Find Research Outputs

Search in all content

Filters for Publications

Search concepts
Selected Filters

Publication Year

  • 2020
  • 2019
  • 2018
  • 2017
  • 2015
  • 2013
  • 2011

Author

  • Rakez Kayed
2017

Cerebral microvascular accumulation of tau oligomers in Alzheimer's disease and related tauopathies

Castillo-Carranza, D. L., Nilson, A. N., Van Skike, C. E., Jahrling, J. B., Patel, K., Garach, P., Gerson, J. E., Sengupta, U., Abisambra, J., Nelson, P., Troncoso, J., Ungvari, Z., Galvan, V. & Kayed, R., 2017, In : Aging and Disease. 8, 3, p. 257-266 10 p.

Research output: Contribution to journalArticle

26 Scopus citations
2018
10 Scopus citations
2013

Dual role of p53 amyloid formation in cancer; loss of function and gain of toxicity

Lasagna-Reeves, C. A., Clos, A. L., Castillo-Carranza, D., Sengupta, U., Guerrero-Muñoz, M., Kelly, B., Wagner, R. & Kayed, R., Jan 18 2013, In : Biochemical and Biophysical Research Communications. 430, 3, p. 963-968 6 p.

Research output: Contribution to journalArticle

47 Scopus citations
2019

Tau oligomers mediate aggregation of RNA-binding proteins Musashi1 and Musashi2 inducing Lamin alteration

Montalbano, M., McAllen, S., Sengupta, U., Puangmalai, N., Bhatt, N., Ellsworth, A. & Kayed, R., Dec 1 2019, In : Aging cell. 18, 6, e13035.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

NLRP3 inflammasome activation drives tau pathology

Ising, C., Venegas, C., Zhang, S., Scheiblich, H., Schmidt, S. V., Vieira-Saecker, A., Schwartz, S., Albasset, S., McManus, R. M., Tejera, D., Griep, A., Santarelli, F., Brosseron, F., Opitz, S., Stunden, J., Merten, M., Kayed, R., Golenbock, D. T., Blum, D., Latz, E. & 2 others, Buée, L. & Heneka, M. T., Nov 28 2019, In : Nature. 575, 7784, p. 669-673 5 p.

Research output: Contribution to journalArticle

71 Scopus citations

Tau Interacts with the C-Terminal Region of α-Synuclein, Promoting Formation of Toxic Aggregates with Distinct Molecular Conformations

Dasari, A. K. R., Kayed, R., Wi, S. & Lim, K. H., Jun 25 2019, In : Biochemistry. 58, 25, p. 2814-2821 8 p.

Research output: Contribution to journalArticle

4 Scopus citations
2015

A native interactor scaffolds and stabilizes toxic Ataxin-1 oligomers in SCA1

Lasagna-Reeves, C. A., Rousseaux, M. W. C., Guerrero-Munoz, M. J., Park, J., Jafar-Nejad, P., Richman, R., Lu, N., Sengupta, U., Litvinchuk, A., Orr, H. T., Kayed, R. & Zoghbi, H. Y., May 19 2015, In : eLife. 4, MAY, p. 1-46 46 p., e07558.

Research output: Contribution to journalArticle

16 Scopus citations
2018

Evaluating Tau Oligomers Passive Immunotherapy using Aged Transgenic Animals of Tauopathy

Al Lahham, R., Bittar, A., Montalbano, M., Carretero Murillo, M., McAllen, S., Bhatt, N., Ellsworth, A. & Kayed, R., Jul 2018, In : Alzheimer's and Dementia. 14, 7, p. 1657

Research output: Contribution to journalMeeting Abstract

2020

RNA-binding proteins Musashi and tau soluble aggregates initiate nuclear dysfunction

Montalbano, M., McAllen, S., Puangmalai, N., Sengupta, U., Bhatt, N., Johnson, O. D., Kharas, M. G. & Kayed, R., Dec 1 2020, In : Nature communications. 11, 1, 4305.

Research output: Contribution to journalArticle

Open Access
2017

Selective lowering of synapsins induced by oligomeric α-synuclein exacerbates memory deficits

Larson, M. E., Greimel, S. J., Amar, F., LaCroix, M., Boyle, G., Sherman, M. A., Schley, H., Miel, C., Schneider, J. A., Kayed, R., Benfenati, F., Lee, M. K., Bennett, D. A. & Lesné, S. E., Jun 6 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 23, p. E4648-E4657

Research output: Contribution to journalArticle

23 Scopus citations
2011

ApoE4-driven accumulation of intraneuronal oligomerized Aß42 following activation of the amyloid cascade in vivo is mediated by a gain of function

Zepa, L., Frenkel, M., Belinson, H., Kariv-Inbal, Z., Kayed, R., Masliah, E. & Michaelson, D. M., 2011, In : International Journal of Alzheimer's Disease. 792070.

Research output: Contribution to journalArticle

21 Scopus citations
2018

α-Synuclein Oligomers Induce a Unique Toxic Tau Strain

Castillo-Carranza, D. L., Guerrero-Muñoz, M. J., Sengupta, U., Gerson, J. E. & Kayed, R., Jan 1 2018, (Accepted/In press) In : Biological Psychiatry.

Research output: Contribution to journalArticle

23 Scopus citations
2017

Oligomeric tau-targeted immunotherapy in Tg4510 mice

Schroeder, S., Joly-Amado, A., Soliman, A., Sengupta, U., Kayed, R., Gordon, M. N. & Morgan, D., Jun 27 2017, In : Alzheimer's Research and Therapy. 9, 1, 46.

Research output: Contribution to journalArticle

5 Scopus citations
2018

Tau oligomers mediate α-synuclein toxicity and can be targeted by immunotherapy

Gerson, J. E., Farmer, K. M., Henson, N., Castillo-Carranza, D. L., Carretero Murillo, M., Sengupta, U., Barrett, A. & Kayed, R., Mar 15 2018, In : Molecular Neurodegeneration. 13, 1, 13.

Research output: Contribution to journalArticle

18 Scopus citations

Soluble tau aggregates, not large fibrils, are the toxic species that display seeding and cross-seeding behavior

Ghag, G., Bhatt, N., Cantu, D. V., Guerrero-Munoz, M. J., Ellsworth, A., Sengupta, U. & Kayed, R., Nov 2018, In : Protein Science. 27, 11, p. 1901-1909 9 p.

Research output: Contribution to journalArticle

16 Scopus citations
2013

Tau aggregates as immunotherapeutic targets

Castillo-Carranza, D. L., Lasagna-Reeves, C. A. & Kayed, R., Jan 1 2013, In : Frontiers in Bioscience - Scholar. 5 S, 2, p. 426-438 13 p.

Research output: Contribution to journalArticle

30 Scopus citations

Rapid accumulation of endogenous Tau oligomers in a rat model of traumatic brain injury: Possible link between traumatic brain injury and sporadic tauopathies

Hawkins, B. E., Krishnamurthy, S., Castillo-Carranza, D. L., Sengupta, U., Prough, D. S., Jackson, G. R., DeWitt, D. S. & Kayed, R., Jun 7 2013, In : Journal of Biological Chemistry. 288, 23, p. 17042-17050 9 p.

Research output: Contribution to journalArticle

87 Scopus citations
2018

Preparation and characterization of tau oligomer strains

Sengupta, U., Carretero-Murillo, M. & Kayed, R., Jan 1 2018, Methods in Molecular Biology. Humana Press Inc., p. 113-146 34 p. (Methods in Molecular Biology; vol. 1779).

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations
2015

Pathological Interface between Oligomeric Alpha-Synuclein and Tau in Synucleinopathies

Sengupta, U., Guerrero-Muñoz, M. J., Castillo-Carranza, D. L., Lasagna-Reeves, C. A., Gerson, J. E., Paulucci-Holthauzen, A. A., Krishnamurthy, S., Farhed, M., Jackson, G. R. & Kayed, R., Nov 15 2015, In : Biological Psychiatry. 78, 10, p. 672-683 12 p.

Research output: Contribution to journalArticle

85 Scopus citations

The interrelationship of proteasome impairment and oligomeric intermediates in neurodegeneration

Deger, J. M., Gerson, J. E. & Kayed, R., Oct 1 2015, In : Aging cell. 14, 5, p. 715-724 10 p.

Research output: Contribution to journalReview article

37 Scopus citations
2013

Molecular mechanisms of amyloid oligomers toxicity

Kayed, R. & Lasagna-Reeves, C. A., Jan 1 2013, In : Journal of Alzheimer's Disease. 33, SUPPL. 1, p. S67-S78

Research output: Contribution to journalReview article

199 Scopus citations
2018

Tau Immunotherapy for Alpha-Synucleinopathy

Aguilar, C., Al Lahham, R., Sengupta, U., Carretero Murillo, M., Kayed, R. & Dineley, K., Jul 2018, In : Alzheimer's and Dementia. 14, 7, p. 1442

Research output: Contribution to journalMeeting Abstract

2015

Ataxin-1 oligomers induce local spread of pathology and decreasing them by passive immunization slows spinocerebellar ataxia type 1 phenotypes

Lasagna-Reeves, C. A., Rousseaux, M. W. C., Guerrero-Munoz, M. J., Vilanova-Velez, L., Park, J., See, L., Jafar-Nejad, P., Richman, R., Orr, H. T., Kayed, R. & Zoghbi, H. Y., Dec 17 2015, In : eLife. 4, DECEMBER2015, e10891.

Research output: Contribution to journalArticle

9 Scopus citations
2018

Formation of Toxic Oligomeric Assemblies of RNA-binding Protein: Musashi in Alzheimer's disease

Sengupta, U., Montalbano, M., McAllen, S., Minuesa, G., Kharas, M. & Kayed, R., Oct 26 2018, In : Acta Neuropathologica Communications. 6, 1, p. 113 1 p.

Research output: Contribution to journalArticle

5 Scopus citations
2013

Formation and propagation of tau oligomeric seeds

Gerson, J. E. & Kayed, R., Sep 11 2013, In : Frontiers in Neurology. 4 JUL, Article 93.

Research output: Contribution to journalReview article

65 Scopus citations
2011

Role of oligomers in the amyloidogenesis of primary cutaneous amyloidosis

Clos, A. L., Lasagna-Reeves, C. A., Kelly, B., Wagner, R., Wilkerson, M., Jackson, G. R. & Kayed, R., Nov 1 2011, In : Journal of the American Academy of Dermatology. 65, 5, p. 1023-1031 9 p.

Research output: Contribution to journalArticle

9 Scopus citations
2018

AAV2-mediated GRP78 transfer alleviates retinal neuronal injury by downregulating ER stress and Tau oligomer formation

Ha, Y., Liu, W., Liu, H., Zhu, S., Xia, F., Gerson, J. E., Azhar, N. A., Tilton, R. G., Motamedi, M., Kayed, R. & Zhang, W., Sep 2018, In : Investigative Ophthalmology and Visual Science. 59, 11, p. 4670-4682 13 p.

Research output: Contribution to journalArticle

5 Scopus citations
2020

Advances and considerations in AD tau-targeted immunotherapy

Bittar, A., Bhatt, N. & Kayed, R., Feb 2020, In : Neurobiology of Disease. 134, 104707.

Research output: Contribution to journalReview article

Open Access
7 Scopus citations
2019

Toxic Tau Oligomers Modulated by Novel Curcumin Derivatives

Lo Cascio, F., Puangmalai, N., Ellsworth, A., Bucchieri, F., Pace, A., Palumbo Piccionello, A. & Kayed, R., Dec 1 2019, In : Scientific reports. 9, 1, 19011.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations
2017

Corrigendum: Pre-amyloid oligomers budding:a metastatic mechanism of proteotoxicity

Bernini, F., Malferrari, D., Pignataro, M., Bortolotti, C. A., Di Rocco, G., Lancellotti, L., Brigatti, M. F., Kayed, R., Borsari, M., Del Monte, F. & Castellini, E., Jan 19 2017, In : Scientific reports. 7, 1 p.

Research output: Contribution to journalComment/debate

Open Access
2011

Tau oligomers as potential targets for immunotherapy for alzheimer's disease and tauopathies

Lasagna-Reeves, C. A., Castillo-Carranza, D. L., Jackson, G. R. & Kayed, R., Sep 1 2011, In : Current Alzheimer Research. 8, 6, p. 659-665 7 p.

Research output: Contribution to journalArticle

56 Scopus citations
2015

Prefibrillar Tau oligomers alter the nucleic acid protective function of Tau in hippocampal neurons in vivo

Violet, M., Chauderlier, A., Delattre, L., Tardivel, M., Chouala, M. S., Sultan, A., Marciniak, E., Humez, S., Binder, L., Kayed, R., Lefebvre, B., Bonnefoy, E., Buée, L. & Galas, M. C., Oct 1 2015, In : Neurobiology of Disease. 82, p. 540-551 12 p.

Research output: Contribution to journalArticle

33 Scopus citations
2018

Tau Immunotherapy for Alpha-Synucleinopathy

Aguilar, C., Al Lahham, R., Sengupta, U., Carretero Murillo, M., Kayed, R. & Dineley, K., Jul 2018, In : Alzheimer's and Dementia. 14, 7, p. 1412

Research output: Contribution to journalArticle

Binding and neurotoxicity mitigation of toxic tau oligomers by synthetic heparin like oligosaccharides

Wang, P., Lo Cascio, F., Gao, J., Kayed, R. & Huang, X., 2018, In : Chemical Communications. 54, 72, p. 10120-10123 4 p.

Research output: Contribution to journalArticle

8 Scopus citations
2011

Astrocytes contain amyloid-β annular protofibrils in Alzheimer's disease brains

Lasagna-Reeves, C. A. & Kayed, R., Oct 3 2011, In : FEBS Letters. 585, 19, p. 3052-3057 6 p.

Research output: Contribution to journalArticle

27 Scopus citations
2015

Tau immunotherapy modulates both pathological tau and upstream amyloid pathology in an alzheimer’s disease mouse model

Castillo-Carranza, D. L., Guerrero-Muñoz, M. J., Sengupta, U., Hernandez, C., Barrett, A. D. T., Dineley, K. & Kayed, R., 2015, In : Journal of Neuroscience. 35, 12, p. 4857-4868 12 p.

Research output: Contribution to journalArticle

79 Scopus citations
2017

Evaluating Tau Oligomers Passive Immunotherapy using Aged Transgenic Animals of Tauopathy

Al Lahham, R., Bittar, A., Carretero Murillo, M., McAllen, S., Bhatt, N., Ellsworth, A. & Kayed, R., Dec 2017, (Unpublished).

Research output: Contribution to conferencePoster

Tau oligomers associate with inflammation in the brain and retina of tauopathy mice and in neurodegenerative diseases

Nilson, A. N., English, K. C., Gerson, J. E., Barton Whittle, T., Nicolas Crain, C., Xue, J., Sengupta, U., Castillo-Carranza, D. L., Zhang, W., Gupta, P. & Kayed, R., 2017, In : Journal of Alzheimer's Disease. 55, 3, p. 1083-1099 17 p.

Research output: Contribution to journalArticle

43 Scopus citations
2018

Evaluating Passive Immunotherapy using Aged Transgenic Animals of Tauopathy

Al Lahham, R., Bittar, A., Montalbano, M., Carretero Murillo, M., McAllen, S., Bhatt, N., Ellsworth, A. & Kayed, R., Apr 2018, (Unpublished).

Research output: Contribution to conferencePoster

2019

Near Infrared Light Treatment Reduces Synaptic Levels of Toxic Tau Oligomers in Two Transgenic Mouse Models of Human Tauopathies

Comerota, M. M., Tumurbaatar, B., Krishnan, B., Kayed, R. & Taglialatela, G., May 1 2019, In : Molecular Neurobiology. 56, 5, p. 3341-3355 15 p.

Research output: Contribution to journalArticle

4 Scopus citations
2017
15 Scopus citations
2018

Azure C Targets and Modulates Toxic Tau Oligomers

Lo Cascio, F. & Kayed, R., Jun 20 2018, In : ACS Chemical Neuroscience. 9, 6, p. 1317-1326 10 p.

Research output: Contribution to journalArticle

15 Scopus citations
2013

Small misfolded tau species are internalized via bulk endocytosis and anterogradely and retrogradely transported in neurons

Wu, J. W., Herman, M., Liu, L., Simoes, S., Acker, C. M., Figueroa, H., Steinberg, J. I., Margittai, M., Kayed, R., Zurzolo, C., Di Paolo, G. & Duff, K. E., Jan 18 2013, In : Journal of Biological Chemistry. 288, 3, p. 1856-1870 15 p.

Research output: Contribution to journalArticle

258 Scopus citations

Design of metastable β-sheet oligomers from natively unstructured peptide

Guerrero-Muñoz, M. J., Castillo-Carranza, D. L., Sengupta, U., White, M. A. & Kayed, R., Dec 18 2013, In : ACS chemical neuroscience. 4, 12, p. 1520-1523 4 p.

Research output: Contribution to journalArticle

9 Scopus citations
2018

Prospects for strain-specific immunotherapy in Alzheimer's disease and tauopathies

Bittar, A., Sengupta, U. & Kayed, R., Dec 1 2018, In : npj Vaccines. 3, 1, 9.

Research output: Contribution to journalArticle

23 Scopus citations

Immunotherapy Targeting Tau Oligomeric Strains in Aged Transgenic Animals of Tauopathy

Al Lahham, R., Bittar, A., Carretero Murillo, M., McAllen, S., Bhatt, N., Ellsworth, A. & Kayed, R., Oct 2018, p. S64.

Research output: Contribution to conferenceAbstract

2017

Tau Oligomers in Sera of Patients with Alzheimer's Disease and Aged Controls

Kolarova, M., Sengupta, U., Bartos, A., Ricny, J. & Kayed, R., 2017, In : Journal of Alzheimer's Disease. 58, 2, p. 471-478 8 p.

Research output: Contribution to journalArticle

10 Scopus citations
2019

Amyloid oligomer interactions and polymorphisms: disease-relevant distinct assembly of α-synuclein and tau

Sengupta, U. & Kayed, R., Jan 1 2019, In : Neuropsychopharmacology. 44, 1, p. 222-223 2 p.

Research output: Contribution to journalComment/debate

1 Scopus citations
2011

Formation of immunoglobulin light chain amyloid oligomers in primary cutaneous nodular amyloidosis

Clos, A. L., Lasagna-Reeves, C. A., Castillo-Carranza, D. L., Sengupta, U., Jackson, G. R., Kelly, B., Beachkofsky, T. M. & Kayed, R., Dec 1 2011, In : British Journal of Dermatology. 165, 6, p. 1349-1354 6 p.

Research output: Contribution to journalArticle

12 Scopus citations
2020

Revisiting the intersection of amyloid, pathologically modified tau and iron in Alzheimer's disease from a ferroptosis perspective

Derry, P. J., Hegde, M. L., Jackson, G. R., Kayed, R., Tour, J. M., Tsai, A. L. & Kent, T. A., Jan 2020, In : Progress in Neurobiology. 184, 101716.

Research output: Contribution to journalReview article

Open Access
9 Scopus citations