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Author

  • Krishna Rajarathnam
2011

Diverging mechanisms of activation of chemokine receptors revealed by novel chemokine agonists

Sarmiento, J., Shumate, C., Suetomi, K., Ravindran, A., Villegas, L., Rajarathnam, K. & Navarro, J., Dec 9 2011, In : PloS one. 6, 12, e27967.

Research output: Contribution to journalArticle

12 Scopus citations
2012

The monomer-dimer equilibrium and glycosaminoglycan interactions of chemokine CXCL8 regulate tissue-specific neutrophil recruitment

Gangavarapu, P., Rajagopalan, L., Kolli, D., Guerrero-Plata, A., Garofalo, R. P. & Rajarathnam, K., Feb 2012, In : Journal of Leukocyte Biology. 91, 2, p. 259-265 7 p.

Research output: Contribution to journalArticle

59 Scopus citations
2013

Chemokine CXCL1 dimer is a potent agonist for the CXCR2 receptor

Ravindran, A., Sawant, K. V., Sarmiento, J., Navarro, J. & Rajarathnam, K., Apr 26 2013, In : Journal of Biological Chemistry. 288, 17, p. 12244-12252 9 p.

Research output: Contribution to journalArticle

39 Scopus citations

Dynamic conformational switching in the chemokine ligand is essential for G-protein-coupled receptor activation

Joseph, P. R. B., Sawant, K. V., Isley, A., Pedroza, M., Garofalo, R. P., Richardson, R. M. & Rajarathnam, K., Dec 1 2013, In : Biochemical Journal. 456, 2, p. 241-251 11 p.

Research output: Contribution to journalArticle

19 Scopus citations

Molecular basis of glycosaminoglycan heparin binding to the chemokine CXCL1 dimer

Poluri, K. M., Joseph, P. R. B., Sawant, K. V. & Rajarathnam, K., Aug 30 2013, In : Journal of Biological Chemistry. 288, 35, p. 25143-25153 11 p.

Research output: Contribution to journalArticle

42 Scopus citations

Organization and dynamics of the N-terminal domain of chemokine receptor CXCR1 in reverse micelles: Effect of graded hydration

Chaudhuri, A., Basu, P., Haldar, S., Kombrabail, M., Krishnamoorthy, G., Rajarathnam, K. & Chattopadhyay, A., Feb 7 2013, In : Journal of Physical Chemistry B. 117, 5, p. 1225-1233 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Proline substitution of dimer interface β-strand residues as a strategy for the design of functional monomeric proteins

Joseph, P. R. B., Poluri, K. M., Gangavarapu, P., Rajagopalan, L., Raghuwanshi, S., Richardson, R. M., Garofalo, R. P. & Rajarathnam, K., Sep 17 2013, In : Biophysical journal. 105, 6, p. 1491-1501 11 p.

Research output: Contribution to journalArticle

17 Scopus citations

Real-time kinetics of high-mobility group box 1 (HMGB1) oxidation in extracellular fluids studied by in situ protein NMR spectroscopy

Zandarashvili, L., Sahu, D., Lee, K., Lee, Y. S., Singh, P., Rajarathnam, K. & Iwahara, J., Apr 26 2013, In : Journal of Biological Chemistry. 288, 17, p. 11621-11627 7 p.

Research output: Contribution to journalArticle

35 Scopus citations
2014

Isothermal titration calorimetry of membrane proteins - Progress and challenges

Rajarathnam, K. & Rösgen, J., 2014, In : Biochimica et Biophysica Acta - Biomembranes. 1838, 1 PARTA, p. 69-77 9 p.

Research output: Contribution to journalReview article

51 Scopus citations

Solution structure of CXCL5 - A novel chemokine and adipokine implicated in inflammation and obesity

Sepuru, K. M., Poluri, K. M. & Rajarathnam, K., Apr 2 2014, In : PloS one. 9, 4, e93228.

Research output: Contribution to journalArticle

17 Scopus citations
2015

Characterizing protein–glycosaminoglycan interactions using solution NMR spectroscopy

Joseph, P. R. B., Poluri, K. M., Sepuru, K. M. & Rajarathnam, K., 2015, In : Methods in Molecular Biology. 1229, p. 325-333 9 p.

Research output: Contribution to journalArticle

5 Scopus citations

Chemokine CXCL1-Mediated Neutrophil Trafficking in the Lung: Role of CXCR2 Activation

Sawant, K. V., Xu, R., Cox, R., Hawkins, H., Sbrana, E., Kolli, D., Garofalo, R. P. & Rajarathnam, K., Oct 16 2015, In : Journal of Innate Immunity. 7, 6, p. 647-658 12 p.

Research output: Contribution to journalArticle

40 Scopus citations

Flexible Linker Modulates Glycosaminoglycan Affinity of Decorin Binding Protein A

Morgan, A., Sepuru, K. M., Feng, W., Rajarathnam, K. & Wang, X., Jul 30 2015, In : Biochemistry. 54, 32, p. 5113-5119 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

Solution NMR characterization of chemokine CXCL8/IL-8 monomer and dimer binding to glycosaminoglycans: Structural plasticity mediates differential binding interactions

Joseph, P. R. B., Mosier, P. D., Desai, U. R. & Rajarathnam, K., Nov 15 2015, In : Biochemical Journal. 472, 1, p. 121-133 13 p.

Research output: Contribution to journalArticle

52 Scopus citations

Solution NMR characterization of WT CXCL8 monomer and dimer binding to CXCR1 N-terminal domain

Joseph, P. R. B. & Rajarathnam, K., Jan 1 2015, In : Protein Science. 24, 1, p. 81-92 12 p.

Research output: Contribution to journalArticle

24 Scopus citations

Using isothermal titration calorimetry to determine thermodynamic parameters of protein–glycosaminoglycan interactions

Dutta, A. K., Rösgen, J. & Rajarathnam, K., 2015, In : Methods in Molecular Biology. 1229, p. 315-324 10 p.

Research output: Contribution to journalArticle

24 Scopus citations
2016

Chemokine CXCL1 mediated neutrophil recruitment: Role of glycosaminoglycan interactions

Sawant, K. V., Poluri, K. M., Dutta, A. K., Sepuru, K. M., Troshkina, A., Garofalo, R. P. & Rajarathnam, K., Sep 14 2016, In : Scientific reports. 6, 33123.

Research output: Contribution to journalArticle

70 Scopus citations
30 Scopus citations

Molecular basis of chemokine CXCL5-glycosaminoglycan interactions

Sepuru, K. M., Nagarajan, B., Desai, U. R. & Rajarathnam, K., Sep 23 2016, In : Journal of Biological Chemistry. 291, 39, p. 20539-20550 12 p.

Research output: Contribution to journalArticle

23 Scopus citations
2017

Chemokine CXCL7 heterodimers: Structural insights, CXCR2 receptor function, and glycosaminoglycan interactions

Brown, A. J., Joseph, P. R. B., Sawant, K. V. & Rajarathnam, K., Apr 2017, In : International journal of molecular sciences. 18, 4, 748.

Research output: Contribution to journalArticle

11 Scopus citations
15 Scopus citations

Platelet-derived chemokine CXCL7 dimer preferentially exists in the glycosaminoglycan-bound form: Implications for neutrophil-platelet crosstalk

Brown, A. J., Sepuru, K. M., Sawant, K. V. & Rajarathnam, K., Oct 2 2017, In : Frontiers in Immunology. 8, OCT, 1248.

Research output: Contribution to journalArticle

17 Scopus citations

Regulation of chemokine function: The roles of GAG-binding and post-translational nitration

Thompson, S., Martínez-Burgo, B., Sepuru, K. M., Rajarathnam, K., Kirby, J. A., Sheerin, N. S. & Ali, S., Aug 3 2017, In : International journal of molecular sciences. 18, 8, 1692.

Research output: Contribution to journalReview article

11 Scopus citations

Structural basis of native CXCL7 monomer binding to CXCR2 receptor N-domain and glycosaminoglycan heparin

Brown, A. J., Sepuru, K. M. & Rajarathnam, K., Mar 2017, In : International journal of molecular sciences. 18, 3, 508.

Research output: Contribution to journalArticle

14 Scopus citations
2020

Neutrophil recruitment by chemokines Cxcl1/KC and Cxcl2/MIP2: Role of Cxcr2 activation and glycosaminoglycan interactions

Sawant, K. V., Sepuru, K. M., Lowry, E., Penaranda, B., Frevert, C. W., Garofalo, R. P. & Rajarathnam, K., 2020, (Accepted/In press) In : Journal of Leukocyte Biology.

Research output: Contribution to journalArticle

Structural Insights Into How Proteoglycans Determine Chemokine-CXCR1/CXCR2 Interactions: Progress and Challenges

Rajarathnam, K. & Desai, U. R., Apr 24 2020, In : Frontiers in immunology. 11, 660.

Research output: Contribution to journalReview article

Open Access
3 Scopus citations