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  • Jian Sha
2014

Functional genomic characterization of virulence factors from necrotizing fasciitis-causing strains of Aeromonas hydrophila

Grim, C. J., Kozlova, E. V., Ponnusamy, D., Fitts, E. C., Sha, J., Kirtley, M. L., van Lier, C. J., Tiner, B. L., Erova, T. E., Joseph, S. J., Read, T. D., Shak, J. R., Joseph, S. W., Singletary, E., Felland, T., Baze, W. B., Horneman, A. J. & Chopra, A. K., 2014, In : Applied and Environmental Microbiology. 80, 14, p. 4162-4183 22 p.

Research output: Contribution to journalArticle

32 Scopus citations
2019

T6SS and ExoA of flesh-eating Aeromonas hydrophila in peritonitis and necrotizing fasciitis during mono- And polymicrobial infections

Fernández-Bravo, A., Kilgore, P. B., Andersson, J. A., Blears, E., Figueras, M. J., Hasan, N. A., Colwell, R. R., Sha, J. & Chopra, A. K., Nov 26 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 48, p. 24084-24092 9 p.

Research output: Contribution to journalArticle

3 Scopus citations
2015

Intramuscular immunization of mice with a live-Attenuated triple mutant of yersinia pestis co92 induces robust humoral and cell-mediated immunity to completely protect animals against pneumonic plague

Tiner, B. L., Sha, J., Ponnusamy, D., Baze, W. B., Fitts, E. C., Popov, V. L., Van Lier, C. J., Erova, T. E. & Chopra, A. K., Dec 2015, In : Clinical and Vaccine Immunology. 22, 12, p. 1255-1268 14 p.

Research output: Contribution to journalArticle

8 Scopus citations
2018

Combating multidrug-resistant pathogens with host-directed nonantibiotic therapeutics

Andersson, J. A., Sha, J., Kirtley, M. L., Reyes, E., Fitts, E. C., Dann, S. M. & Chopra, A. K., Jan 2018, In : Antimicrobial agents and chemotherapy. 62, 1, e01943.

Research output: Contribution to journalArticle

7 Scopus citations
2016

A Replication-Defective human type 5 adenovirus-based trivalent vaccine confers complete protection against plague in mice and nonhuman primates

Sha, J., Kirtley, M. L., Klages, C., Erova, T. E., Telepnev, M., Ponnusamy, D., Fitts, E. C., Baze, W. B., Sivasubramani, S. K., Lawrence, W. S., Patrikeev, I., Peel, J. E., Andersson, J. A., Kozlova, E. V., Tiner, B. L., Peterson, J. W., Mcwilliams, D., Patel, S., Rothe, E., Motin, V. L. & 1 others, Chopra, A. K., Jul 2016, In : Clinical and Vaccine Immunology. 23, 7, p. 586-600 15 p.

Research output: Contribution to journalArticle

10 Scopus citations
2020

New host-directed therapeutics for the treatment of Clostridioides difficile infection

Andersson, J. A., Peniche, A. G., Galindo, C. L., Boonma, P., Sha, J., Luna, R. A., Savidge, T. C., Chopra, A. K. & Dann, S. M., Mar 1 2020, In : mBio. 11, 2, e00053-20.

Research output: Contribution to journalArticle

Open Access
2012
11 Scopus citations

Actin cross-linking domain of Aeromonas hydrophila repeat in toxin A (RtxA) induces host cell rounding and apoptosis

Suarez, G., Khajanchi, B. K., Sierra, J. C., Erova, T. E., Sha, J. & Chopra, A. K., Sep 15 2012, In : Gene. 506, 2, p. 369-376 8 p.

Research output: Contribution to journalArticle

22 Scopus citations
2016

Protective immunity elicited by oral immunization of mice with Salmonella enterica serovar typhimurium braun lipoprotein (Lpp) and acetyltransferase (MsbB) mutants

Erova, T. E., Kirtley, M. L., Fitts, E. C., Ponnusamy, D., Baze, W. B., Andersson, J. A., Cong, Y., Tiner, B. L., Sha, J. & Chopra, A. K., Nov 10 2016, In : Frontiers in Cellular and Infection Microbiology. 6, NOV, 148.

Research output: Contribution to journalArticle

8 Scopus citations

Cross-talk among flesh-eating Aeromonas hydrophila strains in mixed infection leading to necrotizing fasciitis

Ponnusamy, D., Kozlova, E. V., Sha, J., Erova, T. E., Azar, S. R., Fitts, E. C., Kirtley, M. L., Tiner, B. L., Andersson, J. A., Grim, C. J., Isom, R. P., Hasan, N. A., Colwell, R. R. & Chopra, A. K., Jan 19 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 3, p. 722-727 6 p.

Research output: Contribution to journalArticle

32 Scopus citations

New role for FDA-approved drugs in combating antibiotic-resistant bacteria

Andersson, J. A., Fitts, E. C., Kirtley, M. L., Ponnusamy, D., Peniche, A. G., Dann, S. M., Motin, V. L., Chauhan, S., Rosenzweig, J. A., Sha, J. & Chopra, A. K., Jun 2016, In : Antimicrobial agents and chemotherapy. 60, 6, p. 3717-3729 13 p.

Research output: Contribution to journalArticle

17 Scopus citations
2019

A prokaryotic-eukaryotic hybrid viral vector for delivery of large cargos of genes and proteins into human cells

Zhu, J., Tao, P., Mahalingam, M., Sha, J., Kilgore, P., Chopra, A. K. & Rao, V., Aug 21 2019, In : Science Advances. 5, 8, eaax0064.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
2015

Combinational deletion of three membrane protein-encoding genes highly attenuates Yersinia pestis while retaining immunogenicity in a mouse model of pneumonic plague

Tiner, B. L., Sha, J., Kirtley, M. L., Erova, T. E., Popov, V. L., Baze, W. B., van Lier, C. J., Ponnusamy, D., Andersson, J. A., Motin, V. L., Chauhan, S. & Chopra, A. K., Jan 1 2015, In : Infection and immunity. 83, 4, p. 1318-1338 21 p.

Research output: Contribution to journalArticle

12 Scopus citations
5 Scopus citations
2018

A bacteriophage T4 nanoparticle-based dual vaccine against anthrax and plague

Tao, P., Mahalingam, M., Zhu, J., Moayeri, M., Sha, J., Lawrence, W. S., Leppla, S. H., Chopra, A. K. & Rao, V. B., Sep 1 2018, In : mBio. 9, 5, e01926-18.

Research output: Contribution to journalArticle

12 Scopus citations
2016

New insights into autoinducer-2 signaling as a virulence regulator in a mouse model of pneumonic plague

Fitts, E. C., Andersson, J. A., Kirtley, M. L., Sha, J., Erova, T. E., Chauhan, S., Motin, V. L. & Chopra, A. K., Nov 1 2016, In : mSphere. 1, 6, e00342-16.

Research output: Contribution to journalArticle

6 Scopus citations
2014

Deletion of braun lipoprotein and plasminogen-activating protease-encoding genes attenuates Yersinia pestis in mouse models of bubonic and pneumonic plague

Van Lier, C. J., Sha, J., Kirtley, M. L., Cao, A., Tiner, B. L., Erova, T. E., Cong, Y., Kozlova, E. V., Popov, V. L., Baze, W. B. & Chopra, A. K., 2014, In : Infection and immunity. 82, 6, p. 2485-2503 19 p.

Research output: Contribution to journalArticle

19 Scopus citations
2015

High-throughput, signature-tagged mutagenic approach to identify novel virulence factors of Yersinia pestis CO92 in a mouse model of infection

Ponnusamy, D., Fitts, E. C., Sha, J., Erova, T. E., Kozlova, E. V., Kirtley, M. L., Tiner, B. L., Andersson, J. A. & Chopra, A. K., 2015, In : Infection and immunity. 83, 5, p. 2065-2081 17 p.

Research output: Contribution to journalArticle

10 Scopus citations
2016
5 Scopus citations
2012

The two-component QseBC signalling system regulates in vitro and in vivo virulence of Aeromonas hydrophila

Khajanchi, B. K., Kozlova, E. V., Sha, J., Popov, V. L. & Chopra, A. K., Jan 2012, In : Microbiology. 158, 1, p. 259-271 13 p.

Research output: Contribution to journalArticle

43 Scopus citations