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  • Rakez Kayed
2014

TDP-43 phosphorylation by casein kinase iε promotes oligomerization and enhances toxicity in vivo

Choksi, D. K., Roy, B., Chatterjee, S., Yusuff, T., Bakhoum, M. F., Sengupta, U., Ambegaokar, S., Kayed, R. & Jackson, G. R., Feb 1 2014, In : Human Molecular Genetics. 23, 4, p. 1025-1035 11 p., ddt498.

Research output: Contribution to journalArticle

48 Scopus citations
2019

Near Infrared Light Treatment Reduces Synaptic Levels of Toxic Tau Oligomers in Two Transgenic Mouse Models of Human Tauopathies

Comerota, M. M., Tumurbaatar, B., Krishnan, B., Kayed, R. & Taglialatela, G., May 1 2019, In : Molecular Neurobiology. 56, 5, p. 3341-3355 15 p.

Research output: Contribution to journalArticle

4 Scopus citations
2018

Soluble tau aggregates, not large fibrils, are the toxic species that display seeding and cross-seeding behavior

Ghag, G., Bhatt, N., Cantu, D. V., Guerrero-Munoz, M. J., Ellsworth, A., Sengupta, U. & Kayed, R., Nov 1 2018, In : Protein Science. 27, 11, p. 1901-1909 9 p.

Research output: Contribution to journalArticle

11 Scopus citations
2017

Corrigendum: Pre-amyloid oligomers budding:a metastatic mechanism of proteotoxicity

Bernini, F., Malferrari, D., Pignataro, M., Bortolotti, C. A., Di Rocco, G., Lancellotti, L., Brigatti, M. F., Kayed, R., Borsari, M., Del Monte, F. & Castellini, E., Jan 19 2017, In : Scientific reports. 7, 1 p.

Research output: Contribution to journalComment/debate

Open Access
2018

α-Synuclein Oligomers Induce a Unique Toxic Tau Strain

Castillo-Carranza, D. L., Guerrero-Muñoz, M. J., Sengupta, U., Gerson, J. E. & Kayed, R., Jan 1 2018, (Accepted/In press) In : Biological Psychiatry.

Research output: Contribution to journalArticle

17 Scopus citations
2019

Amyloid oligomer interactions and polymorphisms: disease-relevant distinct assembly of α-synuclein and tau

Sengupta, U. & Kayed, R., Jan 1 2019, In : Neuropsychopharmacology. 44, 1, p. 222-223 2 p.

Research output: Contribution to journalComment/debate

1 Scopus citations
2017

The Potential of Small Molecules in Preventing Tau Oligomer Formation and Toxicity

Gerson, J. E., Lo Cascio, F. & Kayed, R., Jan 20 2017, Neuroprotection in Alzheimer's Disease. Elsevier Inc., p. 97-121 25 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Selective lowering of synapsins induced by oligomeric α-synuclein exacerbates memory deficits

Larson, M. E., Greimel, S. J., Amar, F., LaCroix, M., Boyle, G., Sherman, M. A., Schley, H., Miel, C., Schneider, J. A., Kayed, R., Benfenati, F., Lee, M. K., Bennett, D. A. & Lesné, S. E., Jun 6 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 23, p. E4648-E4657

Research output: Contribution to journalArticle

22 Scopus citations
2013

Molecular mechanisms of amyloid oligomers toxicity

Kayed, R. & Lasagna-Reeves, C. A., Jan 1 2013, In : Journal of Alzheimer's Disease. 33, SUPPL. 1, p. S67-S78

Research output: Contribution to journalReview article

190 Scopus citations
2017

Evaluating Tau Oligomers Passive Immunotherapy using Aged Transgenic Animals of Tauopathy

Al Lahham, R., Bittar, A., Carretero Murillo, M., McAllen, S., Bhatt, N., Ellsworth, A. & Kayed, R., Dec 2017, (Unpublished).

Research output: Contribution to conferencePoster

2014

Amyloid-β oligomers as a template for secondary amyloidosis in Alzheimer's disease

Guerrero-Muñoz, M. J., Castillo-Carranza, D. L., Krishnamurthy, S., Paulucci-Holthauzen, A. A., Sengupta, U., Lasagna-Reeves, C. A., Ahmad, Y., Jackson, G. R. & Kayed, R., Nov 2014, In : Neurobiology of Disease. 71, p. 14-23 10 p.

Research output: Contribution to journalArticle

27 Scopus citations

Characterization of tau oligomeric seeds in progressive supranuclear palsy

Gerson, J. E., Sengupta, U., Lasagna-Reeves, C. A., Guerrero-Muñoz, M. J., Troncoso, J. & Kayed, R., Jan 27 2014, In : Acta Neuropathologica Communications. 2, 1, 73.

Research output: Contribution to journalArticle

42 Scopus citations
2012

Vaccination with a non-human random sequence amyloid oligomer mimic results in improved cognitive function and reduced plaque deposition and micro hemorrhage in Tg2576 mice

Rasool, S., Albay, R., Martinez-Coria, H., Breydo, L., Wu, J., Milton, S., Misra, S., Tran, A., Pensalfini, A., Laferla, F., Kayed, R. & Glabe, C. G., 2012, In : Molecular Neurodegeneration. 7, 1, 37.

Research output: Contribution to journalArticle

29 Scopus citations
2018

AAV2-mediated GRP78 transfer alleviates retinal neuronal injury by downregulating ER stress and Tau oligomer formation

Ha, Y., Liu, W., Liu, H., Zhu, S., Xia, F., Gerson, J. E., Azhar, N. A., Tilton, R., Motamedi, M., Kayed, R. & Zhang, W., Sep 1 2018, In : Investigative Ophthalmology and Visual Science. 59, 11, p. 4670-4682 13 p.

Research output: Contribution to journalArticle

5 Scopus citations

Tau oligomers mediate α-synuclein toxicity and can be targeted by immunotherapy

Gerson, J. E., Farmer, K. M., Henson, N., Castillo-Carranza, D. L., Carretero Murillo, M., Sengupta, U., Barrett, A. & Kayed, R., Mar 15 2018, In : Molecular Neurodegeneration. 13, 1, 13.

Research output: Contribution to journalArticle

14 Scopus citations
2012

Molecular mechanisms of amyloid oligomers toxicity

Kayed, R. & Lasagna-Reeves, C. A., Dec 1 2012, Alzheimer'S Disease: Advances For A New Century. Perry, G., Zhu, X., Smith, M., Sorensen, A. & Avila, J. (eds.). p. 67-78 12 p. (Advances in Alzheimer's Disease; vol. 3).

Research output: Chapter in Book/Report/Conference proceedingChapter

16 Scopus citations
2018
10 Scopus citations
2015

Prefibrillar Tau oligomers alter the nucleic acid protective function of Tau in hippocampal neurons in vivo

Violet, M., Chauderlier, A., Delattre, L., Tardivel, M., Chouala, M. S., Sultan, A., Marciniak, E., Humez, S., Binder, L., Kayed, R., Lefebvre, B., Bonnefoy, E., Buée, L. & Galas, M. C., Oct 1 2015, In : Neurobiology of Disease. 82, p. 540-551 12 p.

Research output: Contribution to journalArticle

33 Scopus citations

Ataxin-1 oligomers induce local spread of pathology and decreasing them by passive immunization slows spinocerebellar ataxia type 1 phenotypes

Lasagna-Reeves, C. A., Rousseaux, M. W. C., Guerrero-Munoz, M. J., Vilanova-Velez, L., Park, J., See, L., Jafar-Nejad, P., Richman, R., Orr, H. T., Kayed, R. & Zoghbi, H. Y., Dec 17 2015, In : eLife. 4, DECEMBER2015, e10891.

Research output: Contribution to journalArticle

9 Scopus citations
2012

Tau protein: Function and pathology

Rosenmann, H., Blum, D., Kayed, R. & Ittner, L. M., 2012, In : International Journal of Alzheimer's Disease. 707482.

Research output: Contribution to journalEditorial

5 Scopus citations
2014

Advances in therapeutics for neurodegenerative tauopathies: Moving toward the specific targeting of the most toxic tau species

Gerson, J. E., Castillo-Carranza, D. L. & Kayed, R., Sep 17 2014, In : ACS chemical neuroscience. 5, 9, p. 752-769 18 p.

Research output: Contribution to journalReview article

32 Scopus citations
2013

Molecular mechanisms of amyloid oligomers toxicity

Kayed, R. & Lasagna-Reeves, C. A., Feb 15 2013, Alzheimer's Disease: Advances for a New Century. IOS Press, p. 67-78 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations
2016

Advances in tau immunotherapy

Gerson, J. & Kayed, R., Jan 1 2016, Research Progress in Alzheimer’s Disease and Dementia. Volume 6. Nova Science Publishers, Inc., p. 99-114 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2013

Formation and propagation of tau oligomeric seeds

Gerson, J. E. & Kayed, R., Sep 11 2013, In : Frontiers in Neurology. 4 JUL, Article 93.

Research output: Contribution to journalReview article

64 Scopus citations
2012

Differential activation of the ER stress factor XBP1 by oligomeric assemblies

Castillo-Carranza, D. L., Zhang, Y., Guerrero-Muñoz, M. J., Kayed, R., Rincon-Limas, D. E. & Fernandez-Funez, P., Aug 1 2012, In : Neurochemical Research. 37, 8, p. 1707-1717 11 p.

Research output: Contribution to journalArticle

24 Scopus citations
2013

Dual role of p53 amyloid formation in cancer; loss of function and gain of toxicity

Lasagna-Reeves, C. A., Clos, A. L., Castillo-Carranza, D., Sengupta, U., Guerrero-Muñoz, M., Kelly, B., Wagner, R. & Kayed, R., Jan 18 2013, In : Biochemical and Biophysical Research Communications. 430, 3, p. 963-968 6 p.

Research output: Contribution to journalArticle

45 Scopus citations
2014

Therapeutic approaches against common structural features of toxic oligomers shared by multiple amyloidogenic proteins

Guerrero-Muñoz, M. J., Castillo-Carranza, D. L. & Kayed, R., Apr 15 2014, In : Biochemical Pharmacology. 88, 4, p. 468-478 11 p.

Research output: Contribution to journalReview article

75 Scopus citations
2019

Toxic Tau Oligomers Modulated by Novel Curcumin Derivatives

Lo Cascio, F., Puangmalai, N., Ellsworth, A., Bucchieri, F., Pace, A., Palumbo Piccionello, A. & Kayed, R., Dec 1 2019, In : Scientific reports. 9, 1, 19011.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
2017

Tau oligomers as pathogenic seeds: Preparation and propagation in vitro and in vivo

Gerson, J. E., Sengupta, U. & Kayed, R., 2017, Methods in Molecular Biology. Humana Press Inc., Vol. 1523. p. 141-157 17 p. (Methods in Molecular Biology; vol. 1523).

Research output: Chapter in Book/Report/Conference proceedingChapter

10 Scopus citations
2019

NLRP3 inflammasome activation drives tau pathology

Ising, C., Venegas, C., Zhang, S., Scheiblich, H., Schmidt, S. V., Vieira-Saecker, A., Schwartz, S., Albasset, S., McManus, R. M., Tejera, D., Griep, A., Santarelli, F., Brosseron, F., Opitz, S., Stunden, J., Merten, M., Kayed, R., Golenbock, D. T., Blum, D., Latz, E. & 2 others, Buée, L. & Heneka, M. T., Nov 28 2019, In : Nature. 575, 7784, p. 669-673 5 p.

Research output: Contribution to journalArticle

44 Scopus citations

Tau oligomers mediate aggregation of RNA-binding proteins Musashi1 and Musashi2 inducing Lamin alteration

Montalbano, M., McAllen, S., Sengupta, U., Puangmalai, N., Bhatt, N., Ellsworth, A. & Kayed, R., Dec 1 2019, In : Aging Cell. 18, 6, e13035.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Tau Interacts with the C-Terminal Region of α-Synuclein, Promoting Formation of Toxic Aggregates with Distinct Molecular Conformations

Dasari, A. K. R., Kayed, R., Wi, S. & Lim, K. H., Jun 25 2019, In : Biochemistry. 58, 25, p. 2814-2821 8 p.

Research output: Contribution to journalArticle

2 Scopus citations
2020

Advances and considerations in AD tau-targeted immunotherapy

Bittar, A., Bhatt, N. & Kayed, R., Feb 2020, In : Neurobiology of Disease. 134, 104707.

Research output: Contribution to journalReview article

Open Access
5 Scopus citations
2017

Cerebral microvascular accumulation of tau oligomers in Alzheimer's disease and related tauopathies

Castillo-Carranza, D. L., Nilson, A. N., Van Skike, C. E., Jahrling, J. B., Patel, K., Garach, P., Gerson, J. E., Sengupta, U., Abisambra, J., Nelson, P., Troncoso, J., Ungvari, Z., Galvan, V. & Kayed, R., 2017, In : Aging and Disease. 8, 3, p. 257-266 10 p.

Research output: Contribution to journalArticle

24 Scopus citations
2013

Tau aggregates as immunotherapeutic targets

Castillo-Carranza, D. L., Lasagna-Reeves, C. A. & Kayed, R., Jan 1 2013, In : Frontiers in Bioscience - Scholar. 5 S, 2, p. 426-438 13 p.

Research output: Contribution to journalArticle

30 Scopus citations

Design of metastable β-sheet oligomers from natively unstructured peptide

Guerrero-Muñoz, M. J., Castillo-Carranza, D. L., Sengupta, U., White, M. A. & Kayed, R., Dec 18 2013, In : ACS chemical neuroscience. 4, 12, p. 1520-1523 4 p.

Research output: Contribution to journalArticle

9 Scopus citations
2018

Immunotherapy Targeting Tau Oligomeric Strains in Aged Transgenic Animals of Tauopathy

Al Lahham, R., Bittar, A., Carretero Murillo, M., McAllen, S., Bhatt, N., Ellsworth, A. & Kayed, R., Oct 2018, p. S64.

Research output: Contribution to conferenceAbstract

2016

Aβ Amyloid Pathology Affects the Hearts of Patients With Alzheimer's Disease: Mind the Heart

Troncone, L., Luciani, M., Coggins, M., Wilker, E. H., Ho, C. Y., Codispoti, K. E., Frosch, M. P., Kayed, R. & del Monte, F., Dec 6 2016, In : Journal of the American College of Cardiology. 68, 22, p. 2395-2407 13 p.

Research output: Contribution to journalArticle

52 Scopus citations
2018

Prospects for strain-specific immunotherapy in Alzheimer's disease and tauopathies

Bittar, A., Sengupta, U. & Kayed, R., Dec 1 2018, In : npj Vaccines. 3, 1, 9.

Research output: Contribution to journalArticle

21 Scopus citations
2015

The interrelationship of proteasome impairment and oligomeric intermediates in neurodegeneration

Deger, J. M., Gerson, J. E. & Kayed, R., Oct 1 2015, In : Aging Cell. 14, 5, p. 715-724 10 p.

Research output: Contribution to journalArticle

35 Scopus citations
2012

Identification of oligomers at early stages of tau aggregation in Alzheimer's disease

Lasagna-Reeves, C. A., Castillo-Carranza, D. L., Sengupta, U., Sarmiento, J., Troncoso, J., Jackson, G. R. & Kayed, R., May 1 2012, In : FASEB Journal. 26, 5, p. 1946-1959 14 p.

Research output: Contribution to journalArticle

215 Scopus citations
2018

Azure C Targets and Modulates Toxic Tau Oligomers

Lo Cascio, F. & Kayed, R., Jun 20 2018, In : ACS Chemical Neuroscience. 9, 6, p. 1317-1326 10 p.

Research output: Contribution to journalArticle

13 Scopus citations

Binding and neurotoxicity mitigation of toxic tau oligomers by synthetic heparin like oligosaccharides

Wang, P., Lo Cascio, F., Gao, J., Kayed, R. & Huang, X., Jan 1 2018, In : Chemical Communications. 54, 72, p. 10120-10123 4 p.

Research output: Contribution to journalArticle

7 Scopus citations

Evaluating Passive Immunotherapy using Aged Transgenic Animals of Tauopathy

Al Lahham, R., Bittar, A., Montalbano, M., Carretero Murillo, M., McAllen, S., Bhatt, N., Ellsworth, A. & Kayed, R., Apr 2018, (Unpublished).

Research output: Contribution to conferencePoster

2016

Caspase-cleaved tau exhibits rapid memory impairment associated with tau oligomers in a transgenic mouse model

Kim, Y., Choi, H., Lee, W., Park, H., Kam, T. I., Hong, S. H., Nah, J., Jung, S., Shin, B., Lee, H., Choi, T. Y., Choo, H., Kim, K. K., Choi, S. Y., Kayed, R. & Jung, Y. K., Mar 1 2016, In : Neurobiology of Disease. 87, p. 19-28 10 p.

Research output: Contribution to journalArticle

25 Scopus citations

Oligomer Formation and Cross-Seeding: The New Frontier

Farmer, K., Gerson, J. E. & Kayed, R., 2016, (Accepted/In press) In : Israel Journal of Chemistry.

Research output: Contribution to journalArticle

3 Scopus citations
2014

Passive immunization with tau oligomer monoclonal antibody reverses tauopathy phenotypes without affecting hyperphosphorylated neurofibrillary tangles

Castillo-Carranza, D. L., Sengupta, U., Guerrero-Muñoz, M. J., Lasagna-Reeves, C. A., Gerson, J. E., Singh, G., Mark Estes, D., Barrett, A. D. T., Dineley, K. T., Jackson, G. R. & Kayed, R., Jan 1 2014, In : Journal of Neuroscience. 34, 12, p. 4260-4272 13 p.

Research output: Contribution to journalArticle

148 Scopus citations
2017
15 Scopus citations
2012

Association of skin with the pathogenesis and treatment of neurodegenerative amyloidosis

Clos, A. L., Kayed, R. & Lasagna-Reeves, C. A., Sep 12 2012, In : Frontiers in Neurology. JAN, Article 5.

Research output: Contribution to journalArticle

10 Scopus citations
2014

The formation of tau pore-like structures is prevalent and cell specific: Possible implications for the disease phenotypes

Lasagna-Reeves, C. A., Sengupta, U., Castillo-Carranza, D., Gerson, J. E., Guerrero-Munoz, M., Troncoso, J. C., Jackson, G. R. & Kayed, R., Jan 27 2014, In : Acta Neuropathologica Communications. 2, 1, 56.

Research output: Contribution to journalArticle

32 Scopus citations