201 5 p.

Research output: Contribution to journalArticle

68 Scopus citations
2016

A conserved pocket in the dengue virus polymerase identified through fragment-based screening

Noble, C. G., Lim, S. P., Arora, R., Yokokawa, F., Nilar, S., Seh, C. C., Wright, S. K., Benson, T. E., Smith, P. W. & Shi, P-Y., Apr 15 2016, In : Journal of Biological Chemistry. 291, 16, p. 8541-8548 8 p.

Research output: Contribution to journalArticle

24 Scopus citations
2018

Characterization of a candidate tetravalent vaccine based on 2’-O-methyltransferase mutants

Züst, R., Li, S. H., Xie, X., Velumani, S., Chng, M., Toh, Y. X., Zou, J., Dong, H., Shan, C., Pang, J., Qin, C. F., Newell, E. W., Shi, P-Y. & Fink, K., Jan 1 2018, In : PLoS One. 13, 1, e0189262.

Research output: Contribution to journalArticle

2 Scopus citations
2019

Maternal vaccination and protective immunity against Zika virus vertical transmission

Shan, C., Xie, X., Luo, H., Muruato, A. E., Liu, Y., Wakamiya, M., La, J. H., Chung, J. M., Weaver, S. C., Wang, T. & Shi, P. Y., Dec 1 2019, In : Nature communications. 10, 1, 5677.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
2018

Treatment of human glioblastoma with a live attenuated Zika virus vaccine candidate

Chen, Q., Wu, J., Ye, Q., Ma, F., Zhu, Q., Wu, Y., Shan, C., Xie, X., Li, D., Zhan, X., Li, C., Li, X. F., Qin, X., Zhao, T., Wu, H., Shi, P. Y., Man, J. & Qin, C. F., Sep 1 2018, In : mBio. 9, 5, e01683-18.

Research output: Contribution to journalArticle

16 Scopus citations
2013

Rational design of a flavivirus vaccine by abolishing viral RNA 2′-O methylation

Li, S. H., Dong, H., Li, X. F., Xie, X., Zhao, H., Deng, Y. Q., Wang, X. Y., Ye, Q., Zhu, S. Y., Wang, H. J., Zhang, B., Leng, Q. B., Zuest, R., Qin, E. D., Qin, C. F. & Shi, P. Y., May 1 2013, In : Journal of virology. 87, 10, p. 5812-5819 8 p.

Research output: Contribution to journalArticle

61 Scopus citations
2018

A single-dose plasmid-launched live-attenuated Zika vaccine induces protective immunity

Zou, J., Xie, X., Luo, H., Shan, C., Muruato, A. E., Weaver, S., Wang, T. & Shi, P-Y., Jan 1 2018, (Accepted/In press) In : EBioMedicine.

Research output: Contribution to journalArticle

12 Scopus citations
2013

Membrane topology and function of dengue virus NS2A protein

Xie, X., Gayen, S., Kang, C. B., Yuan, Z. & Shi, P. Y., Apr 1 2013, In : Journal of virology. 87, 8, p. 4609-4622 14 p.

Research output: Contribution to journalArticle

105 Scopus citations
2015

Targeting dengue virus NS4B protein for drug discovery

Xie, X., Zou, J., Wang, Q. Y. & Shi, P. Y., Jun 2015, In : Antiviral research. 118, p. 39-45 7 p., 3603.

Research output: Contribution to journalReview article

40 Scopus citations

The dengue virus NS5 protein as a target for drug discovery

Lim, S. P., Noble, C. G. & Shi, P-Y., Jul 1 2015, In : Antiviral Research. 119, p. 57-67 11 p.

Research output: Contribution to journalArticle

84 Scopus citations
2013

Ten years of dengue drug discovery: Progress and prospects

Lim, S. P., Wang, Q. Y., Noble, C. G., Chen, Y. L., Dong, H., Zou, B., Yokokawa, F., Nilar, S., Smith, P., Beer, D., Lescar, J. & Shi, P. Y., Oct 21 2013, In : Antiviral research. 100, 2, p. 500-519 20 p.

Research output: Contribution to journalReview article

218 Scopus citations
2018

Did Zika Virus Mutate to Cause Severe Outbreaks?

Rossi, S., Ebel, G. D., Shan, C., Shi, P-Y. & Vasilakis, N., Jan 1 2018, (Accepted/In press) In : Trends in Microbiology.

Research output: Contribution to journalArticle

8 Scopus citations
2013

Difficulties and advancements in developing drugs for the treatment of dengue fever

Noble, C. G. & Shi, P. Y., Jan 1 2013, In : Expert Opinion on Orphan Drugs. 1, 12, p. 947-949 3 p.

Research output: Contribution to journalReview article

1 Scopus citations
2015

Flexibility of NS5 methyltransferase-polymerase linker region is essential for dengue virus replication

Zhao, Y., Soh, T. S., Chan, K. W. K., Fung, S. S. Y., Swaminathan, K., Lim, S. P., Shi, P. Y., Huber, T., Lescar, J., Luo, D. & Vasudevan, S. G., Jan 1 2015, In : Journal of virology. 89, 20, p. 10717-10721 5 p.

Research output: Contribution to journalArticle

25 Scopus citations
2016

Zika virus: History, emergence, biology, and prospects for control

Weaver, S., Costa, F., Garcia-Blanco, M., Ko, A. I., Ribeiro, G. S., Saade, G., Shi, P-Y. & Vasilakis, N., Jun 1 2016, In : Antiviral Research. 130, p. 69-80 12 p.

Research output: Contribution to journalArticle

324 Scopus citations
2011

Anti-infectives: Can cellular screening deliver?

Keller, T. H., Shi, P. Y. & Wang, Q. Y., Aug 1 2011, In : Current Opinion in Chemical Biology. 15, 4, p. 529-533 5 p.

Research output: Contribution to journalReview article

22 Scopus citations
2014

Crystal structure of dengue virus methyltransferase without S-adenosyl-L-methionine

Noble, C. G., Li, S. H., Dong, H., Chew, S. H. & Shi, P. Y., Nov 2014, In : Antiviral research. 111, p. 78-81 4 p.

Research output: Contribution to journalArticle

8 Scopus citations
2011

Combination of α-glucosidase inhibitor and ribavirin for the treatment of dengue virus infection in vitro and in vivo

Chang, J., Schul, W., Butters, T. D., Yip, A., Liu, B., Goh, A., Lakshminarayana, S. B., Alonzi, D., Reinkensmeier, G., Pan, X., Qu, X., Weidner, J. M., Wang, L., Yu, W., Borune, N., Kinch, M. A., Rayahin, J. E., Moriarty, R., Xu, X., Shi, P. Y. & 2 others, Guo, J. T. & Block, T. M., Jan 1 2011, In : Antiviral research. 89, 1, p. 26-34 9 p.

Research output: Contribution to journalArticle

58 Scopus citations
2014

Flavivirus NS5 prevents the InSTATement of IFN

Shi, P. Y., Sep 10 2014, In : Cell Host and Microbe. 16, 3, p. 269-271 3 p.

Research output: Contribution to journalShort survey

10 Scopus citations
2018

A Zika virus vaccine expressing premembrane-envelope-NS1 polyprotein

Li, A., Yu, J., Lu, M., Ma, Y., Attia, Z., Shan, C., Xue, M., Liang, X., Craig, K., Makadiya, N., He, J. J., Jennings, R., Shi, P-Y., Peeples, M. E., Liu, S. L., Boyaka, P. N. & Li, J., Dec 1 2018, In : Nature Communications. 9, 1, 3067.

Research output: Contribution to journalArticle

14 Scopus citations
2015

Discovery of dengue virus NS4B inhibitors

Wang, Q. Y., Dong, H., Zou, B., Karuna, R., Wan, K. F., Zou, J., Susila, A., Yip, A., Shan, C., Yeo, K. L., Xu, H., Ding, M., Chan, W. L., Gu, F., Seah, P. G., Liu, W., Lakshminarayana, S. B., Kang, C. B., Lescar, J., Blasco, F. & 2 others, Smith, P. W. & Shi, P-Y., 2015, In : Journal of Virology. 89, 16, p. 8233-8244 12 p.

Research output: Contribution to journalArticle

47 Scopus citations
2017

Generation and characterization of West Nile pseudo-infectious reporter virus for antiviral screening

Zhang, H. L., Ye, H. Q., Deng, C. L., Liu, S. Q., Shi, P-Y., Qin, C. F., Yuan, Z. M. & Zhang, B., May 1 2017, In : Antiviral Research. 141, p. 38-47 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

Evaluation of a novel reporter virus neutralization test for serological diagnosis of Zika and Dengue virus infection

Shan, C., Ortiz, D. A., Yang, Y., Wong, S. J., Kramer, L. D., Shi, P-Y., Loeffelholz, M. J. & Ren, P., Oct 1 2017, In : Journal of Clinical Microbiology. 55, 10, p. 3028-3036 9 p.

Research output: Contribution to journalArticle

20 Scopus citations
2014

Dengue Therapeutics, Chemoprophylaxis, and Allied Tools: State of the Art and Future Directions

Whitehorn, J., Yacoub, S., Anders, K. L., Macareo, L. R., Cassetti, M. C., Nguyen Van, V. C., Shi, P. Y., Wills, B. & Simmons, C. P., Aug 28 2014, In : PLoS neglected tropical diseases. 8, 8, e3025.

Research output: Contribution to journalArticle

42 Scopus citations
2018

Structure-activity relationship of uridine-based nucleoside phosphoramidate prodrugs for inhibition of dengue virus RNA-dependent RNA polymerase

Wang, G., Lim, S. P., Chen, Y. L., Hunziker, J., Rao, R., Gu, F., Seh, C. C., Ghafar, N. A., Xu, H., Chan, K., Lin, X., Saunders, O. L., Fenaux, M., Zhong, W., Shi, P-Y. & Yokokawa, F., Jan 1 2018, (Accepted/In press) In : Bioorganic and Medicinal Chemistry Letters.

Research output: Contribution to journalArticle

4 Scopus citations
2016

Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling

Lim, S. P., Noble, C. G., Seh, C. C., Soh, T. S., El Sahili, A., Chan, G. K. Y., Lescar, J., Arora, R., Benson, T., Nilar, S., Manjunatha, U., Wan, K. F., Dong, H., Xie, X., Shi, P. Y. & Yokokawa, F., Aug 2016, In : PLoS pathogens. 12, 8, e1005737.

Research output: Contribution to journalArticle

51 Scopus citations
2019

Repurposing an HIV Drug for Zika Virus Therapy

Xie, X. & Shi, P. Y., Dec 4 2019, In : Molecular Therapy. 27, 12, p. 2064-2066 3 p.

Research output: Contribution to journalShort survey

2013

A chimeric dengue virus vaccine using japanese encephalitis virus vaccine strain SA14-14-2 as backbone is immunogenic and protective against either parental virus in mice and nonhuman primates

Li, X. F., Deng, Y. Q., Yang, H. Q., Zhao, H., Jiang, T., Yu, X. D., Li, S. H., Ye, Q., Zhu, S. Y., Wang, H. J., Zhang, Y., Ma, J., Yu, Y. X., Liu, Z. Y., Li, Y. H., Qin, E. D., Shi, P. Y. & Qin, C. F., Dec 1 2013, In : Journal of virology. 87, 24, p. 13694-13705 12 p.

Research output: Contribution to journalArticle

41 Scopus citations
2020

An Infectious cDNA Clone of SARS-CoV-2

Xie, X., Muruato, A., Lokugamage, K. G., Narayanan, K., Zhang, X., Zou, J., Liu, J., Schindewolf, C., Bopp, N. E., Aguilar, P. V., Plante, K. S., Weaver, S. C., Makino, S., LeDuc, J. W., Menachery, V. D. & Shi, P. Y., May 13 2020, In : Cell Host and Microbe. 27, 5, p. 841-848.e3

Research output: Contribution to journalArticle

Open Access
2019

Use of the immunoglobulin G avidity assay to differentiate between recent Zika and past dengue virus infections

Furuya, A. K. M., Hunt, D., St. George, K., Dupuis, A. P., Kramer, L. D., Shi, P-Y. & Wong, S., Apr 15 2019, In : Clinical Science. 133, 7, p. 859-867 9 p.

Research output: Contribution to journalArticle

1 Scopus citations

Dengue NS2A Protein Orchestrates Virus Assembly

Xie, X., Zou, J., Zhang, X., Zhou, Y., Routh, A. L., Kang, C., Popov, V. L., Chen, X., Wang, Q. Y., Dong, H. & Shi, P. Y., Nov 13 2019, In : Cell Host and Microbe. 26, 5, p. 606-622.e8

Research output: Contribution to journalArticle

1 Scopus citations
2014

A novel reporter system for neutralizing and enhancing antibody assay against dengue virus

Song, K. Y., Zhao, H., Jiang, Z. Y., Li, X. F., Deng, Y. Q., Jiang, T., Zhu, S. Y., Shi, P. Y., Zhang, B., Zhang, F. C., Qin, E. D. & Qin, C. F., Feb 18 2014, In : BMC Microbiology. 14, 1, 44.

Research output: Contribution to journalArticle

11 Scopus citations
2015

The search for nucleoside/nucleotide analog inhibitors of dengue virus

Chen, Y. L., Yokokawa, F. & Shi, P-Y., Aug 10 2015, In : Antiviral Research. 122, p. 12-19 8 p., 3670.

Research output: Contribution to journalArticle

36 Scopus citations
2014

Anti-dengue-virus activity and structure-activity relationship studies of lycorine derivatives

Wang, P., Li, L. F., Wang, Q. Y., Shang, L. Q., Shi, P. Y. & Yin, Z., Jul 2014, In : ChemMedChem. 9, 7, p. 1522-1533 12 p.

Research output: Contribution to journalArticle

23 Scopus citations
2013

Development and characterization of a stable eGFP enterovirus 71 for antiviral screening

Shang, B., Deng, C., Ye, H., Xu, W., Yuan, Z., Shi, P. Y. & Zhang, B., Feb 1 2013, In : Antiviral research. 97, 2, p. 198-205 8 p.

Research output: Contribution to journalArticle

30 Scopus citations
2012

The stem region of premembrane protein plays an important role in the virus surface protein rearrangement during dengue maturation

Zhang, Q., Hunke, C., Yau, Y. H., Seow, V., Lee, S., Tanner, L. B., Guan, X. L., Wenk, M. R., Fibriansah, G., Chew, P. L., Kukkaro, P., Biuković, G., Shi, P. Y., Shochat, S. G., Grüber, G. & Lok, S. M., Nov 23 2012, In : Journal of Biological Chemistry. 287, 48, p. 40525-40534 10 p.

Research output: Contribution to journalArticle

26 Scopus citations
2014

Modulation of inflammation and pathology during dengue virus infection by p38 MAPK inhibitor SB203580

Fu, Y., Yip, A., Seah, P. G., Blasco, F., Shi, P. Y. & Hervé, M., Jan 1 2014, In : Antiviral research. 110, p. 151-157 7 p.

Research output: Contribution to journalArticle

17 Scopus citations
2016

Secondary Structure and Membrane Topology of the Full-Length Dengue Virus NS4B in Micelles

Li, Y., Wong, Y. L., Lee, M. Y., Li, Q., Wang, Q. Y., Lescar, J., Shi, P-Y. & Kang, C. B., Sep 19 2016, In : Angewandte Chemie - International Edition. 55, 39, p. 12068-12072 5 p.

Research output: Contribution to journalArticle

13 Scopus citations
2017

A live-attenuated Zika virus vaccine candidate induces sterilizing immunity in mouse models

Shan, C., Muruato, A. E., Nunes, B. T. D., Luo, H., Xie, X., Medeiros, D. B. A., Wakamiya, M., Tesh, R. B., Barrett, A. D., Wang, T., Weaver, S. C., Vasconcelos, P. F. C., Rossi, S. L. & Shi, P. Y., Jun 1 2017, In : Nature Medicine. 23, 6, p. 763-767 5 p.

Research output: Contribution to journalArticle

131 Scopus citations
2014

Type I interferon signals in macrophages and dendritic cells control dengue virus infection: Implications for a new mouse model to test dengue vaccines

Züst, R., Toh, Y. X., Valdés, I., Cerny, D., Heinrich, J., Hermida, L., Marcos, E., Guillén, G., Kalinke, U., Shi, P. Y. & Fink, K., 2014, In : Journal of virology. 88, 13, p. 7276-7285 10 p.

Research output: Contribution to journalArticle

47 Scopus citations
2018

Targeting vesicle size

Zou, J. & Shi, P. Y., Nov 1 2018, In : Nature Materials. 17, 11, p. 955-956 2 p.

Research output: Contribution to journalComment/debate

2016

Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure

Qian, X., Nguyen, H. N., Song, M. M., Hadiono, C., Ogden, S. C., Hammack, C., Yao, B., Hamersky, G. R., Jacob, F., Zhong, C., Yoon, K. J., Jeang, W., Lin, L., Li, Y., Thakor, J., Berg, D. A., Zhang, C., Kang, E., Chickering, M., Nauen, D. & 10 others, Ho, C. Y., Wen, Z., Christian, K. M., Shi, P-Y., Maher, B. J., Wu, H., Jin, P., Tang, H., Song, H. & Ming, G. L., May 19 2016, In : Cell. 165, 5, p. 1238-1254 17 p.

Research output: Contribution to journalArticle

601 Scopus citations
2017

A Rapid Zika Diagnostic Assay to Measure Neutralizing Antibodies in Patients

Shan, C., Xie, X., Ren, P., Loeffelholz, M. J., Yang, Y., Furuya, A., Dupuis, A. P., Kramer, L. D., Wong, S. J. & Shi, P-Y., Mar 1 2017, In : EBioMedicine. 17, p. 157-162 6 p.

Research output: Contribution to journalArticle

36 Scopus citations
2016

Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure-Based Drug Design

Yokokawa, F., Nilar, S., Noble, C. G., Lim, S. P., Rao, R., Tania, S., Wang, G., Lee, G., Hunziker, J., Karuna, R., Manjunatha, U., Shi, P-Y. & Smith, P. W., Apr 28 2016, In : Journal of Medicinal Chemistry. 59, 8, p. 3935-3952 18 p.

Research output: Contribution to journalArticle

39 Scopus citations
2018

Human IFIT3 Modulates IFIT1 RNA Binding Specificity and Protein Stability

Johnson, B., VanBlargan, L. A., Xu, W., White, J. P., Shan, C., Shi, P. Y., Zhang, R., Adhikari, J., Gross, M. L., Leung, D. W., Diamond, M. S. & Amarasinghe, G. K., Mar 20 2018, In : Immunity. 48, 3, p. 487-499.e5

Research output: Contribution to journalArticle

17 Scopus citations
2017

Functional Analysis of Glycosylation of Zika Virus Envelope Protein

Fontes-Garfias, C. R., Shan, C., Luo, H., Muruato, A. E., Medeiros, D. B. A., Mays, E., Xie, X., Zou, J., Roundy, C. M., Wakamiya, M., Rossi, S. L., Wang, T., Weaver, S. C. & Shi, P. Y., Oct 31 2017, In : Cell Reports. 21, 5, p. 1180-1190 11 p.

Research output: Contribution to journalArticle

41 Scopus citations
2019

Quantifying the RNA cap epitranscriptome reveals novel caps in cellular and viral RNA

Wang, J., Alvin Chew, B. L., Lai, Y., Dong, H., Xu, L., Balamkundu, S., Cai, W. M., Cui, L., Liu, C. F., Fu, X. Y., Lin, Z., Shi, P. Y., Lu, T. K., Luo, D., Jaffrey, S. R. & Dedon, P. C., Nov 18 2019, In : Nucleic acids research. 47, 20, p. e130

Research output: Contribution to journalArticle

Open Access

Targeting the Achilles Heel of Mosquito-Borne Viruses for Antiviral Therapy

Jackman, J. A., Shi, P-Y. & Cho, N. J., Nov 1 2019, In : ACS Infectious Diseases. 5, 1, p. 4-8 5 p.

Research output: Contribution to journalArticle

4 Scopus citations
2018

A single residue in the αb helix of the e protein is critical for Zika virus thermostability correspondence

Xie, D. Y., Liu, Z. Y., Nian, Q. G., Zhu, L., Wang, N., Deng, Y. Q., Zhao, H., Ji, X., Li, X. F., Wang, X., Shi, P-Y. & Qin, C. F., Dec 1 2018, In : Emerging Microbes and Infections. 7, 1, 0006.

Research output: Contribution to journalLetter

2 Scopus citations
2012

Enterovirus 71 VPg uridylation uses a two-molecular mechanism of 3D polymerase

Sun, Y., Wang, Y., Shan, C., Chen, C., Xu, P., Song, M., Zhou, H., Yang, C., Xu, W., Shi, P. Y., Zhang, B. & Lou, Z., Dec 1 2012, In : Journal of virology. 86, 24, p. 13662-13671 10 p.

Research output: Contribution to journalArticle

29 Scopus citations