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  • Chad Mire
2017

Transcriptome analysis of circulating immune cell subsets highlight the role of monocytes in Zaire Ebola Virus Makona pathogenesis

Menicucci, A. R., Versteeg, K., Woolsey, C., Mire, C., Geisbert, J. B., Cross, R., Agans, K. N., Jankeel, A., Geisbert, T. & Messaoudi, I., Oct 4 2017, In : Frontiers in Immunology. 8, OCT, 1372.

Research output: Contribution to journalArticle

15 Scopus citations
2013

Vesicular Stomatitis Virus-Based Vaccines Protect Nonhuman Primates against Bundibugyo ebolavirus

Mire, C. E., Geisbert, J. B., Marzi, A., Agans, K. N., Feldmann, H. & Geisbert, T. W., 2013, In : PLoS neglected tropical diseases. 7, 12, e2600.

Research output: Contribution to journalArticle

54 Scopus citations
2014

Durability of a vesicular stomatitis virus-based marburg virus vaccine in nonhuman primates

Mire, C. E., Geisbert, J. B., Agans, K. N., Satterfield, B. A., Versteeg, K. M., Fritz, E. A., Feldmann, H., Hensley, L. E. & Geisbert, T. W., Apr 23 2014, In : PloS one. 9, 4, e94355.

Research output: Contribution to journalArticle

41 Scopus citations
2020

A Lethal Aerosol Exposure Model of Nipah Virus Strain Bangladesh in African Green Monkeys

Prasad, A. N., Agans, K. N., Sivasubramani, S. K., Geisbert, J. B., Borisevich, V., Mire, C. E., Lawrence, W. S., Fenton, K. A. & Geisbert, T. W., May 11 2020, In : Journal of Infectious Diseases. 221, p. S431-S435

Research output: Contribution to journalArticle

1 Scopus citations
2019

A Two-Antibody Pan-Ebolavirus Cocktail Confers Broad Therapeutic Protection in Ferrets and Nonhuman Primates

Bornholdt, Z. A., Herbert, A. S., Mire, C. E., He, S., Cross, R. W., Wec, A. Z., Abelson, D. M., Geisbert, J. B., James, R. M., Rahim, M. N., Zhu, W., Borisevich, V., Banadyga, L., Gunn, B. M., Agans, K. N., Wirchnianski, A. S., Goodwin, E., Tierney, K., Shestowsky, W. S., Bohorov, O. & 13 others, Bohorova, N., Velasco, J., Ailor, E., Kim, D., Pauly, M. H., Whaley, K. J., Alter, G., Walker, L. M., Chandran, K., Zeitlin, L., Qiu, X., Geisbert, T. W. & Dye, J. M., Jan 9 2019, In : Cell Host and Microbe. 25, 1, p. 49-58.e5

Research output: Contribution to journalArticle

16 Scopus citations
2015

Modeling the Disease Course of Zaire ebolavirus Infection in the Outbred Guinea Pig

Cross, R., Fenton, K. A., Geisbert, J. B., Mire, C. & Geisbert, T., Oct 1 2015, In : Journal of Infectious Diseases. 212, p. S305-S315

Research output: Contribution to journalArticle

29 Scopus citations
2014

Protection against lethal marburg virus infection mediated by lipid encapsulated small interfering RNA

Ursic-Bedoya, R., Mire, C. E., Robbins, M., Geisbert, J. B., Judge, A., MacLachlan, I. & Geisbert, T. W., Feb 15 2014, In : Journal of Infectious Diseases. 209, 4, p. 562-570 9 p.

Research output: Contribution to journalArticle

31 Scopus citations
2018

A prophylactic multivalent vaccine against different filovirus species is immunogenic and provides protection from lethal infections with Ebolavirus and Marburgvirus species in non-human primates

Callendret, B., Vellinga, J., Wunderlich, K., Rodriguez, A., Steigerwald, R., Dirmeier, U., Cheminay, C., Volkmann, A., Brasel, T., Carrion, R., Giavedoni, L. D., Patterson, J. L., Mire, C. E., Geisbert, T. W., Hooper, J. W., Weijtens, M., Hartkoorn-Pasma, J., Custers, J., Pau, M. G., Schuitemaker, H. & 1 others, Zahn, R., Feb 2018, In : PloS one. 13, 2, e0192312.

Research output: Contribution to journalArticle

16 Scopus citations
2013

Mutual antagonism between the ebola virus VP35 protein and the RIG-I activator PACT determines infection outcome

Luthra, P., Ramanan, P., Mire, C. E., Weisend, C., Tsuda, Y., Yen, B., Liu, G., Leung, D. W., Geisbert, T. W., Ebihara, H., Amarasinghe, G. K. & Basler, C. F., Jul 17 2013, In : Cell Host and Microbe. 14, 1, p. 74-84 11 p.

Research output: Contribution to journalArticle

105 Scopus citations
2017

siRNA rescues nonhuman primates from advanced Marburg and Ravn virus disease

Thi, E. P., Mire, C., Lee, A. C. H., Geisbert, J. B., Ursic-Bedoya, R., Agans, K. N., Robbins, M., Deer, D. J., Cross, R., Kondratowicz, A. S., Fenton, K. A., MacLachlan, I. & Geisbert, T., Dec 1 2017, In : Journal of Clinical Investigation. 127, 12, p. 4437-4448 12 p.

Research output: Contribution to journalArticle

6 Scopus citations
2018

Postexposure Efficacy of Recombinant Vesicular Stomatitis Virus Vectors Against High and Low Doses of Marburg Virus Variant Angola in Nonhuman Primates

Woolsey, C., Geisbert, J. B., Matassov, D., Agans, K. N., Borisevich, V., Cross, R., Deer, D. J., Fenton, K. A., Eldridge, J. H., Mire, C. & Geisbert, T., Nov 22 2018, In : The Journal of infectious diseases. 218, 5, p. S582-S587

Research output: Contribution to journalArticle

5 Scopus citations
2012

Recombinant vesicular stomatitis virus vaccine vectors expressing filovirus glycoproteins lack neurovirulence in nonhuman primates

Mire, C. E., Miller, A. D., Carville, A., Westmoreland, S. V., Geisbert, J. B., Mansfield, K. G., Feldmann, H., Hensley, L. E. & Geisbert, T. W., Mar 2012, In : PLoS neglected tropical diseases. 6, 3, e1567.

Research output: Contribution to journalArticle

66 Scopus citations
2019

Current Ebola Virus Vaccine Progress

Marzi, A. & Mire, C., Jan 1 2019, (Accepted/In press) In : BioDrugs.

Research output: Contribution to journalArticle

10 Scopus citations
2018

Post-exposure treatments for Ebola and Marburg virus infections

Cross, R. W., Mire, C. E., Feldmann, H. & Geisbert, T. W., Jun 1 2018, In : Nature Reviews Drug Discovery. 17, 6, p. 413-434 22 p.

Research output: Contribution to journalReview article

46 Scopus citations
2014

The Marburg Virus VP24 Protein Interacts with Keap1 to Activate the Cytoprotective Antioxidant Response Pathway

Edwards, M. R., Johnson, B., Mire, C. E., Xu, W., Shabman, R. S., Speller, L. N., Leung, D. W., Geisbert, T. W., Amarasinghe, G. K. & Basler, C. F., Mar 27 2014, In : Cell Reports. 6, 6, p. 1017-1025 9 p.

Research output: Contribution to journalArticle

59 Scopus citations
2019

Antibody therapy for Lassa fever

Cross, R. W., Hastie, K. M., Mire, C. E., Robinson, J. E., Geisbert, T. W., Branco, L. M., Ollmann Saphire, E. & Garry, R. F., Aug 2019, In : Current Opinion in Virology. 37, p. 97-104 8 p.

Research output: Contribution to journalReview article

2011

Utilization of fluorescently-labeled tetracysteine-tagged proteins to study virus entry by live cell microscopy

Whitt, M. A. & Mire, C. E., Oct 2011, In : Methods. 55, 2, p. 127-136 10 p.

Research output: Contribution to journalReview article

18 Scopus citations
2015

The immunomodulating v and W proteins of Nipah virus determine disease course

Satterfield, B. A., Cross, R., Fenton, K. A., Agans, K. N., Basler, C. F., Geisbert, T. & Mire, C., Jun 24 2015, In : Nature Communications. 6, 7483.

Research output: Contribution to journalArticle

27 Scopus citations
2020

A Cross-Reactive Humanized Monoclonal Antibody Targeting Fusion Glycoprotein Function Protects Ferrets Against Lethal Nipah Virus and Hendra Virus Infection

Mire, C. E., Chan, Y. P., Borisevich, V., Cross, R. W., Yan, L., Agans, K. N., Dang, H. V., Veesler, D., Fenton, K. A., Geisbert, T. W. & Broder, C. C., May 11 2020, In : Journal of Infectious Diseases. 221, p. S471-S479

Research output: Contribution to journalArticle

Open Access
2019

The FDA-Approved Oral Drug Nitazoxanide Amplifies Host Antiviral Responses and Inhibits Ebola Virus

Jasenosky, L. D., Cadena, C., Mire, C. E., Borisevich, V., Haridas, V., Ranjbar, S., Nambu, A., Bavari, S., Soloveva, V., Sadukhan, S., Cassell, G. H., Geisbert, T. W., Hur, S. & Goldfeld, A. E., Sep 27 2019, In : iScience. 19, p. 1279-1290 12 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations
2011

The protease-sensitive loop of the vesicular stomatitis virus matrix protein is involved in virus assembly and protein translation

Mire, C. E. & Whitt, M. A., Jul 20 2011, In : Virology. 416, 1-2, p. 16-25 10 p.

Research output: Contribution to journalArticle

10 Scopus citations
2018

Single-dose trivalent VesiculoVax vaccine protects macaques from lethal Ebolavirus and Marburgvirus challenge

Matassov, D., Mire, C. E., Latham, T., Geisbert, J. B., Xu, R., Ota-Setlik, A., Agans, K. N., Kobs, D. J., Wendling, M. Q. S., Burnaugh, A., Rudge, T. L., Sabourin, C. L., Egan, M. A., Clarke, D. K., Geisbert, T. W. & Eldridge, J. H., Feb 1 2018, In : Journal of virology. 92, 3, e01190-17.

Research output: Contribution to journalArticle

12 Scopus citations
2014

Deep sequencing identifies noncanonical editing of Ebola and Marburg virus RNAs in infected cells

Shabman, R. S., Jabado, O. J., Mire, C. E., Stockwell, T. B., Edwards, M., Mahajan, M., Geisbert, T. W. & Basler, C. F., 2014, In : mBio. 5, 6, p. e02011

Research output: Contribution to journalArticle

2019

Antagonism of STAT1 by Nipah virus P gene products modulates disease course but not lethal outcome in the ferret model

Satterfield, B. A., Borisevich, V., Foster, S. L., Rodriguez, S. E., Cross, R. W., Fenton, K., Agans, K. N., Basler, C. F., Geisbert, T. W. & Mire, C. E., Dec 1 2019, In : Scientific reports. 9, 1, 16710.

Research output: Contribution to journalArticle

Open Access
2018

Erratum: Correction for Olsen et al., "Polyamines and Hypusination Are Required for Ebolavirus Gene Expression and Replication" (mBio (2016) 7 4 PII: e01065-18)

Olsen, M. E., Filone, C. M., Rozelle, D., Mire, C. E., Agans, K. N., Hensley, L. & Connor, J. H., Jun 5 2018, In : mBio. 9, 3

Research output: Contribution to journalComment/debate

Open Access
2015

Single-dose attenuated Vesiculovax vaccines protect primates against Ebola Makona virus

Mire, C., Matassov, D., Geisbert, J. B., Latham, T. E., Agans, K. N., Xu, R., Ota-Setlik, A., Egan, M. A., Fenton, K. A., Clarke, D. K., Eldridge, J. H. & Geisbert, T., Apr 30 2015, In : Nature. 520, 7549, p. 688-691 4 p.

Research output: Contribution to journalArticle

66 Scopus citations

Comparison of the Pathogenesis of the Angola and Ravn Strains of Marburg Virus in the Outbred Guinea Pig Model

Cross, R., Fenton, K. A., Geisbert, J. B., Ebihara, H., Mire, C. & Geisbert, T., Oct 1 2015, In : Journal of Infectious Diseases. 212, p. S258-S270

Research output: Contribution to journalArticle

24 Scopus citations
2020

Resistance of Cynomolgus Monkeys to Nipah and Hendra Virus Disease Is Associated with Cell-Mediated and Humoral Immunity

Prasad, A. N., Woolsey, C., Geisbert, J. B., Agans, K. N., Borisevich, V., Deer, D. J., Mire, C. E., Cross, R. W., Fenton, K. A., Broder, C. C. & Geisbert, T. W., May 11 2020, In : Journal of Infectious Diseases. 221, p. S436-S447

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2019

A VP35 Mutant Ebola Virus Lacks Virulence but Can Elicit Protective Immunity to Wild-Type Virus Challenge

Woolsey, C., Menicucci, A. R., Cross, R., Luthra, P., Agans, K. N., Borisevich, V., Geisbert, J. B., Mire, C., Fenton, K. A., Jankeel, A., Anand, S., Ebihara, H., Geisbert, T., Messaoudi, I. & Basler, C. F., Sep 17 2019, In : Cell Reports. 28, 12, p. 3032-3046.e6

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
2014

Vaccines and antivirals for filoviruses

Mire, C. & Geisbert, T., Jan 1 2014, Biology and Pathogenesis of Rhabdo- and Filoviruses. World Scientific Publishing Co., p. 587-620 34 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations
2017

Enhanced light microscopy visualization of virus particles from Zika virus to filamentous ebolaviruses

Daaboul, G. G., Freedman, D. S., Scherr, S. M., Carter, E., Rosca, A., Bernstein, D., Mire, C. E., Agans, K. N., Hoenen, T., Geisbert, T. W., Selim Ünlü, M. & Connor, J. H., Jun 2017, In : PloS one. 12, 6, e0179728.

Research output: Contribution to journalArticle

5 Scopus citations
2015

Analytical performance characteristics of the cepheid GeneXpert Ebola Assay for the detection of Ebola virus

Pinsky, B. A., Sahoo, M. K., Sandlund, J., Kleman, M., Kulkarni, M., Grufman, P., Nygren, M., Kwiatkowski, R., Baron, E. J., Tenover, F., Denison, B., Higuchi, R., Van Atta, R., Beer, N. R., Carrillo, A. C., Naraghi-Arani, P., Mire, C. E., Ranadheera, C., Grolla, A., Lagerqvist, N. & 1 others, Persing, D. H., Nov 1 2015, In : PloS one. 10, 11, e0142216.

Research output: Contribution to journalArticle

29 Scopus citations
2019

Use of Single-Injection Recombinant Vesicular Stomatitis Virus Vaccine to Protect Nonhuman Primates Against Lethal Nipah Virus Disease

Mire, C., Geisbert, J. B., Agans, K. N., Versteeg, K. M., Deer, D. J., Satterfield, B. A., Fenton, K. A. & Geisbert, T., Jun 1 2019, In : Emerging infectious diseases. 25, 6, p. 1144-1152 9 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
2020

Quadrivalent VesiculoVax vaccine protects nonhuman primates from viral-induced hemorrhagic fever and death

Cross, R. W., Xu, R., Matassov, D., Hamm, S., Latham, T. E., Gerardi, C. S., Nowak, R. M., Geisbert, J. B., Ota-Setlik, A., Agans, K. N., Luckay, A., Witko, S. E., Soukieh, L., Deer, D. J., Mire, C. E., Feldmann, H., Happi, C., Fenton, K., Eldridge, J. H. & Geisbert, T. W., Jan 2 2020, In : Journal of Clinical Investigation. 130, 1, p. 539-551 13 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2019

An antibody against the F glycoprotein inhibits Nipah and Hendra virus infections

Dang, H. V., Chan, Y. P., Park, Y. J., Snijder, J., Da Silva, S. C., Vu, B., Yan, L., Feng, Y. R., Rockx, B., Geisbert, T. W., Mire, C. E., Broder, C. C. & Veesler, D., Oct 1 2019, In : Nature Structural and Molecular Biology. 26, 10, p. 980-987 8 p.

Research output: Contribution to journalArticle

5 Scopus citations
2014

Therapeutic treatment of Nipah virus infection in nonhuman primates with a neutralizing human monoclonal antibody

Geisbert, T. W., Mire, C. E., Geisbert, J. B., Chan, Y. P., Agans, K. N., Feldmann, F., Fenton, K. A., Zhu, Z., Dimitrov, D. S., Scott, D. P., Bossart, K. N., Feldmann, H. & Broder, C. C., Jun 25 2014, In : Science Translational Medicine. 6, 242, 242ra82.

Research output: Contribution to journalArticle

56 Scopus citations
2017

Infection with the Makona variant results in a delayed and distinct host immune response compared to previous Ebola virus variants

Versteeg, K., Menicucci, A. R., Woolsey, C., Mire, C., Geisbert, J. B., Cross, R., Agans, K. N., Jeske, D., Messaoudi, I. & Geisbert, T., Dec 1 2017, In : Scientific Reports. 7, 1, 9730.

Research output: Contribution to journalArticle

12 Scopus citations
2015

Erratum: Analytical performance characteristics of the cepheid genexpert ebola assay for the detection of ebola virus (PLoS One)

Pinsky, B. A., Sahoo, M. K., Sandlund, J., Kleman, M., Kulkarni, M., Grufman, P., Nygren, M., Kwiatkowski, R., Baron, E. J., Tenover, F., Denison, B., Higuchi, R., Van Atta, R., Beer, N. R., Carrillo, A. C., Naraghi-Arani, P., Mire, C. E., Ranadheera, C., Grolla, A., Lagerqvist, N. & 1 others, Persing, D. H., Dec 1 2015, In : PloS one. 10, 12, 0145896.

Research output: Contribution to journalComment/debate

3 Scopus citations
2019

Author Correction: Infection with the Makona variant results in a delayed and distinct host immune response compared to previous Ebola virus variants (Scientific Reports, (2017), 7, 1, (9730), 10.1038/s41598-017-09963-y)

Versteeg, K., Menicucci, A. R., Woolsey, C., Mire, C., Geisbert, J. B., Cross, R., Agans, K. N., Jeske, D., Messaoudi, I. & Geisbert, T., Dec 1 2019, In : Scientific reports. 9, 1, 7329.

Research output: Contribution to journalComment/debate

Open Access
2015

Aerosolized Ebola vaccine protects primates and elicits lung-resident T cell responses

Meyer, M., Garron, T., Lubaki, N. M., Mire, C., Fenton, K. A., Klages, C., Olinger, G. G., Geisbert, T., Collins, P. L. & Bukreyev, A., Aug 3 2015, In : Journal of Clinical Investigation. 125, 8, p. 3241-3255 15 p.

Research output: Contribution to journalArticle

43 Scopus citations
2013

Single injection recombinant vesicular stomatitis virus vaccines protect ferrets against lethal Nipah virus disease

Mire, C. E., Versteeg, K. M., Cross, R. W., Agans, K. N., Fenton, K. A., Whitt, M. A. & Geisbert, T. W., Dec 13 2013, In : Virology journal. 10, 353.

Research output: Contribution to journalArticle

35 Scopus citations
2014

A recombinant Hendra Virus G glycoprotein subunit vaccine protects nonhuman primates against hendra virus challenge

Mire, C. E., Geisbert, J. B., Agans, K. N., Feng, Y. R., Fenton, K. A., Bossart, K. N., Yan, L., Chan, Y. P., Broder, C. C. & Geisbert, T. W., May 2014, In : Journal of virology. 88, 9, p. 4624-4631 8 p.

Research output: Contribution to journalArticle

23 Scopus citations
2017

Therapeutic treatment of marburg and ravn virus infection in nonhuman primates with a human monoclonal antibody

Mire, C. E., Geisbert, J. B., Borisevich, V., Fenton, K. A., Agans, K. N., Flyak, A. I., Deer, D. J., Steinkellner, H., Bohorov, O., Bohorova, N., Goodman, C., Hiatt, A., Kim, D. H., Pauly, M. H., Velasco, J., Whaley, K. J., Crowe, J. E., Zeitlin, L. & Geisbert, T. W., Apr 5 2017, In : Science Translational Medicine. 9, 384, eaai8711.

Research output: Contribution to journalArticle

27 Scopus citations
2015

Vaccination with a Highly Attenuated Recombinant Vesicular Stomatitis Virus Vector Protects Against Challenge with a Lethal Dose of Ebola Virus

Matassov, D., Marzi, A., Latham, T., Xu, R., Ota-Setlik, A., Feldmann, F., Geisbert, J. B., Mire, C. E., Hamm, S., Nowak, B., Egan, M. A., Geisbert, T. W., Eldridge, J. H., Feldmann, H. & Clarke, D. K., Oct 1 2015, In : Journal of Infectious Diseases. 212, p. S443-S451

Research output: Contribution to journalArticle

31 Scopus citations

A Single-Vector, Single-Injection Trivalent Filovirus Vaccine: Proof of Concept Study in Outbred Guinea Pigs

Mire, C. E., Geisbert, J. B., Versteeg, K. M., Mamaeva, N., Agans, K. N., Geisbert, T. W. & Connor, J. H., Oct 1 2015, In : Journal of Infectious Diseases. 212, p. S384-S388

Research output: Contribution to journalArticle

21 Scopus citations
2018

Efficacy of Human Monoclonal Antibody Monotherapy Against Bundibugyo Virus Infection in Nonhuman Primates

Gilchuk, P., Mire, C., Geisbert, J. B., Agans, K. N., Deer, D. J., Cross, R., Slaughter, J. C., Flyak, A. I., Mani, J., Pauly, M. H., Velasco, J., Whaley, K. J., Zeitlin, L., Geisbert, T. & Crowe, J. E., Nov 22 2018, In : The Journal of infectious diseases. 218, 5, p. S565-S573

Research output: Contribution to journalArticle

1 Scopus citations
2020

An Intranasal Exposure Model of Lethal Nipah Virus Infection in African Green Monkeys

Geisbert, J. B., Borisevich, V., Prasad, A. N., Agans, K. N., Foster, S. L., Deer, D. J., Cross, R. W., Mire, C. E., Geisbert, T. W. & Fenton, K. A., May 11 2020, In : Journal of Infectious Diseases. 221, p. S414-S418

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
2014

Deep sequencing identifies noncanonical editing of Ebola and Marburg virus RNAS in infected cells

Shabman, R. S., Jabado, O. J., Mire, C. E., Stockwell, T. B., Edwards, M., Mahajan, M., Geisbert, T. W. & Basler, C. F., Sep 25 2014, In : mBio. 5, 6, e02011-14.

Research output: Contribution to journalArticle

43 Scopus citations
2015

A Recombinant Vesicular Stomatitis Virus-Based Lassa Fever Vaccine Protects Guinea Pigs and Macaques against Challenge with Geographically and Genetically Distinct Lassa Viruses

Safronetz, D., Mire, C., Rosenke, K., Feldmann, F., Haddock, E., Geisbert, T. & Feldmann, H., Apr 17 2015, In : PLoS Neglected Tropical Diseases. 9, 4, e0003736.

Research output: Contribution to journalArticle

47 Scopus citations
2017

Human-monoclonal-antibody therapy protects nonhuman primates against advanced Lassa fever

Mire, C. E., Cross, R. W., Geisbert, J. B., Borisevich, V., Agans, K. N., Deer, D. J., Heinrich, M. L., Rowland, M. M., Goba, A., Momoh, M., Boisen, M. L., Grant, D. S., Fullah, M., Khan, S. H., Fenton, K. A., Robinson, J. E., Branco, L. M., Garry, R. F. & Geisbert, T. W., Oct 1 2017, In : Nature Medicine. 23, 10, p. 1146-1149 4 p.

Research output: Contribution to journalArticle

35 Scopus citations