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  • Rakez Kayed
2019

Amyloid oligomer interactions and polymorphisms: disease-relevant distinct assembly of α-synuclein and tau

Sengupta, U. & Kayed, R., Jan 1 2019, In : Neuropsychopharmacology. 44, 1, p. 222-223 2 p.

Research output: Contribution to journalComment/debate

1 Scopus citations
2016

Tau Oligomers Derived from Traumatic Brain Injury Cause Cognitive Impairment and Accelerate Onset of Pathology in Htau Mice

Gerson, J., Castillo-Carranza, D. L., Sengupta, U., Bodani, R., Prough, D. S., DeWitt, D. S., Hawkins, B. E. & Kayed, R., Nov 15 2016, In : Journal of neurotrauma. 33, 22, p. 2034-2043 10 p.

Research output: Contribution to journalArticle

35 Scopus citations
2017

The Potential of Small Molecules in Preventing Tau Oligomer Formation and Toxicity

Gerson, J. E., Lo Cascio, F. & Kayed, R., Jan 20 2017, Neuroprotection in Alzheimer's Disease. Elsevier Inc., p. 97-121 25 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2012

α-Synuclein oligomers oppose long-term potentiation and impair memory through a calcineurin-dependent mechanism: Relevance to human synucleopathic diseases

Martin, Z. S., Neugebauer, V., Dineley, K. T., Kayed, R., Zhang, W., Reese, L. C. & Taglialatela, G., Feb 2012, In : Journal of neurochemistry. 120, 3, p. 440-452 13 p.

Research output: Contribution to journalArticle

62 Scopus citations
2019

Tau Interacts with the C-Terminal Region of α-Synuclein, Promoting Formation of Toxic Aggregates with Distinct Molecular Conformations

Dasari, A. K. R., Kayed, R., Wi, S. & Lim, K. H., Jun 25 2019, In : Biochemistry. 58, 25, p. 2814-2821 8 p.

Research output: Contribution to journalArticle

4 Scopus citations
2015

Tau immunotherapy modulates both pathological tau and upstream amyloid pathology in an alzheimer’s disease mouse model

Castillo-Carranza, D. L., Guerrero-Muñoz, M. J., Sengupta, U., Hernandez, C., Barrett, A. D. T., Dineley, K. & Kayed, R., 2015, In : Journal of Neuroscience. 35, 12, p. 4857-4868 12 p.

Research output: Contribution to journalArticle

79 Scopus citations
2020

Advances and considerations in AD tau-targeted immunotherapy

Bittar, A., Bhatt, N. & Kayed, R., Feb 2020, In : Neurobiology of Disease. 134, 104707.

Research output: Contribution to journalReview article

Open Access
7 Scopus citations
2017

iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases

Abud, E. M., Ramirez, R. N., Martinez, E. S., Healy, L. M., Nguyen, C. H. H., Newman, S. A., Yeromin, A. V., Scarfone, V. M., Marsh, S. E., Fimbres, C., Caraway, C. A., Fote, G. M., Madany, A. M., Agrawal, A., Kayed, R., Gylys, K. H., Cahalan, M. D., Cummings, B. J., Antel, J. P., Mortazavi, A. & 3 others, Carson, M. J., Poon, W. W. & Blurton-Jones, M., Apr 19 2017, In : Neuron. 94, 2, p. 278-293.e9

Research output: Contribution to journalArticle

212 Scopus citations

Cerebral microvascular accumulation of tau oligomers in Alzheimer's disease and related tauopathies

Castillo-Carranza, D. L., Nilson, A. N., Van Skike, C. E., Jahrling, J. B., Patel, K., Garach, P., Gerson, J. E., Sengupta, U., Abisambra, J., Nelson, P., Troncoso, J., Ungvari, Z., Galvan, V. & Kayed, R., 2017, In : Aging and Disease. 8, 3, p. 257-266 10 p.

Research output: Contribution to journalArticle

26 Scopus citations
2016

The Role of Amyloid-β Oligomers in Toxicity, Propagation, and Immunotherapy

Sengupta, U., Nilson, A. N. & Kayed, R., Apr 1 2016, In : EBioMedicine. 6, p. 42-49 8 p.

Research output: Contribution to journalReview article

226 Scopus citations
2012

Identification of oligomers at early stages of tau aggregation in Alzheimer's disease

Lasagna-Reeves, C. A., Castillo-Carranza, D. L., Sengupta, U., Sarmiento, J., Troncoso, J., Jackson, G. R. & Kayed, R., May 2012, In : FASEB Journal. 26, 5, p. 1946-1959 14 p.

Research output: Contribution to journalArticle

221 Scopus citations
2015

Pathological Interface between Oligomeric Alpha-Synuclein and Tau in Synucleinopathies

Sengupta, U., Guerrero-Muñoz, M. J., Castillo-Carranza, D. L., Lasagna-Reeves, C. A., Gerson, J. E., Paulucci-Holthauzen, A. A., Krishnamurthy, S., Farhed, M., Jackson, G. R. & Kayed, R., Nov 15 2015, In : Biological Psychiatry. 78, 10, p. 672-683 12 p.

Research output: Contribution to journalArticle

85 Scopus citations
2020

RNA-binding proteins Musashi and tau soluble aggregates initiate nuclear dysfunction

Montalbano, M., McAllen, S., Puangmalai, N., Sengupta, U., Bhatt, N., Johnson, O. D., Kharas, M. G. & Kayed, R., Dec 1 2020, In : Nature communications. 11, 1, 4305.

Research output: Contribution to journalArticle

Open Access
2018

Tau Immunotherapy for Alpha-Synucleinopathy

Aguilar, C., Al Lahham, R., Sengupta, U., Carretero Murillo, M., Kayed, R. & Dineley, K., Jul 2018, In : Alzheimer's and Dementia. 14, 7, p. 1412

Research output: Contribution to journalArticle

2012

Vaccination with a non-human random sequence amyloid oligomer mimic results in improved cognitive function and reduced plaque deposition and micro hemorrhage in Tg2576 mice

Rasool, S., Albay, R., Martinez-Coria, H., Breydo, L., Wu, J., Milton, S., Misra, S., Tran, A., Pensalfini, A., Laferla, F., Kayed, R. & Glabe, C. G., 2012, In : Molecular Neurodegeneration. 7, 1, 37.

Research output: Contribution to journalArticle

29 Scopus citations
2016

Potential mechanisms and implications for the formation of tau oligomeric strains

Gerson, J. E., Mudher, A. & Kayed, R., Nov 1 2016, In : Critical Reviews in Biochemistry and Molecular Biology. 51, 6, p. 482-496 15 p.

Research output: Contribution to journalReview article

24 Scopus citations
2018
10 Scopus citations
2011

Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice

Lasagna-Reeves, C. A., Castillo-Carranza, D. L., Sengupta, U., Clos, A. L., Jackson, G. R. & Kayed, R., Jun 8 2011, In : Molecular Neurodegeneration. 6, 1, 39.

Research output: Contribution to journalArticle

250 Scopus citations