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  • Satya Prakash
2014

A role for DNA polymerase θ in promoting replication through oxidative DNA lesion, thymine glycol, in human cells

Yoon, J. H., Choudhury, J. R., Park, J., Prakash, S. & Prakash, L., Jan 1 2014, In : Journal of Biological Chemistry. 289, 19, p. 13177-13185 9 p.

Research output: Contribution to journalArticle

31 Scopus citations
2016

Human DNA polymerase α in binary complex with a DNA: DNA template-primer

Coloma, J., Johnson, R. E., Prakash, L., Prakash, S. & Aggarwal, A. K., Apr 1 2016, In : Scientific Reports. 6, 23784.

Research output: Contribution to journalArticle

13 Scopus citations
2014

Identification of two functional PCNA-binding domains in human DNA polymerase κ

Yoon, J. H., Acharya, N., Park, J., Basu, D., Prakash, S. & Prakash, L., Jul 2014, In : Genes to Cells. 19, 7, p. 594-601 8 p.

Research output: Contribution to journalArticle

12 Scopus citations
2012
16 Scopus citations
2018

Structural basis for polymerase η–promoted resistance to the anticancer nucleoside analog cytarabine

Rechkoblit, O., Choudhury, J. R., Buku, A., Prakash, L., Prakash, S. & Aggarwal, A. K., Dec 1 2018, In : Scientific Reports. 8, 1, 12702.

Research output: Contribution to journalArticle

3 Scopus citations
2011

Role of human DNA polymerase κ in extension opposite from a cis-syn thymine dimer

Vasquez-Del Carpio, R., Silverstein, T. D., Lone, S., Johnson, R. E., Prakash, L., Prakash, S. & Aggarwal, A. K., Apr 29 2011, In : Journal of Molecular Biology. 408, 2, p. 252-261 10 p.

Research output: Contribution to journalArticle

14 Scopus citations
2018

Genetic control of predominantly error-free replication through an acrolein-derived minor-groove DNA adduct

Yoon, J. H., Hodge, R. P., Hackfeld, L. C., Park, J., Choudhury, J. R., Prakash, S. & Prakash, L., Jan 1 2018, In : Journal of Biological Chemistry. 293, 8, p. 2949-2958 10 p.

Research output: Contribution to journalArticle

2 Scopus citations
2019

DNA polymerase θ accomplishes translesion synthesis opposite 1, N 6 -ethenodeoxyadenosine with a remarkably high fidelity in human cells

Yoon, J. H., Johnson, R. E., Prakash, L. & Prakash, S., Mar 1 2019, In : Genes and Development. 33, 5-6, p. 282-287 6 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
2012
103 Scopus citations
4 Scopus citations
2019

Translesion synthesis DNA polymerases η, ι, and ν promote mutagenic replication through the anticancer nucleoside cytarabine

Yoon, J. H., Choudhury, J. R., Prakash, L. & Prakash, S., Dec 13 2019, In : Journal of Biological Chemistry. 294, 50, p. 19048-19054 7 p.

Research output: Contribution to journalArticle

2015

Rev1 promotes replication through UV lesions in conjunction with DNA polymerases η, ι, and κ but not DNA polymerase ζ

Yoon, J. H., Park, J., Conde, J., Wakamiya, M., Prakash, L. & Prakash, S., Dec 15 2015, In : Genes and Development. 29, 24, p. 2588-2602 15 p.

Research output: Contribution to journalArticle

20 Scopus citations
2013

The Architecture of Yeast DNA Polymerase ζ

Gómez-Llorente, Y., Malik, R., Jain, R., Choudhury, J. R., Johnson, R. E., Prakash, L., Prakash, S., Ubarretxena-Belandia, I. & Aggarwal, A. K., Oct 17 2013, In : Cell Reports. 5, 1, p. 79-86 8 p.

Research output: Contribution to journalArticle

21 Scopus citations
2016

Structure and mechanism of human PrimPol, a DNA polymerase with primase activity

Rechkoblit, O., Gupta, Y. K., Malik, R., Rajashankar, K. R., Johnson, R. E., Prakash, L., Prakash, S. & Aggarwal, A. K., Oct 1 2016, In : Science advances. 2, 10, e1601317.

Research output: Contribution to journalArticle

28 Scopus citations
2017

Translesion synthesis DNA polymerases promote error-free replication through the minor-groove DNA adduct 3-deaza-3-methyladenine

Yoon, J. H., Choudhury, J. R., Park, J., Prakash, S. & Prakash, L., Nov 10 2017, In : Journal of Biological Chemistry. 292, 45, p. 18682-18688 7 p.

Research output: Contribution to journalArticle

7 Scopus citations
2014

Crystal structure of yeast DNA polymerase ε catalytic domain

Jain, R., Rajashankar, K. R., Buku, A., Johnson, R. E., Prakash, L., Prakash, S. & Aggarwal, A. K., Apr 14 2014, In : PloS one. 9, 4, e94835.

Research output: Contribution to journalArticle

21 Scopus citations
2016

Response to Burgers et al.

Johnson, R. E., Klassen, R., Prakash, L. & Prakash, S., Feb 18 2016, In : Molecular Cell. 61, 4, p. 494-495 2 p.

Research output: Contribution to journalArticle

5 Scopus citations
2014

An iron-sulfur cluster in the polymerase domain of yeast DNA polymerase ε

Jain, R., Vanamee, E. S., Dzikovski, B. G., Buku, A., Johnson, R. E., Prakash, L., Prakash, S. & Aggarwal, A. K., Jan 23 2014, In : Journal of Molecular Biology. 426, 2, p. 301-308 8 p.

Research output: Contribution to journalArticle

22 Scopus citations
2019

Cryo-EM structure and dynamics of eukaryotic DNA polymerase δ holoenzyme

Jain, R., Rice, W. J., Malik, R., Johnson, R. E., Prakash, L., Prakash, S., Ubarretxena-Belandia, I. & Aggarwal, A. K., Oct 1 2019, In : Nature Structural and Molecular Biology. 26, 10, p. 955-962 8 p.

Research output: Contribution to journalArticle

2 Scopus citations
2017

Mechanism of error-free DNA synthesis across N1-methyl-deoxyadenosine by human DNA polymerase-l

Jain, R., Choudhury, J. R., Buku, A., Johnson, R. E., Prakash, L., Prakash, S. & Aggarwal, A. K., Mar 8 2017, In : Scientific reports. 7, 43904.

Research output: Contribution to journalArticle

7 Scopus citations
2011

PCNA binding domains in all three subunits of yeast DNA polymerase δ modulate its function in DNA replication

Acharya, N., Klassen, R., Johnson, R. E., Prakash, L. & Prakash, S., Nov 1 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 44, p. 17927-17932 6 p.

Research output: Contribution to journalArticle

38 Scopus citations
2015

Genetic control of replication through N1-methyladenine in human cells

Conde, J., Yoon, J. H., Choudhury, J. R., Prakash, L. & Prakash, S., Dec 11 2015, In : Journal of Biological Chemistry. 290, 50, p. 29794-29800 7 p.

Research output: Contribution to journalArticle

11 Scopus citations
2012

Human DNA polymerase η is pre-aligned for dNTP binding and catalysis

Ummat, A., Silverstein, T. D., Jain, R., Buku, A., Johnson, R. E., Prakash, L., Prakash, S. & Aggarwal, A. K., Jan 27 2012, In : Journal of Molecular Biology. 415, 4, p. 627-634 8 p.

Research output: Contribution to journalArticle

26 Scopus citations
2015

A Major Role of DNA Polymerase δ in Replication of Both the Leading and Lagging DNA Strands

Johnson, R. E., Klassen, R., Prakash, L. & Prakash, S., Jul 16 2015, In : Molecular Cell. 59, 2, p. 163-175 13 p.

Research output: Contribution to journalArticle

114 Scopus citations
2011

DNA synthesis across an abasic lesion by yeast Rev1 DNA polymerase

Nair, D. T., Johnson, R. E., Prakash, L., Prakash, S. & Aggarwal, A. K., Feb 11 2011, In : Journal of Molecular Biology. 406, 1, p. 18-28 11 p.

Research output: Contribution to journalArticle

24 Scopus citations
2019

Structural insights into mutagenicity of anticancer nucleoside analog cytarabine during replication by DNA polymerase η

Rechkoblit, O., Johnson, R. E., Buku, A., Prakash, L., Prakash, S. & Aggarwal, A. K., Dec 1 2019, In : Scientific reports. 9, 1, 16400.

Research output: Contribution to journalArticle

Open Access
2012

Structural basis for cisplatin DNA damage tolerance by human polymerase η during cancer chemotherapy

Ummat, A., Rechkoblit, O., Jain, R., Roy Choudhury, J., Johnson, R. E., Silverstein, T. D., Buku, A., Lone, S., Prakash, L., Prakash, S. & Aggarwal, A. K., Jun 1 2012, In : Nature Structural and Molecular Biology. 19, 6, p. 628-632 5 p.

Research output: Contribution to journalArticle

56 Scopus citations
2011

Requirement of replication checkpoint protein kinases Mec1/Rad53 for postreplication repair in yeast

Gangavarapu, V., Maria, S. R. S., Prakash, S. & Prakash, L., May 1 2011, In : mBio. 2, 3

Research output: Contribution to journalArticle

12 Scopus citations
2019

Error-Prone Replication through UV Lesions by DNA Polymerase θ Protects against Skin Cancers

Yoon, J. H., McArthur, M. J., Park, J., Basu, D., Wakamiya, M., Prakash, L. & Prakash, S., Mar 7 2019, In : Cell. 176, 6, p. 1295-1309.e15

Research output: Contribution to journalArticle

12 Scopus citations
2020
Open Access