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2020
Polymorphic α-Synuclein Strains Modified by Dopamine and Docosahexaenoic Acid Interact Differentially with Tau Protein
Sengupta, U., Puangmalai, N., Bhatt, N., Garcia, S., Zhao, Y. & Kayed, R., Jun 1 2020, In: Molecular Neurobiology. 57, 6, p. 2741-2765 25 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
2016
Oligomer Formation and Cross-Seeding: The New Frontier
Farmer, K., Gerson, J. E. & Kayed, R., 2016, (Accepted/In press) In: Israel Journal of Chemistry.Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
2018
α-Synuclein Oligomers Induce a Unique Toxic Tau Strain
Castillo-Carranza, D. L., Guerrero-Muñoz, M. J., Sengupta, U., Gerson, J. E. & Kayed, R., Oct 1 2018, In: Biological Psychiatry. 84, 7, p. 499-508 10 p.Research output: Contribution to journal › Article › peer-review
29 Scopus citations -
2020
Functional spreading of hyperexcitability induced by human and synthetic intracellular Aβ oligomers
Fernandez-Perez, E. J., Muñoz, B., Bascuñan, D. A., Peters, C., Riffo-Lepe, N. O., Espinoza, M. P., Morgan, P. J., Filippi, C., Bourboulou, R., Sengupta, U., Kayed, R., Epsztein, J. & Aguayo, L. G., Oct 17 2020, In: Unknown Journal.Research output: Contribution to journal › Article › peer-review
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Internalization mechanisms of brain-derived tau oligomers from patients with Alzheimer’s disease, progressive supranuclear palsy and dementia with Lewy bodies
Puangmalai, N., Bhatt, N., Montalbano, M., Sengupta, U., Gaikwad, S., Ventura, F., McAllen, S., Ellsworth, A., Garcia, S. & Kayed, R., May 1 2020, In: Cell Death and Disease. 11, 5, 314.Research output: Contribution to journal › Article › peer-review
Open Access13 Scopus citations -
P53 aggregation, interactions with tau, and impaired DNA damage response in Alzheimer's disease
Farmer, K. M., Ghag, G., Puangmalai, N., Montalbano, M., Bhatt, N. & Kayed, R., Aug 10 2020, In: Acta Neuropathologica Communications. 8, 1, 132.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
2016
Aβ Amyloid Pathology Affects the Hearts of Patients With Alzheimer's Disease: Mind the Heart
Troncone, L., Luciani, M., Coggins, M., Wilker, E. H., Ho, C. Y., Codispoti, K. E., Frosch, M. P., Kayed, R. & del Monte, F., Dec 6 2016, In: Journal of the American College of Cardiology. 68, 22, p. 2395-2407 13 p.Research output: Contribution to journal › Article › peer-review
60 Scopus citations -
2020
Revisiting the intersection of amyloid, pathologically modified tau and iron in Alzheimer's disease from a ferroptosis perspective
Derry, P. J., Hegde, M. L., Jackson, G. R., Kayed, R., Tour, J. M., Tsai, A. L. & Kent, T. A., Jan 2020, In: Progress in Neurobiology. 184, 101716.Research output: Contribution to journal › Review article › peer-review
Open Access12 Scopus citations -
2018
Binding and neurotoxicity mitigation of toxic tau oligomers by synthetic heparin like oligosaccharides
Wang, P., Lo Cascio, F., Gao, J., Kayed, R. & Huang, X., 2018, In: Chemical Communications. 54, 72, p. 10120-10123 4 p.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
Tau Immunotherapy for Alpha-Synucleinopathy
Aguilar, C., Al Lahham, R., Sengupta, U., Carretero Murillo, M., Kayed, R. & Dineley, K., Jul 2018, In: Alzheimer's and Dementia. 14, 7, p. 1412Research output: Contribution to journal › Article › peer-review
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2020
Soluble endogenous oligomeric α-synuclein species in neurodegenerative diseases: Expression, spreading, and cross-talk
Kayed, R., Dettmer, U. & Lesné, S. E., 2020, In: Journal of Parkinson's Disease. 10, 3, p. 791-818 28 p.Research output: Contribution to journal › Review article › peer-review
Open Access1 Scopus citations -
2016
The Role of Amyloid-β Oligomers in Toxicity, Propagation, and Immunotherapy
Sengupta, U., Nilson, A. N. & Kayed, R., Apr 1 2016, In: EBioMedicine. 6, p. 42-49 8 p.Research output: Contribution to journal › Review article › peer-review
259 Scopus citations -
2018
Prospects for strain-specific immunotherapy in Alzheimer's disease and tauopathies
Bittar, A., Sengupta, U. & Kayed, R., Dec 1 2018, In: npj Vaccines. 3, 1, 9.Research output: Contribution to journal › Article › peer-review
24 Scopus citations -
Tau Immunotherapy for Alpha-Synucleinopathy
Aguilar, C., Al Lahham, R., Sengupta, U., Carretero Murillo, M., Kayed, R. & Dineley, K., Jul 2018, In: Alzheimer's and Dementia. 14, 7, p. 1442Research output: Contribution to journal › Meeting Abstract › peer-review
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Evaluating Passive Immunotherapy using Aged Transgenic Animals of Tauopathy
Al Lahham, R., Bittar, A., Montalbano, M., Carretero Murillo, M., McAllen, S., Bhatt, N., Ellsworth, A. & Kayed, R., Apr 2018, (Unpublished).Research output: Contribution to conference › Poster › peer-review
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2020
TDP-43 and Tau Oligomers in Alzheimer's Disease, Amyotrophic Lateral Sclerosis, and Frontotemporal Dementia
Montalbano, M., McAllen, S., Cascio, F. L., Sengupta, U., Garcia, S., Bhatt, N., Ellsworth, A., Heidelman, E. A., Johnson, O. D., Doskocil, S. & Kayed, R., Dec 2020, In: Neurobiology of Disease. 146, 105130.Research output: Contribution to journal › Article › peer-review
Open Access -
2018
Evaluating Tau Oligomers Passive Immunotherapy using Aged Transgenic Animals of Tauopathy
Al Lahham, R., Bittar, A., Montalbano, M., Carretero Murillo, M., McAllen, S., Bhatt, N., Ellsworth, A. & Kayed, R., Jul 2018, In: Alzheimer's and Dementia. 14, 7, p. 1657Research output: Contribution to journal › Meeting Abstract › peer-review
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Azure C Targets and Modulates Toxic Tau Oligomers
Lo Cascio, F. & Kayed, R., Jun 20 2018, In: ACS Chemical Neuroscience. 9, 6, p. 1317-1326 10 p.Research output: Contribution to journal › Article › peer-review
17 Scopus citations -
2016
Therapeutic approaches targeting pathological tau aggregates
Gerson, J. & Kayed, R., Jul 1 2016, In: Current Pharmaceutical Design. 22, 26, p. 4028-4039 12 p.Research output: Contribution to journal › Review article › peer-review
9 Scopus citations -
2018
Formation of Toxic Oligomeric Assemblies of RNA-binding Protein: Musashi in Alzheimer's disease
Sengupta, U., Montalbano, M., McAllen, S., Minuesa, G., Kharas, M. & Kayed, R., Oct 26 2018, In: Acta Neuropathologica Communications. 6, 1, p. 113 1 p.Research output: Contribution to journal › Article › peer-review
9 Scopus citations -
2020
Modulating disease-relevant tau oligomeric strains by small molecules
Cascio, F. L., Garcia, S., Montalbano, M., Puangmalai, N., McAllen, S., Pace, A., Piccionello, A. P. & Kayed, R., Oct 30 2020, In: Journal of Biological Chemistry. 295, 44, p. 14807-14825 19 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
2015
Tau immunotherapy modulates both pathological tau and upstream amyloid pathology in an alzheimer’s disease mouse model
Castillo-Carranza, D. L., Guerrero-Muñoz, M. J., Sengupta, U., Hernandez, C., Barrett, A. D. T., Dineley, K. & Kayed, R., 2015, In: Journal of Neuroscience. 35, 12, p. 4857-4868 12 p.Research output: Contribution to journal › Article › peer-review
83 Scopus citations -
A native interactor scaffolds and stabilizes toxic Ataxin-1 oligomers in SCA1
Lasagna-Reeves, C. A., Rousseaux, M. W. C., Guerrero-Munoz, M. J., Park, J., Jafar-Nejad, P., Richman, R., Lu, N., Sengupta, U., Litvinchuk, A., Orr, H. T., Kayed, R. & Zoghbi, H. Y., May 19 2015, In: eLife. 4, MAY, p. 1-46 46 p., e07558.Research output: Contribution to journal › Article › peer-review
16 Scopus citations -
2018
Soluble tau aggregates, not large fibrils, are the toxic species that display seeding and cross-seeding behavior
Ghag, G., Bhatt, N., Cantu, D. V., Guerrero-Munoz, M. J., Ellsworth, A., Sengupta, U. & Kayed, R., Nov 2018, In: Protein Science. 27, 11, p. 1901-1909 9 p.Research output: Contribution to journal › Article › peer-review
25 Scopus citations -
Preparation and characterization of tau oligomer strains
Sengupta, U., Carretero-Murillo, M. & Kayed, R., 2018, Methods in Molecular Biology. Humana Press Inc., p. 113-146 34 p. (Methods in Molecular Biology; vol. 1779).Research output: Chapter in Book/Report/Conference proceeding › Chapter
6 Scopus citations -
2016
Advances in tau immunotherapy
Gerson, J. & Kayed, R., Jan 1 2016, Research Progress in Alzheimer’s Disease and Dementia. Volume 6. Nova Science Publishers, Inc., p. 99-114 16 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter
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2015
Antibody against Small Aggregated Peptide Specifically Recognizes Toxic Aβ-42 Oligomers in Alzheimer's Disease
Bodani, R. U., Sengupta, U., Castillo-Carranza, D. L., Guerrero-Muñoz, M. J., Gerson, J. E., Rudra, J. & Kayed, R., Dec 16 2015, In: ACS Chemical Neuroscience. 6, 12, p. 1981-1989 9 p.Research output: Contribution to journal › Article › peer-review
13 Scopus citations -
2016
Pre-amyloid oligomers budding: A metastatic mechanism of proteotoxicity
Bernini, F., Malferrari, D., Pignataro, M., Bortolotti, C. A., Di Rocco, G., Lancellotti, L., Brigatti, M. F., Kayed, R., Borsari, M., Del Monte, F. & Castellini, E., Oct 24 2016, In: Scientific reports. 6, 35865.Research output: Contribution to journal › Article › peer-review
8 Scopus citations -
2018
Tau oligomers mediate α-synuclein toxicity and can be targeted by immunotherapy
Gerson, J. E., Farmer, K. M., Henson, N., Castillo-Carranza, D. L., Carretero Murillo, M., Sengupta, U., Barrett, A. & Kayed, R., Mar 15 2018, In: Molecular Neurodegeneration. 13, 1, 13.Research output: Contribution to journal › Article › peer-review
22 Scopus citations -
Immunotherapy Targeting Tau Oligomeric Strains in Aged Transgenic Animals of Tauopathy
Al Lahham, R., Bittar, A., Carretero Murillo, M., McAllen, S., Bhatt, N., Ellsworth, A. & Kayed, R., Oct 2018, p. S64.Research output: Contribution to conference › Abstract › peer-review
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2020
Functional Integrity of Synapses in the Central Nervous System of Cognitively Intact Individuals with High Alzheimer's Disease Neuropathology Is Associated with Absence of Synaptic Tau Oligomers
Singh, A., Allen, D., Fracassi, A., Tumurbaatar, B., Natarajan, C., Scaduto, P., Woltjer, R., Kayed, R., Limon, A., Krishnan, B., Taglialatela, G. & Abisambra, J., 2020, In: Journal of Alzheimer's Disease. 78, 4, p. 1661-1678 18 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Advances and considerations in AD tau-targeted immunotherapy
Bittar, A., Bhatt, N. & Kayed, R., Feb 2020, In: Neurobiology of Disease. 134, 104707.Research output: Contribution to journal › Review article › peer-review
Open Access15 Scopus citations -
2016
Tau Oligomers Derived from Traumatic Brain Injury Cause Cognitive Impairment and Accelerate Onset of Pathology in Htau Mice
Gerson, J., Castillo-Carranza, D. L., Sengupta, U., Bodani, R., Prough, D. S., DeWitt, D. S., Hawkins, B. E. & Kayed, R., Nov 15 2016, In: Journal of neurotrauma. 33, 22, p. 2034-2043 10 p.Research output: Contribution to journal › Article › peer-review
39 Scopus citations -
2018
AAV2-mediated GRP78 transfer alleviates retinal neuronal injury by downregulating ER stress and Tau oligomer formation
Ha, Y., Liu, W., Liu, H., Zhu, S., Xia, F., Gerson, J. E., Azhar, N. A., Tilton, R. G., Motamedi, M., Kayed, R. & Zhang, W., Sep 2018, In: Investigative Ophthalmology and Visual Science. 59, 11, p. 4670-4682 13 p.Research output: Contribution to journal › Article › peer-review
6 Scopus citations -
2020
RNA-binding proteins Musashi and tau soluble aggregates initiate nuclear dysfunction
Montalbano, M., McAllen, S., Puangmalai, N., Sengupta, U., Bhatt, N., Johnson, O. D., Kharas, M. G. & Kayed, R., Dec 1 2020, In: Nature communications. 11, 1, 4305.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
2015
Prefibrillar Tau oligomers alter the nucleic acid protective function of Tau in hippocampal neurons in vivo
Violet, M., Chauderlier, A., Delattre, L., Tardivel, M., Chouala, M. S., Sultan, A., Marciniak, E., Humez, S., Binder, L., Kayed, R., Lefebvre, B., Bonnefoy, E., Buée, L. & Galas, M. C., Oct 1 2015, In: Neurobiology of Disease. 82, p. 540-551 12 p.Research output: Contribution to journal › Article › peer-review
35 Scopus citations -
2018
Elevated phospholipase D isoform 1 in Alzheimer's disease patients’ hippocampus: Relevance to synaptic dysfunction and memory deficits
Krishnan, B., Kayed, R. & Taglialatela, G., 2018, In: Alzheimer's and Dementia: Translational Research and Clinical Interventions. 4, p. 89-102 14 p.Research output: Contribution to journal › Article › peer-review
12 Scopus citations -
2015
The interrelationship of proteasome impairment and oligomeric intermediates in neurodegeneration
Deger, J. M., Gerson, J. E. & Kayed, R., Oct 1 2015, In: Aging cell. 14, 5, p. 715-724 10 p.Research output: Contribution to journal › Review article › peer-review
38 Scopus citations -
Ataxin-1 oligomers induce local spread of pathology and decreasing them by passive immunization slows spinocerebellar ataxia type 1 phenotypes
Lasagna-Reeves, C. A., Rousseaux, M. W. C., Guerrero-Munoz, M. J., Vilanova-Velez, L., Park, J., See, L., Jafar-Nejad, P., Richman, R., Orr, H. T., Kayed, R. & Zoghbi, H. Y., Dec 17 2015, In: eLife. 4, DECEMBER2015, e10891.Research output: Contribution to journal › Article › peer-review
9 Scopus citations -
Pathological Interface between Oligomeric Alpha-Synuclein and Tau in Synucleinopathies
Sengupta, U., Guerrero-Muñoz, M. J., Castillo-Carranza, D. L., Lasagna-Reeves, C. A., Gerson, J. E., Paulucci-Holthauzen, A. A., Krishnamurthy, S., Farhed, M., Jackson, G. R. & Kayed, R., Nov 15 2015, In: Biological Psychiatry. 78, 10, p. 672-683 12 p.Research output: Contribution to journal › Article › peer-review
88 Scopus citations -
2016
Potential mechanisms and implications for the formation of tau oligomeric strains
Gerson, J. E., Mudher, A. & Kayed, R., Nov 1 2016, In: Critical Reviews in Biochemistry and Molecular Biology. 51, 6, p. 482-496 15 p.Research output: Contribution to journal › Review article › peer-review
26 Scopus citations -
Caspase-cleaved tau exhibits rapid memory impairment associated with tau oligomers in a transgenic mouse model
Kim, Y. D., Choi, H., Lee, W. J., Park, H., Kam, T. I., Hong, S. H., Nah, J., Jung, S., Shin, B., Lee, H., Choi, T. Y., Choo, H., Kim, K. K., Choi, S. Y., Kayed, R. & Jung, Y. K., Mar 1 2016, In: Neurobiology of Disease. 87, p. 19-28 10 p.Research output: Contribution to journal › Article › peer-review
33 Scopus citations