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  • Jia Zhou
2019

Design, Synthesis, and Characterization of 4-Undecylpiperidine-2-carboxamides as Positive Allosteric Modulators of the Serotonin (5-HT) 5-HT2C Receptor

Wild, C. T., Miszkiel, J. M., Wold, E. A., Soto, C. A., Ding, C., Hartley, R., White, M. A., Anastasio, N. C., Cunningham, K. A. & Zhou, J., Oct 1 2019, In : Journal of Medicinal Chemistry. 62, 1, p. 288-305 18 p.

Research output: Contribution to journalArticle

9 Scopus citations

Structure-activity relationship studies on Bax activator SMBA1 for the treatment of ER-positive and triple-negative breast cancer

Liu, G., Yin, T., Kim, H., Ding, C., Yu, Z., Wang, H., Chen, H., Yan, R., Wold, E. A., Zou, H., Liu, X., Ding, Y., Shen, Q. & Zhou, J., Sep 15 2019, In : European journal of medicinal chemistry. 178, p. 589-605 17 p.

Research output: Contribution to journalArticle

2016

Discovery and development of natural product oridonin-inspired anticancer agents

Ding, Y., Ding, C., Ye, N., Liu, Z., Wold, E. A., Chen, H., Wild, C., Shen, Q. & Zhou, J., Oct 21 2016, In : European Journal of Medicinal Chemistry. 122, p. 102-117 16 p.

Research output: Contribution to journalReview article

63 Scopus citations
2017

Existing drugs as broad-spectrum and potent inhibitors for Zika virus by targeting NS2B-NS3 interaction

Li, Z., Brecher, M., Deng, Y. Q., Zhang, J., Sakamuru, S., Liu, B., Huang, R., Koetzner, C. A., Allen, C. A., Jones, S. A., Chen, H., Zhang, N. N., Tian, M., Gao, F., Lin, Q., Banavali, N., Zhou, J., Boles, N., Xia, M., Kramer, L. D. & 2 others, Qin, C. F. & Li, H., Aug 1 2017, In : Cell Research. 27, 8, p. 1046-1064 19 p.

Research output: Contribution to journalArticle

52 Scopus citations
2019
3 Scopus citations
2016

Cystathionine-β-synthase inhibition for colon cancer: Enhancement of the efficacy of aminooxyacetic acid via the prodrug approach

Chao, C., Zatarain, J. R., Ding, Y., Coletta, C., Mrazek, A. A., Druzhyna, N., Johnson, P., Chen, H., Hellmich, J. L., Asimakopoulou, A., Yanagi, K., Olah, G., Szoleczky, P., Törö, G., Bohanon, F. J., Cheema, M., Lewis, R., Eckelbarger, D., Ahmad, A., Módis, K. & 6 others, Untereiner, A., Szczesny, B., Papapetropoulos, A., Zhou, J., Hellmich, M. R. & Szabo, C., 2016, In : Molecular Medicine. 22, p. 361-379 19 p.

Research output: Contribution to journalArticle

23 Scopus citations
2019

Methylglyoxal and a spinal TRPA1-AC1-Epac cascade facilitate pain in the db/db mouse model of type 2 diabetes

Griggs, R. B., Santos, D. F., Laird, D. E., Doolen, S., Donahue, R. R., Wessel, C. R., Fu, W., Sinha, G. P., Wang, P., Zhou, J., Brings, S., Fleming, T., Nawroth, P. P., Susuki, K. & Taylor, B. K., Jul 2019, In : Neurobiology of Disease. 127, p. 76-86 11 p.

Research output: Contribution to journalArticle

3 Scopus citations

Synthesis and pharmacological evaluation of non-catechol G protein biased and unbiased dopamine D1 receptor agonists

Wang, P., Felsing, D., Chen, H., Raval, S., Allen, J. & Zhou, J., May 9 2019, In : ACS Medicinal Chemistry Letters. 10.1021/acsmedchemlett.9b00050, p. 792-799 8 p., 10.1021/acsmedchemlett.9b00050.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Gpcr drug discovery: Emerging targets, novel approaches and future trends

Zhou, J. & Wild, C., Jan 1 2019, In : Current topics in medicinal chemistry. 19, 16, p. 1363-1364 2 p.

Research output: Contribution to journalEditorial

Open Access
2017

Structure-activity relationships of 2-substituted phenyl-N-phenyl-2-oxoacetohydrazonoyl cyanides as novel antagonists of exchange proteins directly activated by cAMP (EPACs)

Liu, Z., Zhu, Y., Chen, H., Wang, P., Mei, F. C., Ye, N., Cheng, X. & Zhou, J., Dec 1 2017, In : Bioorganic and Medicinal Chemistry Letters. 27, 23, p. 5163-5166 4 p.

Research output: Contribution to journalArticle

4 Scopus citations
2019
4 Scopus citations
2017

Small-molecule inhibitors of protein-protein interactions

Liu, Z., Chen, H., Wold, E. A. & Zhou, J., Jun 3 2017, Drug Discovery Technologies. Elsevier Inc., Vol. 2-8. p. 329-353 25 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations
2019

An NPY Y1 receptor antagonist unmasks latent sensitization and reveals the contribution of protein kinase A and Epac to chronic inflammatory pain

Fu, W., Nelson, T. S., Santos, D. F., Doolen, S., Gutierrez, J. J. P., Ye, N., Zhou, J. & Taylor, B. K., Aug 1 2019, In : Pain. 160, 8, p. 1754-1765 12 p.

Research output: Contribution to journalArticle

5 Scopus citations
2017

Identification of novel 2-(benzo[d]isoxazol-3-yl)-2-oxo-N-phenylacetohydrazonoyl cyanide analoguesas potent EPAC antagonists

Ye, N., Zhu, Y., Liu, Z., Mei, F. C., Chen, H., Wang, P., Cheng, X. & Zhou, J., Jul 7 2017, In : European Journal of Medicinal Chemistry. 134, p. 62-71 10 p.

Research output: Contribution to journalArticle

3 Scopus citations
2019

Mucosal bromodomain-containing protein 4 mediates aeroallergen-induced inflammation and remodeling

Tian, B., Hosoki, K., Liu, Z., Yang, J., Zhao, Y., Sun, H., Zhou, J., Rytting, E., Kaphalia, L., Calhoun, W. J., Sur, S. & Brasier, A. R., Apr 2019, In : Journal of Allergy and Clinical Immunology. 143, 4, p. 1380-1394.e9

Research output: Contribution to journalArticle

8 Scopus citations
2016

Meet our editorial board member

Zhou, J., Sep 1 2016, In : Current Drug Discovery Technologies. 13, 3, p. 121-122 2 p.

Research output: Contribution to journalEditorial

2017

Exchange proteins directly activated by cAMP (EPACs): Emerging therapeutic targets

Wang, P., Liu, Z., Chen, H., Ye, N., Cheng, X. & Zhou, J., Jan 1 2017, In : Bioorganic and Medicinal Chemistry Letters. 27, 8, p. 1633-1639 7 p.

Research output: Contribution to journalReview article

20 Scopus citations

Modulation of Bax and mTOR for cancer therapeutics

Li, R., Ding, C., Zhang, J., Xie, M., Park, D., Ding, Y., Chen, G., Zhang, G., Gilbert-Ross, M., Zhou, W., Marcus, A. I., Sun, S. Y., Chen, Z. G., Sica, G. L., Ramalingam, S. S., Magis, A. T., Fu, H., Khuri, F. R., Curran, W. J., Owonikoko, T. K. & 3 others, Shin, D. M., Zhou, J. & Deng, X., Jun 1 2017, In : Cancer Research. 77, 11, p. 3001-3012 12 p.

Research output: Contribution to journalArticle

9 Scopus citations
2019

Orphan Receptor GPR88 as an Emerging Neurotherapeutic Target

Ye, N., Li, B., Mao, Q., Wold, E. A., Tian, S., Allen, J. & Zhou, J., Jan 16 2019, In : ACS Chemical Neuroscience. 10, 1, p. 190-200 11 p., 10.1021/acschemneuro.8b00572.

Research output: Contribution to journalReview article

2017

Chemistry and Bioactivity of ent-Kaurene Diterpenoids

Ding, C., Ding, Y., Chen, H. & Zhou, J., 2017, Studies in Natural Products Chemistry. Elsevier B.V., Vol. 54. p. 141-197 57 p. (Studies in Natural Products Chemistry; vol. 54).

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations
2019

Targeting the 5-HT2C Receptor in Biological Context and the Current State of 5-HT2C Receptor Ligand Development

Wold, E. A., Wild, C. T., Cunningham, K. A. & Zhou, J., Jan 1 2019, In : Current topics in medicinal chemistry. 19, 16, p. 1381-1398 18 p.

Research output: Contribution to journalReview article

5 Scopus citations

Dual activity of niclosamide to suppress replication of integrated HIV-1 and Mycobacterium tuberculosis (Beijing)

Fan, X. Z., Xu, J., Files, M., Cirillo, J. D., Endsley, J. J., Zhou, J. & Endsley, M. A., May 2019, In : Tuberculosis. 116, p. S28-S33

Research output: Contribution to journalArticle

3 Scopus citations
2016

Suppression of Cocaine-Evoked Hyperactivity by Self-Adjuvanting and Multivalent Peptide Nanofiber Vaccines

Rudra, J. S., Ding, Y., Neelakantan, H., Ding, C., Appavu, R., Stutz, S., Snook, J. D., Chen, H., Cunningham, K. A. & Zhou, J., May 18 2016, In : ACS Chemical Neuroscience. 7, 5, p. 546-552 7 p.

Research output: Contribution to journalArticle

20 Scopus citations
2017

Fragment-based drug design: Strategic advances and lessons learned

Chen, H., Zhou, X., Gao, Y., Chen, H. & Zhou, J., Jun 3 2017, Drug Discovery Technologies. Elsevier Inc., Vol. 2-8. p. 212-232 21 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations
2016

STAT3 inhibition suppresses hepatic stellate cell fibrogenesis: HJC0123, a potential therapeutic agent for liver fibrosis

Lopez, O. N., Bohanon, F. J., Wang, X., Ye, N., Gorgun, T., Rojas-Khalil, Y., Chen, H., Chen, H., Zhou, J. & Radhakrishnan, R., 2016, In : RSC Advances. 6, 102, p. 100652-100663 12 p.

Research output: Contribution to journalArticle

9 Scopus citations
2017

Targeting 3-phosphoinositide-dependent protein kinase 1 associated with drug-resistant renal cell carcinoma using new oridonin analogs

Zhou, J., Yun, E. J., Chen, W., Ding, Y., Wu, K., Wang, B., Ding, C., Hernandez, E., Santoyo, J., Pong, R. C., Chen, H., He, D., Zhou, J. & Hsieh, J. T., Mar 23 2017, In : Cell death & disease. 8, 3, p. e2701

Research output: Contribution to journalArticle

12 Scopus citations
2019

Efficacy of novel highly specific bromodomain-containing protein 4 inhibitors in innate inflammation–driven airway remodeling

Tian, B., Liu, Z., Litvinov, J., Maroto, R., Jamaluddin, M., Rytting, E., Patrikeev, I., Ochoa, L., Vargas, G., Motamedi, M., Ameredes, B. T., Zhou, J. & Brasier, A. R., Jan 2019, In : American journal of respiratory cell and molecular biology. 60, 1, p. 68-83 16 p.

Research output: Contribution to journalArticle

8 Scopus citations
2017

Drug Discovery Targeting Bromodomain-Containing Protein 4

Liu, Z., Wang, P., Chen, H., Wold, E. A., Tian, B., Brasier, A. R. & Zhou, J., Jun 8 2017, In : Journal of Medicinal Chemistry. 60, 11, p. 4533-4558 26 p.

Research output: Contribution to journalReview article

83 Scopus citations
2019

Recent advances in developing K-ras plasma membrane localization inhibitors

Ye, N., Xu, Q., Li, W., Wang, P. & Zhou, J., Jan 1 2019, In : Current topics in medicinal chemistry. 19, 23, p. 2114-2127 14 p.

Research output: Contribution to journalReview article

2 Scopus citations
2016

Scaffold repurposing of old drugs towards new cancer drug discovery

Chen, H., Wu, J., Gao, Y., Chen, H. & Zhou, J., Aug 1 2016, In : Current Topics in Medicinal Chemistry. 16, 19, p. 2107-2114 8 p.

Research output: Contribution to journalArticle

12 Scopus citations
2019

HFIP-promoted Michael reactions: direct para-selective C-H activation of anilines with maleimides

Li, B., Mao, Q., Zhou, J., Liu, F. & Ye, N., Jan 1 2019, In : Organic and Biomolecular Chemistry. 17, 8, p. 2242-2246 5 p.

Research output: Contribution to journalArticle

6 Scopus citations
2017

Suppression of the growth and invasion of human head and neck squamous cell carcinomas via regulating STAT3 signaling and the miR-21/β-catenin axis with HJC0152

Wang, Y., Wang, S., Wu, Y., Ren, Y., Li, Z., Yao, X., Zhang, C., Ye, N., Jing, C., Dong, J., Zhang, K., Sun, S., Zhao, M., Guo, W., Qu, X., Qiao, Y., Chen, H., Kong, L., Jin, R., Wang, X. & 4 others, Zhang, L., Zhou, J., Shen, Q. & Zhou, X., Apr 2017, In : Molecular Cancer Therapeutics. 16, 4, p. 578-590 13 p.

Research output: Contribution to journalArticle

19 Scopus citations
2019

Effect of N-(2-aminoethyl) ethanolamine on hypertrophic scarring changes in vitro: Finding novel anti-fibrotic therapies

Chen, Z., Gu, J., El Ayadi, A., Oberhauser, A., Zhou, J., Sousse, L., Finnerty, C., Herndon, D. & Boor, P. J., Jan 1 2019, In : Toxicology and Applied Pharmacology. 362, p. 9-19 11 p.

Research output: Contribution to journalArticle

1 Scopus citations
2016

A new oridonin analog suppresses triple-negative breast cancer cells and tumor growth via the induction of death receptor 5

Wu, J., Ding, Y., Chen, C. H., Zhou, Z., Ding, C., Chen, H., Zhou, J. & Chen, C., Oct 1 2016, In : Cancer Letters. 380, 2, p. 393-402 10 p.

Research output: Contribution to journalArticle

34 Scopus citations

Direct Activation of Bax Protein for Cancer Therapy

Liu, Z., Ding, Y., Ye, N., Wild, C., Chen, H. & Zhou, J., Mar 1 2016, In : Medicinal Research Reviews. 36, 2, p. 313-341 29 p.

Research output: Contribution to journalArticle

58 Scopus citations
2019

Exchange protein directly activated by cAMP plays a critical role in regulation of vascular fibrinolysis

He, X., Drelich, A., Yu, S., Chang, Q., Gong, D., Zhou, Y., Qu, Y., Yuan, Y., Su, Z., Qiu, Y., Tang, S-J., Gaitas, A., Ksiazek, T., Xu, Z., Zhou, J., Feng, Z., Wakamiya, M., Lu, F. & Gong, B., Mar 15 2019, In : Life Sciences. 221, p. 1-12 12 p.

Research output: Contribution to journalArticle

1 Scopus citations
2016

Functionalized N,N-Diphenylamines as Potent and Selective EPAC2 Inhibitors

Wild, C. T., Zhu, Y., Na, Y., Mei, F., Ynalvez, M. A., Chen, H., Cheng, X. & Zhou, J., May 12 2016, In : ACS Medicinal Chemistry Letters. 7, 5, p. 460-464 5 p.

Research output: Contribution to journalArticle

8 Scopus citations
2019

Allosteric Modulation of Class A GPCRs: Targets, Agents, and Emerging Concepts

Wold, E. A., Chen, J., Cunningham, K. & Zhou, J., Oct 1 2019, In : Journal of Medicinal Chemistry. 62, 1, p. 88-127 40 p.

Research output: Contribution to journalArticle

15 Scopus citations
2017

YD277 Suppresses Triple-Negative Breast Cancer Partially Through Activating the Endoplasmic Reticulum Stress Pathway

Chen, Z., Wu, Q., Ding, Y., Zhou, W., Liu, R., Chen, H., Zhou, J., Feng, J. & Chen, C., Jan 1 2017, In : Theranostics. 7, 8, p. 2339-2349 11 p.

Research output: Contribution to journalArticle

6 Scopus citations
2019

Applications of bioorthogonal chemistry in tumor-targeted drug discovery

Liu, G., Wold, E. A. & Zhou, J., Jan 1 2019, In : Current topics in medicinal chemistry. 19, 11, p. 892-897 6 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2016

Therapeutic potential of spirooxindoles as antiviral agents

Ye, N., Chen, H., Wold, E. A., Shi, P-Y. & Zhou, J., Jun 10 2016, In : ACS Infectious Diseases. 2, 6, p. 382-392 11 p.

Research output: Contribution to journalReview article

155 Scopus citations
2019

Pharmacoproteomics reveal novel protective activity of bromodomain containing 4 inhibitors on vascular homeostasis in TLR3-mediated airway remodeling

Zhao, Y., Tian, B., Sun, H., Zhang, J., Zhang, Y., Ivannikov, M., Motamedi, M., Liu, Z., Zhou, J., Kaphalia, L., Calhoun, W. J., Maroto, R. & Brasier, A. R., Aug 15 2019, In : Journal of Proteomics. 205, 103415.

Research output: Contribution to journalArticle

4 Scopus citations

Structure-guided drug design identifies a BRD4-selective small molecule that suppresses HIV

Niu, Q., Liu, Z., Alamer, E., Fan, X., Chen, H., Endsley, J., Gelman, B. B., Tian, B., Kim, J. H., Michael, N. L., Robb, M. L., Ananworanich, J., Zhou, J. & Hu, H., Aug 1 2019, In : Journal of Clinical Investigation. 129, 8, p. 3361-3373 13 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations
2016

Hydrogen sulfide contributes to retinal neovascularization in Ischemia-Induced retinopathy

Gersztenkorn, D., Coletta, C., Zhu, S., Ha, Y., Liu, H., Tie, H., Zhou, J., Szabo, C., Zhang, W. & Motamedi, M., Jun 1 2016, In : Investigative Ophthalmology and Visual Science. 57, 7, p. 3002-3009 8 p.

Research output: Contribution to journalArticle

10 Scopus citations

Targeting XBP1-mediated β-catenin expression associated with bladder cancer with newly synthetic Oridonin analogues

Chen, W., Zhou, J., Wu, K., Huang, J., Ding, Y., Yun, E. J., Wang, B., Ding, C., Hernandez, E., Santoyo, J., Chen, H., Lin, H., Sagalowsky, A., He, D., Zhou, J. & Hsieh, J. T., 2016, In : Oncotarget. 7, 35, p. 56842-56854 13 p.

Research output: Contribution to journalArticle

15 Scopus citations