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• 2016

  Chemokine CXCL1 mediated neutrophil recruitment: Role of glycosaminoglycan interactions

  Sawant, K. V., Poluri, K. M., Dutta, A. K., Sepuru, K. M., Troshkina, A., Garofalo, R. P. & Rajarathnam, K., Sep 14 2016, In: Scientific reports. 6, 33123.

  Research output: Contribution to journal › Article › peer-review

  • glycosaminoglycan receptor
  • Chemokine CXCL1
  • Neutrophil Infiltration
  • Glycosaminoglycans
  • Lysine
  84 Scopus citations
• 2012

  The monomer-dimer equilibrium and glycosaminoglycan interactions of chemokine CXCL8 regulate tissue-specific neutrophil recruitment

  Gangavarapu, P., Rajagopalan, L., Kolli, D., Guerrero-Plata, A., Garofalo, R. P. & Rajarathnam, K., Feb 2012, In: Journal of Leukocyte Biology. 91, 2, p. 259-265 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Neutrophil Infiltration
  • Glycosaminoglycans
  • Interleukin-8
  • Chemokines
  • Peritoneum
  62 Scopus citations
• 2016

  Molecular basis of chemokine CXCL5-glycosaminoglycan interactions

  Sepuru, K. M., Nagarajan, B., Desai, U. R. & Rajarathnam, K., Sep 23 2016, In: Journal of Biological Chemistry. 291, 39, p. 20539-20550 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Chemokine CXCL5
  • Glycosaminoglycans
  • Dimers
  • Nuclear magnetic resonance
  • Monomers
  24 Scopus citations
• 2018

  Glycosaminoglycan Interactions Fine-Tune Chemokine-Mediated Neutrophil Trafficking: Structural Insights and Molecular Mechanisms

  Rajarathnam, K., Sepuru, K. M., Joseph, P. R. B., Sawant, K. V. & Brown, A. J., Apr 1 2018, In: Journal of Histochemistry and Cytochemistry. 66, 4, p. 229-239 11 p.

  Research output: Contribution to journal › Review article › peer-review

  • Glycosaminoglycans
  • Chemokines
  • Neutrophils
  • Neutrophil Infiltration
  • Interleukin-8B Receptors
  11 Scopus citations

• Ehrlichia chaffeensis TRP120 nucleomodulin binds DNA with disordered tandem repeat domain

  Klema, V. J., Sepuru, K. M., Füllbrunn, N., Farris, T. R., Dunphy, P. S., McBride, J. W., Rajarathnam, K. & Choi, K. H., Apr 2018, In: PloS one. 13, 4, e0194891.

  Research output: Contribution to journal › Article › peer-review

  • Ehrlichia chaffeensis
  • Tandem Repeat Sequences
  • tandem repeat sequences
  • DNA
  • Proteins
  4 Scopus citations
• 2016

  CXCL1/MGSA Is a novel glycosaminoglycan (GAG)-binding chemokine: Structural evidence for two distinct non-overlapping binding domains

  Sepuru, K. M. & Rajarathnam, K., Feb 19 2016, In: Journal of Biological Chemistry. 291, 8, p. 4247-4255 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Chemokine CXCL1
  • Glycosaminoglycans
  • Chemokines
  • Dimers
  • Interleukin-8
  30 Scopus citations
• 2013

  Molecular basis of glycosaminoglycan heparin binding to the chemokine CXCL1 dimer

  Poluri, K. M., Joseph, P. R. B., Sawant, K. V. & Rajarathnam, K., Aug 30 2013, In: Journal of Biological Chemistry. 288, 35, p. 25143-25153 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Chemokine CXCL1
  • Dimers
  • Glycosaminoglycans
  • Chemokines
  • Heparin
  42 Scopus citations

• Real-time kinetics of high-mobility group box 1 (HMGB1) oxidation in extracellular fluids studied by in situ protein NMR spectroscopy

  Zandarashvili, L., Sahu, D., Lee, K., Lee, Y. S., Singh, P., Rajarathnam, K. & Iwahara, J., Apr 26 2013, In: Journal of Biological Chemistry. 288, 17, p. 11621-11627 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Biomolecular Nuclear Magnetic Resonance
  • Nuclear magnetic resonance spectroscopy
  • Extracellular Fluid
  • Sulfhydryl Compounds
  • Oxidation
  36 Scopus citations
• 2018

  Lysines and Arginines play non-redundant roles in mediating chemokine-glycosaminoglycan interactions

  Joseph, P. R. B., Sawant, K. V., Iwahara, J., Garofalo, R. P., Desai, U. R. & Rajarathnam, K., Dec 1 2018, In: Scientific reports. 8, 1, 12289.

  Research output: Contribution to journal › Article › peer-review

  • Glycosaminoglycans
  • Lysine
  • Chemokines
  • Arginine
  • Neutrophils
  3 Scopus citations
• 2020

  Neutrophil recruitment by chemokines Cxcl1/KC and Cxcl2/MIP2: Role of Cxcr2 activation and glycosaminoglycan interactions

  Sawant, K. V., Sepuru, K. M., Lowry, E., Penaranda, B., Frevert, C. W., Garofalo, R. P. & Rajarathnam, K., 2020, (Accepted/In press) In: Journal of Leukocyte Biology.

  Research output: Contribution to journal › Article › peer-review

  • Neutrophil Infiltration
  • Glycosaminoglycans
  • Chemokines
  • Personnel Selection
  • Neutrophil Activation
• 2013

  Chemokine CXCL1 dimer is a potent agonist for the CXCR2 receptor

  Ravindran, A., Sawant, K. V., Sarmiento, J., Navarro, J. & Rajarathnam, K., Apr 26 2013, In: Journal of Biological Chemistry. 288, 17, p. 12244-12252 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Interleukin-8B Receptors
  • Chemokine CXCL1
  • Dimers
  • Disulfides
  • Neutrophils
  39 Scopus citations

• Dynamic conformational switching in the chemokine ligand is essential for G-protein-coupled receptor activation

  Joseph, P. R. B., Sawant, K. V., Isley, A., Pedroza, M., Garofalo, R. P., Richardson, R. M. & Rajarathnam, K., Dec 1 2013, In: Biochemical Journal. 456, 2, p. 241-251 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Proline
  • Glycine
  • G-Protein-Coupled Receptors
  • Chemokines
  • Chemical activation
  20 Scopus citations
• 2018

  Dynamics-derived insights into complex formation between the CXCL8 monomer and CXCR1 N-terminal domain: An NMR study

  Joseph, P. R. B., Spyracopoulos, L. & Rajarathnam, K., Oct 31 2018, In: Molecules. 23, 11

  Research output: Contribution to journal › Article › peer-review

  • Interleukin-8A Receptors
  • Calorimetry
  • Nuclear magnetic resonance
  • Monomers
  • G-Protein-Coupled Receptors
  4 Scopus citations
• 2013

  Proline substitution of dimer interface β-strand residues as a strategy for the design of functional monomeric proteins

  Joseph, P. R. B., Poluri, K. M., Gangavarapu, P., Rajagopalan, L., Raghuwanshi, S., Richardson, R. M., Garofalo, R. P. & Rajarathnam, K., Sep 17 2013, In: Biophysical journal. 105, 6, p. 1491-1501 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Proline
  • Proteins
  • Catalysis
  • Amides
  • Static Electricity
  19 Scopus citations
• 2018

  Structural basis, stoichiometry, and thermodynamics of binding of the chemokines KC and MIP2 to the glycosaminoglycan heparin

  Sepuru, K. M., Nagarajan, B., Desai, U. R. & Rajarathnam, K., Nov 16 2018, In: Journal of Biological Chemistry. 293, 46, p. 17817-17828 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Stoichiometry
  • Thermodynamics
  • Glycosaminoglycans
  • Chemokines
  • Heparin
  4 Scopus citations
• 2013

  Organization and dynamics of the N-terminal domain of chemokine receptor CXCR1 in reverse micelles: Effect of graded hydration

  Chaudhuri, A., Basu, P., Haldar, S., Kombrabail, M., Krishnamoorthy, G., Rajarathnam, K. & Chattopadhyay, A., Feb 7 2013, In: Journal of Physical Chemistry B. 117, 5, p. 1225-1233 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Interleukin-8A Receptors
  • Micelles
  • Hydration
  • micelles
  • hydration
  6 Scopus citations
• 2020

  Lyophilization of human amniotic fluid is feasible without affecting biological activity

  Coon, J. I., Jain, S., Sepuru, K. M., Chung, Y., Mohankumar, K., Rajarathnam, K. & Jain, S. K., Apr 1 2020, In: Pediatric Research. 87, 5, p. 847-852 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Freeze Drying
  • Amniotic Fluid
  • Interleukin-8
  • Deglutition
  • Dialysis
• 2018

  Direct detection of lysine side chain NH₃⁺ in protein-heparin complexes using NMR spectroscopy

  Sepuru, K. M., Iwahara, J. & Rajarathnam, K., Feb 7 2018, In: Analyst. 143, 3, p. 635-638 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Chemical shift
  • Heparin
  • Nuclear magnetic resonance spectroscopy
  • Lysine
  • nuclear magnetic resonance
  7 Scopus citations
• 2020

  Structural Insights Into How Proteoglycans Determine Chemokine-CXCR1/CXCR2 Interactions: Progress and Challenges

  Rajarathnam, K. & Desai, U. R., Apr 24 2020, In: Frontiers in immunology. 11, 660.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Proteoglycans
  • Glycosaminoglycans
  • Chemokines
  • Interleukin-8A Receptors
  • Interleukin-8B Receptors
  4 Scopus citations
• 2018

  Interleukin-8 mediates neutrophil-endothelial interactions in pig-to-human xenogeneic models

  French, B. M., Sendil, S., Sepuru, K. M., Ranek, J., Burdorf, L., Harris, D., Redding, E., Cheng, X., Laird, C. T., Zhao, Y., Cerel, B., Rajarathnam, K., Pierson, R. N. & Azimzadeh, A. M., Mar 1 2018, In: Xenotransplantation. 25, 2, e12385.

  Research output: Contribution to journal › Article › peer-review

  • Interleukin-8
  • Swine
  • Neutrophils
  • 2-(4-isobutylphenyl)propionylmethanesulfonamide
  • Heterologous Transplantation
  4 Scopus citations

• Distinct Differences in Structural States of Conserved Histidines in Two Related Proteins: NMR Studies of the Chemokines CXCL1 and CXCL8 in the Free Form and Macromolecular Complexes

  Sepuru, K. M. & Rajarathnam, K., Oct 16 2018, In: Biochemistry. 57, 41, p. 5969-5977 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Chemokine CXCL1
  • Macromolecular Substances
  • Nuclear magnetic resonance
  • Histidine
  • Interleukin-8
  3 Scopus citations