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Author

  • Mark Hellmich
2013

Endogenously produced hydrogen sulfide supports tumor cell growth and proliferation

Szabo, C. & Hellmich, M. R., Sep 15 2013, In : Cell Cycle. 12, 18, p. 2915-2916 2 p.

Research output: Contribution to journalEditorial

24 Scopus citations
2015

Gremlin is a key pro-fibrogenic factor in chronic pancreatitis

Staloch, D., Gao, X., Liu, K., Xu, M., Feng, X., Aronson, J., Falzon, M., Greeley, G. H., Rastellini, C., Chao, C., Hellmich, M., Cao, Y. & Ko, T. C., Oct 3 2015, In : Journal of Molecular Medicine. 93, 10, p. 1085-1093 9 p.

Research output: Contribution to journalArticle

22 Scopus citations
2013
287 Scopus citations
2020

3-Mercaptopyruvate sulfurtransferase supports endothelial cell angiogenesis and bioenergetics

Abdollahi Govar, A., Törő, G., Szaniszlo, P., Pavlidou, A., Bibli, S. I., Thanki, K., Resto, V. A., Chao, C., Hellmich, M. R., Szabo, C., Papapetropoulos, A. & Módis, K., Feb 1 2020, In : British Journal of Pharmacology. 177, 4, p. 866-883 18 p.

Research output: Contribution to journalArticle

3 Scopus citations
2011

Regulation of bombesin-stimulated cyclooxygenase-2 expression in prostate cancer cells

Wen, X., Chao, C., Ives, K. & Hellmich, M. R., Jul 11 2011, In : BMC Molecular Biology. 12, 29.

Research output: Contribution to journalArticle

8 Scopus citations
2016

Inhibition of hydrogen sulfide biosynthesis sensitizes lung adenocarcinoma to chemotherapeutic drugs by inhibiting mitochondrial DNA repair and suppressing cellular bioenergetics

Szczesny, B., Marcatti, M., Zatarain, J. R., Druzhyna, N., Wiktorowicz, J. E., Nagy, P., Hellmich, M. & Szabo, C., Nov 3 2016, In : Scientific Reports. 6, 36125.

Research output: Contribution to journalArticle

37 Scopus citations
2011

Translational Research Track for Medical Students: Developing Interprofessional Collaborative Competencies for Translational Research

Aronson, J. F., Valbuena, G. A., Hellmich, M. R. & Asimakis, G., Apr 1 2011, In : Medical Science Educator. 21, 1, p. 63-66 4 p.

Research output: Contribution to journalArticle

1 Scopus citations
2017

H2S-induced S-sulfhydration of lactate dehydrogenase a (LDHA) stimulates cellular bioenergetics in HCT116 colon cancer cells

Untereiner, A. A., Oláh, G., Modis, K., Hellmich, M. & Szabo, C., Feb 7 2017, (Accepted/In press) In : Biochemical Pharmacology.

Research output: Contribution to journalArticle

18 Scopus citations
2015

Hydrogen sulfide and cancer

Hellmich, M. & Szabo, C., 2015, In : Handbook of Experimental Pharmacology. 230, p. 233-241 9 p.

Research output: Contribution to journalArticle

73 Scopus citations
2012

CD133+ colon cancer cells are more interactive with the tumor microenvironment than CD133-cells

Chao, C., Carmical, J. R., Ives, K. L., Wood, T. G., Aronson, J. F., Gomez, G. A., Djukom, C. D. & Hellmich, M. R., Mar 1 2012, In : Laboratory Investigation. 92, 3, p. 420-436 17 p.

Research output: Contribution to journalArticle

32 Scopus citations
2015

Pharmacological inhibition and genetic knockdown of exchange protein directly activated by cAMP 1 reduce pancreatic cancer metastasis in vivos

Almahariq, M., Chao, C., Mei, F. C., Hellmich, M. R., Patrikeev, I., Motamedi, M. & Cheng, X., Feb 1 2015, In : Molecular pharmacology. 87, 2, p. 142-149 8 p.

Research output: Contribution to journalArticle

25 Scopus citations
2017

Patient-derived xenografts from colorectal carcinoma: A temporal and hierarchical study of murine stromal cell replacement

Chao, C., Widen, S., Wood, T., Zatarain, J. R., Johnson, P., Gajjar, A., Gomez, G., Qiu, S., Thompson, J., Spratt, H. & Hellmich, M., Jul 1 2017, In : Anticancer Research. 37, 7, p. 3405-3412 8 p.

Research output: Contribution to journalArticle

8 Scopus citations
2019

Apigenin Decreases Acinar Cell Damage in Pancreatitis

Mrazek, A. A., Bhatia, V., Falzon, M., Spratt, H., Chao, C. & Hellmich, M. R., May 1 2019, In : Pancreas. 48, 5, p. 711-718 8 p.

Research output: Contribution to journalArticle

1 Scopus citations
2013

Noggin attenuates cerulein-induced acute pancreatitis and impaired autophagy

Cao, Y., Yang, W., Tyler, M. A., Gao, X., Duan, C., Kim, S. O., Aronson, J. F., Popov, V., Takahashi, H., Saito, H., Evers, B. M., Chao, C., Hellmich, M. R. & Ko, T. C., Mar 1 2013, In : Pancreas. 42, 2, p. 301-307 7 p.

Research output: Contribution to journalArticle

12 Scopus citations
2015

The Multidisciplinary Translational Team (MTT) Model for Training and Development of Translational Research Investigators

Ameredes, B., Hellmich, M., Cestone, C. M., Wooten, K. C., Ottenbacher, K., Chonmaitree, T., Anderson, K. & Brasier, A. R., 2015, (Accepted/In press) In : Clinical and Translational Science.

Research output: Contribution to journalArticle

12 Scopus citations
2013

PTHrP is a novel mediator for TGF-β-induced apoptosis

Cao, Y., Zhang, W., Gao, X., Zhang, G., Falzon, M., Townsend, C. M., Hellmich, M. R. & Ko, T. C., Jun 1 2013, In : Regulatory Peptides. 184, p. 40-46 7 p.

Research output: Contribution to journalArticle

6 Scopus citations
2016

Screening of a composite library of clinically used drugs and well-characterized pharmacological compounds for cystathionine β-synthase inhibition identifies benserazide as a drug potentially suitable for repurposing for the experimental therapy of colon cancer

Druzhyna, N., Szczesny, B., Olah, G., Módis, K., Asimakopoulou, A., Pavlidou, A., Szoleczky, P., Gerö, D., Yanagi, K., Törö, G., López-García, I., Myrianthopoulos, V., Mikros, E., Zatarain, J. R., Chao, C., Papapetropoulos, A., Hellmich, M. R. & Szabo, C., Nov 1 2016, In : Pharmacological Research. 113, p. 18-37 20 p.

Research output: Contribution to journalArticle

24 Scopus citations

Cystathionine-β-synthase inhibition for colon cancer: Enhancement of the efficacy of aminooxyacetic acid via the prodrug approach

Chao, C., Zatarain, J. R., Ding, Y., Coletta, C., Mrazek, A. A., Druzhyna, N., Johnson, P., Chen, H., Hellmich, J. L., Asimakopoulou, A., Yanagi, K., Olah, G., Szoleczky, P., Törö, G., Bohanon, F. J., Cheema, M., Lewis, R., Eckelbarger, D., Ahmad, A., Módis, K. & 6 others, Untereiner, A., Szczesny, B., Papapetropoulos, A., Zhou, J., Hellmich, M. R. & Szabo, C., 2016, In : Molecular Medicine. 22, p. 361-379 19 p.

Research output: Contribution to journalArticle

23 Scopus citations
2017

Role of endogenous and exogenous nitric oxide, carbon monoxide and hydrogen sulfide in HCT116 colon cancer cell proliferation

Oláh, G., Modis, K., To¨ro¨, G., Hellmich, M., Szczesny, B. & Szabo, C., 2017, (Accepted/In press) In : Biochemical Pharmacology.

Research output: Contribution to journalArticle

18 Scopus citations

Upregulation of cystathionine-β-synthase in colonic epithelia reprograms metabolism and promotes carcinogenesis

Phillips, CN. M., Zatarain, J. R., Nicholls, M. E., Porter, C., Widen, S., Thanki, K., Johnson, P., Jawad, M. U., Moyer, M. P., Randall, J. W., Hellmich, J. L., Maskey, M., Qiu, S., Wood, T., Druzhyna, N., Szczesny, B., Modis, K., Szabo, C., Chao, C. & Hellmich, M., Nov 1 2017, In : Cancer Research. 77, 21, p. 5741-5754 14 p.

Research output: Contribution to journalArticle

21 Scopus citations
2015

The therapeutic potential of cystathionine β-Synthetase/hydrogen sulfide inhibition in cancer

Hellmich, M. R., Coletta, C., Chao, C. & Szabo, C., Feb 10 2015, In : Antioxidants and Redox Signaling. 22, 5, p. 424-448 25 p.

Research output: Contribution to journalReview article

107 Scopus citations
2012

Raf-1 kinase inhibitory protein (RKIP) mediates ethanol-induced sensitization of secretagogue signaling in pancreatic acinar cells

Kim, S. O., Ives, K. L., Wang, X., Davey, R. A., Chao, C. & Hellmich, M. R., Sep 28 2012, In : Journal of Biological Chemistry. 287, 40, p. 33377-33388 12 p.

Research output: Contribution to journalArticle

8 Scopus citations
2013

Overexpression of Evi-1 oncoprotein represses TGF-β signaling in colorectal cancer

Deng, X., Cao, Y., Liu, Y., Li, F., Sambandam, K., Rajaraman, S., Perkins, A. S., Fields, A. P., Hellmich, M. R., Townsend, C. M., Thompson, E. A. & Ko, T. C., Apr 1 2013, In : Molecular Carcinogenesis. 52, 4, p. 255-264 10 p.

Research output: Contribution to journalArticle

20 Scopus citations

BMP2 inhibits TGF-β-induced pancreatic stellate cell activation and extracellular matrix formation

Gao, X., Cao, Y., Yang, W., Duan, C., Aronson, J. F., Rastellini, C., Chao, C., Hellmich, M. R. & Ko, T. C., Jun 10 2013, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 304, 9, p. G804-G813

Research output: Contribution to journalArticle

39 Scopus citations
2017

Drug resistance induces the upregulation of H2S-producing enzymes in HCT116 colon cancer cells

Untereiner, A. A., Pavlidou, A., Druzhyna, N., Papapetropoulos, A., Hellmich, M. & Szabo, C., 2017, (Accepted/In press) In : Biochemical Pharmacology.

Research output: Contribution to journalArticle

14 Scopus citations
2015

Apigenin inhibits pancreatic stellate cell activity in pancreatitis

Mrazek, A. A., Porro, L. J., Bhatia, V., Falzon, M., Spratt, H., Zhou, J., Chao, C. & Hellmich, M., Jun 1 2015, In : Journal of Surgical Research. 196, 1, p. 8-16 9 p.

Research output: Contribution to journalArticle

22 Scopus citations
2016

Isolation of CD 90+ fibroblast/myofibroblasts from human frozen gastrointestinal specimens

Johnson, P., Beswick, E. J., Chao, C., Powell, D. W., Hellmich, M. & Pinchuk, I., Jan 31 2016, In : Journal of Visualized Experiments. 2016, 107, e53691.

Research output: Contribution to journalArticle

8 Scopus citations
2012

Gastrointestinal Peptides: Gastrin, Cholecystokinin, Somatostatin, and Ghrelin

Chao, C. & Hellmich, M. R., Dec 1 2012, Physiology of the Gastrointestinal Tract. Elsevier Inc., Vol. 1. p. 115-154 40 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations
15 Scopus citations