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• 2013

  Molecular basis of glycosaminoglycan heparin binding to the chemokine CXCL1 dimer

  Poluri, K. M., Joseph, P. R. B., Sawant, K. V. & Rajarathnam, K., Aug 30 2013, In: Journal of Biological Chemistry. 288, 35, p. 25143-25153 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Chemokine CXCL1
  • Dimers
  • Glycosaminoglycans
  • Chemokines
  • Heparin
  42 Scopus citations

• Organization and dynamics of the N-terminal domain of chemokine receptor CXCR1 in reverse micelles: Effect of graded hydration

  Chaudhuri, A., Basu, P., Haldar, S., Kombrabail, M., Krishnamoorthy, G., Rajarathnam, K. & Chattopadhyay, A., Feb 7 2013, In: Journal of Physical Chemistry B. 117, 5, p. 1225-1233 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Interleukin-8A Receptors
  • Micelles
  • Hydration
  • micelles
  • hydration
  6 Scopus citations
• 2020

  Structural Insights Into How Proteoglycans Determine Chemokine-CXCR1/CXCR2 Interactions: Progress and Challenges

  Rajarathnam, K. & Desai, U. R., Apr 24 2020, In: Frontiers in immunology. 11, 660.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Proteoglycans
  • Glycosaminoglycans
  • Chemokines
  • Interleukin-8A Receptors
  • Interleukin-8B Receptors
  4 Scopus citations
• 2017

  Structural basis of native CXCL7 monomer binding to CXCR2 receptor N-domain and glycosaminoglycan heparin

  Brown, A. J., Sepuru, K. M. & Rajarathnam, K., Mar 2017, In: International journal of molecular sciences. 18, 3, 508.

  Research output: Contribution to journal › Article › peer-review

  • Glycosaminoglycans
  • Heparin
  • Interleukin-8B Receptors
  • heparins
  • Monomers
  14 Scopus citations

• Platelet-derived chemokine CXCL₇ dimer preferentially exists in the glycosaminoglycan-bound form: Implications for neutrophil-platelet crosstalk

  Brown, A. J., Sepuru, K. M., Sawant, K. V. & Rajarathnam, K., Oct 2 2017, In: Frontiers in immunology. 8, OCT, 1248.

  Research output: Contribution to journal › Article › peer-review

  • Interleukin-8B Receptors
  • Glycosaminoglycans
  • Chemokines
  • Heparin
  • Neutrophils
  19 Scopus citations
• 2015

  Flexible Linker Modulates Glycosaminoglycan Affinity of Decorin Binding Protein A

  Morgan, A., Sepuru, K. M., Feng, W., Rajarathnam, K. & Wang, X., Jul 30 2015, In: Biochemistry. 54, 32, p. 5113-5119 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Decorin
  • Staphylococcal Protein A
  • Glycosaminoglycans
  • Carrier Proteins
  • Borrelia burgdorferi
  4 Scopus citations

• Solution NMR characterization of chemokine CXCL8/IL-8 monomer and dimer binding to glycosaminoglycans: Structural plasticity mediates differential binding interactions

  Joseph, P. R. B., Mosier, P. D., Desai, U. R. & Rajarathnam, K., Nov 15 2015, In: Biochemical Journal. 472, 1, p. 121-133 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Dimers
  • Nuclear magnetic resonance
  • Monomers
  • Glycosaminoglycans
  • Interleukin-8
  53 Scopus citations
• 2017

  Regulation of chemokine function: The roles of GAG-binding and post-translational nitration

  Thompson, S., Martínez-Burgo, B., Sepuru, K. M., Rajarathnam, K., Kirby, J. A., Sheerin, N. S. & Ali, S., Aug 3 2017, In: International journal of molecular sciences. 18, 8, 1692.

  Research output: Contribution to journal › Review article › peer-review

  • Glycosaminoglycans
  • nitration
  • Nitration
  • Chemokines
  • leukocytes
  12 Scopus citations
• 2020

  Lyophilization of human amniotic fluid is feasible without affecting biological activity

  Coon, J. I., Jain, S., Sepuru, K. M., Chung, Y., Mohankumar, K., Rajarathnam, K. & Jain, S. K., Apr 1 2020, In: Pediatric Research. 87, 5, p. 847-852 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Freeze Drying
  • Amniotic Fluid
  • Interleukin-8
  • Deglutition
  • Dialysis
• 2013

  Dynamic conformational switching in the chemokine ligand is essential for G-protein-coupled receptor activation

  Joseph, P. R. B., Sawant, K. V., Isley, A., Pedroza, M., Garofalo, R. P., Richardson, R. M. & Rajarathnam, K., Dec 1 2013, In: Biochemical Journal. 456, 2, p. 241-251 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Proline
  • Glycine
  • G-Protein-Coupled Receptors
  • Chemokines
  • Chemical activation
  20 Scopus citations

• Chemokine CXCL1 dimer is a potent agonist for the CXCR2 receptor

  Ravindran, A., Sawant, K. V., Sarmiento, J., Navarro, J. & Rajarathnam, K., Apr 26 2013, In: Journal of Biological Chemistry. 288, 17, p. 12244-12252 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Interleukin-8B Receptors
  • Chemokine CXCL1
  • Dimers
  • Disulfides
  • Neutrophils
  39 Scopus citations
• 2015

  Chemokine CXCL1-Mediated Neutrophil Trafficking in the Lung: Role of CXCR2 Activation

  Sawant, K. V., Xu, R., Cox, R., Hawkins, H., Sbrana, E., Kolli, D., Garofalo, R. P. & Rajarathnam, K., Oct 16 2015, In: Journal of Innate Immunity. 7, 6, p. 647-658 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Chemokine CXCL1
  • Neutrophils
  • Lung
  • Neutrophil Infiltration
  • Interleukin-8B Receptors
  44 Scopus citations
• 2013

  Real-time kinetics of high-mobility group box 1 (HMGB1) oxidation in extracellular fluids studied by in situ protein NMR spectroscopy

  Zandarashvili, L., Sahu, D., Lee, K., Lee, Y. S., Singh, P., Rajarathnam, K. & Iwahara, J., Apr 26 2013, In: Journal of Biological Chemistry. 288, 17, p. 11621-11627 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Biomolecular Nuclear Magnetic Resonance
  • Nuclear magnetic resonance spectroscopy
  • Extracellular Fluid
  • Sulfhydryl Compounds
  • Oxidation
  36 Scopus citations
• 2020

  Neutrophil recruitment by chemokines Cxcl1/KC and Cxcl2/MIP2: Role of Cxcr2 activation and glycosaminoglycan interactions

  Sawant, K. V., Sepuru, K. M., Lowry, E., Penaranda, B., Frevert, C. W., Garofalo, R. P. & Rajarathnam, K., 2020, (Accepted/In press) In: Journal of Leukocyte Biology.

  Research output: Contribution to journal › Article › peer-review

  • Neutrophil Infiltration
  • Glycosaminoglycans
  • Chemokines
  • Personnel Selection
  • Neutrophil Activation
• 2012

  The monomer-dimer equilibrium and glycosaminoglycan interactions of chemokine CXCL8 regulate tissue-specific neutrophil recruitment

  Gangavarapu, P., Rajagopalan, L., Kolli, D., Guerrero-Plata, A., Garofalo, R. P. & Rajarathnam, K., Feb 2012, In: Journal of Leukocyte Biology. 91, 2, p. 259-265 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Neutrophil Infiltration
  • Glycosaminoglycans
  • Interleukin-8
  • Chemokines
  • Peritoneum
  62 Scopus citations
• 2017

  Heparin-bound chemokine CXCL8 monomer and dimer are impaired for CXCR1 and CXCR2 activation: Implications for gradients and neutrophil trafficking

  Joseph, P. R. B., Sawant, K. V. & Rajarathnam, K., 2017, In: Open Biology. 7, 11, 170168.

  Research output: Contribution to journal › Article › peer-review

  • Dimers
  • Monomers
  • Glycosaminoglycans
  • Interleukin-8
  • Heparin
  17 Scopus citations
• 2015

  Solution NMR characterization of WT CXCL8 monomer and dimer binding to CXCR1 N-terminal domain

  Joseph, P. R. B. & Rajarathnam, K., Jan 1 2015, In: Protein Science. 24, 1, p. 81-92 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Dimers
  • Nuclear magnetic resonance
  • Monomers
  • Protein Domains
  • Interleukin-8A Receptors
  25 Scopus citations
• 2017

  Chemokine CXCL7 heterodimers: Structural insights, CXCR2 receptor function, and glycosaminoglycan interactions

  Brown, A. J., Joseph, P. R. B., Sawant, K. V. & Rajarathnam, K., Apr 2017, In: International journal of molecular sciences. 18, 4, 748.

  Research output: Contribution to journal › Article › peer-review

  • Glycosaminoglycans
  • Interleukin-8B Receptors
  • Chemokines
  • disulfides
  • infectious diseases
  11 Scopus citations
• 2015

  Using isothermal titration calorimetry to determine thermodynamic parameters of protein–glycosaminoglycan interactions

  Dutta, A. K., Rösgen, J. & Rajarathnam, K., 2015, In: Methods in Molecular Biology. 1229, p. 315-324 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Calorimetry
  • Thermodynamics
  • Entropy
  • Kinetics
  25 Scopus citations

• Characterizing protein–glycosaminoglycan interactions using solution NMR spectroscopy

  Joseph, P. R. B., Poluri, K. M., Sepuru, K. M. & Rajarathnam, K., 2015, In: Methods in Molecular Biology. 1229, p. 325-333 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Magnetic Resonance Spectroscopy
  • Macromolecular Substances
  • Data Accuracy
  • Proteins
  5 Scopus citations
• 2013

  Proline substitution of dimer interface β-strand residues as a strategy for the design of functional monomeric proteins

  Joseph, P. R. B., Poluri, K. M., Gangavarapu, P., Rajagopalan, L., Raghuwanshi, S., Richardson, R. M., Garofalo, R. P. & Rajarathnam, K., Sep 17 2013, In: Biophysical journal. 105, 6, p. 1491-1501 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Proline
  • Proteins
  • Catalysis
  • Amides
  • Static Electricity
  19 Scopus citations