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• 2011

  Biophysics of substrate interaction: Influence on neural motility, differentiation, and repair

  Moore, S. W. & Sheetz, M. P., Nov 2011, In: Developmental Neurobiology. 71, 11, p. 1090-1101 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Biophysics
  • Cues
  • Neuronal Plasticity
  • Axons
  • Cell Movement
  53 Scopus citations

• Cellular mechanotransduction: Filamin A strains to regulate motility

  Lynch, C. D. & Sheetz, M. P., Nov 22 2011, In: Current Biology. 21, 22, p. R916-R918

  Research output: Contribution to journal › Short survey › peer-review

  Open Access

  • Cellular Mechanotransduction
  • filamin
  • mechanotransduction
  • Filamins
  • microfilament proteins
  6 Scopus citations

• Controlled confinement of DNA at the nanoscale: nanofabrication and surface bio-functionalization.

  Palma, M., Abramson, J. J., Gorodetsky, A. A., Nuckolls, C., Sheetz, M. P., Wind, S. J. & Hone, J., 2011, In: Methods in molecular biology (Clifton, N.J.). 749, p. 169-185 17 p.

  Research output: Contribution to journal › Article › peer-review

  • DNA
  • Oligonucleotides
  • Proteins
  7 Scopus citations

• Differential mechanical stability of filamin A rod segments

  Chen, H., Zhu, X., Cong, P., Sheetz, M. P., Nakamura, F. & Yan, J., Sep 7 2011, In: Biophysical journal. 101, 5, p. 1231-1237 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Filamins
  • Actins
  • Spectrin
  • Immunoglobulin Domains
  • Proteins
  34 Scopus citations

• Early integrin binding to Arg-Gly-Asp peptide activates actin polymerization and contractile movement that stimulates outward translocation

  Yu, C. H., Law, J. B. K., Suryana, M., Low, H. Y. & Sheetz, M. P., Dec 20 2011, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 51, p. 20585-20590 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Polymerization
  • Integrins
  • Actins
  • Peptides
  • Myosin Type II
  131 Scopus citations

• Filamin depletion blocks endoplasmic spreading and destabilizes force-bearing adhesions

  Lynch, C. D., Gauthier, N. C., Biais, N., Lazar, A. M., Roca-Cusachs, P., Yu, C. H. & Sheetz, M. P., Apr 15 2011, In: Molecular Biology of the Cell. 22, 8, p. 1263-1273 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Filamins
  • Actins
  • Stress Fibers
  • Fibroblasts
  • Traction
  44 Scopus citations

• Mechanotransduction in vivo by repeated talin stretch-relaxation events depends upon vinculin

  Margadant, F., Chew, L. L., Hu, X., Yu, H., Bate, N., Zhang, X. & Sheetz, M., Dec 2011, In: PLoS Biology. 9, 12, e1001223.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • talin
  • mechanotransduction
  • Talin
  • Vinculin
  • Actins
  132 Scopus citations

• Nanolithographic control of the spatial organization of cellular adhesion receptors at the single-molecule level

  Schvartzman, M., Palma, M., Sable, J., Abramson, J., Hu, X., Sheetz, M. P. & Wind, S. J., Mar 9 2011, In: Nano Letters. 11, 3, p. 1306-1312 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Binding sites
  • adhesion receptor
  • Molecules
  • Binding Sites
  • Nanolithography
  155 Scopus citations

• New approach for measuring protrusive forces in cells

  Mathur, A., Roca-Cusachs, P., Rossier, O. M., Wind, S. J., Sheetz, M. & Hone, J., Jan 1 2011, In: Journal of Vacuum Science and Technology B:Nanotechnology and Microelectronics. 29, 6, 06FA02.

  Research output: Contribution to journal › Article › peer-review

  • Cell signaling
  • Fibroblasts
  • elastomeric
  • cells
  • Sensors
  3 Scopus citations

• Selective biomolecular nanoarrays for parallel single-molecule investigations

  Palma, M., Abramson, J. J., Gorodetsky, A. A., Penzo, E., Gonzalez, R. L., Sheetz, M. P., Nuckolls, C., Hone, J. & Wind, S. J., May 25 2011, In: Journal of the American Chemical Society. 133, 20, p. 7656-7659 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Self assembly
  • Environmental Monitoring
  • DNA-Binding Proteins
  • Adsorption
  • Molecules
  33 Scopus citations

• Signaling network triggers and membrane physical properties control the actin cytoskeleton-driven isotropic phase of cell spreading

  Rangamani, P., Fardin, M. A., Xiong, Y., Lipshtat, A., Rossier, O., Sheetz, M. P. & Iyengar, R., Feb 16 2011, In: Biophysical journal. 100, 4, p. 845-857 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Actin Cytoskeleton
  • Integrins
  • Membranes
  • Cell Membrane
  • Cell Shape
  22 Scopus citations

• Temporary increase in plasma membrane tension coordinates the activation of exocytosis and contraction during cell spreading

  Gauthier, N. C., Fardin, M. A., Roca-Cusachs, P. & Sheetz, M. P., Aug 30 2011, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 35, p. 14467-14472 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Exocytosis
  • Cell Membrane
  • Actomyosin
  • Pseudopodia
  • Membranes
  189 Scopus citations
• 2012

  Cell crawling mediates collective cell migration to close undamaged epithelial gaps

  Anon, E., Serra-Picamal, X., Hersen, P., Gauthier, N. C., Sheetz, M. P., Trepat, X. & Ladoux, B., Jul 3 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 27, p. 10891-10896 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Pseudopodia
  • Cell Movement
  • Myosin-Light-Chain Kinase
  • Actomyosin
  • rho-Associated Kinases
  121 Scopus citations

• Cells test substrate rigidity by local contractions on submicrometer pillars

  Ghassemi, S., Meacci, G., Liu, S., Gondarenko, A. A., Mathur, A., Roca-Cusachs, P., Sheetz, M. P. & Hone, J., Apr 3 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 14, p. 5328-5333 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Myosins
  • elastomeric
  • Cell Differentiation
  • Growth
  133 Scopus citations

• Finding the weakest link-exploring integrin-mediated mechanical molecular pathways

  Roca-Cusachs, P., Iskratsch, T. & Sheetz, M. P., Jul 1 2012, In: Journal of Cell Science. 125, 13, p. 3025-3038 14 p.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  • Integrins
  • Actins
  • Proteins
  • Protein Conformation
  • Cytoskeleton
  159 Scopus citations

• Following nature’s challenges

  Sheetz, M. P. & Kenan, W. R., Oct 2012, In: Nature Medicine. 18, 10, p. 1483-1485 3 p.

  Research output: Contribution to journal › Article › peer-review

• Force-dependent cell signaling in stem cell differentiation

  Yim, E. K. F. & Sheetz, M. P., 2012, In: Stem Cell Research and Therapy. 3, 5, 41.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Cell signaling
  • Stem cells
  • Cell Differentiation
  • Stem Cells
  • rho GTP-Binding Proteins
  90 Scopus citations

• Mechanical feedback between membrane tension and dynamics

  Gauthier, N. C., Masters, T. A. & Sheetz, M., Oct 1 2012, In: Trends in Cell Biology. 22, 10, p. 527-535 9 p.

  Research output: Contribution to journal › Review article › peer-review

  • Membranes
  • Architectural Accessibility
  • Cytoskeleton
  • Buffers
  • Cell Membrane
  226 Scopus citations

• Microarray with micro- and nano-topographies enables identification of the optimal topography for directing the differentiation of primary murine neural progenitor cells

  Moe, A. A. K., Suryana, M., Marcy, G., Lim, S. K., Ankam, S., Goh, J. Z. W., Jin, J., Teo, B. K. K., Law, J. B. K., Low, H. Y., Goh, E. L. K., Sheetz, M. P. & Yim, E. K. F., Oct 8 2012, In: Small. 8, 19, p. 3050-3061 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Microarrays
  • Topography
  • Cues
  • Stem Cells
  • Cell Communication
  79 Scopus citations

• Modularity and functional plasticity of scaffold proteins as p(l)acemakers in cell signaling

  Pan, C. Q., Sudol, M., Sheetz, M. & Low, B. C., Nov 2012, In: Cellular Signalling. 24, 11, p. 2143-2165 23 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Proteins
  • Cell Plasticity
  • Intercellular Junctions
  • Focal Adhesions
  • Golgi Apparatus
  50 Scopus citations

• Netrin-1 Attracts axons through FAK-dependent mechanotransduction

  Moore Dr., S. W., Zhang, X., Lynch, C. D. & Sheetz, M. P., Aug 22 2012, In: Journal of Neuroscience. 32, 34, p. 11574-11585 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Netrin-1
  • Focal Adhesion Protein-Tyrosine Kinases
  • Axons
  • Growth Cones
  • Crk-Associated Substrate Protein
  55 Scopus citations

• Second-generation covalent TMP-tag for live cell imaging

  Chen, Z., Jing, C., Gallagher, S. S., Sheetz, M. P. & Cornish, V. W., Aug 22 2012, In: Journal of the American Chemical Society. 134, 33, p. 13692-13699 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Thymidine Monophosphate
  • Proteins
  • Imaging techniques
  • Fluorophores
  • Oxidoreductases
  83 Scopus citations

• Spatial-temporal reorganization of activated integrins

  Yu, C. H., Luo, W. & Sheetz, M. P., 2012, In: Cell Adhesion and Migration. 6, 3, p. 280-284 5 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Integrins
  • Cluster Analysis
  • cyclic arginine-glycine-aspartic acid peptide
  • arginyl-glycyl-aspartic acid
  • Focal Adhesions
  11 Scopus citations

• The lasker awards: Motors take centre stage

  Sheetz, M., Spudich, J. & Vale, R., Nov 2012, In: Nature Cell Biology. 14, 11, p. 1113 1 p.

  Research output: Contribution to journal › Editorial › peer-review

  Open Access

• The role of feature curvature in contact guidance

  Mathur, A., Moore, S. W., Sheetz, M. & Hone, J., Jul 1 2012, In: Acta Biomaterialia. 8, 7, p. 2595-2601 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Stress Fibers
  • Topography
  • Tissue Engineering
  • Polarization
  • Fibroblasts
  34 Scopus citations

• T lymphocyte myosin IIA is required for maturation of the immunological synapse

  Kumari, S., Vardhana, S., Cammer, M., Curado, S., Santos, L., Sheetz, M. P. & Dustin, M. L., 2012, In: Frontiers in immunology. 3, AUG, Article 230.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Nonmuscle Myosin Type IIA
  • Immunological Synapses
  • T-Cell Antigen Receptor
  • Small Interfering RNA
  • T-Lymphocytes
  51 Scopus citations
• 2015

  Cyclic stretching of soft substrates induces spreading and growth

  Cui, Y., Hameed, F. M., Yang, B., Lee, K., Pan, C. Q., Park, S. & Sheetz, M., Feb 23 2015, In: Nature communications. 6, 6333.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Stretching
  • myocardin
  • Substrates
  • Stress Fibers
  • Growth
  128 Scopus citations

• Integrin-beta3 clusters recruit clathrin-mediated endocytic machinery in the absence of traction force

  Yu, C. H., Rafiq, N. B. M., Cao, F., Zhou, Y., Krishnasamy, A., Biswas, K. H., Ravasio, A., Chen, Z., Wang, Y. H., Kawauchi, K., Jones, G. E. & Sheetz, M. P., Oct 28 2015, In: Nature communications. 6, 8672.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Integrin beta3
  • Clathrin
  • machinery
  • traction
  • Traction
  41 Scopus citations

• Mechanobiology

  Shivashankar, G. V., Sheetz, M. & Matsudaira, P., Oct 1 2015, In: Integrative Biology (United Kingdom). 7, 10, p. 1091-1092 2 p.

  Research output: Contribution to journal › Editorial › peer-review
  5 Scopus citations

• Micropatterning of TCR and LFA-1 ligands reveals complementary effects on cytoskeleton mechanics in T cells

  Tabdanov, E., Gondarenko, S., Kumari, S., Liapis, A., Dustin, M. L., Sheetz, M. P., Kam, L. C. & Iskratsch, T., Oct 1 2015, In: Integrative Biology (United Kingdom). 7, 10, p. 1272-1284 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • T-cells
  • Lymphocyte Function-Associated Antigen-1
  • Mechanics
  • T-Cell Antigen Receptor
  • Cytoskeleton
  39 Scopus citations

• Nascent Integrin Adhesions Form on All Matrix Rigidities after Integrin Activation

  Changede, R., Xu, X., Margadant, F. & Sheetz, M. P., 2015, In: Developmental cell. 35, 5, p. 614-621 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Talin
  • Rigidity
  • Integrins
  • Adhesion
  • Chemical activation
  58 Scopus citations

• Parallel near-field photolithography with metal-coated elastomeric masks

  Wu, J., Yu, C. H., Li, S., Zou, B., Liu, Y., Zhu, X., Guo, Y., Xu, H., Zhang, W., Zhang, L., Liu, B., Tian, D., Huang, W., Sheetz, M. & Huo, F., Jan 27 2015, In: Langmuir. 31, 3, p. 1210-1217 8 p.

  Research output: Contribution to journal › Article › peer-review

  • elastomeric
  • Photolithography
  • photolithography
  • Masks
  • Metals
  19 Scopus citations

• Talin Dependent Mechanosensitivity of Cell Focal Adhesions

  Yan, J., Yao, M., Goult, B. T. & Sheetz, M. P., 2015, In: Cellular and Molecular Bioengineering. 8, 1, p. 151-159 9 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Talin
  • Mechanobiology
  • Adhesion
  • Integrin
  • Focal Adhesions
  49 Scopus citations
• 2016

  Actin polymerization-dependent activation of Cas-L promotes immunological synapse stability

  Santos, L. C., Blair, D. A., Kumari, S., Cammer, M., Iskratsch, T., Herbin, O., Alexandropoulos, K., Dustin, M. L. & Sheetz, M. P., Nov 1 2016, In: Immunology and Cell Biology. 94, 10, p. 981-993 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Immunological Synapses
  • Polymerization
  • T-Cell Antigen Receptor
  • Actins
  • T-Lymphocytes
  18 Scopus citations

• Cell contractility arising from topography and shear flow determines human mesenchymal stem cell fate

  Sonam, S., Sathe, S. R., Yim, E. K. F., Sheetz, M. P. & Lim, C. T., Feb 16 2016, In: Scientific reports. 6, 20415.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Mesenchymal Stem Cells
  • Stem Cells
  • Extracellular Matrix
  • Actomyosin
  • Focal Adhesions
  35 Scopus citations

• Cooperative vinculin binding to talin mapped by time-resolved super resolution microscopy

  Hu, X., Jing, C., Xu, X., Nakazawa, N., Cornish, V. W., Margadant, F. M. & Sheetz, M. P., Jul 13 2016, In: Nano Letters. 16, 7, p. 4062-4068 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Dimers
  • Talin
  • Vinculin
  • Microscopic examination
  • microscopy
  20 Scopus citations

• F-actin waves, actin cortex disassembly and focal exocytosis driven by actin-phosphoinositide positive feedback

  Masters, T. A., Sheetz, M. & Gauthier, N. C., Apr 1 2016, In: Cytoskeleton. 73, 4, p. 180-196 17 p.

  Research output: Contribution to journal › Article › peer-review

  • Exocytosis
  • Phosphatidylinositols
  • Actins
  • Lipids
  • Cell Membrane
  11 Scopus citations

• Formin DAAM1 organizes actin filaments in the cytoplasmic nodal actin network

  Luo, W., Lieu, Z. Z., Manser, E., Bershadsky, A. D. & Sheetz, M. P., Oct 2016, In: PloS one. 11, 10, e0163915.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • microfilaments
  • Actin Cytoskeleton
  • actin
  • Actins
  • latrunculin A
  10 Scopus citations

• High-Throughput Mechanobiology Screening Platform Using Micro- and Nanotopography

  Hu, J., Gondarenko, A. A., Dang, A. P., Bashour, K. T., O'Connor, R. S., Lee, S., Liapis, A., Ghassemi, S., Milone, M. C., Sheetz, M. P., Dustin, M. L., Kam, L. C. & Hone, J. C., Apr 13 2016, In: Nano Letters. 16, 4, p. 2198-2204 7 p.

  Research output: Contribution to journal › Article › peer-review

  • T-cells
  • Screening
  • screening
  • platforms
  • interleukins
  22 Scopus citations

• Matrix mechanics controls FHL2 movement to the nucleus to activate p21 expression

  Nakazawa, N., Sathe, A. R., Shivashankar, G. V. & Sheetz, M. P., Nov 1 2016, In: Proceedings of the National Academy of Sciences of the United States of America. 113, 44, p. E6813-E6822

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Mechanics
  • Phosphorylation
  • Focal Adhesion Protein-Tyrosine Kinases
  • Gene Expression
  • Focal Adhesions
  24 Scopus citations

• Mechanical confinement triggers glioma linear migration dependent on formin FHOD3

  Monzo, P., Chong, Y. K., Guetta-Terrier, C., Krishnasamy, A., Sathe, S. R., Yim, E. K. F., Ng, W. H., Ang, B. T., Tang, C., Ladoux, B., Gauthier, N. C. & Sheetz, M. P., Apr 15 2016, In: Molecular Biology of the Cell. 27, 8, p. 1246-1261 16 p.

  Research output: Contribution to journal › Article › peer-review

  • Glioma
  • Laminin
  • Paxillin
  • Blood Vessels
  • Glioblastoma
  27 Scopus citations

• Mechanosensing Controlled Directly by Tyrosine Kinases

  Yang, B., Lieu, Z. Z., Wolfenson, H., Hameed, F. M., Bershadsky, A. D. & Sheetz, M. P., Sep 14 2016, In: Nano Letters. 16, 9, p. 5951-5961 11 p.

  Research output: Contribution to journal › Article › peer-review

  • tyrosine
  • rigidity
  • Rigidity
  • Filamins
  • contraction
  44 Scopus citations

• Molecular Occupancy of Nanodot Arrays

  Cai, H., Wolfenson, H., Depoil, D., Dustin, M. L., Sheetz, M. P. & Wind, S. J., Apr 26 2016, In: ACS Nano. 10, 4, p. 4173-4183 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Nanodots
  • proteins
  • nucleic acids
  • nanofabrication
  • bleaching
  18 Scopus citations

• Nuclear transport of paxillin depends on focal adhesion dynamics and FAT domains

  Sathe, A. R., Shivashankar, G. V. & Sheetz, M. P., May 15 2016, In: Journal of Cell Science. 129, 10, p. 1981-1988 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Paxillin
  • Focal Adhesions
  • Cell Nucleus Active Transport
  • Islands
  • Fluorescence Recovery After Photobleaching
  14 Scopus citations

• The mechanical response of talin

  Yao, M., Goult, B. T., Klapholz, B., Hu, X., Toseland, C. P., Guo, Y., Cong, P., Sheetz, M. P. & Yan, J., Jul 7 2016, In: Nature communications. 7, 11966.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Talin
  • Cell adhesion
  • rods
  • bundles
  • Kinetics
  121 Scopus citations

• Tropomyosin controls sarcomere-like contractions for rigidity sensing and suppressing growth on soft matrices

  Wolfenson, H., Meacci, G., Liu, S., Stachowiak, M. R., Iskratsch, T., Ghassemi, S., Roca-Cusachs, P., O'Shaughnessy, B., Hone, J. & Sheetz, M. P., Jan 1 2016, In: Nature Cell Biology. 18, 1, p. 33-42 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Tropomyosin
  • Sarcomeres
  • Actomyosin
  • Growth
  • elastomeric
  87 Scopus citations

• α-Actinin links extracellular matrix rigidity-sensing contractile units with periodic cell-edge retractions

  Meacci, G., Wolfenson, H., Liu, S., Stachowiak, M. R., Iskratsch, T., Mathur, A., Ghassemi, S., Gauthier, N., Tabdanov, E., Lohner, J., Gondarenko, A., Chander, A. C., Roca-Cusachs, P., O'Shaughnessy, B., Hone, J. & Sheetz, M. P., Nov 7 2016, In: Molecular Biology of the Cell. 27, 22, p. 3471-3479 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Actinin
  • Extracellular Matrix
  • Actins
  • Cytoskeletal Proteins
  38 Scopus citations
• 2017

  DNA damage causes rapid accumulation of phosphoinositides for ATR signaling

  Wang, Y. H., Hariharan, A., Bastianello, G., Toyama, Y., Shivashankar, G. V., Foiani, M. & Sheetz, M. P., Dec 1 2017, In: Nature communications. 8, 1, 2118.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • ataxia
  • Ataxia Telangiectasia
  • Phosphatidylinositols
  • lipids
  • deoxyribonucleic acid
  27 Scopus citations

• EGFR and HER2 activate rigidity sensing only on rigid matrices

  Saxena, M., Liu, S., Yang, B., Hajal, C., Changede, R., Hu, J., Wolfenson, H., Hone, J. & Sheetz, M. P., Jul 1 2017, In: Nature Materials. 16, 7, p. 775-781 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Epidermal Growth Factor
  • rigidity
  • Rigidity
  • ErbB Receptors
  • matrices
  33 Scopus citations

• Force-Induced Calpain Cleavage of Talin Is Critical for Growth, Adhesion Development, and Rigidity Sensing

  Saxena, M., Changede, R., Hone, J., Wolfenson, H. & Sheetz, M. P., Dec 13 2017, In: Nano Letters. 17, 12, p. 7242-7251 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Talin
  • Calpain
  • rigidity
  • cleavage
  • Rigidity
  21 Scopus citations