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  • Chad Mire
2016

Targeting innate immunity for antiviral therapy through small molecule agonists of the RLR pathway

Pattabhi, S., Wilkins, C. R., Dong, R., Knoll, M. L., Posakony, J., Kaiser, S., Mire, C., Wang, M. L., Ireton, R. C., Geisbert, T., Bedard, K. M., Iadonato, S. P., Loo, Y. M. & Gale, M., 2016, In : Journal of Virology. 90, 5, p. 2372-2387 16 p.

Research output: Contribution to journalArticle

24 Scopus citations
2018

Erratum: Correction for Olsen et al., "Polyamines and Hypusination Are Required for Ebolavirus Gene Expression and Replication" (mBio (2016) 7 4 PII: e01065-18)

Olsen, M. E., Filone, C. M., Rozelle, D., Mire, C. E., Agans, K. N., Hensley, L. & Connor, J. H., Jun 5 2018, In : mBio. 9, 3

Research output: Contribution to journalComment/debate

Open Access

Marburg and Ravn Viruses Fail to Cause Disease in the Domestic Ferret (Mustela putorius furo)

Cross, R., Mire, C., Agans, K. N., Borisevich, V., Fenton, K. A. & Geisbert, T., Nov 22 2018, In : The Journal of infectious diseases. 218, 5, p. S448-S452

Research output: Contribution to journalArticle

6 Scopus citations
2020

Analysis of a Therapeutic Antibody Cocktail Reveals Determinants for Cooperative and Broad Ebolavirus Neutralization

Gilchuk, P., Murin, C. D., Milligan, J. C., Cross, R. W., Mire, C. E., Ilinykh, P. A., Huang, K., Kuzmina, N., Altman, P. X., Hui, S., Gunn, B. M., Bryan, A. L., Davidson, E., Doranz, B. J., Turner, H. L., Alkutkar, T., Flinko, R., Orlandi, C., Carnahan, R., Nargi, R. & 13 others, Bombardi, R. G., Vodzak, M. E., Li, S., Okoli, A., Ibeawuchi, M., Ohiaeri, B., Lewis, G. K., Alter, G., Bukreyev, A., Saphire, E. O., Geisbert, T. W., Ward, A. B. & Crowe, J. E., Feb 18 2020, In : Immunity. 52, 2, p. 388-403.e12

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
2019

An antibody against the F glycoprotein inhibits Nipah and Hendra virus infections

Dang, H. V., Chan, Y. P., Park, Y. J., Snijder, J., Da Silva, S. C., Vu, B., Yan, L., Feng, Y. R., Rockx, B., Geisbert, T. W., Mire, C. E., Broder, C. C. & Veesler, D., Oct 1 2019, In : Nature Structural and Molecular Biology. 26, 10, p. 980-987 8 p.

Research output: Contribution to journalArticle

5 Scopus citations
2018

Post-exposure treatments for Ebola and Marburg virus infections

Cross, R. W., Mire, C. E., Feldmann, H. & Geisbert, T. W., Jun 1 2018, In : Nature Reviews Drug Discovery. 17, 6, p. 413-434 22 p.

Research output: Contribution to journalReview article

46 Scopus citations
2017

Therapeutic treatment of marburg and ravn virus infection in nonhuman primates with a human monoclonal antibody

Mire, C. E., Geisbert, J. B., Borisevich, V., Fenton, K. A., Agans, K. N., Flyak, A. I., Deer, D. J., Steinkellner, H., Bohorov, O., Bohorova, N., Goodman, C., Hiatt, A., Kim, D. H., Pauly, M. H., Velasco, J., Whaley, K. J., Crowe, J. E., Zeitlin, L. & Geisbert, T. W., Apr 5 2017, In : Science Translational Medicine. 9, 384, eaai8711.

Research output: Contribution to journalArticle

27 Scopus citations
2015

Aerosolized Ebola vaccine protects primates and elicits lung-resident T cell responses

Meyer, M., Garron, T., Lubaki, N. M., Mire, C., Fenton, K. A., Klages, C., Olinger, G. G., Geisbert, T., Collins, P. L. & Bukreyev, A., Aug 3 2015, In : Journal of Clinical Investigation. 125, 8, p. 3241-3255 15 p.

Research output: Contribution to journalArticle

43 Scopus citations

Current and emerging strategies for the diagnosis, prevention and treatment of Lassa fever

Hartnett, J. N., Boisen, M. L., Oottamasathien, D., Jones, A. B., Millett, M. M., Nelson, D. S., Muncy, I. J., Goba, A., Momoh, M., Fullah, M., Mire, C. E., Geisbert, J. B., Geisbert, T. W., Holton, D. L., Rouelle, J. A., Kannadka, C. B., Reyna, A. A., Moses, L. M., Khan, S. H., Gevao, S. M. & 6 others, Grant, D. S., Robinson, J. E., Happi, C., Pitts, K. R., Garry, R. F. & Branco, L. M., May 1 2015, In : Future Virology. 10, 5, p. 559-584 26 p.

Research output: Contribution to journalReview article

9 Scopus citations
2017

Infection with the Makona variant results in a delayed and distinct host immune response compared to previous Ebola virus variants

Versteeg, K., Menicucci, A. R., Woolsey, C., Mire, C., Geisbert, J. B., Cross, R., Agans, K. N., Jeske, D., Messaoudi, I. & Geisbert, T., Dec 1 2017, In : Scientific Reports. 7, 1, 9730.

Research output: Contribution to journalArticle

12 Scopus citations
2016

Treatment of Lassa virus infection in outbred guinea pigs with first-in-class human monoclonal antibodies

Cross, R., Mire, C., Branco, L. M., Geisbert, J. B., Rowland, M. M., Heinrich, M. L., Goba, A., Momoh, M., Grant, D. S., Fullah, M., Khan, S. H., Robinson, J. E., Geisbert, T. & Garry, R. F., Sep 1 2016, In : Antiviral Research. 133, p. 218-222 5 p.

Research output: Contribution to journalArticle

26 Scopus citations
2018

Postexposure Efficacy of Recombinant Vesicular Stomatitis Virus Vectors Against High and Low Doses of Marburg Virus Variant Angola in Nonhuman Primates

Woolsey, C., Geisbert, J. B., Matassov, D., Agans, K. N., Borisevich, V., Cross, R., Deer, D. J., Fenton, K. A., Eldridge, J. H., Mire, C. & Geisbert, T., Nov 22 2018, In : The Journal of infectious diseases. 218, 5, p. S582-S587

Research output: Contribution to journalArticle

5 Scopus citations

A prophylactic multivalent vaccine against different filovirus species is immunogenic and provides protection from lethal infections with Ebolavirus and Marburgvirus species in non-human primates

Callendret, B., Vellinga, J., Wunderlich, K., Rodriguez, A., Steigerwald, R., Dirmeier, U., Cheminay, C., Volkmann, A., Brasel, T., Carrion, R., Giavedoni, L. D., Patterson, J. L., Mire, C. E., Geisbert, T. W., Hooper, J. W., Weijtens, M., Hartkoorn-Pasma, J., Custers, J., Pau, M. G., Schuitemaker, H. & 1 others, Zahn, R., Feb 2018, In : PloS one. 13, 2, e0192312.

Research output: Contribution to journalArticle

16 Scopus citations
2015

The immunomodulating v and W proteins of Nipah virus determine disease course

Satterfield, B. A., Cross, R., Fenton, K. A., Agans, K. N., Basler, C. F., Geisbert, T. & Mire, C., Jun 24 2015, In : Nature Communications. 6, 7483.

Research output: Contribution to journalArticle

27 Scopus citations
2016

Ebola virus vaccines – reality or fiction?

Mire, C., Geisbert, T., Feldmann, H. & Marzi, A., Nov 1 2016, In : Expert Review of Vaccines. 15, 11, p. 1421-1430 10 p.

Research output: Contribution to journalReview article

22 Scopus citations
2014

Marburg virus infection in nonhuman primates: Therapeutic treatment by lipid-encapsulated siRNA

Thi, E. P., Mire, C. E., Ursic-Bedoya, R., Geisbert, J. B., Lee, A. C. H., Agans, K. N., Robbins, M., Deer, D. J., Fenton, K. A., MacLachlan, I. & Geisbert, T. W., Aug 20 2014, In : Science Translational Medicine. 6, 250, 250ra116.

Research output: Contribution to journalArticle

47 Scopus citations
2016

Inhibition of the host antiviral response by Nipah virus: Current understanding and future perspectives

Satterfield, B. A., Geisbert, T. & Mire, C., May 1 2016, In : Future Virology. 11, 5, p. 331-344 14 p.

Research output: Contribution to journalArticle

5 Scopus citations
2013

Mutual antagonism between the ebola virus VP35 protein and the RIG-I activator PACT determines infection outcome

Luthra, P., Ramanan, P., Mire, C. E., Weisend, C., Tsuda, Y., Yen, B., Liu, G., Leung, D. W., Geisbert, T. W., Ebihara, H., Amarasinghe, G. K. & Basler, C. F., Jul 17 2013, In : Cell Host and Microbe. 14, 1, p. 74-84 11 p.

Research output: Contribution to journalArticle

105 Scopus citations
2019

Current Ebola Virus Vaccine Progress

Marzi, A. & Mire, C., Jan 1 2019, (Accepted/In press) In : BioDrugs.

Research output: Contribution to journalArticle

10 Scopus citations
2015

Lipid nanoparticle siRNA treatment of Ebola-virus-Makona-infected nonhuman primates

Thi, E. P., Mire, C., Lee, A. C. H., Geisbert, J. B., Zhou, J. Z., Agans, K. N., Snead, N. M., Deer, D. J., Barnard, T. R., Fenton, K. A., Maclachlan, I. & Geisbert, T., May 21 2015, In : Nature. 521, 7552, p. 362-365 4 p.

Research output: Contribution to journalArticle

151 Scopus citations
2014

Viral-vectored vaccines to control pathogenic filoviruses

Mire, C. & Geisbert, T., Jul 1 2014, Novel Technologies for Vaccine Development. Springer-Verlag Wien, Vol. 9783709118184. p. 33-60 28 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations
2017

Disposable cartridge platform for rapid detection of viral hemorrhagic fever viruses

Scherr, S. M., Freedman, D. S., Agans, K. N., Rosca, A., Carter, E., Kuroda, M., Fawcett, H. E., Mire, C. E., Geisbert, T. W., Ünlü, M. S. & Connor, J. H., Mar 7 2017, In : Lab on a Chip. 17, 5, p. 917-925 9 p.

Research output: Contribution to journalArticle

9 Scopus citations
2015

Modeling the Disease Course of Zaire ebolavirus Infection in the Outbred Guinea Pig

Cross, R., Fenton, K. A., Geisbert, J. B., Mire, C. & Geisbert, T., Oct 1 2015, In : Journal of Infectious Diseases. 212, p. S305-S315

Research output: Contribution to journalArticle

29 Scopus citations
2018

Efficacy of Human Monoclonal Antibody Monotherapy Against Bundibugyo Virus Infection in Nonhuman Primates

Gilchuk, P., Mire, C., Geisbert, J. B., Agans, K. N., Deer, D. J., Cross, R., Slaughter, J. C., Flyak, A. I., Mani, J., Pauly, M. H., Velasco, J., Whaley, K. J., Zeitlin, L., Geisbert, T. & Crowe, J. E., Nov 22 2018, In : The Journal of infectious diseases. 218, 5, p. S565-S573

Research output: Contribution to journalArticle

1 Scopus citations
2020

A Lethal Aerosol Exposure Model of Nipah Virus Strain Bangladesh in African Green Monkeys

Prasad, A. N., Agans, K. N., Sivasubramani, S. K., Geisbert, J. B., Borisevich, V., Mire, C. E., Lawrence, W. S., Fenton, K. A. & Geisbert, T. W., May 11 2020, In : Journal of Infectious Diseases. 221, p. S431-S435

Research output: Contribution to journalArticle

1 Scopus citations
2015

Vaccination with a Highly Attenuated Recombinant Vesicular Stomatitis Virus Vector Protects Against Challenge with a Lethal Dose of Ebola Virus

Matassov, D., Marzi, A., Latham, T., Xu, R., Ota-Setlik, A., Feldmann, F., Geisbert, J. B., Mire, C. E., Hamm, S., Nowak, B., Egan, M. A., Geisbert, T. W., Eldridge, J. H., Feldmann, H. & Clarke, D. K., Oct 1 2015, In : Journal of Infectious Diseases. 212, p. S443-S451

Research output: Contribution to journalArticle

31 Scopus citations
2018

Single-dose trivalent VesiculoVax vaccine protects macaques from lethal Ebolavirus and Marburgvirus challenge

Matassov, D., Mire, C. E., Latham, T., Geisbert, J. B., Xu, R., Ota-Setlik, A., Agans, K. N., Kobs, D. J., Wendling, M. Q. S., Burnaugh, A., Rudge, T. L., Sabourin, C. L., Egan, M. A., Clarke, D. K., Geisbert, T. W. & Eldridge, J. H., Feb 1 2018, In : Journal of virology. 92, 3, e01190-17.

Research output: Contribution to journalArticle

12 Scopus citations
2014

A recombinant Hendra Virus G glycoprotein subunit vaccine protects nonhuman primates against hendra virus challenge

Mire, C. E., Geisbert, J. B., Agans, K. N., Feng, Y. R., Fenton, K. A., Bossart, K. N., Yan, L., Chan, Y. P., Broder, C. C. & Geisbert, T. W., May 2014, In : Journal of virology. 88, 9, p. 4624-4631 8 p.

Research output: Contribution to journalArticle

23 Scopus citations
2016

Pathogenic Differences between Nipah Virus Bangladesh and Malaysia Strains in Primates: Implications for Antibody Therapy

Mire, C., Satterfield, B. A., Geisbert, J. B., Agans, K. N., Borisevich, V., Yan, L., Chan, Y. P., Cross, R., Fenton, K. A., Broder, C. C. & Geisbert, T., Aug 3 2016, In : Scientific Reports. 6, 30916.

Research output: Contribution to journalArticle

38 Scopus citations

The domestic ferret (mustela putorius furo) as a lethal infection model for 3 species of ebolavirus

Cross, R., Mire, C., Borisevich, V., Geisbert, J. B., Fenton, K. A. & Geisbert, T., Aug 15 2016, In : Journal of Infectious Diseases. 214, 4, p. 565-569 5 p.

Research output: Contribution to journalArticle

40 Scopus citations
2014

Deep sequencing identifies noncanonical editing of Ebola and Marburg virus RNAs in infected cells

Shabman, R. S., Jabado, O. J., Mire, C. E., Stockwell, T. B., Edwards, M., Mahajan, M., Geisbert, T. W. & Basler, C. F., 2014, In : mBio. 5, 6, p. e02011

Research output: Contribution to journalArticle

The Marburg Virus VP24 Protein Interacts with Keap1 to Activate the Cytoprotective Antioxidant Response Pathway

Edwards, M. R., Johnson, B., Mire, C. E., Xu, W., Shabman, R. S., Speller, L. N., Leung, D. W., Geisbert, T. W., Amarasinghe, G. K. & Basler, C. F., Mar 27 2014, In : Cell Reports. 6, 6, p. 1017-1025 9 p.

Research output: Contribution to journalArticle

59 Scopus citations
2015

A Recombinant Vesicular Stomatitis Virus-Based Lassa Fever Vaccine Protects Guinea Pigs and Macaques against Challenge with Geographically and Genetically Distinct Lassa Viruses

Safronetz, D., Mire, C., Rosenke, K., Feldmann, F., Haddock, E., Geisbert, T. & Feldmann, H., Apr 17 2015, In : PLoS Neglected Tropical Diseases. 9, 4, e0003736.

Research output: Contribution to journalArticle

47 Scopus citations
2017

Assessment of the potential for host-targeted iminosugars UV-4 and UV-5 activity against filovirus infections in vitro and in vivo

Warfield, K. L., Warren, T. K., Qiu, X., Wells, J., Mire, C., Geisbert, J. B., Stuthman, K. S., Garza, N. L., Van Tongeren, S. A., Shurtleff, A. C., Agans, K. N., Wong, G., Callahan, M. V., Geisbert, T., Klose, B., Ramstedt, U. & Treston, A. M., Feb 1 2017, In : Antiviral Research. 138, p. 22-31 10 p.

Research output: Contribution to journalArticle

9 Scopus citations
2013

Single injection recombinant vesicular stomatitis virus vaccines protect ferrets against lethal Nipah virus disease

Mire, C. E., Versteeg, K. M., Cross, R. W., Agans, K. N., Fenton, K. A., Whitt, M. A. & Geisbert, T. W., Dec 13 2013, In : Virology journal. 10, 353.

Research output: Contribution to journalArticle

35 Scopus citations
2017

Evaluation of medical countermeasures against ebolaviruses in nonhuman primate models

Mire, C. & Geisbert, T., 2017, Methods in Molecular Biology. Humana Press Inc., Vol. 1628. p. 293-307 15 p. (Methods in Molecular Biology; vol. 1628).

Research output: Chapter in Book/Report/Conference proceedingChapter

2014

Protection against lethal marburg virus infection mediated by lipid encapsulated small interfering RNA

Ursic-Bedoya, R., Mire, C. E., Robbins, M., Geisbert, J. B., Judge, A., MacLachlan, I. & Geisbert, T. W., Feb 15 2014, In : Journal of Infectious Diseases. 209, 4, p. 562-570 9 p.

Research output: Contribution to journalArticle

31 Scopus citations
2016

Polyamines and hypusination are required for ebolavirus gene expression and replication

Olsen, M. E., Filone, C. M., Rozelle, D., Mire, C. E., Agans, K. N., Hensley, L. & Connor, J. H., Jul 1 2016, In : mBio. 7, 4, e00882-16.

Research output: Contribution to journalArticle

22 Scopus citations
2014

Vaccines and antivirals for filoviruses

Mire, C. & Geisbert, T., Jan 1 2014, Biology and Pathogenesis of Rhabdo- and Filoviruses. World Scientific Publishing Co., p. 587-620 34 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations
2016

Oral and Conjunctival Exposure of Nonhuman Primates to Low Doses of Ebola Makona Virus

Mire, C., Geisbert, J. B., Agans, K. N., Deer, D. J., Fenton, K. A. & Geisbert, T., Oct 15 2016, In : Journal of Infectious Diseases. 214, p. S263-S267

Research output: Contribution to journalArticle

13 Scopus citations
2014

Durability of a vesicular stomatitis virus-based marburg virus vaccine in nonhuman primates

Mire, C. E., Geisbert, J. B., Agans, K. N., Satterfield, B. A., Versteeg, K. M., Fritz, E. A., Feldmann, H., Hensley, L. E. & Geisbert, T. W., Apr 23 2014, In : PloS one. 9, 4, e94355.

Research output: Contribution to journalArticle

41 Scopus citations
2012

Recombinant vesicular stomatitis virus vaccine vectors expressing filovirus glycoproteins lack neurovirulence in nonhuman primates

Mire, C. E., Miller, A. D., Carville, A., Westmoreland, S. V., Geisbert, J. B., Mansfield, K. G., Feldmann, H., Hensley, L. E. & Geisbert, T. W., Mar 2012, In : PLoS neglected tropical diseases. 6, 3, e1567.

Research output: Contribution to journalArticle

66 Scopus citations
2014

Deep sequencing identifies noncanonical editing of Ebola and Marburg virus RNAS in infected cells

Shabman, R. S., Jabado, O. J., Mire, C. E., Stockwell, T. B., Edwards, M., Mahajan, M., Geisbert, T. W. & Basler, C. F., Sep 25 2014, In : mBio. 5, 6, e02011-14.

Research output: Contribution to journalArticle

43 Scopus citations
2016

Rescue of non-human primates from advanced Sudan ebolavirus infection with lipid encapsulated siRNA

Thi, E. P., Lee, A. C. H., Geisbert, J. B., Ursic-Bedoya, R., Agans, K. N., Robbins, M., Deer, D. J., Fenton, K. A., Kondratowicz, A. S., MacLachlan, I., Geisbert, T. & Mire, C., Aug 22 2016, In : Nature Microbiology. 1, 16142.

Research output: Contribution to journalArticle

18 Scopus citations
2019

Use of Single-Injection Recombinant Vesicular Stomatitis Virus Vaccine to Protect Nonhuman Primates Against Lethal Nipah Virus Disease

Mire, C., Geisbert, J. B., Agans, K. N., Versteeg, K. M., Deer, D. J., Satterfield, B. A., Fenton, K. A. & Geisbert, T., Jun 1 2019, In : Emerging infectious diseases. 25, 6, p. 1144-1152 9 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Vesicular Stomatitis Virus-Based Vaccine Protects Mice against Crimean-Congo Hemorrhagic Fever

Rodriguez, S. E., Cross, R. W., Fenton, K. A., Bente, D. A., Mire, C. E. & Geisbert, T. W., Dec 1 2019, In : Scientific reports. 9, 1, 7755.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations
2013

Vesicular Stomatitis Virus-Based Vaccines Protect Nonhuman Primates against Bundibugyo ebolavirus

Mire, C. E., Geisbert, J. B., Marzi, A., Agans, K. N., Feldmann, H. & Geisbert, T. W., 2013, In : PLoS neglected tropical diseases. 7, 12, e2600.

Research output: Contribution to journalArticle

54 Scopus citations
2015

A Single-Vector, Single-Injection Trivalent Filovirus Vaccine: Proof of Concept Study in Outbred Guinea Pigs

Mire, C. E., Geisbert, J. B., Versteeg, K. M., Mamaeva, N., Agans, K. N., Geisbert, T. W. & Connor, J. H., Oct 1 2015, In : Journal of Infectious Diseases. 212, p. S384-S388

Research output: Contribution to journalArticle

21 Scopus citations
2019

A Two-Antibody Pan-Ebolavirus Cocktail Confers Broad Therapeutic Protection in Ferrets and Nonhuman Primates

Bornholdt, Z. A., Herbert, A. S., Mire, C. E., He, S., Cross, R. W., Wec, A. Z., Abelson, D. M., Geisbert, J. B., James, R. M., Rahim, M. N., Zhu, W., Borisevich, V., Banadyga, L., Gunn, B. M., Agans, K. N., Wirchnianski, A. S., Goodwin, E., Tierney, K., Shestowsky, W. S., Bohorov, O. & 13 others, Bohorova, N., Velasco, J., Ailor, E., Kim, D., Pauly, M. H., Whaley, K. J., Alter, G., Walker, L. M., Chandran, K., Zeitlin, L., Qiu, X., Geisbert, T. W. & Dye, J. M., Jan 9 2019, In : Cell Host and Microbe. 25, 1, p. 49-58.e5

Research output: Contribution to journalArticle

16 Scopus citations
2015

Erratum: Analytical performance characteristics of the cepheid genexpert ebola assay for the detection of ebola virus (PLoS One)

Pinsky, B. A., Sahoo, M. K., Sandlund, J., Kleman, M., Kulkarni, M., Grufman, P., Nygren, M., Kwiatkowski, R., Baron, E. J., Tenover, F., Denison, B., Higuchi, R., Van Atta, R., Beer, N. R., Carrillo, A. C., Naraghi-Arani, P., Mire, C. E., Ranadheera, C., Grolla, A., Lagerqvist, N. & 1 others, Persing, D. H., Dec 1 2015, In : PloS one. 10, 12, 0145896.

Research output: Contribution to journalComment/debate

3 Scopus citations