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• 2018

  Inventing new therapies without reinventing the wheel: the power of drug repurposing

  Papapetropoulos, A. & Szabo, C., 2018, In: British Journal of Pharmacology. 175, 2, p. 165-167 3 p.

  Research output: Contribution to journal › Editorial › peer-review

  • Drug Repositioning
  • Therapeutics
  20 Scopus citations

• Mercaptopyruvate acts as endogenous vasodilator independently of 3-mercaptopyruvate sulfurtransferase activity

  Mitidieri, E., Tramontano, T., Gurgone, D., Citi, V., Calderone, V., Brancaleone, V., Katsouda, A., Nagahara, N., Papapetropoulos, A., Cirino, G., d'Emmanuele di Villa Bianca, R. & Sorrentino, R., May 1 2018, In: Nitric Oxide - Biology and Chemistry. 75, p. 53-59 7 p.

  Research output: Contribution to journal › Article › peer-review

  • 3-mercaptopyruvic acid
  • Vasodilator Agents
  • N(G)-iminoethylornithine
  • Cystathionine
  • Endothelium
  16 Scopus citations

• Mitochondrial DNA damage and subsequent activation of Z-DNA binding protein 1 links oxidative stress to inflammation in epithelial cells

  Szczesny, B., Marcatti, M., Ahmad, A., Montalbano, M., Brunyánszki, A., Bibli, S. I., Papapetropoulos, A. & Szabo, C., Dec 1 2018, In: Scientific reports. 8, 1, 914.

  Research output: Contribution to journal › Article › peer-review

  • Z-Form DNA
  • DNA-Binding Proteins
  • Mitochondrial DNA
  • DNA Damage
  • Oxidative Stress
  31 Scopus citations

• Reduced adipose tissue H₂S in obesity

  Katsouda, A., Szabo, C. & Papapetropoulos, A., Feb 2018, In: Pharmacological Research. 128, p. 190-199 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Cystathionine
  • 3-mercaptopyruvic acid
  • Lyases
  • Adipose Tissue
  • Obesity
  11 Scopus citations
• 2019

  Association study of the CTH 1364 G>T polymorphism with coronary artery disease in the Greek population

  Giannakopoulou, E., Konstantinou, F., Ragia, G., Gerontitis, Z., Tavridou, A., Papapetropoulos, A., Mikroulis, D. & Manolopoulos, V. G., Jan 1 2019, In: Drug Metabolism and Personalized Therapy. 34, 1, 20180033.

  Research output: Contribution to journal › Article › peer-review

  • Coronary Artery Bypass
  • Coronary Artery Disease
  • Genotype
  • Population
  • Cystathionine
  2 Scopus citations

• Cystathionine γ Lyase Sulfhydrates the RNA Binding Protein Human Antigen R to Preserve Endothelial Cell Function and Delay Atherogenesis

  Bibli, S. I., Hu, J., Sigala, F., Wittig, I., Heidler, J., Zukunft, S., Tsilimigras, D. I., Randriamboavonjy, V., Wittig, J., Kojonazarov, B., Schürmann, C., Siragusa, M., Siuda, D., Luck, B., Abdel Malik, R., Filis, K. A., Zografos, G., Chen, C., Wang, D. W., Pfeilschifter, J. & 4 others, Brandes, R. P., Szabo, C., Papapetropoulos, A. & Fleming, I., Jan 2 2019, In: Circulation. 139, 1, p. 101-114 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Cystathionine
  • Lyases
  • RNA-Binding Proteins
  • Atherosclerosis
  • Endothelial Cells
  29 Scopus citations

• Investigating and re-evaluating the role of glycogen synthase kinase 3 beta kinase as a molecular target for cardioprotection by using novel pharmacological inhibitors

  Nikolaou, P. E., Boengler, K., Efentakis, P., Vouvogiannopoulou, K., Zoga, A., Gaboriaud-Kolar, N., Myrianthopoulos, V., Alexakos, P., Kostomitsopoulos, N., Rerras, I., Tsantili-Kakoulidou, A., Skaltsounis, A. L., Papapetropoulos, A., Iliodromitis, E. K., Schulz, R. & Andreadou, I., Jun 1 2019, In: Cardiovascular research. 115, 7, p. 1228-1243 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Glycogen Synthase Kinase 3 beta
  • Phosphotransferases
  • Pharmacology
  • 6-bromoindirubin-3'-oxime
  • Autophagy-Related Proteins
  11 Scopus citations

• Nitroglycerine limits infarct size through S-nitrosation of cyclophilin D: A novel mechanism for an old drug

  Bibli, S. I., Papapetropoulos, A., Iliodromitis, E. K., Daiber, A., Randriamboavonjy, V., Steven, S., Brouckaert, P., Chatzianastasiou, A., Kypreos, K. E., Hausenloy, D. J., Fleming, I. & Andreadou, I., Mar 1 2019, In: Cardiovascular research. 115, 3, p. 625-636 12 p.

  Research output: Contribution to journal › Article › peer-review

  • cyclophilin D
  • Nitrosation
  • Nitroglycerin
  • Nitric Oxide Synthase Type III
  • Pharmaceutical Preparations
  12 Scopus citations

• THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Enzymes

  CGTP Collaborators, Dec 1 2019, In: British Journal of Pharmacology. 176, S1, p. S297-S396

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Terminology
  • Pharmacology
  • Enzymes
  • Ligands
  • Drug Receptors
  209 Scopus citations
• 2020

  3-Mercaptopyruvate sulfurtransferase supports endothelial cell angiogenesis and bioenergetics

  Abdollahi Govar, A., Törő, G., Szaniszlo, P., Pavlidou, A., Bibli, S. I., Thanki, K., Resto, V. A., Chao, C., Hellmich, M. R., Szabo, C., Papapetropoulos, A. & Módis, K., Feb 1 2020, In: British Journal of Pharmacology. 177, 4, p. 866-883 18 p.

  Research output: Contribution to journal › Article › peer-review

  • 3-mercaptopyruvic acid
  • Energy Metabolism
  • Endothelial Cells
  • Hydrogen Sulfide
  • Small Interfering RNA
  9 Scopus citations

• Backbone and side chain NMR assignments of the H-NOX domain from Nostoc sp. in complex with BAY58-2667 (cinaciguat)

  Makrynitsa, G. I., Argyriou, A. I., Dalkas, G., Georgopoulou, D. A., Bantzi, M., Giannis, A., Papapetropoulos, A. & Spyroulias, G. A., 2020, (Accepted/In press) In: Biomolecular NMR Assignments.

  Research output: Contribution to journal › Article › peer-review

  • BAY 58-2667
  • Nostoc
  • Nuclear magnetic resonance
  • Heme
  • Soluble Guanylyl Cyclase

• Cardiovascular phenotype of mice lacking 3-mercaptopyruvate sulfurtransferase

  Peleli, M., Bibli, S. I., Li, Z., Chatzianastasiou, A., Varela, A., Katsouda, A., Zukunft, S., Bucci, M., Vellecco, V., Davos, C. H., Nagahara, N., Cirino, G., Fleming, I., Lefer, D. J. & Papapetropoulos, A., Jun 2020, In: Biochemical Pharmacology. 176, 113833.

  Research output: Contribution to journal › Article › peer-review

  • 3-mercaptopyruvic acid
  • Phenotype
  • Cystathionine
  • Lyases
  • Cardiovascular system
  4 Scopus citations

• Endothelial-tumor cell interaction in brain and CNS malignancies

  Peleli, M., Moustakas, A. & Papapetropoulos, A., Oct 1 2020, In: International journal of molecular sciences. 21, 19, p. 1-28 28 p., 7371.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Tumors
  • Cells
  • tumors
  • brain
  • Cell Communication

• From primordial gas to the medicine cabinet

  Papapetropoulos, A., Wallace, J. L. & Wang, R., Feb 1 2020, In: British Journal of Pharmacology. 177, 4, p. 715-719 5 p.

  Research output: Contribution to journal › Editorial › peer-review

  Open Access

  • Hydrogen Sulfide
  • Gases
  • Medicine

• Generation and characterization of a CRISPR/Cas9-induced 3-mst deficient zebrafish

  Katsouda, A., Peleli, M., Asimakopoulou, A., Papapetropoulos, A. & Beis, D., Feb 2020, In: Biomolecules. 10, 2, 317.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • 3-mercaptopyruvic acid
  • Clustered Regularly Interspaced Short Palindromic Repeats
  • Zebrafish
  • polysulfide
  • Oxidative stress
  1 Scopus citations

• Hydrogen sulfide: An endogenous regulator of the immune system

  Dilek, N., Papapetropoulos, A., Toliver-Kinsky, T. & Szabo, C., Nov 2020, In: Pharmacological Research. 161, 105119.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Hydrogen Sulfide
  • Immune System
  • Cystathionine
  • Immune System Diseases
  • 3-mercaptopyruvic acid
  1 Scopus citations

• Levosimendan prevents doxorubicin-induced cardiotoxicity in time- and dose-dependent manner: Implications for inotropy

  Efentakis, P., Varela, A., Chavdoula, E., Sigala, F., Sanoudou, D., Tenta, R., Gioti, K., Kostomitsopoulos, N., Papapetropoulos, A., Tasouli, A., Farmakis, D., Davos, C. H., Klinakis, A., Suter, T., Cokkinos, D. V., Iliodromitis, E. K., Wenzel, P. & Andreadou, I., Mar 1 2020, In: Cardiovascular research. 116, 3, p. 576-591 16 p.

  Research output: Contribution to journal › Article › peer-review

  • Simendan
  • Cardiotoxicity
  • Doxorubicin
  • phospholamban
  • Nitric Oxide Synthase Type III
  6 Scopus citations

• Screening of Heteroaromatic Scaffolds against Cystathionine Beta-Synthase Enables Identification of Substituted Pyrazolo[3,4-c]Pyridines as Potent and Selective Orthosteric Inhibitors

  Fantel, A. M., Myrianthopoulos, V., Georgoulis, A., Lougiakis, N., Zantza, I., Lamprinidis, G., Augsburger, F., Marakos, P., Vorgias, C. E., Szabo, C., Pouli, N., Papapetropoulos, A. & Mikros, E., Aug 2020, In: Molecules. 25, 16, 3739.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • pyrazolo(3,4-b)pyridine
  • Cystathionine
  • Cystathionine beta-Synthase
  • Hydrogen Sulfide
  • pyridines

• Shear stress regulates cystathionine γ lyase expression to preserve endothelial redox balance and reduce membrane lipid peroxidation: Regulation of CSE by KLF2 and miR-27b

  Bibli, S. I., Hu, J., Leisegang, M. S., Wittig, J., Zukunft, S., Kapasakalidi, A., Fisslthaler, B., Tsilimigras, D., Zografos, G., Filis, K., Brandes, R. P., Papapetropoulos, A., Sigala, F. & Fleming, I., Jan 2020, In: Redox Biology. 28, 101379.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cystathionine
  • Lyases
  • Oxidation-Reduction
  • Membrane Lipids
  • Lipid Peroxidation
  4 Scopus citations

• The protective role of the 3-mercaptopyruvate sulfurtransferase (3-MST)-hydrogen sulfide (H₂S) pathway against experimental osteoarthritis

  Nasi, S., Ehirchiou, D., Chatzianastasiou, A., Nagahara, N., Papapetropoulos, A., Bertrand, J., Cirino, G., So, A. & Busso, N., Mar 17 2020, In: Arthritis Research and Therapy. 22, 1, 49.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • 3-mercaptopyruvic acid
  • Hydrogen Sulfide
  • Osteoarthritis
  • Cartilage
  • Chondrocytes
  8 Scopus citations

• The role of mitochondrial reactive oxygen species, NO and H₂S in ischaemia/reperfusion injury and cardioprotection

  Andreadou, I., Schulz, R., Papapetropoulos, A., Turan, B., Ytrehus, K., Ferdinandy, P., Daiber, A. & Di Lisa, F., Jun 1 2020, In: Journal of Cellular and Molecular Medicine. 24, 12, p. 6510-6522 13 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Nitric Oxide
  • Reactive Oxygen Species
  • Mitochondria
  • Reactive Nitrogen Species
  • Hydrogen Sulfide
  8 Scopus citations