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• 2012

  The two-component QseBC signalling system regulates in vitro and in vivo virulence of Aeromonas hydrophila

  Khajanchi, B. K., Kozlova, E. V., Sha, J., Popov, V. L. & Chopra, A. K., Jan 2012, In: Microbiology. 158, 1, p. 259-271 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Aeromonas hydrophila
  • Quorum Sensing
  • Virulence
  • N-(3-oxohexanoyl)-3-aminodihydro-2(3H)-furanone
  • N-octanoylhomoserine lactone
  44 Scopus citations
• 2015

  High-throughput, signature-tagged mutagenic approach to identify novel virulence factors of Yersinia pestis CO92 in a mouse model of infection

  Ponnusamy, D., Fitts, E. C., Sha, J., Erova, T. E., Kozlova, E. V., Kirtley, M. L., Tiner, B. L., Andersson, J. A. & Chopra, A. K., 2015, In: Infection and immunity. 83, 5, p. 2065-2081 17 p.

  Research output: Contribution to journal › Article › peer-review

  • Yersinia pestis
  • Lethal Dose 50
  • Virulence Factors
  • Plague
  • Infection
  10 Scopus citations
• 2016

  New role for FDA-approved drugs in combating antibiotic-resistant bacteria

  Andersson, J. A., Fitts, E. C., Kirtley, M. L., Ponnusamy, D., Peniche, A. G., Dann, S. M., Motin, V. L., Chauhan, S., Rosenzweig, J. A., Sha, J. & Chopra, A. K., Jun 2016, In: Antimicrobial agents and chemotherapy. 60, 6, p. 3717-3729 13 p.

  Research output: Contribution to journal › Article › peer-review

  • United States Food and Drug Administration
  • Yersinia pestis
  • Trifluoperazine
  • Bacteria
  • Anti-Bacterial Agents
  18 Scopus citations

• A Replication-Defective human type 5 adenovirus-based trivalent vaccine confers complete protection against plague in mice and nonhuman primates

  Sha, J., Kirtley, M. L., Klages, C., Erova, T. E., Telepnev, M., Ponnusamy, D., Fitts, E. C., Baze, W. B., Sivasubramani, S. K., Lawrence, W. S., Patrikeev, I., Peel, J. E., Andersson, J. A., Kozlova, E. V., Tiner, B. L., Peterson, J. W., Mcwilliams, D., Patel, S., Rothe, E., Motin, V. L. & 1 others, Chopra, A. K., Jul 2016, In: Clinical and Vaccine Immunology. 23, 7, p. 586-600 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Human Adenoviruses
  • Plague
  • Primates
  • Vaccines
  • Antigens
  11 Scopus citations

• Protective immunity elicited by oral immunization of mice with Salmonella enterica serovar typhimurium braun lipoprotein (Lpp) and acetyltransferase (MsbB) mutants

  Erova, T. E., Kirtley, M. L., Fitts, E. C., Ponnusamy, D., Baze, W. B., Andersson, J. A., Cong, Y., Tiner, B. L., Sha, J. & Chopra, A. K., Nov 10 2016, In: Frontiers in Cellular and Infection Microbiology. 6, NOV, 148.

  Research output: Contribution to journal › Article › peer-review

  • Acetyltransferases
  • Salmonella enterica
  • Lipoproteins
  • Serogroup
  • Immunization
  8 Scopus citations

• Immunisation of two rodent species with new live-attenuated mutants of Yersinia pestis CO92 induces protective long-term humoral- and cell-mediated immunity against pneumonic plague

  Tiner, B. L., Sha, J., Cong, Y., Kirtley, M. L., Andersson, J. A. & Chopra, A. K., Oct 13 2016, In: npj Vaccines. 1, 16020.

  Research output: Contribution to journal › Article › peer-review

  • Yersinia pestis
  • Plague
  • Cellular Immunity
  • Immunization
  • Rodentia
  6 Scopus citations
• 2019

  A prokaryotic-eukaryotic hybrid viral vector for delivery of large cargos of genes and proteins into human cells

  Zhu, J., Tao, P., Mahalingam, M., Sha, J., Kilgore, P., Chopra, A. K. & Rao, V., Aug 21 2019, In: Science Advances. 5, 8, eaax0064.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • viruses
  • genes
  • delivery
  • proteins
  • biotin
  2 Scopus citations
• 2012

  Actin cross-linking domain of Aeromonas hydrophila repeat in toxin A (RtxA) induces host cell rounding and apoptosis

  Suarez, G., Khajanchi, B. K., Sierra, J. C., Erova, T. E., Sha, J. & Chopra, A. K., Sep 15 2012, In: Gene. 506, 2, p. 369-376 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Aeromonas hydrophila
  • Actins
  • Apoptosis
  • Vibrio
  • Operon
  23 Scopus citations

• DNA adenine methyltransferase (Dam) controls the expression of the cytotoxic enterotoxin (act) gene of Aeromonas hydrophila via tRNA modifying enzyme-glucose-inhibited division protein (GidA)

  Erova, T. E., Kosykh, V. G., Sha, J. & Chopra, A. K., May 1 2012, In: Gene. 498, 2, p. 280-287 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Aeromonas hydrophila
  • Enterotoxins
  • Adenine
  • Methyltransferases
  • Transfer RNA
  11 Scopus citations
• 2015

  Further characterization of a highly attenuated Yersinia pestis CO92 mutant deleted for the genes encoding Braun lipoprotein and plasminogen activator protease in murine alveolar and primary human macrophages

  van Lier, C. J., Tiner, B. L., Chauhan, S., Motin, V. L., Fitts, E. C., Huante, M. B., Endsley, J. J., Ponnusamy, D., Sha, J. & Chopra, A. K., Mar 1 2015, In: Microbial Pathogenesis. 80, p. 27-38 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Yersinia pestis
  • Plasminogen Activators
  • Lipoproteins
  • Peptide Hydrolases
  • Macrophages
  6 Scopus citations

• Intramuscular immunization of mice with a live-Attenuated triple mutant of yersinia pestis co92 induces robust humoral and cell-mediated immunity to completely protect animals against pneumonic plague

  Tiner, B. L., Sha, J., Ponnusamy, D., Baze, W. B., Fitts, E. C., Popov, V. L., Van Lier, C. J., Erova, T. E. & Chopra, A. K., Dec 2015, In: Clinical and Vaccine Immunology. 22, 12, p. 1255-1268 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Immunization
  • Yersinia pestis
  • Plague
  • Animals
  • Cellular Immunity
  8 Scopus citations
• 2016

  Cross-talk among flesh-eating Aeromonas hydrophila strains in mixed infection leading to necrotizing fasciitis

  Ponnusamy, D., Kozlova, E. V., Sha, J., Erova, T. E., Azar, S. R., Fitts, E. C., Kirtley, M. L., Tiner, B. L., Andersson, J. A., Grim, C. J., Isom, R. P., Hasan, N. A., Colwell, R. R. & Chopra, A. K., Jan 19 2016, In: Proceedings of the National Academy of Sciences of the United States of America. 113, 3, p. 722-727 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Aeromonas hydrophila
  • Exotoxins
  • Necrotizing Fasciitis
  • Coinfection
  • Virulence
  34 Scopus citations
• 2015

  Combinational deletion of three membrane protein-encoding genes highly attenuates Yersinia pestis while retaining immunogenicity in a mouse model of pneumonic plague

  Tiner, B. L., Sha, J., Kirtley, M. L., Erova, T. E., Popov, V. L., Baze, W. B., van Lier, C. J., Ponnusamy, D., Andersson, J. A., Motin, V. L., Chauhan, S. & Chopra, A. K., Jan 1 2015, In: Infection and immunity. 83, 4, p. 1318-1338 21 p.

  Research output: Contribution to journal › Article › peer-review

  • Yersinia pestis
  • Plague
  • Membrane Proteins
  • Genes
  • Lethal Dose 50
  12 Scopus citations
• 2019

  T6SS and ExoA of flesh-eating Aeromonas hydrophila in peritonitis and necrotizing fasciitis during mono- And polymicrobial infections

  Fernández-Bravo, A., Kilgore, P. B., Andersson, J. A., Blears, E., Figueras, M. J., Hasan, N. A., Colwell, R. R., Sha, J. & Chopra, A. K., Nov 26 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 48, p. 24084-24092 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Type VI Secretion Systems
  • Aeromonas hydrophila
  • Exotoxins
  • Necrotizing Fasciitis
  • Peritonitis
  3 Scopus citations
• 2020

  New host-directed therapeutics for the treatment of Clostridioides difficile infection

  Andersson, J. A., Peniche, A. G., Galindo, C. L., Boonma, P., Sha, J., Luna, R. A., Savidge, T. C., Chopra, A. K. & Dann, S. M., Mar 1 2020, In: mBio. 11, 2, e00053-20.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Amoxapine
  • Infection
  • Interleukin-33
  • Pharmaceutical Preparations
  • Doxapram
• 2016

  New insights into autoinducer-2 signaling as a virulence regulator in a mouse model of pneumonic plague

  Fitts, E. C., Andersson, J. A., Kirtley, M. L., Sha, J., Erova, T. E., Chauhan, S., Motin, V. L. & Chopra, A. K., Nov 1 2016, In: mSphere. 1, 6, e00342-16.

  Research output: Contribution to journal › Article › peer-review

  • N-octanoylhomoserine lactone
  • Plague
  • Virulence
  • Yersinia pestis
  • Bacterial Genes
  6 Scopus citations