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  • Krishna Rajarathnam
2013

Organization and dynamics of the N-terminal domain of chemokine receptor CXCR1 in reverse micelles: Effect of graded hydration

Chaudhuri, A., Basu, P., Haldar, S., Kombrabail, M., Krishnamoorthy, G., Rajarathnam, K. & Chattopadhyay, A., Feb 7 2013, In : Journal of Physical Chemistry B. 117, 5, p. 1225-1233 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Real-time kinetics of high-mobility group box 1 (HMGB1) oxidation in extracellular fluids studied by in situ protein NMR spectroscopy

Zandarashvili, L., Sahu, D., Lee, K., Lee, Y. S., Singh, P., Rajarathnam, K. & Iwahara, J., Apr 26 2013, In : Journal of Biological Chemistry. 288, 17, p. 11621-11627 7 p.

Research output: Contribution to journalArticle

35 Scopus citations
2020

Structural Insights Into How Proteoglycans Determine Chemokine-CXCR1/CXCR2 Interactions: Progress and Challenges

Rajarathnam, K. & Desai, U. R., Apr 24 2020, In : Frontiers in immunology. 11, 660.

Research output: Contribution to journalReview article

Open Access
3 Scopus citations
2018

Glycosaminoglycan Interactions Fine-Tune Chemokine-Mediated Neutrophil Trafficking: Structural Insights and Molecular Mechanisms

Rajarathnam, K., Sepuru, K. M., Joseph, P. R. B., Sawant, K. V. & Brown, A. J., Apr 1 2018, In : Journal of Histochemistry and Cytochemistry. 66, 4, p. 229-239 11 p.

Research output: Contribution to journalReview article

11 Scopus citations
2020

Neutrophil recruitment by chemokines Cxcl1/KC and Cxcl2/MIP2: Role of Cxcr2 activation and glycosaminoglycan interactions

Sawant, K. V., Sepuru, K. M., Lowry, E., Penaranda, B., Frevert, C. W., Garofalo, R. P. & Rajarathnam, K., 2020, (Accepted/In press) In : Journal of Leukocyte Biology.

Research output: Contribution to journalArticle

2016
30 Scopus citations
2018

Structural basis, stoichiometry, and thermodynamics of binding of the chemokines KC and MIP2 to the glycosaminoglycan heparin

Sepuru, K. M., Nagarajan, B., Desai, U. R. & Rajarathnam, K., Nov 16 2018, In : Journal of Biological Chemistry. 293, 46, p. 17817-17828 12 p.

Research output: Contribution to journalArticle

4 Scopus citations
2016

Chemokine CXCL1 mediated neutrophil recruitment: Role of glycosaminoglycan interactions

Sawant, K. V., Poluri, K. M., Dutta, A. K., Sepuru, K. M., Troshkina, A., Garofalo, R. P. & Rajarathnam, K., Sep 14 2016, In : Scientific reports. 6, 33123.

Research output: Contribution to journalArticle

70 Scopus citations
2018

Direct detection of lysine side chain NH3+ in protein-heparin complexes using NMR spectroscopy

Sepuru, K. M., Iwahara, J. & Rajarathnam, K., Feb 7 2018, In : Analyst. 143, 3, p. 635-638 4 p.

Research output: Contribution to journalArticle

7 Scopus citations
2011

Diverging mechanisms of activation of chemokine receptors revealed by novel chemokine agonists

Sarmiento, J., Shumate, C., Suetomi, K., Ravindran, A., Villegas, L., Rajarathnam, K. & Navarro, J., Dec 9 2011, In : PloS one. 6, 12, e27967.

Research output: Contribution to journalArticle

12 Scopus citations
2018
2 Scopus citations
2013

Proline substitution of dimer interface β-strand residues as a strategy for the design of functional monomeric proteins

Joseph, P. R. B., Poluri, K. M., Gangavarapu, P., Rajagopalan, L., Raghuwanshi, S., Richardson, R. M., Garofalo, R. P. & Rajarathnam, K., Sep 17 2013, In : Biophysical journal. 105, 6, p. 1491-1501 11 p.

Research output: Contribution to journalArticle

17 Scopus citations

Molecular basis of glycosaminoglycan heparin binding to the chemokine CXCL1 dimer

Poluri, K. M., Joseph, P. R. B., Sawant, K. V. & Rajarathnam, K., Aug 30 2013, In : Journal of Biological Chemistry. 288, 35, p. 25143-25153 11 p.

Research output: Contribution to journalArticle

42 Scopus citations
2014

Solution structure of CXCL5 - A novel chemokine and adipokine implicated in inflammation and obesity

Sepuru, K. M., Poluri, K. M. & Rajarathnam, K., Apr 2 2014, In : PloS one. 9, 4, e93228.

Research output: Contribution to journalArticle

17 Scopus citations
2018

Ehrlichia chaffeensis TRP120 nucleomodulin binds DNA with disordered tandem repeat domain

Klema, V. J., Sepuru, K. M., Füllbrunn, N., Farris, T. R., Dunphy, P. S., McBride, J. W., Rajarathnam, K. & Choi, K. H., Apr 2018, In : PloS one. 13, 4, e0194891.

Research output: Contribution to journalArticle

3 Scopus citations
2014

Isothermal titration calorimetry of membrane proteins - Progress and challenges

Rajarathnam, K. & Rösgen, J., 2014, In : Biochimica et Biophysica Acta - Biomembranes. 1838, 1 PARTA, p. 69-77 9 p.

Research output: Contribution to journalReview article

51 Scopus citations
2012

The monomer-dimer equilibrium and glycosaminoglycan interactions of chemokine CXCL8 regulate tissue-specific neutrophil recruitment

Gangavarapu, P., Rajagopalan, L., Kolli, D., Guerrero-Plata, A., Garofalo, R. P. & Rajarathnam, K., Feb 2012, In : Journal of Leukocyte Biology. 91, 2, p. 259-265 7 p.

Research output: Contribution to journalArticle

59 Scopus citations
2013

Dynamic conformational switching in the chemokine ligand is essential for G-protein-coupled receptor activation

Joseph, P. R. B., Sawant, K. V., Isley, A., Pedroza, M., Garofalo, R. P., Richardson, R. M. & Rajarathnam, K., Dec 1 2013, In : Biochemical Journal. 456, 2, p. 241-251 11 p.

Research output: Contribution to journalArticle

19 Scopus citations
2016

Molecular basis of chemokine CXCL5-glycosaminoglycan interactions

Sepuru, K. M., Nagarajan, B., Desai, U. R. & Rajarathnam, K., Sep 23 2016, In : Journal of Biological Chemistry. 291, 39, p. 20539-20550 12 p.

Research output: Contribution to journalArticle

23 Scopus citations
2018

Lysines and Arginines play non-redundant roles in mediating chemokine-glycosaminoglycan interactions

Joseph, P. R. B., Sawant, K. V., Iwahara, J., Garofalo, R. P., Desai, U. R. & Rajarathnam, K., Dec 1 2018, In : Scientific reports. 8, 1, 12289.

Research output: Contribution to journalArticle

3 Scopus citations

Interleukin-8 mediates neutrophil-endothelial interactions in pig-to-human xenogeneic models

French, B. M., Sendil, S., Sepuru, K. M., Ranek, J., Burdorf, L., Harris, D., Redding, E., Cheng, X., Laird, C. T., Zhao, Y., Cerel, B., Rajarathnam, K., Pierson, R. N. & Azimzadeh, A. M., Jan 1 2018, (Accepted/In press) In : Xenotransplantation.

Research output: Contribution to journalArticle

4 Scopus citations
2013

Chemokine CXCL1 dimer is a potent agonist for the CXCR2 receptor

Ravindran, A., Sawant, K. V., Sarmiento, J., Navarro, J. & Rajarathnam, K., Apr 26 2013, In : Journal of Biological Chemistry. 288, 17, p. 12244-12252 9 p.

Research output: Contribution to journalArticle

39 Scopus citations
2018

Dynamics-derived insights into complex formation between the CXCL8 monomer and CXCR1 N-terminal domain: An NMR study

Joseph, P. R. B., Spyracopoulos, L. & Rajarathnam, K., Oct 31 2018, In : Molecules. 23, 11

Research output: Contribution to journalArticle

3 Scopus citations