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• 2018

  Structural basis, stoichiometry, and thermodynamics of binding of the chemokines KC and MIP2 to the glycosaminoglycan heparin

  Sepuru, K. M., Nagarajan, B., Desai, U. R. & Rajarathnam, K., Nov 16 2018, In: Journal of Biological Chemistry. 293, 46, p. 17817-17828 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Stoichiometry
  • Thermodynamics
  • Glycosaminoglycans
  • Chemokines
  • Heparin
  4 Scopus citations
• 2017

  Regulation of chemokine function: The roles of GAG-binding and post-translational nitration

  Thompson, S., Martínez-Burgo, B., Sepuru, K. M., Rajarathnam, K., Kirby, J. A., Sheerin, N. S. & Ali, S., Aug 3 2017, In: International journal of molecular sciences. 18, 8, 1692.

  Research output: Contribution to journal › Review article › peer-review

  • Glycosaminoglycans
  • nitration
  • Nitration
  • Chemokines
  • leukocytes
  12 Scopus citations
• 2020

  Structural Insights Into How Proteoglycans Determine Chemokine-CXCR1/CXCR2 Interactions: Progress and Challenges

  Rajarathnam, K. & Desai, U. R., Apr 24 2020, In: Frontiers in immunology. 11, 660.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Proteoglycans
  • Glycosaminoglycans
  • Chemokines
  • Interleukin-8A Receptors
  • Interleukin-8B Receptors
  5 Scopus citations
• 2018

  Direct detection of lysine side chain NH₃⁺ in protein-heparin complexes using NMR spectroscopy

  Sepuru, K. M., Iwahara, J. & Rajarathnam, K., Feb 7 2018, In: Analyst. 143, 3, p. 635-638 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Chemical shift
  • Heparin
  • Nuclear magnetic resonance spectroscopy
  • Lysine
  • nuclear magnetic resonance
  7 Scopus citations
• 2017

  Structural basis of native CXCL7 monomer binding to CXCR2 receptor N-domain and glycosaminoglycan heparin

  Brown, A. J., Sepuru, K. M. & Rajarathnam, K., Mar 2017, In: International journal of molecular sciences. 18, 3, 508.

  Research output: Contribution to journal › Article › peer-review

  • Glycosaminoglycans
  • Heparin
  • Interleukin-8B Receptors
  • heparins
  • Monomers
  14 Scopus citations

• Chemokine CXCL7 heterodimers: Structural insights, CXCR2 receptor function, and glycosaminoglycan interactions

  Brown, A. J., Joseph, P. R. B., Sawant, K. V. & Rajarathnam, K., Apr 2017, In: International journal of molecular sciences. 18, 4, 748.

  Research output: Contribution to journal › Article › peer-review

  • Glycosaminoglycans
  • Interleukin-8B Receptors
  • Chemokines
  • disulfides
  • infectious diseases
  11 Scopus citations

• Platelet-derived chemokine CXCL₇ dimer preferentially exists in the glycosaminoglycan-bound form: Implications for neutrophil-platelet crosstalk

  Brown, A. J., Sepuru, K. M., Sawant, K. V. & Rajarathnam, K., Oct 2 2017, In: Frontiers in immunology. 8, OCT, 1248.

  Research output: Contribution to journal › Article › peer-review

  • Interleukin-8B Receptors
  • Glycosaminoglycans
  • Chemokines
  • Heparin
  • Neutrophils
  19 Scopus citations

• Heparin-bound chemokine CXCL8 monomer and dimer are impaired for CXCR1 and CXCR2 activation: Implications for gradients and neutrophil trafficking

  Joseph, P. R. B., Sawant, K. V. & Rajarathnam, K., 2017, In: Open Biology. 7, 11, 170168.

  Research output: Contribution to journal › Article › peer-review

  • Dimers
  • Monomers
  • Glycosaminoglycans
  • Interleukin-8
  • Heparin
  17 Scopus citations
• 2020

  Lyophilization of human amniotic fluid is feasible without affecting biological activity

  Coon, J. I., Jain, S., Sepuru, K. M., Chung, Y., Mohankumar, K., Rajarathnam, K. & Jain, S. K., Apr 1 2020, In: Pediatric Research. 87, 5, p. 847-852 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Freeze Drying
  • Amniotic Fluid
  • Interleukin-8
  • Deglutition
  • Dialysis
• 2018

  Glycosaminoglycan Interactions Fine-Tune Chemokine-Mediated Neutrophil Trafficking: Structural Insights and Molecular Mechanisms

  Rajarathnam, K., Sepuru, K. M., Joseph, P. R. B., Sawant, K. V. & Brown, A. J., Apr 1 2018, In: Journal of Histochemistry and Cytochemistry. 66, 4, p. 229-239 11 p.

  Research output: Contribution to journal › Review article › peer-review

  • Glycosaminoglycans
  • Chemokines
  • Neutrophils
  • Neutrophil Infiltration
  • Interleukin-8B Receptors
  11 Scopus citations

• Dynamics-derived insights into complex formation between the CXCL8 monomer and CXCR1 N-terminal domain: An NMR study

  Joseph, P. R. B., Spyracopoulos, L. & Rajarathnam, K., Oct 31 2018, In: Molecules. 23, 11

  Research output: Contribution to journal › Article › peer-review

  • Interleukin-8A Receptors
  • Calorimetry
  • Nuclear magnetic resonance
  • Monomers
  • G-Protein-Coupled Receptors
  4 Scopus citations

• Lysines and Arginines play non-redundant roles in mediating chemokine-glycosaminoglycan interactions

  Joseph, P. R. B., Sawant, K. V., Iwahara, J., Garofalo, R. P., Desai, U. R. & Rajarathnam, K., Dec 1 2018, In: Scientific reports. 8, 1, 12289.

  Research output: Contribution to journal › Article › peer-review

  • Glycosaminoglycans
  • Lysine
  • Chemokines
  • Arginine
  • Neutrophils
  3 Scopus citations

• Ehrlichia chaffeensis TRP120 nucleomodulin binds DNA with disordered tandem repeat domain

  Klema, V. J., Sepuru, K. M., Füllbrunn, N., Farris, T. R., Dunphy, P. S., McBride, J. W., Rajarathnam, K. & Choi, K. H., Apr 2018, In: PloS one. 13, 4, e0194891.

  Research output: Contribution to journal › Article › peer-review

  • Ehrlichia chaffeensis
  • Tandem Repeat Sequences
  • tandem repeat sequences
  • DNA
  • Proteins
  5 Scopus citations

• Distinct Differences in Structural States of Conserved Histidines in Two Related Proteins: NMR Studies of the Chemokines CXCL1 and CXCL8 in the Free Form and Macromolecular Complexes

  Sepuru, K. M. & Rajarathnam, K., Oct 16 2018, In: Biochemistry. 57, 41, p. 5969-5977 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Chemokine CXCL1
  • Macromolecular Substances
  • Nuclear magnetic resonance
  • Histidine
  • Interleukin-8
  3 Scopus citations

• Interleukin-8 mediates neutrophil-endothelial interactions in pig-to-human xenogeneic models

  French, B. M., Sendil, S., Sepuru, K. M., Ranek, J., Burdorf, L., Harris, D., Redding, E., Cheng, X., Laird, C. T., Zhao, Y., Cerel, B., Rajarathnam, K., Pierson, R. N. & Azimzadeh, A. M., Mar 1 2018, In: Xenotransplantation. 25, 2, e12385.

  Research output: Contribution to journal › Article › peer-review

  • Interleukin-8
  • Swine
  • Neutrophils
  • 2-(4-isobutylphenyl)propionylmethanesulfonamide
  • Heterologous Transplantation
  5 Scopus citations
• 2020

  Neutrophil recruitment by chemokines Cxcl1/KC and Cxcl2/MIP2: Role of Cxcr2 activation and glycosaminoglycan interactions

  Sawant, K. V., Sepuru, K. M., Lowry, E., Penaranda, B., Frevert, C. W., Garofalo, R. P. & Rajarathnam, K., 2020, (Accepted/In press) In: Journal of Leukocyte Biology.

  Research output: Contribution to journal › Article › peer-review

  • Neutrophil Infiltration
  • Glycosaminoglycans
  • Chemokines
  • Personnel Selection
  • Neutrophil Activation
• 2012

  The monomer-dimer equilibrium and glycosaminoglycan interactions of chemokine CXCL8 regulate tissue-specific neutrophil recruitment

  Gangavarapu, P., Rajagopalan, L., Kolli, D., Guerrero-Plata, A., Garofalo, R. P. & Rajarathnam, K., Feb 2012, In: Journal of Leukocyte Biology. 91, 2, p. 259-265 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Neutrophil Infiltration
  • Glycosaminoglycans
  • Interleukin-8
  • Chemokines
  • Peritoneum
  62 Scopus citations