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2020
TDP-43 and Tau Oligomers in Alzheimer's Disease, Amyotrophic Lateral Sclerosis, and Frontotemporal Dementia
Montalbano, M., McAllen, S., Cascio, F. L., Sengupta, U., Garcia, S., Bhatt, N., Ellsworth, A., Heidelman, E. A., Johnson, O. D., Doskocil, S. & Kayed, R., Dec 2020, In: Neurobiology of Disease. 146, 105130.Research output: Contribution to journal › Article › peer-review
Open Access -
2015
Antibody against Small Aggregated Peptide Specifically Recognizes Toxic Aβ-42 Oligomers in Alzheimer's Disease
Bodani, R. U., Sengupta, U., Castillo-Carranza, D. L., Guerrero-Muñoz, M. J., Gerson, J. E., Rudra, J. & Kayed, R., Dec 16 2015, In: ACS Chemical Neuroscience. 6, 12, p. 1981-1989 9 p.Research output: Contribution to journal › Article › peer-review
13 Scopus citations -
2019
Near Infrared Light Treatment Reduces Synaptic Levels of Toxic Tau Oligomers in Two Transgenic Mouse Models of Human Tauopathies
Comerota, M. M., Tumurbaatar, B., Krishnan, B., Kayed, R. & Taglialatela, G., May 1 2019, In: Molecular Neurobiology. 56, 5, p. 3341-3355 15 p.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
2013
Accelerated neurodegeneration through chaperone-mediated oligomerization of tau
Blair, L. J., Nordhues, B. A., Hill, S. E., Scaglione, K. M., O'Leary, J. C., Fontaine, S. N., Breydo, L., Zhang, B., Li, P., Wang, L., Cotman, C., Paulson, H. L., Muschol, M., Uversky, V. N., Klengel, T., Binder, E. B., Kayed, R., Golde, T. E., Berchtold, N. & Dickey, C. A., Oct 1 2013, In: Journal of Clinical Investigation. 123, 10, p. 4158-4169 12 p.Research output: Contribution to journal › Article › peer-review
128 Scopus citations -
2020
Revisiting the intersection of amyloid, pathologically modified tau and iron in Alzheimer's disease from a ferroptosis perspective
Derry, P. J., Hegde, M. L., Jackson, G. R., Kayed, R., Tour, J. M., Tsai, A. L. & Kent, T. A., Jan 2020, In: Progress in Neurobiology. 184, 101716.Research output: Contribution to journal › Review article › peer-review
Open Access11 Scopus citations -
Advances and considerations in AD tau-targeted immunotherapy
Bittar, A., Bhatt, N. & Kayed, R., Feb 2020, In: Neurobiology of Disease. 134, 104707.Research output: Contribution to journal › Review article › peer-review
Open Access14 Scopus citations -
2016
Aβ Amyloid Pathology Affects the Hearts of Patients With Alzheimer's Disease: Mind the Heart
Troncone, L., Luciani, M., Coggins, M., Wilker, E. H., Ho, C. Y., Codispoti, K. E., Frosch, M. P., Kayed, R. & del Monte, F., Dec 6 2016, In: Journal of the American College of Cardiology. 68, 22, p. 2395-2407 13 p.Research output: Contribution to journal › Article › peer-review
58 Scopus citations -
2020
Internalization mechanisms of brain-derived tau oligomers from patients with Alzheimer’s disease, progressive supranuclear palsy and dementia with Lewy bodies
Puangmalai, N., Bhatt, N., Montalbano, M., Sengupta, U., Gaikwad, S., Ventura, F., McAllen, S., Ellsworth, A., Garcia, S. & Kayed, R., May 1 2020, In: Cell Death and Disease. 11, 5, 314.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
2013
Molecular mechanisms of amyloid oligomers toxicity
Kayed, R. & Lasagna-Reeves, C. A., Feb 15 2013, Alzheimer's Disease: Advances for a New Century. IOS Press, p. 67-78 12 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter
2 Scopus citations -
Rapid accumulation of endogenous Tau oligomers in a rat model of traumatic brain injury: Possible link between traumatic brain injury and sporadic tauopathies
Hawkins, B. E., Krishnamurthy, S., Castillo-Carranza, D. L., Sengupta, U., Prough, D. S., Jackson, G. R., DeWitt, D. S. & Kayed, R., Jun 7 2013, In: Journal of Biological Chemistry. 288, 23, p. 17042-17050 9 p.Research output: Contribution to journal › Article › peer-review
90 Scopus citations -
2015
Prefibrillar Tau oligomers alter the nucleic acid protective function of Tau in hippocampal neurons in vivo
Violet, M., Chauderlier, A., Delattre, L., Tardivel, M., Chouala, M. S., Sultan, A., Marciniak, E., Humez, S., Binder, L., Kayed, R., Lefebvre, B., Bonnefoy, E., Buée, L. & Galas, M. C., Oct 1 2015, In: Neurobiology of Disease. 82, p. 540-551 12 p.Research output: Contribution to journal › Article › peer-review
34 Scopus citations -
2016
Advances in tau immunotherapy
Gerson, J. & Kayed, R., Jan 1 2016, Research Progress in Alzheimer’s Disease and Dementia. Volume 6. Nova Science Publishers, Inc., p. 99-114 16 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter
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Therapeutic approaches targeting pathological tau aggregates
Gerson, J. & Kayed, R., Jul 1 2016, In: Current Pharmaceutical Design. 22, 26, p. 4028-4039 12 p.Research output: Contribution to journal › Review article › peer-review
9 Scopus citations -
2020
Functional Integrity of Synapses in the Central Nervous System of Cognitively Intact Individuals with High Alzheimer's Disease Neuropathology Is Associated with Absence of Synaptic Tau Oligomers
Singh, A., Allen, D., Fracassi, A., Tumurbaatar, B., Natarajan, C., Scaduto, P., Woltjer, R., Kayed, R., Limon, A., Krishnan, B., Taglialatela, G. & Abisambra, J., 2020, In: Journal of Alzheimer's Disease. 78, 4, p. 1661-1678 18 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2019
Tau Interacts with the C-Terminal Region of α-Synuclein, Promoting Formation of Toxic Aggregates with Distinct Molecular Conformations
Dasari, A. K. R., Kayed, R., Wi, S. & Lim, K. H., Jun 25 2019, In: Biochemistry. 58, 25, p. 2814-2821 8 p.Research output: Contribution to journal › Article › peer-review
6 Scopus citations -
2016
The Role of Amyloid-β Oligomers in Toxicity, Propagation, and Immunotherapy
Sengupta, U., Nilson, A. N. & Kayed, R., Apr 1 2016, In: EBioMedicine. 6, p. 42-49 8 p.Research output: Contribution to journal › Review article › peer-review
252 Scopus citations -
2020
Modulating disease-relevant tau oligomeric strains by small molecules
Cascio, F. L., Garcia, S., Montalbano, M., Puangmalai, N., McAllen, S., Pace, A., Piccionello, A. P. & Kayed, R., Oct 30 2020, In: Journal of Biological Chemistry. 295, 44, p. 14807-14825 19 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
2013
Dual role of p53 amyloid formation in cancer; loss of function and gain of toxicity
Lasagna-Reeves, C. A., Clos, A. L., Castillo-Carranza, D., Sengupta, U., Guerrero-Muñoz, M., Kelly, B., Wagner, R. & Kayed, R., Jan 18 2013, In: Biochemical and Biophysical Research Communications. 430, 3, p. 963-968 6 p.Research output: Contribution to journal › Article › peer-review
48 Scopus citations -
2019
Tau oligomers mediate aggregation of RNA-binding proteins Musashi1 and Musashi2 inducing Lamin alteration
Montalbano, M., McAllen, S., Sengupta, U., Puangmalai, N., Bhatt, N., Ellsworth, A. & Kayed, R., Dec 1 2019, In: Aging cell. 18, 6, e13035.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
NLRP3 inflammasome activation drives tau pathology
Ising, C., Venegas, C., Zhang, S., Scheiblich, H., Schmidt, S. V., Vieira-Saecker, A., Schwartz, S., Albasset, S., McManus, R. M., Tejera, D., Griep, A., Santarelli, F., Brosseron, F., Opitz, S., Stunden, J., Merten, M., Kayed, R., Golenbock, D. T., Blum, D., Latz, E. & 2 others, , Nov 28 2019, In: Nature. 575, 7784, p. 669-673 5 p.Research output: Contribution to journal › Article › peer-review
109 Scopus citations -
2016
Oligomer Formation and Cross-Seeding: The New Frontier
Farmer, K., Gerson, J. E. & Kayed, R., 2016, (Accepted/In press) In: Israel Journal of Chemistry.Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
2020
Polymorphic α-Synuclein Strains Modified by Dopamine and Docosahexaenoic Acid Interact Differentially with Tau Protein
Sengupta, U., Puangmalai, N., Bhatt, N., Garcia, S., Zhao, Y. & Kayed, R., Jun 1 2020, In: Molecular Neurobiology. 57, 6, p. 2741-2765 25 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
RNA-binding proteins Musashi and tau soluble aggregates initiate nuclear dysfunction
Montalbano, M., McAllen, S., Puangmalai, N., Sengupta, U., Bhatt, N., Johnson, O. D., Kharas, M. G. & Kayed, R., Dec 1 2020, In: Nature communications. 11, 1, 4305.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
2013
Formation and propagation of tau oligomeric seeds
Gerson, J. E. & Kayed, R., Sep 11 2013, In: Frontiers in Neurology. 4 JUL, Article 93.Research output: Contribution to journal › Review article › peer-review
66 Scopus citations -
2016
Caspase-cleaved tau exhibits rapid memory impairment associated with tau oligomers in a transgenic mouse model
Kim, Y., Choi, H., Lee, W., Park, H., Kam, T. I., Hong, S. H., Nah, J., Jung, S., Shin, B., Lee, H., Choi, T. Y., Choo, H., Kim, K. K., Choi, S. Y., Kayed, R. & Jung, Y. K., Mar 1 2016, In: Neurobiology of Disease. 87, p. 19-28 10 p.Research output: Contribution to journal › Article › peer-review
32 Scopus citations -
2015
Tau immunotherapy modulates both pathological tau and upstream amyloid pathology in an alzheimer’s disease mouse model
Castillo-Carranza, D. L., Guerrero-Muñoz, M. J., Sengupta, U., Hernandez, C., Barrett, A. D. T., Dineley, K. & Kayed, R., 2015, In: Journal of Neuroscience. 35, 12, p. 4857-4868 12 p.Research output: Contribution to journal › Article › peer-review
82 Scopus citations -
A native interactor scaffolds and stabilizes toxic Ataxin-1 oligomers in SCA1
Lasagna-Reeves, C. A., Rousseaux, M. W. C., Guerrero-Munoz, M. J., Park, J., Jafar-Nejad, P., Richman, R., Lu, N., Sengupta, U., Litvinchuk, A., Orr, H. T., Kayed, R. & Zoghbi, H. Y., May 19 2015, In: eLife. 4, MAY, p. 1-46 46 p., e07558.Research output: Contribution to journal › Article › peer-review
16 Scopus citations -
2016
Pre-amyloid oligomers budding: A metastatic mechanism of proteotoxicity
Bernini, F., Malferrari, D., Pignataro, M., Bortolotti, C. A., Di Rocco, G., Lancellotti, L., Brigatti, M. F., Kayed, R., Borsari, M., Del Monte, F. & Castellini, E., Oct 24 2016, In: Scientific reports. 6, 35865.Research output: Contribution to journal › Article › peer-review
8 Scopus citations -
2013
Design of metastable β-sheet oligomers from natively unstructured peptide
Guerrero-Muñoz, M. J., Castillo-Carranza, D. L., Sengupta, U., White, M. A. & Kayed, R., Dec 18 2013, In: ACS chemical neuroscience. 4, 12, p. 1520-1523 4 p.Research output: Contribution to journal › Article › peer-review
9 Scopus citations -
2020
P53 aggregation, interactions with tau, and impaired DNA damage response in Alzheimer's disease
Farmer, K. M., Ghag, G., Puangmalai, N., Montalbano, M., Bhatt, N. & Kayed, R., Aug 10 2020, In: Acta Neuropathologica Communications. 8, 1, 132.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
2013
Tau aggregates as immunotherapeutic targets
Castillo-Carranza, D. L., Lasagna-Reeves, C. A. & Kayed, R., Jan 1 2013, In: Frontiers in Bioscience - Scholar. 5 S, 2, p. 426-438 13 p.Research output: Contribution to journal › Article › peer-review
30 Scopus citations -
2016
Tau Oligomers Derived from Traumatic Brain Injury Cause Cognitive Impairment and Accelerate Onset of Pathology in Htau Mice
Gerson, J., Castillo-Carranza, D. L., Sengupta, U., Bodani, R., Prough, D. S., DeWitt, D. S., Hawkins, B. E. & Kayed, R., Nov 15 2016, In: Journal of neurotrauma. 33, 22, p. 2034-2043 10 p.Research output: Contribution to journal › Article › peer-review
39 Scopus citations -
2019
Toxic Tau Oligomers Modulated by Novel Curcumin Derivatives
Lo Cascio, F., Puangmalai, N., Ellsworth, A., Bucchieri, F., Pace, A., Palumbo Piccionello, A. & Kayed, R., Dec 1 2019, In: Scientific reports. 9, 1, 19011.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
Amyloid oligomer interactions and polymorphisms: disease-relevant distinct assembly of α-synuclein and tau
Sengupta, U. & Kayed, R., Jan 1 2019, In: Neuropsychopharmacology. 44, 1, p. 222-223 2 p.Research output: Contribution to journal › Comment/debate › peer-review
1 Scopus citations -
2013
Molecular mechanisms of amyloid oligomers toxicity
Kayed, R. & Lasagna-Reeves, C. A., 2013, In: Journal of Alzheimer's Disease. 33, SUPPL. 1, p. S67-S78Research output: Contribution to journal › Review article › peer-review
210 Scopus citations -
Small misfolded tau species are internalized via bulk endocytosis and anterogradely and retrogradely transported in neurons
Wu, J. W., Herman, M., Liu, L., Simoes, S., Acker, C. M., Figueroa, H., Steinberg, J. I., Margittai, M., Kayed, R., Zurzolo, C., Di Paolo, G. & Duff, K. E., Jan 18 2013, In: Journal of Biological Chemistry. 288, 3, p. 1856-1870 15 p.Research output: Contribution to journal › Article › peer-review
273 Scopus citations -
2015
Pathological Interface between Oligomeric Alpha-Synuclein and Tau in Synucleinopathies
Sengupta, U., Guerrero-Muñoz, M. J., Castillo-Carranza, D. L., Lasagna-Reeves, C. A., Gerson, J. E., Paulucci-Holthauzen, A. A., Krishnamurthy, S., Farhed, M., Jackson, G. R. & Kayed, R., Nov 15 2015, In: Biological Psychiatry. 78, 10, p. 672-683 12 p.Research output: Contribution to journal › Article › peer-review
86 Scopus citations -
The interrelationship of proteasome impairment and oligomeric intermediates in neurodegeneration
Deger, J. M., Gerson, J. E. & Kayed, R., Oct 1 2015, In: Aging cell. 14, 5, p. 715-724 10 p.Research output: Contribution to journal › Review article › peer-review
38 Scopus citations -
2020
Soluble endogenous oligomeric α-synuclein species in neurodegenerative diseases: Expression, spreading, and cross-talk
Kayed, R., Dettmer, U. & Lesné, S. E., 2020, In: Journal of Parkinson's Disease. 10, 3, p. 791-818 28 p.Research output: Contribution to journal › Review article › peer-review
Open Access1 Scopus citations -
2015
Ataxin-1 oligomers induce local spread of pathology and decreasing them by passive immunization slows spinocerebellar ataxia type 1 phenotypes
Lasagna-Reeves, C. A., Rousseaux, M. W. C., Guerrero-Munoz, M. J., Vilanova-Velez, L., Park, J., See, L., Jafar-Nejad, P., Richman, R., Orr, H. T., Kayed, R. & Zoghbi, H. Y., Dec 17 2015, In: eLife. 4, DECEMBER2015, e10891.Research output: Contribution to journal › Article › peer-review
9 Scopus citations -
2016
Potential mechanisms and implications for the formation of tau oligomeric strains
Gerson, J. E., Mudher, A. & Kayed, R., Nov 1 2016, In: Critical Reviews in Biochemistry and Molecular Biology. 51, 6, p. 482-496 15 p.Research output: Contribution to journal › Review article › peer-review
25 Scopus citations