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  • Rakez Kayed
2011

Role of oligomers in the amyloidogenesis of primary cutaneous amyloidosis

Clos, A. L., Lasagna-Reeves, C. A., Kelly, B., Wagner, R., Wilkerson, M., Jackson, G. R. & Kayed, R., Nov 1 2011, In : Journal of the American Academy of Dermatology. 65, 5, p. 1023-1031 9 p.

Research output: Contribution to journalArticle

9 Scopus citations
2012

Association of skin with the pathogenesis and treatment of neurodegenerative amyloidosis

Clos, A. L., Kayed, R. & Lasagna-Reeves, C. A., 2012, In : Frontiers in Neurology. JAN, Article 5.

Research output: Contribution to journalArticle

10 Scopus citations
2017

Oligomeric tau-targeted immunotherapy in Tg4510 mice

Schroeder, S., Joly-Amado, A., Soliman, A., Sengupta, U., Kayed, R., Gordon, M. N. & Morgan, D., Jun 27 2017, In : Alzheimer's Research and Therapy. 9, 1, 46.

Research output: Contribution to journalArticle

5 Scopus citations

Corrigendum: Pre-amyloid oligomers budding:a metastatic mechanism of proteotoxicity

Bernini, F., Malferrari, D., Pignataro, M., Bortolotti, C. A., Di Rocco, G., Lancellotti, L., Brigatti, M. F., Kayed, R., Borsari, M., Del Monte, F. & Castellini, E., Jan 19 2017, In : Scientific reports. 7, 1 p.

Research output: Contribution to journalComment/debate

Open Access
2011

ApoE4-driven accumulation of intraneuronal oligomerized Aß42 following activation of the amyloid cascade in vivo is mediated by a gain of function

Zepa, L., Frenkel, M., Belinson, H., Kariv-Inbal, Z., Kayed, R., Masliah, E. & Michaelson, D. M., 2011, In : International Journal of Alzheimer's Disease. 792070.

Research output: Contribution to journalArticle

21 Scopus citations
2017

Evaluating Tau Oligomers Passive Immunotherapy using Aged Transgenic Animals of Tauopathy

Al Lahham, R., Bittar, A., Carretero Murillo, M., McAllen, S., Bhatt, N., Ellsworth, A. & Kayed, R., Dec 2017, (Unpublished).

Research output: Contribution to conferencePoster

2012

α-Synuclein oligomers oppose long-term potentiation and impair memory through a calcineurin-dependent mechanism: Relevance to human synucleopathic diseases

Martin, Z. S., Neugebauer, V., Dineley, K. T., Kayed, R., Zhang, W., Reese, L. C. & Taglialatela, G., Feb 2012, In : Journal of neurochemistry. 120, 3, p. 440-452 13 p.

Research output: Contribution to journalArticle

62 Scopus citations
2015

Antibody against Small Aggregated Peptide Specifically Recognizes Toxic Aβ-42 Oligomers in Alzheimer's Disease

Bodani, R. U., Sengupta, U., Castillo-Carranza, D. L., Guerrero-Muñoz, M. J., Gerson, J. E., Rudra, J. & Kayed, R., Dec 16 2015, In : ACS Chemical Neuroscience. 6, 12, p. 1981-1989 9 p.

Research output: Contribution to journalArticle

12 Scopus citations
2011

Formation of immunoglobulin light chain amyloid oligomers in primary cutaneous nodular amyloidosis

Clos, A. L., Lasagna-Reeves, C. A., Castillo-Carranza, D. L., Sengupta, U., Jackson, G. R., Kelly, B., Beachkofsky, T. M. & Kayed, R., Dec 1 2011, In : British Journal of Dermatology. 165, 6, p. 1349-1354 6 p.

Research output: Contribution to journalArticle

12 Scopus citations

Tau oligomers as potential targets for immunotherapy for alzheimer's disease and tauopathies

Lasagna-Reeves, C. A., Castillo-Carranza, D. L., Jackson, G. R. & Kayed, R., Sep 1 2011, In : Current Alzheimer Research. 8, 6, p. 659-665 7 p.

Research output: Contribution to journalArticle

56 Scopus citations
2012

Vaccination with a non-human random sequence amyloid oligomer mimic results in improved cognitive function and reduced plaque deposition and micro hemorrhage in Tg2576 mice

Rasool, S., Albay, R., Martinez-Coria, H., Breydo, L., Wu, J., Milton, S., Misra, S., Tran, A., Pensalfini, A., Laferla, F., Kayed, R. & Glabe, C. G., 2012, In : Molecular Neurodegeneration. 7, 1, 37.

Research output: Contribution to journalArticle

29 Scopus citations
2013

Small misfolded tau species are internalized via bulk endocytosis and anterogradely and retrogradely transported in neurons

Wu, J. W., Herman, M., Liu, L., Simoes, S., Acker, C. M., Figueroa, H., Steinberg, J. I., Margittai, M., Kayed, R., Zurzolo, C., Di Paolo, G. & Duff, K. E., Jan 18 2013, In : Journal of Biological Chemistry. 288, 3, p. 1856-1870 15 p.

Research output: Contribution to journalArticle

258 Scopus citations
2012

Tau protein: Function and pathology

Rosenmann, H., Blum, D., Kayed, R. & Ittner, L. M., 2012, In : International Journal of Alzheimer's Disease. 707482.

Research output: Contribution to journalEditorial

6 Scopus citations

Molecular mechanisms of amyloid oligomers toxicity

Kayed, R. & Lasagna-Reeves, C. A., Dec 1 2012, Alzheimer'S Disease: Advances For A New Century. Perry, G., Zhu, X., Smith, M., Sorensen, A. & Avila, J. (eds.). p. 67-78 12 p. (Advances in Alzheimer's Disease; vol. 3).

Research output: Chapter in Book/Report/Conference proceedingChapter

17 Scopus citations
2013

Molecular mechanisms of amyloid oligomers toxicity

Kayed, R. & Lasagna-Reeves, C. A., Jan 1 2013, In : Journal of Alzheimer's Disease. 33, SUPPL. 1, p. S67-S78

Research output: Contribution to journalReview article

199 Scopus citations
2015

Tau immunotherapy modulates both pathological tau and upstream amyloid pathology in an alzheimer’s disease mouse model

Castillo-Carranza, D. L., Guerrero-Muñoz, M. J., Sengupta, U., Hernandez, C., Barrett, A. D. T., Dineley, K. & Kayed, R., 2015, In : Journal of Neuroscience. 35, 12, p. 4857-4868 12 p.

Research output: Contribution to journalArticle

79 Scopus citations
2018

Azure C Targets and Modulates Toxic Tau Oligomers

Lo Cascio, F. & Kayed, R., Jun 20 2018, In : ACS Chemical Neuroscience. 9, 6, p. 1317-1326 10 p.

Research output: Contribution to journalArticle

15 Scopus citations
2012

Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau

Lasagna-Reeves, C. A., Castillo-Carranza, D. L., Sengupta, U., Guerrero-Munoz, M. J., Kiritoshi, T., Neugebauer, V., Jackson, G. R. & Kayed, R., 2012, In : Scientific reports. 2, 700.

Research output: Contribution to journalArticle

242 Scopus citations
2017

Selective lowering of synapsins induced by oligomeric α-synuclein exacerbates memory deficits

Larson, M. E., Greimel, S. J., Amar, F., LaCroix, M., Boyle, G., Sherman, M. A., Schley, H., Miel, C., Schneider, J. A., Kayed, R., Benfenati, F., Lee, M. K., Bennett, D. A. & Lesné, S. E., Jun 6 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 23, p. E4648-E4657

Research output: Contribution to journalArticle

23 Scopus citations

Tau oligomers as pathogenic seeds: Preparation and propagation in vitro and in vivo

Gerson, J. E., Sengupta, U. & Kayed, R., 2017, Methods in Molecular Biology. Humana Press Inc., Vol. 1523. p. 141-157 17 p. (Methods in Molecular Biology; vol. 1523).

Research output: Chapter in Book/Report/Conference proceedingChapter

14 Scopus citations
2018
10 Scopus citations
2013

Formation and propagation of tau oligomeric seeds

Gerson, J. E. & Kayed, R., Sep 11 2013, In : Frontiers in Neurology. 4 JUL, Article 93.

Research output: Contribution to journalReview article

65 Scopus citations
2019

Tau oligomers mediate aggregation of RNA-binding proteins Musashi1 and Musashi2 inducing Lamin alteration

Montalbano, M., McAllen, S., Sengupta, U., Puangmalai, N., Bhatt, N., Ellsworth, A. & Kayed, R., Dec 1 2019, In : Aging cell. 18, 6, e13035.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

NLRP3 inflammasome activation drives tau pathology

Ising, C., Venegas, C., Zhang, S., Scheiblich, H., Schmidt, S. V., Vieira-Saecker, A., Schwartz, S., Albasset, S., McManus, R. M., Tejera, D., Griep, A., Santarelli, F., Brosseron, F., Opitz, S., Stunden, J., Merten, M., Kayed, R., Golenbock, D. T., Blum, D., Latz, E. & 2 others, Buée, L. & Heneka, M. T., Nov 28 2019, In : Nature. 575, 7784, p. 669-673 5 p.

Research output: Contribution to journalArticle

71 Scopus citations
2018

Immunotherapy Targeting Tau Oligomeric Strains in Aged Transgenic Animals of Tauopathy

Al Lahham, R., Bittar, A., Carretero Murillo, M., McAllen, S., Bhatt, N., Ellsworth, A. & Kayed, R., Oct 2018, p. S64.

Research output: Contribution to conferenceAbstract

2011

Astrocytes contain amyloid-β annular protofibrils in Alzheimer's disease brains

Lasagna-Reeves, C. A. & Kayed, R., Oct 3 2011, In : FEBS Letters. 585, 19, p. 3052-3057 6 p.

Research output: Contribution to journalArticle

27 Scopus citations
2017

The Potential of Small Molecules in Preventing Tau Oligomer Formation and Toxicity

Gerson, J. E., Lo Cascio, F. & Kayed, R., Jan 20 2017, Neuroprotection in Alzheimer's Disease. Elsevier Inc., p. 97-121 25 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2013

Design of metastable β-sheet oligomers from natively unstructured peptide

Guerrero-Muñoz, M. J., Castillo-Carranza, D. L., Sengupta, U., White, M. A. & Kayed, R., Dec 18 2013, In : ACS chemical neuroscience. 4, 12, p. 1520-1523 4 p.

Research output: Contribution to journalArticle

9 Scopus citations

Accelerated neurodegeneration through chaperone-mediated oligomerization of tau

Blair, L. J., Nordhues, B. A., Hill, S. E., Scaglione, K. M., O'Leary, J. C., Fontaine, S. N., Breydo, L., Zhang, B., Li, P., Wang, L., Cotman, C., Paulson, H. L., Muschol, M., Uversky, V. N., Klengel, T., Binder, E. B., Kayed, R., Golde, T. E., Berchtold, N. & Dickey, C. A., Oct 1 2013, In : Journal of Clinical Investigation. 123, 10, p. 4158-4169 12 p.

Research output: Contribution to journalArticle

122 Scopus citations

Rapid accumulation of endogenous Tau oligomers in a rat model of traumatic brain injury: Possible link between traumatic brain injury and sporadic tauopathies

Hawkins, B. E., Krishnamurthy, S., Castillo-Carranza, D. L., Sengupta, U., Prough, D. S., Jackson, G. R., DeWitt, D. S. & Kayed, R., Jun 7 2013, In : Journal of Biological Chemistry. 288, 23, p. 17042-17050 9 p.

Research output: Contribution to journalArticle

87 Scopus citations
2015

Ataxin-1 oligomers induce local spread of pathology and decreasing them by passive immunization slows spinocerebellar ataxia type 1 phenotypes

Lasagna-Reeves, C. A., Rousseaux, M. W. C., Guerrero-Munoz, M. J., Vilanova-Velez, L., Park, J., See, L., Jafar-Nejad, P., Richman, R., Orr, H. T., Kayed, R. & Zoghbi, H. Y., Dec 17 2015, In : eLife. 4, DECEMBER2015, e10891.

Research output: Contribution to journalArticle

9 Scopus citations

Prefibrillar Tau oligomers alter the nucleic acid protective function of Tau in hippocampal neurons in vivo

Violet, M., Chauderlier, A., Delattre, L., Tardivel, M., Chouala, M. S., Sultan, A., Marciniak, E., Humez, S., Binder, L., Kayed, R., Lefebvre, B., Bonnefoy, E., Buée, L. & Galas, M. C., Oct 1 2015, In : Neurobiology of Disease. 82, p. 540-551 12 p.

Research output: Contribution to journalArticle

33 Scopus citations
2017

iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases

Abud, E. M., Ramirez, R. N., Martinez, E. S., Healy, L. M., Nguyen, C. H. H., Newman, S. A., Yeromin, A. V., Scarfone, V. M., Marsh, S. E., Fimbres, C., Caraway, C. A., Fote, G. M., Madany, A. M., Agrawal, A., Kayed, R., Gylys, K. H., Cahalan, M. D., Cummings, B. J., Antel, J. P., Mortazavi, A. & 3 others, Carson, M. J., Poon, W. W. & Blurton-Jones, M., Apr 19 2017, In : Neuron. 94, 2, p. 278-293.e9

Research output: Contribution to journalArticle

212 Scopus citations
15 Scopus citations
2015

Pathological Interface between Oligomeric Alpha-Synuclein and Tau in Synucleinopathies

Sengupta, U., Guerrero-Muñoz, M. J., Castillo-Carranza, D. L., Lasagna-Reeves, C. A., Gerson, J. E., Paulucci-Holthauzen, A. A., Krishnamurthy, S., Farhed, M., Jackson, G. R. & Kayed, R., Nov 15 2015, In : Biological Psychiatry. 78, 10, p. 672-683 12 p.

Research output: Contribution to journalArticle

85 Scopus citations

The interrelationship of proteasome impairment and oligomeric intermediates in neurodegeneration

Deger, J. M., Gerson, J. E. & Kayed, R., Oct 1 2015, In : Aging cell. 14, 5, p. 715-724 10 p.

Research output: Contribution to journalReview article

37 Scopus citations
2012

Identification of oligomers at early stages of tau aggregation in Alzheimer's disease

Lasagna-Reeves, C. A., Castillo-Carranza, D. L., Sengupta, U., Sarmiento, J., Troncoso, J., Jackson, G. R. & Kayed, R., May 2012, In : FASEB Journal. 26, 5, p. 1946-1959 14 p.

Research output: Contribution to journalArticle

221 Scopus citations
2018

Tau Immunotherapy for Alpha-Synucleinopathy

Aguilar, C., Al Lahham, R., Sengupta, U., Carretero Murillo, M., Kayed, R. & Dineley, K., Jul 2018, In : Alzheimer's and Dementia. 14, 7, p. 1442

Research output: Contribution to journalMeeting Abstract

2012

Differential activation of the ER stress factor XBP1 by oligomeric assemblies

Castillo-Carranza, D. L., Zhang, Y., Guerrero-Muñoz, M. J., Kayed, R., Rincon-Limas, D. E. & Fernandez-Funez, P., Aug 2012, In : Neurochemical Research. 37, 8, p. 1707-1717 11 p.

Research output: Contribution to journalArticle

24 Scopus citations
2017

Tau Oligomers in Sera of Patients with Alzheimer's Disease and Aged Controls

Kolarova, M., Sengupta, U., Bartos, A., Ricny, J. & Kayed, R., 2017, In : Journal of Alzheimer's Disease. 58, 2, p. 471-478 8 p.

Research output: Contribution to journalArticle

10 Scopus citations
2018

Binding and neurotoxicity mitigation of toxic tau oligomers by synthetic heparin like oligosaccharides

Wang, P., Lo Cascio, F., Gao, J., Kayed, R. & Huang, X., 2018, In : Chemical Communications. 54, 72, p. 10120-10123 4 p.

Research output: Contribution to journalArticle

8 Scopus citations

Soluble tau aggregates, not large fibrils, are the toxic species that display seeding and cross-seeding behavior

Ghag, G., Bhatt, N., Cantu, D. V., Guerrero-Munoz, M. J., Ellsworth, A., Sengupta, U. & Kayed, R., Nov 2018, In : Protein Science. 27, 11, p. 1901-1909 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

Prospects for strain-specific immunotherapy in Alzheimer's disease and tauopathies

Bittar, A., Sengupta, U. & Kayed, R., Dec 1 2018, In : npj Vaccines. 3, 1, 9.

Research output: Contribution to journalArticle

23 Scopus citations

Formation of Toxic Oligomeric Assemblies of RNA-binding Protein: Musashi in Alzheimer's disease

Sengupta, U., Montalbano, M., McAllen, S., Minuesa, G., Kharas, M. & Kayed, R., Oct 26 2018, In : Acta Neuropathologica Communications. 6, 1, p. 113 1 p.

Research output: Contribution to journalArticle

5 Scopus citations
2019

Tau Interacts with the C-Terminal Region of α-Synuclein, Promoting Formation of Toxic Aggregates with Distinct Molecular Conformations

Dasari, A. K. R., Kayed, R., Wi, S. & Lim, K. H., Jun 25 2019, In : Biochemistry. 58, 25, p. 2814-2821 8 p.

Research output: Contribution to journalArticle

4 Scopus citations
2015

A native interactor scaffolds and stabilizes toxic Ataxin-1 oligomers in SCA1

Lasagna-Reeves, C. A., Rousseaux, M. W. C., Guerrero-Munoz, M. J., Park, J., Jafar-Nejad, P., Richman, R., Lu, N., Sengupta, U., Litvinchuk, A., Orr, H. T., Kayed, R. & Zoghbi, H. Y., May 19 2015, In : eLife. 4, MAY, p. 1-46 46 p., e07558.

Research output: Contribution to journalArticle

16 Scopus citations
2013

Tau aggregates as immunotherapeutic targets

Castillo-Carranza, D. L., Lasagna-Reeves, C. A. & Kayed, R., Jan 1 2013, In : Frontiers in Bioscience - Scholar. 5 S, 2, p. 426-438 13 p.

Research output: Contribution to journalArticle

30 Scopus citations
2011

Amyloid-β annular protofibrils evade fibrillar fate in Alzheimer disease brain

Lasagna-Reeves, C. A., Glabe, C. G. & Kayed, R., Jun 24 2011, In : Journal of Biological Chemistry. 286, 25, p. 22122-22130 9 p.

Research output: Contribution to journalArticle

99 Scopus citations
2018

Evaluating Tau Oligomers Passive Immunotherapy using Aged Transgenic Animals of Tauopathy

Al Lahham, R., Bittar, A., Montalbano, M., Carretero Murillo, M., McAllen, S., Bhatt, N., Ellsworth, A. & Kayed, R., Jul 2018, In : Alzheimer's and Dementia. 14, 7, p. 1657

Research output: Contribution to journalMeeting Abstract

Tau Immunotherapy for Alpha-Synucleinopathy

Aguilar, C., Al Lahham, R., Sengupta, U., Carretero Murillo, M., Kayed, R. & Dineley, K., Jul 2018, In : Alzheimer's and Dementia. 14, 7, p. 1412

Research output: Contribution to journalArticle