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• 2014

  Solution structure of CXCL5 - A novel chemokine and adipokine implicated in inflammation and obesity

  Sepuru, K. M., Poluri, K. M. & Rajarathnam, K., Apr 2 2014, In: PloS one. 9, 4, e93228.

  Research output: Contribution to journal › Article › peer-review

  • adipokines
  • chemokines
  • Adipokines
  • obesity
  • Chemokines
  18 Scopus citations

• Isothermal titration calorimetry of membrane proteins - Progress and challenges

  Rajarathnam, K. & Rösgen, J., 2014, In: Biochimica et Biophysica Acta - Biomembranes. 1838, 1 PARTA, p. 69-77 9 p.

  Research output: Contribution to journal › Review article › peer-review

  • Titration
  • Calorimetry
  • Membrane Proteins
  • Thermodynamics
  • Ligands
  56 Scopus citations
• 2013

  Dynamic conformational switching in the chemokine ligand is essential for G-protein-coupled receptor activation

  Joseph, P. R. B., Sawant, K. V., Isley, A., Pedroza, M., Garofalo, R. P., Richardson, R. M. & Rajarathnam, K., Dec 1 2013, In: Biochemical Journal. 456, 2, p. 241-251 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Proline
  • Glycine
  • G-Protein-Coupled Receptors
  • Chemokines
  • Chemical activation
  20 Scopus citations

• Real-time kinetics of high-mobility group box 1 (HMGB1) oxidation in extracellular fluids studied by in situ protein NMR spectroscopy

  Zandarashvili, L., Sahu, D., Lee, K., Lee, Y. S., Singh, P., Rajarathnam, K. & Iwahara, J., Apr 26 2013, In: Journal of Biological Chemistry. 288, 17, p. 11621-11627 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Biomolecular Nuclear Magnetic Resonance
  • Nuclear magnetic resonance spectroscopy
  • Extracellular Fluid
  • Sulfhydryl Compounds
  • Oxidation
  37 Scopus citations

• Molecular basis of glycosaminoglycan heparin binding to the chemokine CXCL1 dimer

  Poluri, K. M., Joseph, P. R. B., Sawant, K. V. & Rajarathnam, K., Aug 30 2013, In: Journal of Biological Chemistry. 288, 35, p. 25143-25153 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Chemokine CXCL1
  • Dimers
  • Glycosaminoglycans
  • Chemokines
  • Heparin
  42 Scopus citations
• 2017

  Heparin-bound chemokine CXCL8 monomer and dimer are impaired for CXCR1 and CXCR2 activation: Implications for gradients and neutrophil trafficking

  Joseph, P. R. B., Sawant, K. V. & Rajarathnam, K., 2017, In: Open Biology. 7, 11, 170168.

  Research output: Contribution to journal › Article › peer-review

  • Dimers
  • Monomers
  • Glycosaminoglycans
  • Interleukin-8
  • Heparin
  17 Scopus citations

• Structural basis of native CXCL7 monomer binding to CXCR2 receptor N-domain and glycosaminoglycan heparin

  Brown, A. J., Sepuru, K. M. & Rajarathnam, K., Mar 2017, In: International journal of molecular sciences. 18, 3, 508.

  Research output: Contribution to journal › Article › peer-review

  • Glycosaminoglycans
  • Heparin
  • Interleukin-8B Receptors
  • heparins
  • Monomers
  14 Scopus citations

• Chemokine CXCL7 heterodimers: Structural insights, CXCR2 receptor function, and glycosaminoglycan interactions

  Brown, A. J., Joseph, P. R. B., Sawant, K. V. & Rajarathnam, K., Apr 2017, In: International journal of molecular sciences. 18, 4, 748.

  Research output: Contribution to journal › Article › peer-review

  • Glycosaminoglycans
  • Interleukin-8B Receptors
  • Chemokines
  • disulfides
  • infectious diseases
  11 Scopus citations

• Platelet-derived chemokine CXCL₇ dimer preferentially exists in the glycosaminoglycan-bound form: Implications for neutrophil-platelet crosstalk

  Brown, A. J., Sepuru, K. M., Sawant, K. V. & Rajarathnam, K., Oct 2 2017, In: Frontiers in immunology. 8, OCT, 1248.

  Research output: Contribution to journal › Article › peer-review

  • Interleukin-8B Receptors
  • Glycosaminoglycans
  • Chemokines
  • Heparin
  • Neutrophils
  20 Scopus citations
• 2013

  Proline substitution of dimer interface β-strand residues as a strategy for the design of functional monomeric proteins

  Joseph, P. R. B., Poluri, K. M., Gangavarapu, P., Rajagopalan, L., Raghuwanshi, S., Richardson, R. M., Garofalo, R. P. & Rajarathnam, K., Sep 17 2013, In: Biophysical journal. 105, 6, p. 1491-1501 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Proline
  • Proteins
  • Catalysis
  • Amides
  • Static Electricity
  19 Scopus citations
• 2017

  Regulation of chemokine function: The roles of GAG-binding and post-translational nitration

  Thompson, S., Martínez-Burgo, B., Sepuru, K. M., Rajarathnam, K., Kirby, J. A., Sheerin, N. S. & Ali, S., Aug 3 2017, In: International journal of molecular sciences. 18, 8, 1692.

  Research output: Contribution to journal › Review article › peer-review

  • Glycosaminoglycans
  • nitration
  • Nitration
  • Chemokines
  • leukocytes
  12 Scopus citations
• 2013

  Organization and dynamics of the N-terminal domain of chemokine receptor CXCR1 in reverse micelles: Effect of graded hydration

  Chaudhuri, A., Basu, P., Haldar, S., Kombrabail, M., Krishnamoorthy, G., Rajarathnam, K. & Chattopadhyay, A., Feb 7 2013, In: Journal of Physical Chemistry B. 117, 5, p. 1225-1233 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Interleukin-8A Receptors
  • Micelles
  • Hydration
  • micelles
  • hydration
  7 Scopus citations

• Chemokine CXCL1 dimer is a potent agonist for the CXCR2 receptor

  Ravindran, A., Sawant, K. V., Sarmiento, J., Navarro, J. & Rajarathnam, K., Apr 26 2013, In: Journal of Biological Chemistry. 288, 17, p. 12244-12252 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Interleukin-8B Receptors
  • Chemokine CXCL1
  • Dimers
  • Disulfides
  • Neutrophils
  40 Scopus citations