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• 2016

  CXCL1/MGSA Is a novel glycosaminoglycan (GAG)-binding chemokine: Structural evidence for two distinct non-overlapping binding domains

  Sepuru, K. M. & Rajarathnam, K., Feb 19 2016, In: Journal of Biological Chemistry. 291, 8, p. 4247-4255 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Chemokine CXCL1
  • Glycosaminoglycans
  • Chemokines
  • Dimers
  • Interleukin-8
  31 Scopus citations
• 2018

  Structural basis, stoichiometry, and thermodynamics of binding of the chemokines KC and MIP2 to the glycosaminoglycan heparin

  Sepuru, K. M., Nagarajan, B., Desai, U. R. & Rajarathnam, K., Nov 16 2018, In: Journal of Biological Chemistry. 293, 46, p. 17817-17828 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Stoichiometry
  • Thermodynamics
  • Glycosaminoglycans
  • Chemokines
  • Heparin
  4 Scopus citations
• 2014

  Solution structure of CXCL5 - A novel chemokine and adipokine implicated in inflammation and obesity

  Sepuru, K. M., Poluri, K. M. & Rajarathnam, K., Apr 2 2014, In: PloS one. 9, 4, e93228.

  Research output: Contribution to journal › Article › peer-review

  • adipokines
  • chemokines
  • Adipokines
  • obesity
  • Chemokines
  18 Scopus citations

• Isothermal titration calorimetry of membrane proteins - Progress and challenges

  Rajarathnam, K. & Rösgen, J., 2014, In: Biochimica et Biophysica Acta - Biomembranes. 1838, 1 PARTA, p. 69-77 9 p.

  Research output: Contribution to journal › Review article › peer-review

  • Titration
  • Calorimetry
  • Membrane Proteins
  • Thermodynamics
  • Ligands
  55 Scopus citations
• 2012

  The monomer-dimer equilibrium and glycosaminoglycan interactions of chemokine CXCL8 regulate tissue-specific neutrophil recruitment

  Gangavarapu, P., Rajagopalan, L., Kolli, D., Guerrero-Plata, A., Garofalo, R. P. & Rajarathnam, K., Feb 2012, In: Journal of Leukocyte Biology. 91, 2, p. 259-265 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Neutrophil Infiltration
  • Glycosaminoglycans
  • Interleukin-8
  • Chemokines
  • Peritoneum
  63 Scopus citations
• 2018

  Direct detection of lysine side chain NH₃⁺ in protein-heparin complexes using NMR spectroscopy

  Sepuru, K. M., Iwahara, J. & Rajarathnam, K., Feb 7 2018, In: Analyst. 143, 3, p. 635-638 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Chemical shift
  • Heparin
  • Nuclear magnetic resonance spectroscopy
  • Lysine
  • nuclear magnetic resonance
  7 Scopus citations

• Lysines and Arginines play non-redundant roles in mediating chemokine-glycosaminoglycan interactions

  Joseph, P. R. B., Sawant, K. V., Iwahara, J., Garofalo, R. P., Desai, U. R. & Rajarathnam, K., Dec 1 2018, In: Scientific reports. 8, 1, 12289.

  Research output: Contribution to journal › Article › peer-review

  • Glycosaminoglycans
  • Lysine
  • Chemokines
  • Arginine
  • Neutrophils
  3 Scopus citations
• 2016

  Chemokine CXCL1 mediated neutrophil recruitment: Role of glycosaminoglycan interactions

  Sawant, K. V., Poluri, K. M., Dutta, A. K., Sepuru, K. M., Troshkina, A., Garofalo, R. P. & Rajarathnam, K., Sep 14 2016, In: Scientific reports. 6, 33123.

  Research output: Contribution to journal › Article › peer-review

  • glycosaminoglycan receptor
  • Chemokine CXCL1
  • Neutrophil Infiltration
  • Glycosaminoglycans
  • Lysine
  87 Scopus citations
• 2018

  Glycosaminoglycan Interactions Fine-Tune Chemokine-Mediated Neutrophil Trafficking: Structural Insights and Molecular Mechanisms

  Rajarathnam, K., Sepuru, K. M., Joseph, P. R. B., Sawant, K. V. & Brown, A. J., Apr 1 2018, In: Journal of Histochemistry and Cytochemistry. 66, 4, p. 229-239 11 p.

  Research output: Contribution to journal › Review article › peer-review

  • Glycosaminoglycans
  • Chemokines
  • Neutrophils
  • Neutrophil Infiltration
  • Interleukin-8B Receptors
  12 Scopus citations

• Dynamics-derived insights into complex formation between the CXCL8 monomer and CXCR1 N-terminal domain: An NMR study

  Joseph, P. R. B., Spyracopoulos, L. & Rajarathnam, K., Oct 31 2018, In: Molecules. 23, 11

  Research output: Contribution to journal › Article › peer-review

  • Interleukin-8A Receptors
  • Calorimetry
  • Nuclear magnetic resonance
  • Monomers
  • G-Protein-Coupled Receptors
  4 Scopus citations

• Distinct Differences in Structural States of Conserved Histidines in Two Related Proteins: NMR Studies of the Chemokines CXCL1 and CXCL8 in the Free Form and Macromolecular Complexes

  Sepuru, K. M. & Rajarathnam, K., Oct 16 2018, In: Biochemistry. 57, 41, p. 5969-5977 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Chemokine CXCL1
  • Macromolecular Substances
  • Nuclear magnetic resonance
  • Histidine
  • Interleukin-8
  3 Scopus citations

• Interleukin-8 mediates neutrophil-endothelial interactions in pig-to-human xenogeneic models

  French, B. M., Sendil, S., Sepuru, K. M., Ranek, J., Burdorf, L., Harris, D., Redding, E., Cheng, X., Laird, C. T., Zhao, Y., Cerel, B., Rajarathnam, K., Pierson, R. N. & Azimzadeh, A. M., Mar 1 2018, In: Xenotransplantation. 25, 2, e12385.

  Research output: Contribution to journal › Article › peer-review

  • Interleukin-8
  • Swine
  • Neutrophils
  • 2-(4-isobutylphenyl)propionylmethanesulfonamide
  • Heterologous Transplantation
  6 Scopus citations

• Ehrlichia chaffeensis TRP120 nucleomodulin binds DNA with disordered tandem repeat domain

  Klema, V. J., Sepuru, K. M., Füllbrunn, N., Farris, T. R., Dunphy, P. S., McBride, J. W., Rajarathnam, K. & Choi, K. H., Apr 2018, In: PloS one. 13, 4, e0194891.

  Research output: Contribution to journal › Article › peer-review

  • Ehrlichia chaffeensis
  • Tandem Repeat Sequences
  • tandem repeat sequences
  • DNA
  • Proteins
  6 Scopus citations
• 2016

  Molecular basis of chemokine CXCL5-glycosaminoglycan interactions

  Sepuru, K. M., Nagarajan, B., Desai, U. R. & Rajarathnam, K., Sep 23 2016, In: Journal of Biological Chemistry. 291, 39, p. 20539-20550 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Chemokine CXCL5
  • Glycosaminoglycans
  • Dimers
  • Nuclear magnetic resonance
  • Monomers
  24 Scopus citations