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  • Rakez Kayed
2020

Internalization mechanisms of brain-derived tau oligomers from patients with Alzheimer’s disease, progressive supranuclear palsy and dementia with Lewy bodies

Puangmalai, N., Bhatt, N., Montalbano, M., Sengupta, U., Gaikwad, S., Ventura, F., McAllen, S., Ellsworth, A., Garcia, S. & Kayed, R., May 1 2020, In : Cell Death and Disease. 11, 5, 314.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
2018

Formation of Toxic Oligomeric Assemblies of RNA-binding Protein: Musashi in Alzheimer's disease

Sengupta, U., Montalbano, M., McAllen, S., Minuesa, G., Kharas, M. & Kayed, R., Oct 26 2018, In : Acta Neuropathologica Communications. 6, 1, p. 113 1 p.

Research output: Contribution to journalArticle

5 Scopus citations
2016

Potential mechanisms and implications for the formation of tau oligomeric strains

Gerson, J. E., Mudher, A. & Kayed, R., Nov 1 2016, In : Critical Reviews in Biochemistry and Molecular Biology. 51, 6, p. 482-496 15 p.

Research output: Contribution to journalReview article

23 Scopus citations
2013

Rapid accumulation of endogenous Tau oligomers in a rat model of traumatic brain injury: Possible link between traumatic brain injury and sporadic tauopathies

Hawkins, B. E., Krishnamurthy, S., Castillo-Carranza, D. L., Sengupta, U., Prough, D. S., Jackson, G. R., DeWitt, D. S. & Kayed, R., Jun 7 2013, In : Journal of Biological Chemistry. 288, 23, p. 17042-17050 9 p.

Research output: Contribution to journalArticle

86 Scopus citations
2019

Tau Interacts with the C-Terminal Region of α-Synuclein, Promoting Formation of Toxic Aggregates with Distinct Molecular Conformations

Dasari, A. K. R., Kayed, R., Wi, S. & Lim, K. H., Jun 25 2019, In : Biochemistry. 58, 25, p. 2814-2821 8 p.

Research output: Contribution to journalArticle

4 Scopus citations
2017

Tau oligomers as pathogenic seeds: Preparation and propagation in vitro and in vivo

Gerson, J. E., Sengupta, U. & Kayed, R., 2017, Methods in Molecular Biology. Humana Press Inc., Vol. 1523. p. 141-157 17 p. (Methods in Molecular Biology; vol. 1523).

Research output: Chapter in Book/Report/Conference proceedingChapter

13 Scopus citations

iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases

Abud, E. M., Ramirez, R. N., Martinez, E. S., Healy, L. M., Nguyen, C. H. H., Newman, S. A., Yeromin, A. V., Scarfone, V. M., Marsh, S. E., Fimbres, C., Caraway, C. A., Fote, G. M., Madany, A. M., Agrawal, A., Kayed, R., Gylys, K. H., Cahalan, M. D., Cummings, B. J., Antel, J. P., Mortazavi, A. & 3 others, Carson, M. J., Poon, W. W. & Blurton-Jones, M., Apr 19 2017, In : Neuron. 94, 2, p. 278-293.e9

Research output: Contribution to journalArticle

199 Scopus citations
2018

Tau oligomers mediate α-synuclein toxicity and can be targeted by immunotherapy

Gerson, J. E., Farmer, K. M., Henson, N., Castillo-Carranza, D. L., Carretero Murillo, M., Sengupta, U., Barrett, A. & Kayed, R., Mar 15 2018, In : Molecular Neurodegeneration. 13, 1, 13.

Research output: Contribution to journalArticle

17 Scopus citations
2019

Tau oligomers mediate aggregation of RNA-binding proteins Musashi1 and Musashi2 inducing Lamin alteration

Montalbano, M., McAllen, S., Sengupta, U., Puangmalai, N., Bhatt, N., Ellsworth, A. & Kayed, R., Dec 1 2019, In : Aging cell. 18, 6, e13035.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations
2016

The Role of Amyloid-β Oligomers in Toxicity, Propagation, and Immunotherapy

Sengupta, U., Nilson, A. N. & Kayed, R., Apr 1 2016, In : EBioMedicine. 6, p. 42-49 8 p.

Research output: Contribution to journalArticle

220 Scopus citations
2017

Selective lowering of synapsins induced by oligomeric α-synuclein exacerbates memory deficits

Larson, M. E., Greimel, S. J., Amar, F., LaCroix, M., Boyle, G., Sherman, M. A., Schley, H., Miel, C., Schneider, J. A., Kayed, R., Benfenati, F., Lee, M. K., Bennett, D. A. & Lesné, S. E., Jun 6 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 23, p. E4648-E4657

Research output: Contribution to journalArticle

23 Scopus citations
2019

Toxic Tau Oligomers Modulated by Novel Curcumin Derivatives

Lo Cascio, F., Puangmalai, N., Ellsworth, A., Bucchieri, F., Pace, A., Palumbo Piccionello, A. & Kayed, R., Dec 1 2019, In : Scientific reports. 9, 1, 19011.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations
2013

Accelerated neurodegeneration through chaperone-mediated oligomerization of tau

Blair, L. J., Nordhues, B. A., Hill, S. E., Scaglione, K. M., O'Leary, J. C., Fontaine, S. N., Breydo, L., Zhang, B., Li, P., Wang, L., Cotman, C., Paulson, H. L., Muschol, M., Uversky, V. N., Klengel, T., Binder, E. B., Kayed, R., Golde, T. E., Berchtold, N. & Dickey, C. A., Oct 1 2013, In : Journal of Clinical Investigation. 123, 10, p. 4158-4169 12 p.

Research output: Contribution to journalArticle

121 Scopus citations
2017

Oligomeric tau-targeted immunotherapy in Tg4510 mice

Schroeder, S., Joly-Amado, A., Soliman, A., Sengupta, U., Kayed, R., Gordon, M. N. & Morgan, D., Jun 27 2017, In : Alzheimer's Research and Therapy. 9, 1, 46.

Research output: Contribution to journalArticle

5 Scopus citations
2015

A native interactor scaffolds and stabilizes toxic Ataxin-1 oligomers in SCA1

Lasagna-Reeves, C. A., Rousseaux, M. W. C., Guerrero-Munoz, M. J., Park, J., Jafar-Nejad, P., Richman, R., Lu, N., Sengupta, U., Litvinchuk, A., Orr, H. T., Kayed, R. & Zoghbi, H. Y., May 19 2015, In : eLife. 4, MAY, p. 1-46 46 p., e07558.

Research output: Contribution to journalArticle

16 Scopus citations
2018

Evaluating Tau Oligomers Passive Immunotherapy using Aged Transgenic Animals of Tauopathy

Al Lahham, R., Bittar, A., Montalbano, M., Carretero Murillo, M., McAllen, S., Bhatt, N., Ellsworth, A. & Kayed, R., Jul 2018, In : Alzheimer's and Dementia. 14, 7, p. 1657

Research output: Contribution to journalMeeting Abstract

2017

Corrigendum: Pre-amyloid oligomers budding:a metastatic mechanism of proteotoxicity

Bernini, F., Malferrari, D., Pignataro, M., Bortolotti, C. A., Di Rocco, G., Lancellotti, L., Brigatti, M. F., Kayed, R., Borsari, M., Del Monte, F. & Castellini, E., Jan 19 2017, In : Scientific reports. 7, 1 p.

Research output: Contribution to journalComment/debate

Open Access
2013

Small misfolded tau species are internalized via bulk endocytosis and anterogradely and retrogradely transported in neurons

Wu, J. W., Herman, M., Liu, L., Simoes, S., Acker, C. M., Figueroa, H., Steinberg, J. I., Margittai, M., Kayed, R., Zurzolo, C., Di Paolo, G. & Duff, K. E., Jan 18 2013, In : Journal of Biological Chemistry. 288, 3, p. 1856-1870 15 p.

Research output: Contribution to journalArticle

252 Scopus citations
2018

Preparation and characterization of tau oligomer strains

Sengupta, U., Carretero-Murillo, M. & Kayed, R., Jan 1 2018, Methods in Molecular Biology. Humana Press Inc., p. 113-146 34 p. (Methods in Molecular Biology; vol. 1779).

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations
2015

The interrelationship of proteasome impairment and oligomeric intermediates in neurodegeneration

Deger, J. M., Gerson, J. E. & Kayed, R., Oct 1 2015, In : Aging cell. 14, 5, p. 715-724 10 p.

Research output: Contribution to journalReview article

35 Scopus citations

Prefibrillar Tau oligomers alter the nucleic acid protective function of Tau in hippocampal neurons in vivo

Violet, M., Chauderlier, A., Delattre, L., Tardivel, M., Chouala, M. S., Sultan, A., Marciniak, E., Humez, S., Binder, L., Kayed, R., Lefebvre, B., Bonnefoy, E., Buée, L. & Galas, M. C., Oct 1 2015, In : Neurobiology of Disease. 82, p. 540-551 12 p.

Research output: Contribution to journalArticle

33 Scopus citations
2013

Molecular mechanisms of amyloid oligomers toxicity

Kayed, R. & Lasagna-Reeves, C. A., Jan 1 2013, In : Journal of Alzheimer's Disease. 33, SUPPL. 1, p. S67-S78

Research output: Contribution to journalReview article

193 Scopus citations
2012

Identification of oligomers at early stages of tau aggregation in Alzheimer's disease

Lasagna-Reeves, C. A., Castillo-Carranza, D. L., Sengupta, U., Sarmiento, J., Troncoso, J., Jackson, G. R. & Kayed, R., May 2012, In : FASEB Journal. 26, 5, p. 1946-1959 14 p.

Research output: Contribution to journalArticle

218 Scopus citations
2018

Tau Immunotherapy for Alpha-Synucleinopathy

Aguilar, C., Al Lahham, R., Sengupta, U., Carretero Murillo, M., Kayed, R. & Dineley, K., Jul 2018, In : Alzheimer's and Dementia. 14, 7, p. 1442

Research output: Contribution to journalMeeting Abstract

2016

Advances in tau immunotherapy

Gerson, J. & Kayed, R., Jan 1 2016, Research Progress in Alzheimer’s Disease and Dementia. Volume 6. Nova Science Publishers, Inc., p. 99-114 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2013

Formation and propagation of tau oligomeric seeds

Gerson, J. E. & Kayed, R., Sep 11 2013, In : Frontiers in Neurology. 4 JUL, Article 93.

Research output: Contribution to journalReview article

65 Scopus citations