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2018
Systematic Analysis of Monoclonal Antibodies against Ebola Virus GP Defines Features that Contribute to Protection
the Viral Hemorrhagic Fever Immunotherapeutic Consortium, Aug 9 2018, In: Cell. 174, 4, p. 938-952.e13Research output: Contribution to journal › Article › peer-review
63 Scopus citations -
Corrigendum: Ebola VP40 in exosomes can cause immune cell dysfunction [Front. Microbiol., 7, (2016), (1765)] doi: 10.3389/fmicb.2016.01765
Pleet, M. L., Mathiesen, A., DeMarino, C., Akpamagbo, Y. A., Barclay, R. A., Schwab, A., Iordanskiy, S., Sampey, G. C., Lepene, B., Ilinykh, P. A., Bukreyev, A., Nekhai, S., Aman, M. J. & Kashanchi, F., Apr 17 2018, In: Frontiers in Microbiology. 9, APR, 692.Research output: Contribution to journal › Comment/debate › peer-review
1 Scopus citations -
Protein Phosphatase 1-Targeting Small-Molecule C31 Inhibits Ebola Virus Replication
Ammosova, T., Pietzsch, C. A., Saygideǧer, Y., Ilatovsky, A., Lin, X., Ivanov, A., Kumari, N., Jerebtsova, M., Kulkarni, A., Petukhov, M., Üren, A., Bukreyev, A. & Nekhai, S., Nov 22 2018, In: Journal of Infectious Diseases. 218, p. S627-S635Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Disruption of Phosphatidylserine Synthesis or Trafficking Reduces Infectivity of Ebola Virus
Younan, P., Iampietro, M., Santos, R. I., Ramanathan, P., Popov, V. L. & Bukreyev, A., Nov 22 2018, In: Journal of Infectious Diseases. 218, p. S475-S485Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
2020
Analysis of a Therapeutic Antibody Cocktail Reveals Determinants for Cooperative and Broad Ebolavirus Neutralization
Gilchuk, P., Murin, C. D., Milligan, J. C., Cross, R. W., Mire, C. E., Ilinykh, P. A., Huang, K., Kuzmina, N., Altman, P. X., Hui, S., Gunn, B. M., Bryan, A. L., Davidson, E., Doranz, B. J., Turner, H. L., Alkutkar, T., Flinko, R., Orlandi, C., Carnahan, R., Nargi, R. & 13 others, , Feb 18 2020, In: Immunity. 52, 2, p. 388-403.e12Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
2018
A high throughput screen identifies benzoquinoline compounds as inhibitors of Ebola virus replication
Luthra, P., Liang, J., Pietzsch, C. A., Khadka, S., Edwards, M. R., Wei, S., De, S., Posner, B., Bukreyev, A., Ready, J. M. & Basler, C. F., Feb 2018, In: Antiviral research. 150, p. 193-201 9 p.Research output: Contribution to journal › Article › peer-review
19 Scopus citations -
Inhibiting pyrimidine biosynthesis impairs Ebola virus replication through depletion of nucleoside pools and activation of innate immune responses
Luthra, P., Naidoo, J., Pietzsch, C. A., De, S., Khadka, S., Anantpadma, M., Williams, C. G., Edwards, M. R., Davey, R. A., Bukreyev, A., Ready, J. M. & Basler, C. F., Oct 2018, In: Antiviral research. 158, p. 288-302 15 p.Research output: Contribution to journal › Article › peer-review
22 Scopus citations -
2019
Taxonomy of the order Mononegavirales: second update 2018
Maes, P., Amarasinghe, G. K., Ayllón, M. A., Basler, C. F., Bavari, S., Blasdell, K. R., Briese, T., Brown, P. A., Bukreyev, A., Balkema-Buschmann, A., Buchholz, U. J., Chandran, K., Crozier, I., de Swart, R. L., Dietzgen, R. G., Dolnik, O., Domier, L. L., Drexler, J. F., Dürrwald, R., Dundon, W. G. & 57 others, , Apr 3 2019, In: Archives of virology. 164, 4, p. 1233-1244 12 p.Research output: Contribution to journal › Article › peer-review
Open Access35 Scopus citations -
Structural basis of broad ebolavirus neutralization by a human survivor antibody
West, B. R., Wec, A. Z., Moyer, C. L., Fusco, M. L., Ilinykh, P. A., Huang, K., Wirchnianski, A. S., James, R. M., Herbert, A. S., Hui, S., Goodwin, E., Howell, K. A., Kailasan, S., Aman, M. J., Walker, L. M., Dye, J. M., Bukreyev, A., Chandran, K. & Saphire, E. O., Mar 1 2019, In: Nature Structural and Molecular Biology. 26, 3, p. 204-212 9 p.Research output: Contribution to journal › Article › peer-review
7 Scopus citations -
Antibody-mediated protective mechanisms induced by a trivalent parainfluenza virus-vectored ebolavirus vaccine
Brian Kimble, J., Malherbe, D. C., Meyer, M., Gunn, B. M., Karim, M. M., Ilinykh, P. A., Iampietro, M., Mohamed, K. S., Negi, S., Gilchuk, P., Huang, K., Wolf, Y. I., Braun, W., Crowe, J. E., Alter, G. & Bukreyev, A., Feb 1 2019, In: Journal of virology. 93, 4, e0184518.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
2018
Role of Transmembrane Protein 16F in the Incorporation of Phosphatidylserine into Budding Ebola Virus Virions
Younan, P., Iampietro, M., Santos, R. I., Ramanathan, P., Popov, V. L. & Bukreyev, A., Nov 22 2018, In: Journal of Infectious Diseases. 218, p. S335-S345Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
2020
Species-Specific Evolution of Ebola Virus during Replication in Human and Bat Cells
Whitfield, Z. J., Prasad, A. N., Ronk, A. J., Kuzmin, I. V., Ilinykh, P. A., Andino, R. & Bukreyev, A., Aug 18 2020, In: Cell Reports. 32, 7, 108028.Research output: Contribution to journal › Article › peer-review
Open Access -
2015
Adapting high-throughput screening methods and assays for biocontainment laboratories
Rasmussen, L., Tigabu, B., White, E. L., Bostwick, R., Tower, N., Bukreyev, A., Rockx, B., Leduc, J. W. & Noah, J. W., Feb 1 2015, In: Assay and Drug Development Technologies. 13, 1, p. 44-54 11 p.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
Mechanism of Human Antibody-Mediated Neutralization of Marburg Virus
Flyak, A. I., Ilinykh, P. A., Murin, C. D., Garron, T., Shen, X., Fusco, M. L., Hashiguchi, T., Bornholdt, Z. A., Slaughter, J. C., Sapparapu, G., Klages, C., Ksiazek, T. G., Ward, A. B., Saphire, E. O., Bukreyev, A. & Crowe, J. E., Feb 26 2015, In: Cell. 160, 5, p. 893-903 11 p.Research output: Contribution to journal › Article › peer-review
83 Scopus citations -
2019
Taxonomy of the order Mononegavirales: update 2019
Amarasinghe, G. K., Ayllón, M. A., Bào, Y., Basler, C. F., Bavari, S., Blasdell, K. R., Briese, T., Brown, P. A., Bukreyev, A., Balkema-Buschmann, A., Buchholz, U. J., Chabi-Jesus, C., Chandran, K., Chiapponi, C., Crozier, I., de Swart, R. L., Dietzgen, R. G., Dolnik, O., Drexler, J. F., Dürrwald, R. & 64 others, , Jul 1 2019, In: Archives of virology. 164, 7, p. 1967-1980 14 p.Research output: Contribution to journal › Article › peer-review
Open Access65 Scopus citations -
Can Ebola Virus Vaccines Have Universal Immune Correlates of protection?
Meyer, M., Malherbe, D. C. & Bukreyev, A., Jan 2019, In: Trends in Microbiology. 27, 1, p. 8-16 9 p.Research output: Contribution to journal › Review article › peer-review
7 Scopus citations -
2018
Broadly neutralizing antibodies from human survivors target a conserved site in the ebola virus glycoprotein hr2-mper region
Flyak, A. I., Kuzmina, N., Murin, C. D., Bryan, C., Davidson, E., Gilchuk, P., Gulka, C. P., Ilinykh, P. A., Shen, X., Huang, K., Ramanathan, P., Turner, H., Fusco, M. L., Lampley, R., Kose, N., King, H., Sapparapu, G., Doranz, B. J., Ksiazek, T. G., Wright, D. W. & 4 others, , Jun 1 2018, In: Nature Microbiology. 3, 6, p. 670-677 8 p.Research output: Contribution to journal › Article › peer-review
27 Scopus citations -
2019
Targeting the Non-catalytic RVxF Site of Protein Phosphatase-1 With Small Molecules for Ebola Virus Inhibition
Lin, X., Ammosova, T., Choy, M. S., Pietzsch, C. A., Ivanov, A., Ahmad, A., Saygideğer, Y., Kumari, N., Kovalskyy, D., Üren, A., Peti, W., Bukreyev, A. & Nekhai, S., Sep 13 2019, In: Frontiers in Microbiology. 10, 2145.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
2020
Small Molecule Compounds That Inhibit Antioxidant Response Gene Expression in an Inducer-Dependent Manner
Edwards, M. R., Liu, G., De, S., Sourimant, J., Pietzsch, C., Johnson, B., Amarasinghe, G. K., Leung, D. W., Bukreyev, A., Plemper, R. K., Aron, Z., Bowlin, T. L., Moir, D. T. & Basler, C. F., Mar 13 2020, In: ACS Infectious Diseases. 6, 3, p. 489-502 14 p.Research output: Contribution to journal › Article › peer-review
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Global phosphoproteomic analysis of Ebola virions reveals a novel role for VP35 phosphorylation-dependent regulation of genome transcription
Ivanov, A., Ramanathan, P., Parry, C., Ilinykh, P. A., Lin, X., Petukhov, M., Obukhov, Y., Ammosova, T., Amarasinghe, G. K., Bukreyev, A. & Nekhai, S., Jul 1 2020, In: Cellular and Molecular Life Sciences. 77, 13, p. 2579-2603 25 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
2018
Staufen1 interacts with multiple components of the ebola virus ribonucleoprotein and enhances viral RNA synthesis
Fang, J., Pietzsch, C., Ramanathan, P., Santos, R. I., Ilinykh, P. A., Garcia-Blanco, M. A., Bukreyev, A. & Bradrick, S. S., Sep 1 2018, In: mBio. 9, 5, e01771-18.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
2015
Aerosolized Ebola vaccine protects primates and elicits lung-resident T cell responses
Meyer, M., Garron, T., Lubaki, N. M., Mire, C. E., Fenton, K. A., Klages, C., Olinger, G. G., Geisbert, T. W., Collins, P. L. & Bukreyev, A., Aug 3 2015, In: Journal of Clinical Investigation. 125, 8, p. 3241-3255 15 p.Research output: Contribution to journal › Article › peer-review
45 Scopus citations -
2018
The Marburgvirus-Neutralizing Human Monoclonal Antibody MR191 Targets a Conserved Site to Block Virus Receptor Binding
King, L. B., Fusco, M. L., Flyak, A. I., Ilinykh, P. A., Huang, K., Gunn, B., Kirchdoerfer, R. N., Hastie, K. M., Sangha, A. K., Meiler, J., Alter, G., Bukreyev, A., Crowe, J. E. & Saphire, E. O., Jan 10 2018, In: Cell Host and Microbe. 23, 1, p. 101-109.e4Research output: Contribution to journal › Article › peer-review
11 Scopus citations -
Antibody Repertoires to the Same Ebola Vaccine Antigen Are Differentially Affected by Vaccine Vectors
Meyer, M., Yoshida, A., Ramanathan, P., Saphire, E. O., Collins, P. L., Crowe, J. E., Samal, S. & Bukreyev, A., Aug 14 2018, In: Cell Reports. 24, 7, p. 1816-1829 14 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
2019
Cross-reactive neutralizing human survivor monoclonal antibody BDBV223 targets the ebolavirus stalk
King, L. B., West, B. R., Moyer, C. L., Gilchuk, P., Flyak, A., Ilinykh, P. A., Bombardi, R., Hui, S., Huang, K., Bukreyev, A., Crowe, J. E. & Saphire, E. O., Dec 1 2019, In: Nature communications. 10, 1, 1788.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
2020
Non-neutralizing Antibodies from a Marburg Infection Survivor Mediate Protection by Fc-Effector Functions and by Enhancing Efficacy of Other Antibodies
Ilinykh, P. A., Huang, K., Santos, R. I., Gilchuk, P., Gunn, B. M., Karim, M. M., Liang, J., Fouch, M. E., Davidson, E., Parekh, D. V., Kimble, J. B., Pietzsch, C. A., Meyer, M., Kuzmina, N. A., Zeitlin, L., Saphire, E. O., Alter, G., Crowe, J. E. & Bukreyev, A., Jun 10 2020, In: Cell Host and Microbe. 27, 6, p. 976-991.e11Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
Annexin a2 depletion exacerbates the intracerebral microhemorrhage induced by acute rickettsia and ebola virus infections
Su, Z., Chang, Q., Drelich, A., Shelite, T., Judy, B., Liu, Y., Xiao, J., Zhou, C., He, X., Jin, Y., Saito, T., Tang, S., Soong, L., Wakamiya, M., Fang, X., Bukreyev, A., Ksiazek, T., Russell, W. K. & Gong, B., Jul 2020, In: PLoS neglected tropical diseases. 14, 7, p. 1-30 30 p., e0007960.Research output: Contribution to journal › Article › peer-review
Open Access -
Topoisomerase III-β is required for efficient replication of positive-sense RNA viruses
Prasanth, K. R., Hirano, M., Fagg, W. S., McAnarney, E. T., Shan, C., Xie, X., Hage, A., Pietzsch, C. A., Bukreyev, A., Rajsbaum, R., Shi, P. Y., Bedford, M. T., Bradrick, S. S., Menachery, V. & Garcia-Blanco, M. A., Oct 2020, In: Antiviral research. 182, 104874.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
2012
The secreted g protein of human respiratory syncytial virus antagonizes antibody-mediated restriction of replication involving macrophages and complement
Bukreyev, A., Yang, L. & Collins, P. L., Oct 2012, In: Journal of virology. 86, 19, p. 10880-10884 5 p.Research output: Contribution to journal › Article › peer-review
26 Scopus citations -
2019
Ebola virus-mediated T-lymphocyte depletion is the result of an abortive infection
Younan, P., Santos, R. I., Ramanathan, P., Iampietro, M., Nishida, A., Dutta, M., Ammosova, T., Meyer, M., Katze, M. G., Popov, V. L., Nekhai, S. & Bukreyev, A., 2019, In: PLoS pathogens. 15, 10, e1008068.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
2015
Partial attenuation of respiratory syncytial virus with a deletion of a small hydrophobic gene is associated with elevated interleukin-1β responses
Russell, R. F., McDonald, J. U., Ivanova, M., Zhong, Z., Bukreyev, A. & Tregoning, J. S., 2015, In: Journal of virology. 89, 17, p. 8974-8981 8 p.Research output: Contribution to journal › Article › peer-review
33 Scopus citations -
2018
Disabling of lymphocyte immune response by Ebola virus
Younan, P., Iampietro, M. & Bukreyev, A., Apr 2018, In: PLoS pathogens. 14, 4, e1006932.Research output: Contribution to journal › Article › peer-review
12 Scopus citations -
Multifunctional Pan-ebolavirus Antibody Recognizes a Site of Broad Vulnerability on the Ebolavirus Glycoprotein
Gilchuk, P., Kuzmina, N., Ilinykh, P. A., Huang, K., Gunn, B. M., Bryan, A., Davidson, E., Doranz, B. J., Turner, H. L., Fusco, M. L., Bramble, M. S., Hoff, N. A., Binshtein, E., Kose, N., Flyak, A. I., Flinko, R., Orlandi, C., Carnahan, R., Parrish, E. H., Sevy, A. M. & 12 others, , Aug 21 2018, In: Immunity. 49, 2, p. 363-374.e10Research output: Contribution to journal › Article › peer-review
20 Scopus citations -
Ebola Virus Shed Glycoprotein Triggers Differentiation, Infection, and Death of Monocytes Through Toll-Like Receptor 4 Activation
Iampietro, M., Santos, R. I., Lubaki, N. M. & Bukreyev, A., Nov 22 2018, In: Journal of Infectious Diseases. 218, p. S327-S334Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Modified mRNA-Based Vaccines Elicit Robust Immune Responses and Protect Guinea Pigs from Ebola Virus Disease
Meyer, M., Huang, E., Yuzhakov, O., Ramanathan, P., Ciaramella, G. & Bukreyev, A., Jan 17 2018, In: Journal of Infectious Diseases. 217, 3, p. 451-455 5 p.Research output: Contribution to journal › Article › peer-review
24 Scopus citations -
Asymmetric antiviral effects of ebolavirus antibodies targeting glycoprotein stem and glycan cap
Ilinykh, P. A., Santos, R. I., Gunn, B. M., Kuzmina, N. A., Shen, X., Huang, K., Gilchuk, P., Flyak, A. I., Younan, P., Alter, G., Crowe, J. E. & Bukreyev, A., Aug 2018, In: PLoS pathogens. 14, 8, e1007204.Research output: Contribution to journal › Article › peer-review
6 Scopus citations -
2015
Different temporal effects of Ebola virus VP35 and VP24 proteins on global gene expression in human dendritic cells
Ilinykh, P. A., Lubaki, N. M., Widen, S. G., Renn, L. A., Theisen, T. C., Rabin, R. L., Wood, T. G. & Bukreyev, A., 2015, In: Journal of virology. 89, 15, p. 7567-7583 17 p.Research output: Contribution to journal › Article › peer-review
32 Scopus citations -
2018
Taxonomy of the order Mononegavirales: update 2018
Amarasinghe, G. K., Aréchiga Ceballos, N. G., Banyard, A. C., Basler, C. F., Bavari, S., Bennett, A. J., Blasdell, K. R., Briese, T., Bukreyev, A., Caì, Y., Calisher, C. H., Campos Lawson, C., Chandran, K., Chapman, C. A., Chiu, C. Y., Choi, K. S., Collins, P. L., Dietzgen, R. G., Dolja, V. V., Dolnik, O. & 71 others, , Aug 1 2018, In: Archives of virology. 163, 8, p. 2283-2294 12 p.Research output: Contribution to journal › Article › peer-review
88 Scopus citations -
2020
Modified vaccinia Ankara vaccine expressing Marburg virus-like particles protects guinea pigs from lethal Marburg virus infection
Malherbe, D. C., Domi, A., Hauser, M. J., Meyer, M., Gunn, B. M., Alter, G., Bukreyev, A. & Guirakhoo, F., Dec 1 2020, In: npj Vaccines. 5, 1, 78.Research output: Contribution to journal › Article › peer-review
Open Access -
2018
Ebolavirus Chimerization for the Development of a Mouse Model for Screening of Bundibugyo-Specific Antibodies
Ilinykh, P. A., Graber, J., Kuzmina, N. A., Huang, K., Ksiazek, T. G., Crowe, J. E. & Bukreyev, A., Nov 22 2018, In: Journal of Infectious Diseases. 218, p. S418-S422Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
2020
Ebola virus produces discrete small noncoding RNAs independently of the host MicroRNA pathway which lack RNA interference activity in bat and human cells
Prasad, A. N., Ronk, A. J., Widen, S. G., Wood, T. G., Basler, C. F. & Bukreyev, A., Mar 1 2020, In: Journal of virology. 94, 6, e01441-19.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
2020 taxonomic update for phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales
Kuhn, J. H., Adkins, S., Alioto, D., Alkhovsky, S. V., Amarasinghe, G. K., Anthony, S. J., Avšič-Županc, T., Ayllón, M. A., Bahl, J., Balkema-Buschmann, A., Ballinger, M. J., Bartonička, T., Basler, C., Bavari, S., Beer, M., Bente, D. A., Bergeron, É., Bird, B. H., Blair, C., Blasdell, K. R. & 209 others, , Dec 1 2020, In: Archives of virology. 165, 12, p. 3023-3072 50 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
2018
Antibody-Dependent Enhancement of Ebola Virus Infection by Human Antibodies Isolated from Survivors
Kuzmina, N. A., Younan, P., Gilchuk, P., Santos, R. I., Flyak, A. I., Ilinykh, P. A., Huang, K., Lubaki, N. M., Ramanathan, P., Crowe, J. E. & Bukreyev, A., Aug 14 2018, In: Cell Reports. 24, 7, p. 1802-1815.e5Research output: Contribution to journal › Article › peer-review
23 Scopus citations -
2019
ICTV virus taxonomy profile: Filoviridae
ICTV Report Consortium, Jun 2019, In: Journal of General Virology. 100, 6, p. 911-912 2 p.Research output: Contribution to journal › Article › peer-review
11 Scopus citations -
2018
Phosphorylated VP30 of marburg virus is a repressor of transcription
Tigabu, B., Ramanathan, P., Ivanov, A., Lin, X., Ilinykh, P. A., Parry, C. S., Freiberg, A. N., Nekhai, S. & Bukreyev, A., Nov 1 2018, In: Journal of virology. 92, 21, e00426.Research output: Contribution to journal › Article › peer-review
7 Scopus citations -
2012
The human respiratory syncytial virus nonstructural protein 1 regulates type I and type II interferon pathways
Hastie, M. L., Headlam, M. J., Patel, N. B., Bukreyev, A. A., Buchholz, U. J., Dave, K. A., Norris, E. L., Wright, C. L., Spann, K. M., Collins, P. L. & Gorman, J. J., May 2012, In: Molecular and Cellular Proteomics. 11, 5, p. 108-127 20 p.Research output: Contribution to journal › Article › peer-review
38 Scopus citations