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  • Michael Sheetz
2015

Talin Dependent Mechanosensitivity of Cell Focal Adhesions

Yan, J., Yao, M., Goult, B. T. & Sheetz, M., Jan 1 2015, In : Cellular and Molecular Bioengineering. 8, 1, p. 151-159 9 p.

Research output: Contribution to journalReview article

Open Access
46 Scopus citations
2011

Controlled confinement of DNA at the nanoscale: nanofabrication and surface bio-functionalization.

Palma, M., Abramson, J. J., Gorodetsky, A. A., Nuckolls, C., Sheetz, M., Wind, S. J. & Hone, J., Jan 1 2011, In : Methods in molecular biology (Clifton, N.J.). 749, p. 169-185 17 p.

Research output: Contribution to journalArticle

7 Scopus citations
2017

Mechanotransmission and Mechanosensing of Human alpha-Actinin 1

Le, S., Hu, X., Yao, M., Chen, H., Yu, M., Xu, X., Nakazawa, N., Margadant, F. M., Sheetz, M. & Yan, J., Dec 5 2017, In : Cell Reports. 21, 10, p. 2714-2723 10 p.

Research output: Contribution to journalArticle

Open Access
15 Scopus citations
2012

Cell crawling mediates collective cell migration to close undamaged epithelial gaps

Anon, E., Serra-Picamal, X., Hersen, P., Gauthier, N. C., Sheetz, M., Trepat, X. & Ladoux, B., Jul 3 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 27, p. 10891-10896 6 p.

Research output: Contribution to journalArticle

Open Access
110 Scopus citations
2019

Integrin nanoclusters can bridge thin matrix fibres to form cell–matrix adhesions

Changede, R., Cai, H., Wind, S. J. & Sheetz, M., Jan 1 2019, (Accepted/In press) In : Nature Materials.

Research output: Contribution to journalArticle

2 Scopus citations
2015

Micropatterning of TCR and LFA-1 ligands reveals complementary effects on cytoskeleton mechanics in T cells

Tabdanov, E., Gondarenko, S., Kumari, S., Liapis, A., Dustin, M. L., Sheetz, M., Kam, L. C. & Iskratsch, T., Oct 1 2015, In : Integrative Biology (United Kingdom). 7, 10, p. 1272-1284 13 p.

Research output: Contribution to journalArticle

Open Access
35 Scopus citations
2014

N-WASP-directed actin polymerization activates Cas phosphorylation and lamellipodium spreading

Zhang, X., Moore, S. W., Iskratsch, T. & Sheetz, M., Jan 1 2014, In : Journal of Cell Science. 127, 7, p. 1394-1405 12 p.

Research output: Contribution to journalArticle

Open Access
22 Scopus citations
2012

Mechanical feedback between membrane tension and dynamics

Gauthier, N. C., Masters, T. A. & Sheetz, M., Oct 1 2012, In : Trends in Cell Biology. 22, 10, p. 527-535 9 p.

Research output: Contribution to journalReview article

209 Scopus citations
2013

Integrin-dependent force transmission to the extracellular matrix by α-actinin triggers adhesion maturation

Roca-Cusachs, P., Del Rio, A., Puklin-Faucher, E., Gauthier, N. C., Biais, N. & Sheetz, M., Apr 9 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 15

Research output: Contribution to journalArticle

Open Access
151 Scopus citations
2016

α-Actinin links extracellular matrix rigidity-sensing contractile units with periodic cell-edge retractions

Meacci, G., Wolfenson, H., Liu, S., Stachowiak, M. R., Iskratsch, T., Mathur, A., Ghassemi, S., Gauthier, N., Tabdanov, E., Lohner, J., Gondarenko, A., Chander, A. C., Roca-Cusachs, P., O'Shaughnessy, B., Hone, J. & Sheetz, M., Nov 7 2016, In : Molecular Biology of the Cell. 27, 22, p. 3471-3479 9 p.

Research output: Contribution to journalArticle

35 Scopus citations
2013

Myosin 1E localizes to actin polymerization sites in lamellipodia, affecting actin dynamics and adhesion formation

Gupta, P., Gauthier, N. C., Cheng-Han, Y., Zuanning, Y., Pontes, B., Ohmstede, M., Martin, R., Knölker, H. J., Döbereiner, H. G., Krendel, M. & Sheetz, M., Jan 1 2013, In : Biology Open. 2, 12, p. 1-12 12 p.

Research output: Contribution to journalArticle

Open Access
16 Scopus citations
2018

Full control of ligand positioning reveals spatial thresholds for T cell receptor triggering

Cai, H., Muller, J., Depoil, D., Mayya, V., Sheetz, M., Dustin, M. L. & Wind, S. J., Jul 1 2018, In : Nature Nanotechnology. 13, 7, p. 610-617 8 p.

Research output: Contribution to journalArticle

23 Scopus citations
2016

The mechanical response of talin

Yao, M., Goult, B. T., Klapholz, B., Hu, X., Toseland, C. P., Guo, Y., Cong, P., Sheetz, M. & Yan, J., Jul 7 2016, In : Nature communications. 7, 11966.

Research output: Contribution to journalArticle

Open Access
95 Scopus citations
2017

Polymer fiber-based models of connective tissue repair and healing

Lee, N. M., Erisken, C., Iskratsch, T., Sheetz, M., Levine, W. N. & Lu, H. H., Jan 1 2017, In : Biomaterials. 112, p. 303-312 10 p.

Research output: Contribution to journalArticle

22 Scopus citations

MDia1 senses both force and torque during F-actin filament polymerization

Yu, M., Yuan, X., Lu, C., Le, S., Kawamura, R., Efremov, A. K., Zhao, Z., Kozlov, M. M., Sheetz, M., Bershadsky, A. & Yan, J., Dec 1 2017, In : Nature communications. 8, 1, 1650.

Research output: Contribution to journalArticle

Open Access
30 Scopus citations
2016

Cooperative vinculin binding to talin mapped by time-resolved super resolution microscopy

Hu, X., Jing, C., Xu, X., Nakazawa, N., Cornish, V. W., Margadant, F. M. & Sheetz, M., Jul 13 2016, In : Nano Letters. 16, 7, p. 4062-4068 7 p.

Research output: Contribution to journalArticle

Open Access
18 Scopus citations
2012

T lymphocyte myosin IIA is required for maturation of the immunological synapse

Kumari, S., Vardhana, S., Cammer, M., Curado, S., Santos, L., Sheetz, M. & Dustin, M. L., Dec 1 2012, In : Frontiers in immunology. 3, AUG, Article 230.

Research output: Contribution to journalArticle

Open Access
46 Scopus citations
2015

Parallel near-field photolithography with metal-coated elastomeric masks

Wu, J., Yu, C. H., Li, S., Zou, B., Liu, Y., Zhu, X., Guo, Y., Xu, H., Zhang, W., Zhang, L., Liu, B., Tian, D., Huang, W., Sheetz, M. & Huo, F., Jan 27 2015, In : Langmuir. 31, 3, p. 1210-1217 8 p.

Research output: Contribution to journalArticle

18 Scopus citations
2011

Temporary increase in plasma membrane tension coordinates the activation of exocytosis and contraction during cell spreading

Gauthier, N. C., Fardin, M. A., Roca-Cusachs, P. & Sheetz, M., Aug 30 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 35, p. 14467-14472 6 p.

Research output: Contribution to journalArticle

Open Access
171 Scopus citations

Nanolithographic control of the spatial organization of cellular adhesion receptors at the single-molecule level

Schvartzman, M., Palma, M., Sable, J., Abramson, J., Hu, X., Sheetz, M. & Wind, S. J., Mar 9 2011, In : Nano Letters. 11, 3, p. 1306-1312 7 p.

Research output: Contribution to journalArticle

147 Scopus citations
2016

Mechanosensing Controlled Directly by Tyrosine Kinases

Yang, B., Lieu, Z. Z., Wolfenson, H., Hameed, F. M., Bershadsky, A. D. & Sheetz, M., Sep 14 2016, In : Nano Letters. 16, 9, p. 5951-5961 11 p.

Research output: Contribution to journalArticle

37 Scopus citations

Nuclear transport of paxillin depends on focal adhesion dynamics and FAT domains

Sathe, A. R., Shivashankar, G. V. & Sheetz, M., May 15 2016, In : Journal of Cell Science. 129, 10, p. 1981-1988 8 p.

Research output: Contribution to journalArticle

Open Access
13 Scopus citations
2011

Signaling network triggers and membrane physical properties control the actin cytoskeleton-driven isotropic phase of cell spreading

Rangamani, P., Fardin, M. A., Xiong, Y., Lipshtat, A., Rossier, O., Sheetz, M. & Iyengar, R., Feb 16 2011, In : Biophysical Journal. 100, 4, p. 845-857 13 p.

Research output: Contribution to journalArticle

Open Access
21 Scopus citations
2012

Following nature’s challenges

Sheetz, M. & Kenan, W. R., Jan 1 2012, In : Nature Medicine. 18, 10, p. 1483-1485 3 p.

Research output: Contribution to journalArticle

Modularity and functional plasticity of scaffold proteins as p(l)acemakers in cell signaling

Pan, C. Q., Sudol, M., Sheetz, M. & Low, B. C., Nov 1 2012, In : Cellular Signalling. 24, 11, p. 2143-2165 23 p.

Research output: Contribution to journalReview article

Open Access
45 Scopus citations
2014

Can small institutes address some problems facing biomedical researchers?

Sheetz, M., Nov 1 2014, In : Molecular Biology of the Cell. 25, 21, p. 3267-3269 3 p.

Research output: Contribution to journalShort survey

2 Scopus citations
2011

Filamin depletion blocks endoplasmic spreading and destabilizes force-bearing adhesions

Lynch, C. D., Gauthier, N. C., Biais, N., Lazar, A. M., Roca-Cusachs, P., Yu, C. H. & Sheetz, M., Apr 15 2011, In : Molecular Biology of the Cell. 22, 8, p. 1263-1273 11 p.

Research output: Contribution to journalArticle

40 Scopus citations
2014

YAP/TAZ as mechanosensors and mechanotransducers in regulating organ size and tumor growth

Low, B. C., Pan, C. Q., Shivashankar, G. V., Bershadsky, A., Sudol, M. & Sheetz, M., Aug 19 2014, In : FEBS Letters. 588, 16, p. 2663-2670 8 p.

Research output: Contribution to journalReview article

Open Access
192 Scopus citations
2012

The role of feature curvature in contact guidance

Mathur, A., Moore, S. W., Sheetz, M. & Hone, J., Jul 1 2012, In : Acta Biomaterialia. 8, 7, p. 2595-2601 7 p.

Research output: Contribution to journalArticle

33 Scopus citations

Spatial-temporal reorganization of activated integrins

Yu, C. H., Luo, W. & Sheetz, M., Jan 1 2012, In : Cell Adhesion and Migration. 6, 3, p. 280-284 5 p.

Research output: Contribution to journalReview article

Open Access
11 Scopus citations
2015

Early events in cell spreading as a model for quantitative analysis of biomechanical events

Wolfenson, H., Iskratsch, T. & Sheetz, M., Aug 2 2015, In : Biophysical Journal. 107, 11, p. 2508-2514 7 p.

Research output: Contribution to journalReview article

Open Access
24 Scopus citations
2016

F-actin waves, actin cortex disassembly and focal exocytosis driven by actin-phosphoinositide positive feedback

Masters, T. A., Sheetz, M. & Gauthier, N. C., Apr 1 2016, In : Cytoskeleton. 73, 4, p. 180-196 17 p.

Research output: Contribution to journalArticle

10 Scopus citations
2018

EGFR family and Src family kinase interactions: mechanics matters?

Chen, Z., Oh, D., Dubey, A. K., Yao, M., Yang, B., Groves, J. T. & Sheetz, M., Apr 1 2018, In : Current Opinion in Cell Biology. 51, p. 97-102 6 p.

Research output: Contribution to journalReview article

14 Scopus citations
2016

Cell contractility arising from topography and shear flow determines human mesenchymal stem cell fate

Sonam, S., Sathe, S. R., Yim, E. K. F., Sheetz, M. & Lim, C. T., Feb 16 2016, In : Scientific reports. 6, 20415.

Research output: Contribution to journalArticle

Open Access
31 Scopus citations

Molecular Occupancy of Nanodot Arrays

Cai, H., Wolfenson, H., Depoil, D., Dustin, M. L., Sheetz, M. & Wind, S. J., Apr 26 2016, In : ACS Nano. 10, 4, p. 4173-4183 11 p.

Research output: Contribution to journalArticle

17 Scopus citations
2013

Toward a modular analysis of cell mechanosensing and mechanotransduction: A manual for cell mechanics

Dubin-Thaler, B. J. & Sheetz, M., Jan 1 2013, Cellular Mechanotransduction: Diverse Perspectives from Molecules to Tissues. Cambridge University Press, Vol. 9780521895231. p. 181-195 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2014

Appreciating force and shape-the rise of mechanotransduction in cell biology

Iskratsch, T., Wolfenson, H. & Sheetz, M., Dec 11 2014, In : Nature Reviews Molecular Cell Biology. 15, 12, p. 825-833 9 p.

Research output: Contribution to journalReview article

269 Scopus citations
2013

Bifunctional nanoarrays for probing the immune response at the single-molecule level

Cai, H., Depoil, D., Palma, M., Sheetz, M., Dustin, M. L. & Wind, S. J., Nov 1 2013, In : Journal of Vacuum Science and Technology B: Microelectronics and Nanometer Structures. 31, 6, 6F902.

Research output: Contribution to journalArticle

12 Scopus citations
2011

Selective biomolecular nanoarrays for parallel single-molecule investigations

Palma, M., Abramson, J. J., Gorodetsky, A. A., Penzo, E., Gonzalez, R. L., Sheetz, M., Nuckolls, C., Hone, J. & Wind, S. J., May 25 2011, In : Journal of the American Chemical Society. 133, 20, p. 7656-7659 4 p.

Research output: Contribution to journalArticle

31 Scopus citations
2013

Substrate topography and size determine the fate of human embryonic stem cells to neuronal or glial lineage

Ankam, S., Suryana, M., Chan, L. Y., Moe, A. A. K., Teo, B. K. K., Law, J. B. K., Sheetz, M., Low, H. Y. & Yim, E. K. F., Jan 1 2013, In : Acta Biomaterialia. 9, 1, p. 4535-4545 11 p.

Research output: Contribution to journalArticle

94 Scopus citations

Heart extracellular matrix supports cardiomyocyte differentiation of mouse embryonic stem cells

Higuchi, S., Lin, Q., Wang, J., Lim, T. K., Joshi, S. B., Anand, G. S., Chung, M. C. M., Sheetz, M. & Fujita, H., Mar 1 2013, In : Journal of Bioscience and Bioengineering. 115, 3, p. 320-325 6 p.

Research output: Contribution to journalArticle

31 Scopus citations
2019

Myosin IIA and formin dependent mechanosensitivity of filopodia adhesion

Alieva, N. O., Efremov, A. K., Hu, S., Oh, D., Chen, Z., Natarajan, M., Ong, H. T., Jégou, A., Romet-Lemonne, G., Groves, J. T., Sheetz, M., Yan, J. & Bershadsky, A. D., Dec 1 2019, In : Nature communications. 10, 1, 3593.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations
2015

Mechanobiology

Shivashankar, G. V., Sheetz, M. & Matsudaira, P., Oct 1 2015, In : Integrative Biology (United Kingdom). 7, 10, p. 1091-1092 2 p.

Research output: Contribution to journalEditorial

3 Scopus citations
2017

DNA damage causes rapid accumulation of phosphoinositides for ATR signaling

Wang, Y. H., Hariharan, A., Bastianello, G., Toyama, Y., Shivashankar, G. V., Foiani, M. & Sheetz, M. P., Dec 1 2017, In : Nature communications. 8, 1, 2118.

Research output: Contribution to journalArticle

Open Access
20 Scopus citations
2018

Erratum: Cardiomyocytes Sense Matrix Rigidity through a Combination of Muscle and Non-muscle Myosin Contractions (Developmental cell (2018) 44 3 (326-336.e3) PII: S1534-5807(18)30409-X)

Pandey, P., Hawkes, W., Hu, J., Megone, W. V., Gautrot, J., Anilkumar, N., Zhang, M., Hirvonen, L., Cox, S., Ehler, E., Hone, J., Sheetz, M. & Iskratsch, T., Jun 4 2018, In : Developmental cell. 45, 5, 1 p.

Research output: Contribution to journalComment/debate

Open Access
2017

Integrin and cadherin clusters: A robust way to organize adhesions for cell mechanics

Changede, R. & Sheetz, M., Jan 1 2017, In : BioEssays. 39, 1, p. 1-12 12 p.

Research output: Contribution to journalArticle

Open Access
33 Scopus citations
2019

Large and reversible myosin-dependent forces in rigidity sensing

Lohner, J., Rupprecht, J. F., Hu, J., Mandriota, N., Saxena, M., de Araujo, D. P., Hone, J., Sahin, O., Prost, J. & Sheetz, M., Jul 1 2019, In : Nature Physics. 15, 7, p. 689-695 7 p.

Research output: Contribution to journalArticle

4 Scopus citations
2013

FHOD1 is needed for directed forces and adhesion maturation during cell spreading and migration

Iskratsch, T., Yu, C. H., Mathur, A., Liu, S., Stévenin, V., Dwyer, J., Hone, J., Ehler, E. & Sheetz, M., Dec 9 2013, In : Developmental Cell. 27, 5, p. 545-559 15 p.

Research output: Contribution to journalArticle

Open Access
59 Scopus citations

Mechanical perturbation of filamin A immunoglobulin repeats 20-21 reveals potential non-equilibrium mechanochemical partner binding function

Chen, H., Chandrasekar, S., Sheetz, M., Stossel, T. P., Nakamura, F. & Yan, J., Apr 10 2013, In : Scientific reports. 3, 01642.

Research output: Contribution to journalArticle

Open Access
27 Scopus citations
2012

Force-dependent cell signaling in stem cell differentiation

Yim, E. K. F. & Sheetz, M., Nov 6 2012, In : Stem Cell Research and Therapy. 3, 5, 41.

Research output: Contribution to journalReview article

Open Access
85 Scopus citations