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Author

  • Krishna Rajarathnam
2017

Regulation of chemokine function: The roles of GAG-binding and post-translational nitration

Thompson, S., Martínez-Burgo, B., Sepuru, K. M., Rajarathnam, K., Kirby, J. A., Sheerin, N. S. & Ali, S., Aug 3 2017, In : International journal of molecular sciences. 18, 8, 1692.

Research output: Contribution to journalReview article

11 Scopus citations
2018

Structural basis, stoichiometry, and thermodynamics of binding of the chemokines KC and MIP2 to the glycosaminoglycan heparin

Sepuru, K. M., Nagarajan, B., Desai, U. R. & Rajarathnam, K., Nov 16 2018, In : Journal of Biological Chemistry. 293, 46, p. 17817-17828 12 p.

Research output: Contribution to journalArticle

3 Scopus citations
2015

Flexible Linker Modulates Glycosaminoglycan Affinity of Decorin Binding Protein A

Morgan, A., Sepuru, K. M., Feng, W., Rajarathnam, K. & Wang, X., Jul 30 2015, In : Biochemistry. 54, 32, p. 5113-5119 7 p.

Research output: Contribution to journalArticle

4 Scopus citations
2017
15 Scopus citations
2019

Lyophilization of human amniotic fluid is feasible without affecting biological activity

Coon, J. I., Jain, S., Sepuru, K. M., Chung, Y., Mohankumar, K., Rajarathnam, K. & Jain, S. K., Jan 1 2019, (Accepted/In press) In : Pediatric Research.

Research output: Contribution to journalArticle

2015

Chemokine CXCL1-Mediated Neutrophil Trafficking in the Lung: Role of CXCR2 Activation

Sawant, K. V., Xu, R., Cox, R., Hawkins, H., Sbrana, E., Kolli, D., Garofalo, R. P. & Rajarathnam, K., Oct 16 2015, In : Journal of Innate Immunity. 7, 6, p. 647-658 12 p.

Research output: Contribution to journalArticle

38 Scopus citations
2012

The monomer-dimer equilibrium and glycosaminoglycan interactions of chemokine CXCL8 regulate tissue-specific neutrophil recruitment

Gangavarapu, P., Rajagopalan, L., Kolli, D., Guerrero-Plata, A., Garofalo, R. P. & Rajarathnam, K., Feb 2012, In : Journal of Leukocyte Biology. 91, 2, p. 259-265 7 p.

Research output: Contribution to journalArticle

59 Scopus citations
2019

How do chemokines navigate neutrophils to the target site: Dissecting the structural mechanisms and signaling pathways

Rajarathnam, K., Schnoor, M., Richardson, R. M. & Rajagopal, S., Feb 2019, In : Cellular Signalling. 54, p. 69-80 12 p.

Research output: Contribution to journalReview article

25 Scopus citations
2017

Platelet-derived chemokine CXCL7 dimer preferentially exists in the glycosaminoglycan-bound form: Implications for neutrophil-platelet crosstalk

Brown, A. J., Sepuru, K. M., Sawant, K. V. & Rajarathnam, K., Oct 2 2017, In : Frontiers in Immunology. 8, OCT, 1248.

Research output: Contribution to journalArticle

16 Scopus citations
2018
2 Scopus citations
2015

Characterizing protein–glycosaminoglycan interactions using solution NMR spectroscopy

Joseph, P. R. B., Poluri, K. M., Sepuru, K. M. & Rajarathnam, K., Jan 1 2015, In : Methods in Molecular Biology. 1229, p. 325-333 9 p.

Research output: Contribution to journalArticle

5 Scopus citations
2014

Solution structure of CXCL5 - A novel chemokine and adipokine implicated in inflammation and obesity

Sepuru, K. M., Poluri, K. M. & Rajarathnam, K., Apr 2 2014, In : PloS one. 9, 4, e93228.

Research output: Contribution to journalArticle

16 Scopus citations
2015

Solution NMR characterization of chemokine CXCL8/IL-8 monomer and dimer binding to glycosaminoglycans: Structural plasticity mediates differential binding interactions

Joseph, P. R. B., Mosier, P. D., Desai, U. R. & Rajarathnam, K., Nov 15 2015, In : Biochemical Journal. 472, 1, p. 121-133 13 p.

Research output: Contribution to journalArticle

50 Scopus citations
2018

Interleukin-8 mediates neutrophil-endothelial interactions in pig-to-human xenogeneic models

French, B. M., Sendil, S., Sepuru, K. M., Ranek, J., Burdorf, L., Harris, D., Redding, E., Cheng, X., Laird, C. T., Zhao, Y., Cerel, B., Rajarathnam, K., Pierson, R. N. & Azimzadeh, A. M., Jan 1 2018, (Accepted/In press) In : Xenotransplantation.

Research output: Contribution to journalArticle

4 Scopus citations

Dynamics-derived insights into complex formation between the CXCL8 monomer and CXCR1 N-terminal domain: An NMR study

Joseph, P. R. B., Spyracopoulos, L. & Rajarathnam, K., Oct 31 2018, In : Molecules. 23, 11

Research output: Contribution to journalArticle

3 Scopus citations

Glycosaminoglycan Interactions Fine-Tune Chemokine-Mediated Neutrophil Trafficking: Structural Insights and Molecular Mechanisms

Rajarathnam, K., Sepuru, K. M., Joseph, P. R. B., Sawant, K. V. & Brown, A. J., Apr 1 2018, In : Journal of Histochemistry and Cytochemistry. 66, 4, p. 229-239 11 p.

Research output: Contribution to journalReview article

10 Scopus citations
2019

Attenuation of murine allergic airway inflammation with a CXCR1/CXCR2 chemokine receptor inhibitor

Hosoki, K., Rajarathnam, K. & Sur, S., Jan 2019, In : Clinical and Experimental Allergy. 49, 1, p. 130-132 3 p.

Research output: Contribution to journalLetter

1 Scopus citations
2017

Structural basis of native CXCL7 monomer binding to CXCR2 receptor N-domain and glycosaminoglycan heparin

Brown, A. J., Sepuru, K. M. & Rajarathnam, K., Mar 1 2017, In : International Journal of Molecular Sciences. 18, 3, 508.

Research output: Contribution to journalArticle

14 Scopus citations

Chemokine CXCL7 heterodimers: Structural insights, CXCR2 receptor function, and glycosaminoglycan interactions

Brown, A. J., Joseph, P. R. B., Sawant, K. V. & Rajarathnam, K., Apr 1 2017, In : International Journal of Molecular Sciences. 18, 4, 748.

Research output: Contribution to journalArticle

10 Scopus citations
2019

Structural basis of chemokine interactions with heparan sulfate, chondroitin sulfate, and dermatan sulfate

Sepuru, K. M. & Rajarathnam, K., Oct 25 2019, In : Journal of Biological Chemistry. 294, 43, p. 15650-15661 12 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
2011

Diverging mechanisms of activation of chemokine receptors revealed by novel chemokine agonists

Sarmiento, J., Shumate, C., Suetomi, K., Ravindran, A., Villegas, L., Rajarathnam, K. & Navarro, J., Dec 9 2011, In : PloS one. 6, 12, e27967.

Research output: Contribution to journalArticle

12 Scopus citations
2014

Isothermal titration calorimetry of membrane proteins - Progress and challenges

Rajarathnam, K. & Rösgen, J., Jan 1 2014, In : Biochimica et Biophysica Acta - Biomembranes. 1838, 1 PARTA, p. 69-77 9 p.

Research output: Contribution to journalReview article

51 Scopus citations
2020

Structural Insights Into How Proteoglycans Determine Chemokine-CXCR1/CXCR2 Interactions: Progress and Challenges

Rajarathnam, K. & Desai, U. R., Apr 24 2020, In : Frontiers in immunology. 11, 660.

Research output: Contribution to journalReview article

Open Access
2 Scopus citations
2018

Direct detection of lysine side chain NH3+ in protein-heparin complexes using NMR spectroscopy

Sepuru, K. M., Iwahara, J. & Rajarathnam, K., Feb 7 2018, In : Analyst. 143, 3, p. 635-638 4 p.

Research output: Contribution to journalArticle

6 Scopus citations

Lysines and Arginines play non-redundant roles in mediating chemokine-glycosaminoglycan interactions

Joseph, P. R. B., Sawant, K. V., Iwahara, J., Garofalo, R. P., Desai, U. R. & Rajarathnam, K., Dec 1 2018, In : Scientific reports. 8, 1, 12289.

Research output: Contribution to journalArticle

3 Scopus citations
2015

Solution NMR characterization of WT CXCL8 monomer and dimer binding to CXCR1 N-terminal domain

Joseph, P. R. B. & Rajarathnam, K., Jan 1 2015, In : Protein Science. 24, 1, p. 81-92 12 p.

Research output: Contribution to journalArticle

23 Scopus citations
2018

Ehrlichia chaffeensis TRP120 nucleomodulin binds DNA with disordered tandem repeat domain

Klema, V. J., Sepuru, K. M., Füllbrunn, N., Farris, T. R., Dunphy, P. S., McBride, J. W., Rajarathnam, K. & Choi, K. H., Apr 2018, In : PloS one. 13, 4, e0194891.

Research output: Contribution to journalArticle

3 Scopus citations
2015

Using isothermal titration calorimetry to determine thermodynamic parameters of protein–glycosaminoglycan interactions

Dutta, A. K., Rösgen, J. & Rajarathnam, K., 2015, In : Methods in Molecular Biology. 1229, p. 315-324 10 p.

Research output: Contribution to journalArticle

24 Scopus citations