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  • Chad Mire
2016

Treatment of Lassa virus infection in outbred guinea pigs with first-in-class human monoclonal antibodies

Cross, R., Mire, C., Branco, L. M., Geisbert, J. B., Rowland, M. M., Heinrich, M. L., Goba, A., Momoh, M., Grant, D. S., Fullah, M., Khan, S. H., Robinson, J. E., Geisbert, T. & Garry, R. F., Sep 1 2016, In : Antiviral Research. 133, p. 218-222 5 p.

Research output: Contribution to journalArticle

26 Scopus citations
2017

Disposable cartridge platform for rapid detection of viral hemorrhagic fever viruses

Scherr, S. M., Freedman, D. S., Agans, K. N., Rosca, A., Carter, E., Kuroda, M., Fawcett, H. E., Mire, C. E., Geisbert, T. W., Ünlü, M. S. & Connor, J. H., Mar 7 2017, In : Lab on a Chip. 17, 5, p. 917-925 9 p.

Research output: Contribution to journalArticle

9 Scopus citations
2014

Viral-vectored vaccines to control pathogenic filoviruses

Mire, C. & Geisbert, T., Jul 1 2014, Novel Technologies for Vaccine Development. Springer-Verlag Wien, Vol. 9783709118184. p. 33-60 28 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations
2015

Modeling the Disease Course of Zaire ebolavirus Infection in the Outbred Guinea Pig

Cross, R., Fenton, K. A., Geisbert, J. B., Mire, C. & Geisbert, T., Oct 1 2015, In : Journal of Infectious Diseases. 212, p. S305-S315

Research output: Contribution to journalArticle

29 Scopus citations

Lipid nanoparticle siRNA treatment of Ebola-virus-Makona-infected nonhuman primates

Thi, E. P., Mire, C., Lee, A. C. H., Geisbert, J. B., Zhou, J. Z., Agans, K. N., Snead, N. M., Deer, D. J., Barnard, T. R., Fenton, K. A., Maclachlan, I. & Geisbert, T., May 21 2015, In : Nature. 521, 7552, p. 362-365 4 p.

Research output: Contribution to journalArticle

151 Scopus citations
2019

Current Ebola Virus Vaccine Progress

Marzi, A. & Mire, C., Jan 1 2019, (Accepted/In press) In : BioDrugs.

Research output: Contribution to journalArticle

10 Scopus citations
2018

Efficacy of Human Monoclonal Antibody Monotherapy Against Bundibugyo Virus Infection in Nonhuman Primates

Gilchuk, P., Mire, C., Geisbert, J. B., Agans, K. N., Deer, D. J., Cross, R., Slaughter, J. C., Flyak, A. I., Mani, J., Pauly, M. H., Velasco, J., Whaley, K. J., Zeitlin, L., Geisbert, T. & Crowe, J. E., Nov 22 2018, In : The Journal of infectious diseases. 218, 5, p. S565-S573

Research output: Contribution to journalArticle

1 Scopus citations
2011

The protease-sensitive loop of the vesicular stomatitis virus matrix protein is involved in virus assembly and protein translation

Mire, C. E. & Whitt, M. A., Jul 20 2011, In : Virology. 416, 1-2, p. 16-25 10 p.

Research output: Contribution to journalArticle

10 Scopus citations
2016

The domestic ferret (mustela putorius furo) as a lethal infection model for 3 species of ebolavirus

Cross, R., Mire, C., Borisevich, V., Geisbert, J. B., Fenton, K. A. & Geisbert, T., Aug 15 2016, In : Journal of Infectious Diseases. 214, 4, p. 565-569 5 p.

Research output: Contribution to journalArticle

40 Scopus citations
2013

Single injection recombinant vesicular stomatitis virus vaccines protect ferrets against lethal Nipah virus disease

Mire, C. E., Versteeg, K. M., Cross, R. W., Agans, K. N., Fenton, K. A., Whitt, M. A. & Geisbert, T. W., Dec 13 2013, In : Virology journal. 10, 353.

Research output: Contribution to journalArticle

35 Scopus citations
2017

Neutralizing the Threat: Pan-Ebolavirus Antibodies Close the Loop

Mire, C. & Geisbert, T., Aug 1 2017, In : Trends in Molecular Medicine. 23, 8, p. 669-671 3 p.

Research output: Contribution to journalShort survey

6 Scopus citations
2011

Utilization of fluorescently-labeled tetracysteine-tagged proteins to study virus entry by live cell microscopy

Whitt, M. A. & Mire, C. E., Oct 2011, In : Methods. 55, 2, p. 127-136 10 p.

Research output: Contribution to journalReview article

18 Scopus citations
2014

A recombinant Hendra Virus G glycoprotein subunit vaccine protects nonhuman primates against hendra virus challenge

Mire, C. E., Geisbert, J. B., Agans, K. N., Feng, Y. R., Fenton, K. A., Bossart, K. N., Yan, L., Chan, Y. P., Broder, C. C. & Geisbert, T. W., May 2014, In : Journal of virology. 88, 9, p. 4624-4631 8 p.

Research output: Contribution to journalArticle

23 Scopus citations
2017

Evaluation of medical countermeasures against ebolaviruses in nonhuman primate models

Mire, C. & Geisbert, T., 2017, Methods in Molecular Biology. Humana Press Inc., Vol. 1628. p. 293-307 15 p. (Methods in Molecular Biology; vol. 1628).

Research output: Chapter in Book/Report/Conference proceedingChapter

2016

Ebola virus vaccines – reality or fiction?

Mire, C., Geisbert, T., Feldmann, H. & Marzi, A., Nov 1 2016, In : Expert Review of Vaccines. 15, 11, p. 1421-1430 10 p.

Research output: Contribution to journalReview article

22 Scopus citations
2018

Postexposure Efficacy of Recombinant Vesicular Stomatitis Virus Vectors Against High and Low Doses of Marburg Virus Variant Angola in Nonhuman Primates

Woolsey, C., Geisbert, J. B., Matassov, D., Agans, K. N., Borisevich, V., Cross, R., Deer, D. J., Fenton, K. A., Eldridge, J. H., Mire, C. & Geisbert, T., Nov 22 2018, In : The Journal of infectious diseases. 218, 5, p. S582-S587

Research output: Contribution to journalArticle

5 Scopus citations
2014

Protection against lethal marburg virus infection mediated by lipid encapsulated small interfering RNA

Ursic-Bedoya, R., Mire, C. E., Robbins, M., Geisbert, J. B., Judge, A., MacLachlan, I. & Geisbert, T. W., Feb 15 2014, In : Journal of Infectious Diseases. 209, 4, p. 562-570 9 p.

Research output: Contribution to journalArticle

31 Scopus citations
2020

Resistance of Cynomolgus Monkeys to Nipah and Hendra Virus Disease Is Associated with Cell-Mediated and Humoral Immunity

Prasad, A. N., Woolsey, C., Geisbert, J. B., Agans, K. N., Borisevich, V., Deer, D. J., Mire, C. E., Cross, R. W., Fenton, K. A., Broder, C. C. & Geisbert, T. W., May 11 2020, In : Journal of Infectious Diseases. 221, p. S436-S447

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2015

A Single-Vector, Single-Injection Trivalent Filovirus Vaccine: Proof of Concept Study in Outbred Guinea Pigs

Mire, C. E., Geisbert, J. B., Versteeg, K. M., Mamaeva, N., Agans, K. N., Geisbert, T. W. & Connor, J. H., Oct 1 2015, In : Journal of Infectious Diseases. 212, p. S384-S388

Research output: Contribution to journalArticle

21 Scopus citations
2020

An Intranasal Exposure Model of Lethal Nipah Virus Infection in African Green Monkeys

Geisbert, J. B., Borisevich, V., Prasad, A. N., Agans, K. N., Foster, S. L., Deer, D. J., Cross, R. W., Mire, C. E., Geisbert, T. W. & Fenton, K. A., May 11 2020, In : Journal of Infectious Diseases. 221, p. S414-S418

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
2019

Author Correction: Infection with the Makona variant results in a delayed and distinct host immune response compared to previous Ebola virus variants (Scientific Reports, (2017), 7, 1, (9730), 10.1038/s41598-017-09963-y)

Versteeg, K., Menicucci, A. R., Woolsey, C., Mire, C., Geisbert, J. B., Cross, R., Agans, K. N., Jeske, D., Messaoudi, I. & Geisbert, T., Dec 1 2019, In : Scientific reports. 9, 1, 7329.

Research output: Contribution to journalComment/debate

Open Access

The FDA-Approved Oral Drug Nitazoxanide Amplifies Host Antiviral Responses and Inhibits Ebola Virus

Jasenosky, L. D., Cadena, C., Mire, C. E., Borisevich, V., Haridas, V., Ranjbar, S., Nambu, A., Bavari, S., Soloveva, V., Sadukhan, S., Cassell, G. H., Geisbert, T. W., Hur, S. & Goldfeld, A. E., Sep 27 2019, In : iScience. 19, p. 1279-1290 12 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations
2014

Vaccines and antivirals for filoviruses

Mire, C. & Geisbert, T., Jan 1 2014, Biology and Pathogenesis of Rhabdo- and Filoviruses. World Scientific Publishing Co., p. 587-620 34 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations
2013

Vesicular Stomatitis Virus-Based Vaccines Protect Nonhuman Primates against Bundibugyo ebolavirus

Mire, C. E., Geisbert, J. B., Marzi, A., Agans, K. N., Feldmann, H. & Geisbert, T. W., 2013, In : PLoS neglected tropical diseases. 7, 12, e2600.

Research output: Contribution to journalArticle

54 Scopus citations
2016

Rescue of non-human primates from advanced Sudan ebolavirus infection with lipid encapsulated siRNA

Thi, E. P., Lee, A. C. H., Geisbert, J. B., Ursic-Bedoya, R., Agans, K. N., Robbins, M., Deer, D. J., Fenton, K. A., Kondratowicz, A. S., MacLachlan, I., Geisbert, T. & Mire, C., Aug 22 2016, In : Nature Microbiology. 1, 16142.

Research output: Contribution to journalArticle

18 Scopus citations
2014

Deep sequencing identifies noncanonical editing of Ebola and Marburg virus RNAS in infected cells

Shabman, R. S., Jabado, O. J., Mire, C. E., Stockwell, T. B., Edwards, M., Mahajan, M., Geisbert, T. W. & Basler, C. F., Sep 25 2014, In : mBio. 5, 6, e02011-14.

Research output: Contribution to journalArticle

43 Scopus citations
2017

Transcriptome analysis of circulating immune cell subsets highlight the role of monocytes in Zaire Ebola Virus Makona pathogenesis

Menicucci, A. R., Versteeg, K., Woolsey, C., Mire, C., Geisbert, J. B., Cross, R., Agans, K. N., Jankeel, A., Geisbert, T. & Messaoudi, I., Oct 4 2017, In : Frontiers in Immunology. 8, OCT, 1372.

Research output: Contribution to journalArticle

15 Scopus citations
2016

The synthetic antiviral drug arbidol inhibits globally prevalent pathogenic viruses

Pécheur, E. I., Borisevich, V., Halfmann, P., Morrey, J. D., Smee, D. F., Prichard, M., Mire, C. E., Kawaoka, Y., Geisbert, T. W. & Polyak, S. J., 2016, In : Journal of virology. 90, 6, p. 3086-3092 7 p.

Research output: Contribution to journalArticle

34 Scopus citations
2015

Single-dose attenuated Vesiculovax vaccines protect primates against Ebola Makona virus

Mire, C., Matassov, D., Geisbert, J. B., Latham, T. E., Agans, K. N., Xu, R., Ota-Setlik, A., Egan, M. A., Fenton, K. A., Clarke, D. K., Eldridge, J. H. & Geisbert, T., Apr 30 2015, In : Nature. 520, 7549, p. 688-691 4 p.

Research output: Contribution to journalArticle

66 Scopus citations
2016

Isolation and characterization of a novel gammaherpesvirus from a microbat cell line

Shabman, R. S., Shrivastava, S., Tsibane, T., Attie, O., Jayaprakash, A., Mire, C. E., Dilley, K. E., Puri, V., Stockwell, T. B., Geisbert, T. W., Sachidanandam, R. & Basler, C. F., Jan 1 2016, In : mSphere. 1, 1, e00070-15.

Research output: Contribution to journalArticle

10 Scopus citations
2020

A Lethal Aerosol Exposure Model of Nipah Virus Strain Bangladesh in African Green Monkeys

Prasad, A. N., Agans, K. N., Sivasubramani, S. K., Geisbert, J. B., Borisevich, V., Mire, C. E., Lawrence, W. S., Fenton, K. A. & Geisbert, T. W., May 11 2020, In : Journal of Infectious Diseases. 221, p. S431-S435

Research output: Contribution to journalArticle

1 Scopus citations
2017

Human-monoclonal-antibody therapy protects nonhuman primates against advanced Lassa fever

Mire, C. E., Cross, R. W., Geisbert, J. B., Borisevich, V., Agans, K. N., Deer, D. J., Heinrich, M. L., Rowland, M. M., Goba, A., Momoh, M., Boisen, M. L., Grant, D. S., Fullah, M., Khan, S. H., Fenton, K. A., Robinson, J. E., Branco, L. M., Garry, R. F. & Geisbert, T. W., Oct 1 2017, In : Nature Medicine. 23, 10, p. 1146-1149 4 p.

Research output: Contribution to journalArticle

35 Scopus citations
2018

Erratum: Correction for Olsen et al., "Polyamines and Hypusination Are Required for Ebolavirus Gene Expression and Replication" (mBio (2016) 7 4 PII: e01065-18)

Olsen, M. E., Filone, C. M., Rozelle, D., Mire, C. E., Agans, K. N., Hensley, L. & Connor, J. H., Jun 5 2018, In : mBio. 9, 3

Research output: Contribution to journalComment/debate

Open Access
2015

Current and emerging strategies for the diagnosis, prevention and treatment of Lassa fever

Hartnett, J. N., Boisen, M. L., Oottamasathien, D., Jones, A. B., Millett, M. M., Nelson, D. S., Muncy, I. J., Goba, A., Momoh, M., Fullah, M., Mire, C. E., Geisbert, J. B., Geisbert, T. W., Holton, D. L., Rouelle, J. A., Kannadka, C. B., Reyna, A. A., Moses, L. M., Khan, S. H., Gevao, S. M. & 6 others, Grant, D. S., Robinson, J. E., Happi, C., Pitts, K. R., Garry, R. F. & Branco, L. M., May 1 2015, In : Future Virology. 10, 5, p. 559-584 26 p.

Research output: Contribution to journalReview article

9 Scopus citations
2016

Pathogenic Differences between Nipah Virus Bangladesh and Malaysia Strains in Primates: Implications for Antibody Therapy

Mire, C., Satterfield, B. A., Geisbert, J. B., Agans, K. N., Borisevich, V., Yan, L., Chan, Y. P., Cross, R., Fenton, K. A., Broder, C. C. & Geisbert, T., Aug 3 2016, In : Scientific Reports. 6, 30916.

Research output: Contribution to journalArticle

38 Scopus citations
2018

Marburg and Ravn Viruses Fail to Cause Disease in the Domestic Ferret (Mustela putorius furo)

Cross, R., Mire, C., Agans, K. N., Borisevich, V., Fenton, K. A. & Geisbert, T., Nov 22 2018, In : The Journal of infectious diseases. 218, 5, p. S448-S452

Research output: Contribution to journalArticle

6 Scopus citations
2017

Infection with the Makona variant results in a delayed and distinct host immune response compared to previous Ebola virus variants

Versteeg, K., Menicucci, A. R., Woolsey, C., Mire, C., Geisbert, J. B., Cross, R., Agans, K. N., Jeske, D., Messaoudi, I. & Geisbert, T., Dec 1 2017, In : Scientific Reports. 7, 1, 9730.

Research output: Contribution to journalArticle

12 Scopus citations
2015

Aerosolized Ebola vaccine protects primates and elicits lung-resident T cell responses

Meyer, M., Garron, T., Lubaki, N. M., Mire, C., Fenton, K. A., Klages, C., Olinger, G. G., Geisbert, T., Collins, P. L. & Bukreyev, A., Aug 3 2015, In : Journal of Clinical Investigation. 125, 8, p. 3241-3255 15 p.

Research output: Contribution to journalArticle

43 Scopus citations
2012

Recombinant vesicular stomatitis virus vaccine vectors expressing filovirus glycoproteins lack neurovirulence in nonhuman primates

Mire, C. E., Miller, A. D., Carville, A., Westmoreland, S. V., Geisbert, J. B., Mansfield, K. G., Feldmann, H., Hensley, L. E. & Geisbert, T. W., Mar 2012, In : PLoS neglected tropical diseases. 6, 3, e1567.

Research output: Contribution to journalArticle

66 Scopus citations
2016

Inhibition of the host antiviral response by Nipah virus: Current understanding and future perspectives

Satterfield, B. A., Geisbert, T. & Mire, C., May 1 2016, In : Future Virology. 11, 5, p. 331-344 14 p.

Research output: Contribution to journalArticle

5 Scopus citations
2014

Marburg virus infection in nonhuman primates: Therapeutic treatment by lipid-encapsulated siRNA

Thi, E. P., Mire, C. E., Ursic-Bedoya, R., Geisbert, J. B., Lee, A. C. H., Agans, K. N., Robbins, M., Deer, D. J., Fenton, K. A., MacLachlan, I. & Geisbert, T. W., Aug 20 2014, In : Science Translational Medicine. 6, 250, 250ra116.

Research output: Contribution to journalArticle

47 Scopus citations

Therapeutic treatment of Nipah virus infection in nonhuman primates with a neutralizing human monoclonal antibody

Geisbert, T. W., Mire, C. E., Geisbert, J. B., Chan, Y. P., Agans, K. N., Feldmann, F., Fenton, K. A., Zhu, Z., Dimitrov, D. S., Scott, D. P., Bossart, K. N., Feldmann, H. & Broder, C. C., Jun 25 2014, In : Science Translational Medicine. 6, 242, 242ra82.

Research output: Contribution to journalArticle

56 Scopus citations
2020

Analysis of a Therapeutic Antibody Cocktail Reveals Determinants for Cooperative and Broad Ebolavirus Neutralization

Gilchuk, P., Murin, C. D., Milligan, J. C., Cross, R. W., Mire, C. E., Ilinykh, P. A., Huang, K., Kuzmina, N., Altman, P. X., Hui, S., Gunn, B. M., Bryan, A. L., Davidson, E., Doranz, B. J., Turner, H. L., Alkutkar, T., Flinko, R., Orlandi, C., Carnahan, R., Nargi, R. & 13 others, Bombardi, R. G., Vodzak, M. E., Li, S., Okoli, A., Ibeawuchi, M., Ohiaeri, B., Lewis, G. K., Alter, G., Bukreyev, A., Saphire, E. O., Geisbert, T. W., Ward, A. B. & Crowe, J. E., Feb 18 2020, In : Immunity. 52, 2, p. 388-403.e12

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
2019

An antibody against the F glycoprotein inhibits Nipah and Hendra virus infections

Dang, H. V., Chan, Y. P., Park, Y. J., Snijder, J., Da Silva, S. C., Vu, B., Yan, L., Feng, Y. R., Rockx, B., Geisbert, T. W., Mire, C. E., Broder, C. C. & Veesler, D., Oct 1 2019, In : Nature Structural and Molecular Biology. 26, 10, p. 980-987 8 p.

Research output: Contribution to journalArticle

5 Scopus citations
2015

Vaccination with a Highly Attenuated Recombinant Vesicular Stomatitis Virus Vector Protects Against Challenge with a Lethal Dose of Ebola Virus

Matassov, D., Marzi, A., Latham, T., Xu, R., Ota-Setlik, A., Feldmann, F., Geisbert, J. B., Mire, C. E., Hamm, S., Nowak, B., Egan, M. A., Geisbert, T. W., Eldridge, J. H., Feldmann, H. & Clarke, D. K., Oct 1 2015, In : Journal of Infectious Diseases. 212, p. S443-S451

Research output: Contribution to journalArticle

31 Scopus citations
2016

Oral and Conjunctival Exposure of Nonhuman Primates to Low Doses of Ebola Makona Virus

Mire, C., Geisbert, J. B., Agans, K. N., Deer, D. J., Fenton, K. A. & Geisbert, T., Oct 15 2016, In : Journal of Infectious Diseases. 214, p. S263-S267

Research output: Contribution to journalArticle

13 Scopus citations
2014

Durability of a vesicular stomatitis virus-based marburg virus vaccine in nonhuman primates

Mire, C. E., Geisbert, J. B., Agans, K. N., Satterfield, B. A., Versteeg, K. M., Fritz, E. A., Feldmann, H., Hensley, L. E. & Geisbert, T. W., Apr 23 2014, In : PloS one. 9, 4, e94355.

Research output: Contribution to journalArticle

41 Scopus citations
2019

Antibody therapy for Lassa fever

Cross, R. W., Hastie, K. M., Mire, C. E., Robinson, J. E., Geisbert, T. W., Branco, L. M., Ollmann Saphire, E. & Garry, R. F., Aug 2019, In : Current Opinion in Virology. 37, p. 97-104 8 p.

Research output: Contribution to journalReview article

2016

Polyamines and hypusination are required for ebolavirus gene expression and replication

Olsen, M. E., Filone, C. M., Rozelle, D., Mire, C. E., Agans, K. N., Hensley, L. & Connor, J. H., Jul 1 2016, In : mBio. 7, 4, e00882-16.

Research output: Contribution to journalArticle

22 Scopus citations
2019

A Two-Antibody Pan-Ebolavirus Cocktail Confers Broad Therapeutic Protection in Ferrets and Nonhuman Primates

Bornholdt, Z. A., Herbert, A. S., Mire, C. E., He, S., Cross, R. W., Wec, A. Z., Abelson, D. M., Geisbert, J. B., James, R. M., Rahim, M. N., Zhu, W., Borisevich, V., Banadyga, L., Gunn, B. M., Agans, K. N., Wirchnianski, A. S., Goodwin, E., Tierney, K., Shestowsky, W. S., Bohorov, O. & 13 others, Bohorova, N., Velasco, J., Ailor, E., Kim, D., Pauly, M. H., Whaley, K. J., Alter, G., Walker, L. M., Chandran, K., Zeitlin, L., Qiu, X., Geisbert, T. W. & Dye, J. M., Jan 9 2019, In : Cell Host and Microbe. 25, 1, p. 49-58.e5

Research output: Contribution to journalArticle

16 Scopus citations