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  • William Calhoun
2011

Airway microbiota and bronchial hyperresponsiveness in patients with suboptimally controlled asthma

Huang, Y. J., Nelson, C. E., Brodie, E. L., Desantis, T. Z., Baek, M. S., Liu, J., Woyke, T., Allgaier, M., Bristow, J., Wiener-Kronish, J. P., Sutherland, E. R., King, T. S., Icitovic, N., Martin, R. J., Calhoun, W. J., Castro, M., Denlinger, L. C., Dimango, E., Kraft, M., Peters, S. P. & 4 others, Wasserman, S. I., Wechsler, M. E., Boushey, H. A. & Lynch, S. V., Feb 2011, In : Journal of Allergy and Clinical Immunology. 127, 2, p. 372-381.e3

Research output: Contribution to journalArticle

412 Scopus citations

Can anti-IgE therapy prevent airway remodeling in allergic asthma?

Rabe, K. F., Calhoun, W. J., Smith, N. & Jimenez, P., Sep 2011, In : Allergy: European Journal of Allergy and Clinical Immunology. 66, 9, p. 1142-1151 10 p.

Research output: Contribution to journalReview article

44 Scopus citations

Current prospective of aldose reductase inhibition in the therapy of allergic airway inflammation in asthma

Ramana, K. V., Yadav, U. C. S., Calhoun, W. J. & Srivastava, S. K., Jan 1 2011, In : Current molecular medicine. 11, 7, p. 599-608 10 p.

Research output: Contribution to journalReview article

6 Scopus citations

Determinants of exhaled breath condensate pH in a large population with asthma

Liu, L., Teague, W. G., Erzurum, S., Fitzpatrick, A., Mantri, S., Dweik, R. A., Bleecker, E. R., Meyers, D., Busse, W. W., Calhoun, W. J., Castro, M., Chung, K. F., Curran-Everett, D., Israel, E., Jarjour, W. N., Moore, W., Peters, S. P., Wenzel, S., Hunt, J. F. & Gaston, B., Feb 1 2011, In : Chest. 139, 2, p. 328-336 9 p.

Research output: Contribution to journalArticle

53 Scopus citations

Detrimental effects of environmental tobacco smoke in relation to asthma severity

Comhair, S. A. A., Gaston, B. M., Ricci, K. S., Hammel, J., Dweik, R. A., Teague, W. G., Meyers, D., Ampleford, E. J., Bleecker, E. R., Busse, W. W., Calhoun, W. J., Castro, M., Chung, K. F., Curran-Everett, D., Israel, E., Jarjour, W. N., Moore, W., Peters, S. P., Wenzel, S., Hazen, S. L. & 1 others, Erzurum, S. C., 2011, In : PloS one. 6, 5, e18574.

Research output: Contribution to journalArticle

78 Scopus citations

How cytokines co-occur across asthma patients: From bipartite network analysis to a molecular-based classification

Bhavnani, S. K., Victor, S., Calhoun, W. J., Busse, W. W., Bleecker, E., Castro, M., Ju, H., Pillai, R., Oezguen, N., Bellala, G. & Brasier, A. R., Dec 2011, In : Journal of Biomedical Informatics. 44, SUPPL. 1, p. S24-S30

Research output: Contribution to journalArticle

21 Scopus citations

Impact of race on asthma treatment failures in the Asthma Clinical Research Network

Wechsler, M. E., Castro, M., Lehman, E., Chinchilli, V. M., Sutherland, E. R., Denlinger, L., Lazarus, S. C., Peters, S. P., Israel, E., Martin, R. J., Szefler, S. J., Cherniack, R., Lemanske, R. F., Sorkness, C. A., Jarjour, N., Craig, T., Kunselman, S. J., Boushey, H. A., Fahy, J. V., Kraft, M. & 9 others, Wasserman, S., Ramsdell, J., Calhoun, W. J., Ameredes, B., Walter, M., Bleecker, E., DiMango, E., Pesola, G. R. & Smith, R., Dec 1 2011, In : American Journal of Respiratory and Critical Care Medicine. 184, 11, p. 1247-1253 7 p.

Research output: Contribution to journalArticle

59 Scopus citations

Importance of hedgehog interacting protein and other lung function genes in asthma

Li, X., Howard, T. D., Moore, W. C., Ampleford, E. J., Li, H., Busse, W. W., Calhoun, W. J., Castro, M., Chung, K. F., Erzurum, S. C., Fitzpatrick, A. M., Gaston, B., Israel, E., Jarjour, N. N., Teague, W. G., Wenzel, S. E., Peters, S. P., Hawkins, G. A., Bleecker, E. R. & Meyers, D. A., Jun 2011, In : Journal of Allergy and Clinical Immunology. 127, 6, p. 1457-1465 9 p.

Research output: Contribution to journalArticle

92 Scopus citations

Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations

Torgerson, D. G., Ampleford, E. J., Chiu, G. Y., Gauderman, W. J., Gignoux, C. R., Graves, P. E., Himes, B. E., Levin, A. M., Mathias, R. A., Hancock, D. B., Baurley, J. W., Eng, C., Stern, D. A., Celedón, J. C., Rafaels, N., Capurso, D., Conti, D. V., Roth, L. A., Soto-Quiros, M., Togias, A. & 55 others, Li, X., Myers, R. A., Romieu, I., Berg, D. J. V. D., Hu, D., Hansel, N. N., Hernandez, R. D., Israel, E., Salam, M. T., Galanter, J., Avila, P. C., Avila, L., Rodriquez-Santana, J. R., Chapela, R., Rodriguez-Cintron, W., Diette, G. B., Adkinson, N. F., Abel, R. A., Ross, K. D., Shi, M., Faruque, M. U., Dunston, G. M., Watson, H. R., Mantese, V. J., Ezurum, S. C., Liang, L., Ruczinski, I., Ford, J. G., Huntsman, S., Chung, K. F., Vora, H., Li, X., Calhoun, W. J., Castro, M., Sienra-Monge, J. J., Del Rio-Navarro, B., Deichmann, K. A., Heinzmann, A., Wenzel, S. E., Busse, W. W., Gern, J. E., Lemanske, R. F., Beaty, T. H., Bleecker, E. R., Raby, B. A., Meyers, D. A., London, S. J., Gilliland, F. D., Burchard, E. G., Martinez, F. D., Weiss, S. T., Williams, L. K., Barnes, K. C., Ober, C. & Nicolae, D. L., Sep 2011, In : Nature Genetics. 43, 9, p. 887-892 6 p.

Research output: Contribution to journalArticle

515 Scopus citations

Obesity and asthma: An association modified by age of asthma onset

Holguin, F., Bleecker, E. R., Busse, W. W., Calhoun, W. J., Castro, M., Erzurum, S. C., Fitzpatrick, A. M., Gaston, B., Israel, E., Jarjour, N. N., Moore, W. C., Peters, S. P., Yonas, M., Teague, W. G. & Wenzel, S. E., Jun 2011, In : Journal of Allergy and Clinical Immunology. 127, 6, p. 1486-1493.e2

Research output: Contribution to journalArticle

208 Scopus citations

Omalizumab in asthma: Is the therapeutic window too small?

Bhat, K. D. & Calhoun, W. J., Jan 1 2011, In : Chest. 139, 1, p. 8-10 3 p.

Research output: Contribution to journalEditorial

6 Scopus citations

Proteomic insights into inflammatory airway diseases

Brasier, A. R. & Calhoun, W. J., Jul 1 2011, In : Current Proteomics. 8, 2, p. 84-96 13 p.

Research output: Contribution to journalReview article

2 Scopus citations

Safety of investigative bronchoscopy in the Severe Asthma Research Program

Moore, W. C., Evans, M. D., Bleecker, E. R., Busse, W. W., Calhoun, W. J., Castro, M., Chung, K. F., Erzurum, S. C., Curran-Everett, D., Dweik, R. A., Gaston, B., Hew, M., Israel, E., Mayse, M. L., Pascual, R. M., Peters, S. P., Silveira, L., Wenzel, S. E. & Jarjour, N. N., Aug 2011, In : Journal of Allergy and Clinical Immunology. 128, 2, p. 328-336.e3

Research output: Contribution to journalArticle

37 Scopus citations

Symptom-adjusted therapy in asthma: It is time to listen to our patients

Bhat, K. D. & Calhoun, W. J., May 1 2011, In : Expert Review of Clinical Immunology. 7, 3, p. 259-261 3 p.

Research output: Contribution to journalEditorial

1 Scopus citations
2012
102 Scopus citations

Comparison of physician-, biomarker-, and symptom-based strategies for adjustment of inhaled corticosteroid therapy in adults with asthma: The BASALT randomized controlled trial

Calhoun, W. J., Ameredes, B. T., King, T. S., Icitovic, N., Bleecker, E. R., Castro, M., Cherniack, R. M., Chinchilli, V. M., Craig, T., Denlinger, L., DiMango, E. A., Engle, L. L., Fahy, J. V., Grant, J. A., Israel, E., Jarjour, N., Kazani, S. D., Kraft, M., Kunselman, S. J., Lazarus, S. C. & 15 others, Lemanske, R. F., Lugogo, N., Martin, R. J., Meyers, D. A., Moore, W. C., Pascual, R., Peters, S. P., Ramsdell, J., Sorkness, C. A., Sutherland, E. R., Szefler, S. J., Wasserman, S. I., Walter, M. J., Wechsler, M. E. & Boushey, H. A., Sep 5 2012, In : JAMA - Journal of the American Medical Association. 308, 10, p. 987-997 11 p.

Research output: Contribution to journalArticle

118 Scopus citations

Key observations from the NHLBI Asthma Clinical Research Network

Szefler, S. J., Chinchilli, V. M., Israel, E., Denlinger, L. C., Lemanske, R. F., Calhoun, W. & Peters, S. P., May 2012, In : Thorax. 67, 5, p. 450-455 6 p.

Research output: Contribution to journalReview article

10 Scopus citations

Severe asthma: Lessons learned from the National Heart, Lung, and Blood Institute Severe Asthma Research Program

Jarjour, N. N., Erzurum, S. C., Bleecker, E. R., Calhoun, W. J., Castro, M., Comhair, S. A. A., Chung, K. F., Curran-Everett, D., Dweik, R. A., Fain, S. B., Fitzpatrick, A. M., Gaston, B. M., Israel, E., Hastie, A., Hoffman, E. A., Holguin, F., Levy, B. D., Meyers, D. A., Moore, W. C., Peters, S. P. & 4 others, Sorkness, R. L., Teague, W. G., Wenzel, S. E. & Busse, W. W., Feb 15 2012, In : American Journal of Respiratory and Critical Care Medicine. 185, 4, p. 356-362 7 p.

Research output: Contribution to journalReview article

162 Scopus citations

Sleep quality and asthma control and quality of life in non-severe and severe asthma

Luyster, F. S., Teodorescu, M., Bleecker, E., Busse, W., Calhoun, W., Castro, M., Chung, K. F., Erzurum, S., Israel, E., Strollo, P. J. & Wenzel, S. E., Dec 2012, In : Sleep and Breathing. 16, 4, p. 1129-1137 9 p.

Research output: Contribution to journalArticle

47 Scopus citations

Strategies for molecular classification of asthma using bipartite network analysis of cytokine expression

Pillai, R. R., Divekar, R., Brasier, A., Bhavnani, S. & Calhoun, W. J., Oct 1 2012, In : Current Allergy and Asthma Reports. 12, 5, p. 388-395 8 p.

Research output: Contribution to journalArticle

15 Scopus citations
2013

Alcoholic lung injury: Metabolic, biochemical and immunological aspects

Kaphalia, L. & Calhoun, W. J., Oct 4 2013, In : Toxicology Letters. 222, 2, p. 171-179 9 p.

Research output: Contribution to journalReview article

53 Scopus citations

Aldose Reductase Inhibition Prevents Allergic Airway Remodeling through PI3K/AKT/GSK3β Pathway in Mice

Yadav, U. C. S., Naura, A. S., Aguilera-Aguirre, L., Boldogh, I., Boulares, H. A., Calhoun, W. J., Ramana, K. V. & Srivastava, S. K., Feb 27 2013, In : PloS one. 8, 2, e57442.

Research output: Contribution to journalArticle

27 Scopus citations

An association between L-arginine/asymmetric dimethyl arginine balance, obesity, and the age of asthma onset phenotype

Holguin, F., Comhair, S. A. A., Hazen, S. L., Powers, R. W., Khatri, S. S., Bleecker, E. R., Busse, W. W., Calhoun, W. J., Castro, M., Fitzpatrick, A. M., Gaston, B., Israel, E., Jarjour, N. N., Moore, W. C., Peters, S. P., Teague, W. G., Chung, K. F., Erzurum, S. C. & Wenzel, S. E., Jan 15 2013, In : American Journal of Respiratory and Critical Care Medicine. 187, 2, p. 153-159 7 p.

Research output: Contribution to journalArticle

91 Scopus citations

Characteristics of perimenstrual asthma and its relation to asthma severity and control: Data from the Severe Asthma Research Program

Rao, C. K., Moore, C. G., Bleecker, E., Busse, W. W., Calhoun, W., Castro, M., Chung, K. F., Erzurum, S. C., Israel, E., Curran-Everett, D. & Wenzel, S. E., Apr 2013, In : Chest. 143, 4, p. 984-992 9 p.

Research output: Contribution to journalArticle

47 Scopus citations

Genome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patients

Li, X., Hawkins, G. A., Ampleford, E. J., Moore, W. C., Li, H., Hastie, A. T., Howard, T. D., Boushey, H. A., Busse, W. W., Calhoun, W. J., Castro, M., Erzurum, S. C., Israel, E., Lemanske, R. F., Szefler, S. J., Wasserman, S. I., Wenzel, S. E., Peters, S. P., Meyers, D. A. & Bleecker, E. R., Aug 2013, In : Journal of Allergy and Clinical Immunology. 132, 2, p. 313-320.e15

Research output: Contribution to journalArticle

64 Scopus citations

P2X7-regulated protection from exacerbations and loss of control is independent of asthma maintenance therapy

Denlinger, L. C., Manthei, D. M., Seibold, M. A., Ahn, K., Bleecker, E., Boushey, H. A., Calhoun, W. J., Castro, M., Chinchili, V. M., Fahy, J. V., Hawkins, G. A., Icitovic, N., Israel, E., Jarjour, N. N., King, T., Kraft, M., Lazarus, S. C., Lehman, E., Martin, R. J., Meyers, D. A. & 8 others, Peters, S. P., Sheerar, D., Shi, L., Sutherland, E. R., Szefler, S. J., Wechsler, M. E., Sorkness, C. A. & Lemanske, R. F., Jan 1 2013, In : American Journal of Respiratory and Critical Care Medicine. 187, 1, p. 28-33 6 p.

Research output: Contribution to journalArticle

13 Scopus citations

Predictors of response to tiotropium versus salmeterol in asthmatic adults

Peters, S. P., Bleecker, E. R., Kunselman, S. J., Icitovic, N., Moore, W. C., Pascual, R., Ameredes, B. T., Boushey, H. A., Calhoun, W. J., Castro, M., Cherniack, R. M., Craig, T., Denlinger, L. C., Engle, L. L., Dimango, E. A., Israel, E., Kraft, M., Lazarus, S. C., Lemanske, R. F., Lugogo, N. & 10 others, Martin, R. J., Meyers, D. A., Ramsdell, J., Sorkness, C. A., Sutherland, E. R., Wasserman, S. I., Walter, M. J., Wechsler, M. E., Chinchilli, V. M. & Szefler, S. J., Nov 2013, In : Journal of Allergy and Clinical Immunology. 132, 5, p. 1068-1074.e1

Research output: Contribution to journalArticle

82 Scopus citations

Strategies for Tailoring Asthma Treatment in Adults-Reply

Calhoun, W. J., Boushey, H. A. & Ameredes, B. T., Jan 9 2013, In : JAMA - Journal of the American Medical Association. 309, 2, p. 136-137 2 p.

Research output: Contribution to journalLetter

Symptom-based controller therapy: A new paradigm for asthma management

Divekar, R., Ameredes, B. T. & Calhoun, W. J., Oct 2013, In : Current Allergy and Asthma Reports. 13, 5, p. 427-433 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

The CTSA as an Exemplar Framework for Developing Multidisciplinary Translational Teams

Calhoun, W. J., Wooten, K., Bhavnani, S., Anderson, K. E., Freeman, J. & Brasier, A. R., Feb 2013, In : Clinical and translational science. 6, 1, p. 60-71 12 p.

Research output: Contribution to journalArticle

19 Scopus citations
2014

Assessing and Evaluating Multidisciplinary Translational Teams: A Mixed Methods Approach

Wooten, K. C., Rose, R. M., Ostir, G. V., Calhoun, W. J., Ameredes, B. T. & Brasier, A. R., 2014, In : Evaluation and the Health Professions. 37, 1, p. 33-49 17 p.

Research output: Contribution to journalArticle

12 Scopus citations

Clinical burden and predictors of asthma exacerbations in patients on guideline-based steps 4-6 asthma therapy in the TENOR cohort

Calhoun, W. J., Haselkorn, T., Mink, D. R., Miller, D. P., Dorenbaum, A. & Zeiger, R. S., Mar 2014, In : Journal of Allergy and Clinical Immunology: In Practice. 2, 2, p. 193-200.e3

Research output: Contribution to journalArticle

28 Scopus citations

Conclusions and future directions

Calhoun, W. & Brasier, A. R., 2014, Advances in Experimental Medicine and Biology. Springer New York LLC, Vol. 795. p. 335-343 9 p. (Advances in Experimental Medicine and Biology; vol. 795).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Conclusions and future directions

Calhoun, W. J. & Brasier, A. R., 2014, Advances in Experimental Medicine and Biology. Vol. 795. p. 335-343 9 p. (Advances in Experimental Medicine and Biology; vol. 795).

Research output: Chapter in Book/Report/Conference proceedingChapter

17 Scopus citations

Heterogeneity of asthma in society

Divekar, R. & Calhoun, W. J., 2014, Advances in Experimental Medicine and Biology. Vol. 795. p. 31-41 11 p. (Advances in Experimental Medicine and Biology; vol. 795).

Research output: Chapter in Book/Report/Conference proceedingChapter

Heterogeneity of asthma in society

Divekar, R. & Calhoun, W., 2014, Advances in Experimental Medicine and Biology. Springer New York LLC, Vol. 795. p. 31-41 11 p. (Advances in Experimental Medicine and Biology; vol. 795).

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Heterogeneity of response to therapy

Calhoun, W. J., 2014, Advances in Experimental Medicine and Biology. Vol. 795. p. 117-122 6 p. (Advances in Experimental Medicine and Biology; vol. 795).

Research output: Chapter in Book/Report/Conference proceedingChapter

Heterogeneity of response to therapy

Calhoun, W., 2014, Advances in Experimental Medicine and Biology. Springer New York LLC, Vol. 795. p. 117-122 6 p. (Advances in Experimental Medicine and Biology; vol. 795).

Research output: Chapter in Book/Report/Conference proceedingChapter

Introduction to asthma and phenotyping

Pillai, R. A. & Calhoun, W. J., 2014, Advances in Experimental Medicine and Biology. Vol. 795. p. 5-15 11 p. (Advances in Experimental Medicine and Biology; vol. 795).

Research output: Chapter in Book/Report/Conference proceedingChapter

Introduction to asthma and phenotyping

Pillai, R. A. & Calhoun, W., 2014, Advances in Experimental Medicine and Biology. Springer New York LLC, Vol. 795. p. 5-15 11 p. (Advances in Experimental Medicine and Biology; vol. 795).

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

The spectrum of asthma: an introduction.

Calhoun, W. J., 2014, In : Advances in experimental medicine and biology. 795, p. 1-4 4 p.

Research output: Contribution to journalEditorial

Unsupervised phenotyping of Severe Asthma Research Program participants using expanded lung data

Wu, W., Bleecker, E., Moore, W., Busse, W. W., Castro, M., Chung, K. F., Calhoun, W. J., Erzurum, S., Gaston, B., Israel, E., Curran-Everett, D. & Wenzel, S. E., May 2014, In : Journal of Allergy and Clinical Immunology. 133, 5, p. 1280-1288 9 p.

Research output: Contribution to journalArticle

142 Scopus citations
2015

Anticholinergic vs long-acting β-Agonist in combination with inhaled corticosteroids in black adults with asthma: The BELT randomized clinical trial

Wechsler, M. E., Yawn, B. P., Fuhlbrigge, A. L., Pace, W. D., Pencina, M. J., Doros, G., Kazani, S., Raby, B. A., Lanzillotti, J., Madison, S., Israel, E., Ansari, A., Raum, D., Marthur, M., Avila, P., Bailey, J. E., Calhoun, W. J., Chang, K. L., Coto, M., Davis, C. & 8 others, Dawson, R., Ferguson, M. L. F., Dransfield, M. T., Ferguson, F., Greiner, A., Jingo, A., Pankey, W. & Schear, M., Oct 27 2015, In : JAMA - Journal of the American Medical Association. 314, 16, p. 1720-1730 11 p.

Research output: Contribution to journalArticle

37 Scopus citations

Asthma characteristics and biomarkers from the Airways Disease Endotyping for Personalized Therapeutics (ADEPT) longitudinal profiling study

Silkoff, P. E., Strambu, I., Laviolette, M., Singh, D., FitzGerald, J. M., Lam, S., Kelsen, S., Eich, A., Ludwig-Sengpiel, A., hupp, G. C., Backer, V., Porsbjerg, C., Girodet, P. O., Berger, P., Leigh, R., Kline, J. N., Dransfield, M., Calhoun, W., Hussaini, A., Khatri, S. & 8 others, Chanez, P., Susulic, V. S., Barnathan, E. S., Curran, M., Das, A. M., Brodmerkel, C., Baribaud, F. & Loza, M. J., Nov 17 2015, In : Respiratory Research. 16, 1, 142.

Research output: Contribution to journalArticle

31 Scopus citations

Asthma exacerbations and lung function in patients with severe or difficult-to-treat asthma

Calhoun, W., Haselkorn, T., Miller, D. P. & Omachi, T. A., Oct 1 2015, In : Journal of Allergy and Clinical Immunology. 136, 4, p. 1125-1127e4

Research output: Contribution to journalArticle

18 Scopus citations

Asthma is more severe in older adults

Zein, J. G., Dweik, R. A., Comhair, S. A., Bleecker, E. R., Moore, W. C., Peters, S. P., Busse, W. W., Jarjour, N. N., Calhoun, W. J., Castro, M., Chung, K. F., Fitzpatrick, A., Israel, E., Teague, W. G., Wenzel, S. E., Love, T. E., Gaston, B. M. & Erzurum, S. C., Jul 22 2015, In : PloS one. 10, 7, e0133490.

Research output: Contribution to journalArticle

36 Scopus citations

Children and Adults With Frequent Hospitalizations for Asthma Exacerbation, 2012-2013: A Multicenter Observational Study

Multicenter Airway Research Collaboration-37 Investigators, Sep 1 2015, In : Journal of Allergy and Clinical Immunology: In Practice. 3, 5, p. 751-758.e1

Research output: Contribution to journalArticle

23 Scopus citations

Clinical implications of having reduced mid forced expiratory flow rates (FEF25-75), independently of FEV1, in adult patients with asthma

Riley, C. M., Wenzel, S. E., Castro, M., Erzurum, S. C., Chung, K. F., Fitzpatrick, A. M., Gaston, B., Israel, E., Moore, W. C., Bleecker, E. R., Calhoun, W. J., Jarjour, N. N., Busse, W. W., Peters, S. P., Teague, W. G., Sorkness, R. & Holguin, F., Dec 2015, In : PloS one. 10, 12, e0145476.

Research output: Contribution to journalArticle

17 Scopus citations