Find Research Outputs

Search results

• 2011

  Amyloid-β annular protofibrils evade fibrillar fate in Alzheimer disease brain

  Lasagna-Reeves, C. A., Glabe, C. G. & Kayed, R., Jun 24 2011, In: Journal of Biological Chemistry. 286, 25, p. 22122-22130 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Amyloid
  • Brain
  • Alzheimer Disease
  • Toxicity
  • In Vitro Techniques
  101 Scopus citations

• ApoE4-driven accumulation of intraneuronal oligomerized Aß42 following activation of the amyloid cascade in vivo is mediated by a gain of function

  Zepa, L., Frenkel, M., Belinson, H., Kariv-Inbal, Z., Kayed, R., Masliah, E. & Michaelson, D. M., 2011, In: International Journal of Alzheimer's Disease. 792070.

  Research output: Contribution to journal › Article › peer-review

  • Apolipoprotein E4
  • Amyloid
  • Apolipoprotein E3
  • Apolipoproteins E
  • Neprilysin
  21 Scopus citations

• Astrocytes contain amyloid-β annular protofibrils in Alzheimer's disease brains

  Lasagna-Reeves, C. A. & Kayed, R., Oct 3 2011, In: FEBS Letters. 585, 19, p. 3052-3057 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Astrocytes
  • Amyloid
  • Brain
  • Alzheimer Disease
  • Conformations
  28 Scopus citations

• Formation of immunoglobulin light chain amyloid oligomers in primary cutaneous nodular amyloidosis

  Clos, A. L., Lasagna-Reeves, C. A., Castillo-Carranza, D. L., Sengupta, U., Jackson, G. R., Kelly, B., Beachkofsky, T. M. & Kayed, R., Dec 1 2011, In: British Journal of Dermatology. 165, 6, p. 1349-1354 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Primary Cutaneous Amyloidosis
  • Immunoglobulin Light Chains
  • Amyloid
  • Immunoglobulins
  • Keratinocytes
  12 Scopus citations

• Role of oligomers in the amyloidogenesis of primary cutaneous amyloidosis

  Clos, A. L., Lasagna-Reeves, C. A., Kelly, B., Wagner, R., Wilkerson, M., Jackson, G. R. & Kayed, R., Nov 1 2011, In: Journal of the American Academy of Dermatology. 65, 5, p. 1023-1031 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Primary Cutaneous Amyloidosis
  • Amyloid
  • Skin
  • antibiotic I-11
  • thioflavin T
  10 Scopus citations

• Tau oligomers as potential targets for immunotherapy for alzheimer's disease and tauopathies

  Lasagna-Reeves, C. A., Castillo-Carranza, D. L., Jackson, G. R. & Kayed, R., Sep 1 2011, In: Current Alzheimer Research. 8, 6, p. 659-665 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Tauopathies
  • Immunotherapy
  • Alzheimer Disease
  • Neurofibrillary Tangles
  • tau Proteins
  57 Scopus citations

• Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice

  Lasagna-Reeves, C. A., Castillo-Carranza, D. L., Sengupta, U., Clos, A. L., Jackson, G. R. & Kayed, R., 2011, In: Molecular Neurodegeneration. 6, 1, 39.

  Research output: Contribution to journal › Article › peer-review

  • Electron Transport Complex I
  • Tauopathies
  • human MAPT protein
  • Alzheimer Disease
  • Septins
  278 Scopus citations
• 2012

  Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau

  Lasagna-Reeves, C. A., Castillo-Carranza, D. L., Sengupta, U., Guerrero-Munoz, M. J., Kiritoshi, T., Neugebauer, V., Jackson, G. R. & Kayed, R., 2012, In: Scientific reports. 2, 700.

  Research output: Contribution to journal › Article › peer-review

  • Pathology
  • Brain
  • Alzheimer Disease
  • Amyloid angiopathy
  • Genetically Modified Animals
  259 Scopus citations

• Association of skin with the pathogenesis and treatment of neurodegenerative amyloidosis

  Clos, A. L., Kayed, R. & Lasagna-Reeves, C. A., 2012, In: Frontiers in Neurology. JAN, Article 5.

  Research output: Contribution to journal › Article › peer-review

  • Amyloidosis
  • Skin
  • Brain
  • Protein Aggregates
  • Amyloid Plaques
  10 Scopus citations

• Differential activation of the ER stress factor XBP1 by oligomeric assemblies

  Castillo-Carranza, D. L., Zhang, Y., Guerrero-Muñoz, M. J., Kayed, R., Rincon-Limas, D. E. & Fernandez-Funez, P., Aug 2012, In: Neurochemical Research. 37, 8, p. 1707-1717 11 p.

  Research output: Contribution to journal › Article › peer-review

  • X-Box Binding Protein 1
  • Factor X
  • Oligomers
  • Amyloid
  • Chemical activation
  25 Scopus citations

• Identification of oligomers at early stages of tau aggregation in Alzheimer's disease

  Lasagna-Reeves, C. A., Castillo-Carranza, D. L., Sengupta, U., Sarmiento, J., Troncoso, J., Jackson, G. R. & Kayed, R., May 2012, In: FASEB Journal. 26, 5, p. 1946-1959 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Oligomers
  • Neurofibrillary Tangles
  • Agglomeration
  • Alzheimer Disease
  • Brain
  241 Scopus citations

• Molecular mechanisms of amyloid oligomers toxicity

  Kayed, R. & Lasagna-Reeves, C. A., Dec 1 2012, Alzheimer'S Disease: Advances For A New Century. Perry, G., Zhu, X., Smith, M., Sorensen, A. & Avila, J. (eds.). p. 67-78 12 p. (Advances in Alzheimer's Disease; vol. 3).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Amyloid
  • Amyloid Plaques
  • Cell Death
  • Poisons
  • Memory
  17 Scopus citations

• Tau protein: Function and pathology

  Rosenmann, H., Blum, D., Kayed, R. & Ittner, L. M., 2012, In: International Journal of Alzheimer's Disease. 707482.

  Research output: Contribution to journal › Editorial › peer-review
  6 Scopus citations

• Vaccination with a non-human random sequence amyloid oligomer mimic results in improved cognitive function and reduced plaque deposition and micro hemorrhage in Tg2576 mice

  Rasool, S., Albay, R., Martinez-Coria, H., Breydo, L., Wu, J., Milton, S., Misra, S., Tran, A., Pensalfini, A., Laferla, F., Kayed, R. & Glabe, C. G., 2012, In: Molecular Neurodegeneration. 7, 1, 37.

  Research output: Contribution to journal › Article › peer-review

  • Amyloid
  • Vaccination
  • Cognition
  • Hemorrhage
  • Vaccines
  29 Scopus citations

• α-Synuclein oligomers oppose long-term potentiation and impair memory through a calcineurin-dependent mechanism: Relevance to human synucleopathic diseases

  Martin, Z. S., Neugebauer, V., Dineley, K. T., Kayed, R., Zhang, W., Reese, L. C. & Taglialatela, G., Feb 2012, In: Journal of neurochemistry. 120, 3, p. 440-452 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Synucleins
  • Oligomers
  • Calcineurin
  • Long-Term Potentiation
  • Memory
  64 Scopus citations
• 2015

  A native interactor scaffolds and stabilizes toxic Ataxin-1 oligomers in SCA1

  Lasagna-Reeves, C. A., Rousseaux, M. W. C., Guerrero-Munoz, M. J., Park, J., Jafar-Nejad, P., Richman, R., Lu, N., Sengupta, U., Litvinchuk, A., Orr, H. T., Kayed, R. & Zoghbi, H. Y., May 19 2015, In: eLife. 4, MAY, p. 1-46 46 p., e07558.

  Research output: Contribution to journal › Article › peer-review

  • Ataxin-1
  • Oligomers
  • Spinocerebellar Ataxias
  • Scaffolds
  • Drive
  16 Scopus citations

• Antibody against Small Aggregated Peptide Specifically Recognizes Toxic Aβ-42 Oligomers in Alzheimer's Disease

  Bodani, R. U., Sengupta, U., Castillo-Carranza, D. L., Guerrero-Muñoz, M. J., Gerson, J. E., Rudra, J. & Kayed, R., Dec 16 2015, In: ACS Chemical Neuroscience. 6, 12, p. 1981-1989 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Oligomers
  • Amyloid
  • Alzheimer Disease
  • Poisons
  • Peptides
  13 Scopus citations

• Ataxin-1 oligomers induce local spread of pathology and decreasing them by passive immunization slows spinocerebellar ataxia type 1 phenotypes

  Lasagna-Reeves, C. A., Rousseaux, M. W. C., Guerrero-Munoz, M. J., Vilanova-Velez, L., Park, J., See, L., Jafar-Nejad, P., Richman, R., Orr, H. T., Kayed, R. & Zoghbi, H. Y., Dec 17 2015, In: eLife. 4, DECEMBER2015, e10891.

  Research output: Contribution to journal › Article › peer-review

  • Ataxin-1
  • Immunization
  • Oligomers
  • Spinocerebellar Ataxias
  • Passive Immunization
  9 Scopus citations

• Pathological Interface between Oligomeric Alpha-Synuclein and Tau in Synucleinopathies

  Sengupta, U., Guerrero-Muñoz, M. J., Castillo-Carranza, D. L., Lasagna-Reeves, C. A., Gerson, J. E., Paulucci-Holthauzen, A. A., Krishnamurthy, S., Farhed, M., Jackson, G. R. & Kayed, R., Nov 15 2015, In: Biological Psychiatry. 78, 10, p. 672-683 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Synucleins
  • alpha-Synuclein
  • Antibodies
  • Brain
  • Lewy Body Disease
  88 Scopus citations

• Prefibrillar Tau oligomers alter the nucleic acid protective function of Tau in hippocampal neurons in vivo

  Violet, M., Chauderlier, A., Delattre, L., Tardivel, M., Chouala, M. S., Sultan, A., Marciniak, E., Humez, S., Binder, L., Kayed, R., Lefebvre, B., Bonnefoy, E., Buée, L. & Galas, M. C., Oct 1 2015, In: Neurobiology of Disease. 82, p. 540-551 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Nucleic Acids
  • Neurons
  • Induced Hyperthermia
  • Alzheimer Disease
  • Pathology
  35 Scopus citations

• Tau immunotherapy modulates both pathological tau and upstream amyloid pathology in an alzheimer’s disease mouse model

  Castillo-Carranza, D. L., Guerrero-Muñoz, M. J., Sengupta, U., Hernandez, C., Barrett, A. D. T., Dineley, K. & Kayed, R., 2015, In: Journal of Neuroscience. 35, 12, p. 4857-4868 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Amyloid
  • Immunotherapy
  • Alzheimer Disease
  • Memory Disorders
  • Pathology
  83 Scopus citations

• The interrelationship of proteasome impairment and oligomeric intermediates in neurodegeneration

  Deger, J. M., Gerson, J. E. & Kayed, R., Oct 1 2015, In: Aging cell. 14, 5, p. 715-724 10 p.

  Research output: Contribution to journal › Review article › peer-review

  • Proteasome Endopeptidase Complex
  • Neurodegenerative Diseases
  • Ubiquitin
  • Sumoylation
  • Amyloidogenic Proteins
  38 Scopus citations
• 2017

  Cerebral microvascular accumulation of tau oligomers in Alzheimer's disease and related tauopathies

  Castillo-Carranza, D. L., Nilson, A. N., Van Skike, C. E., Jahrling, J. B., Patel, K., Garach, P., Gerson, J. E., Sengupta, U., Abisambra, J., Nelson, P., Troncoso, J., Ungvari, Z., Galvan, V. & Kayed, R., 2017, In: Aging and Disease. 8, 3, p. 257-266 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Tauopathies
  • Alzheimer Disease
  • Progressive Supranuclear Palsy
  • Lewy Body Disease
  • Blood Vessels
  32 Scopus citations

• Corrigendum: Pre-amyloid oligomers budding:a metastatic mechanism of proteotoxicity

  Bernini, F., Malferrari, D., Pignataro, M., Bortolotti, C. A., Di Rocco, G., Lancellotti, L., Brigatti, M. F., Kayed, R., Borsari, M., Del Monte, F. & Castellini, E., Jan 19 2017, In: Scientific reports. 7, 1 p.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

• Critical Role of the CXCL10/C-X-C Chemokine Receptor 3 Axis in Promoting Leukocyte Recruitment and Neuronal Injury during Traumatic Optic Neuropathy Induced by Optic Nerve Crush

  Ha, Y., Liu, H., Zhu, S., Yi, P., Liu, W., Nathanson, J., Kayed, R., Loucas, B., Sun, J., Frishman, L. J., Motamedi, M. & Zhang, W., Feb 1 2017, In: American Journal of Pathology. 187, 2, p. 352-365 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Optic Nerve Injuries
  • Nerve Crush
  • CXC Chemokines
  • Chemokine Receptors
  • Optic Nerve
  17 Scopus citations

• Evaluating Tau Oligomers Passive Immunotherapy using Aged Transgenic Animals of Tauopathy

  Al Lahham, R., Bittar, A., Carretero Murillo, M., McAllen, S., Bhatt, N., Ellsworth, A. & Kayed, R., Dec 2017, (Unpublished).

  Research output: Contribution to conference › Poster

  • Tauopathies
  • Genetically Modified Animals
  • Passive Immunization
  • Monoclonal Antibodies
  • Clone Cells

• iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases

  Abud, E. M., Ramirez, R. N., Martinez, E. S., Healy, L. M., Nguyen, C. H. H., Newman, S. A., Yeromin, A. V., Scarfone, V. M., Marsh, S. E., Fimbres, C., Caraway, C. A., Fote, G. M., Madany, A. M., Agrawal, A., Kayed, R., Gylys, K. H., Cahalan, M. D., Cummings, B. J., Antel, J. P., Mortazavi, A. & 3 others, Carson, M. J., Poon, W. W. & Blurton-Jones, M., Apr 19 2017, In: Neuron. 94, 2, p. 278-293.e9

  Research output: Contribution to journal › Article › peer-review

  • Microglia
  • Alzheimer Disease
  • Brain
  • Organoids
  • Gene Expression Profiling
  255 Scopus citations

• Oligomeric tau-targeted immunotherapy in Tg4510 mice

  Schroeder, S., Joly-Amado, A., Soliman, A., Sengupta, U., Kayed, R., Gordon, M. N. & Morgan, D., Jun 27 2017, In: Alzheimer's Research and Therapy. 9, 1, 46.

  Research output: Contribution to journal › Article › peer-review

  • Immunotherapy
  • Monoclonal Antibodies
  • Immunoglobulin G
  • Brain
  • Tauopathies
  7 Scopus citations

• Selective lowering of synapsins induced by oligomeric α-synuclein exacerbates memory deficits

  Larson, M. E., Greimel, S. J., Amar, F., LaCroix, M., Boyle, G., Sherman, M. A., Schley, H., Miel, C., Schneider, J. A., Kayed, R., Benfenati, F., Lee, M. K., Bennett, D. A. & Lesné, S. E., Jun 6 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 23, p. E4648-E4657

  Research output: Contribution to journal › Article › peer-review

  • Synucleins
  • Synapsins
  • Memory Disorders
  • Amyloidogenic Proteins
  • Response Elements
  25 Scopus citations

• Tau oligomers as pathogenic seeds: Preparation and propagation in vitro and in vivo

  Gerson, J. E., Sengupta, U. & Kayed, R., 2017, Methods in Molecular Biology. Humana Press Inc., p. 141-157 17 p. (Methods in Molecular Biology; vol. 1523).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Seeds
  • In Vitro Techniques
  • Neurodegenerative Diseases
  • Poisons
  • Antibodies
  16 Scopus citations

• Tau oligomers associate with inflammation in the brain and retina of tauopathy mice and in neurodegenerative diseases

  Nilson, A. N., English, K. C., Gerson, J. E., Barton Whittle, T., Nicolas Crain, C., Xue, J., Sengupta, U., Castillo-Carranza, D. L., Zhang, W., Gupta, P. & Kayed, R., 2017, In: Journal of Alzheimer's Disease. 55, 3, p. 1083-1099 17 p.

  Research output: Contribution to journal › Article › peer-review

  • Tauopathies
  • Encephalitis
  • Neurodegenerative Diseases
  • Retina
  • Inflammation
  49 Scopus citations

• Tau Oligomers in Sera of Patients with Alzheimer's Disease and Aged Controls

  Kolarova, M., Sengupta, U., Bartos, A., Ricny, J. & Kayed, R., 2017, In: Journal of Alzheimer's Disease. 58, 2, p. 471-478 8 p.

  Research output: Contribution to journal › Article › peer-review

  • tau Proteins
  • Cognitive Dysfunction
  • Alzheimer Disease
  • Serum
  • Extracellular Space
  11 Scopus citations

• The Potential of Small Molecules in Preventing Tau Oligomer Formation and Toxicity

  Gerson, J. E., Lo Cascio, F. & Kayed, R., Jan 20 2017, Neuroprotection in Alzheimer's Disease. Elsevier Inc., p. 97-121 25 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Amyloid
  • Neurodegenerative Diseases
  • Poisons
  • Tauopathies
  • Amyloidogenic Proteins
  1 Scopus citations
• 2019

  Amyloid oligomer interactions and polymorphisms: disease-relevant distinct assembly of α-synuclein and tau

  Sengupta, U. & Kayed, R., Jan 1 2019, In: Neuropsychopharmacology. 44, 1, p. 222-223 2 p.

  Research output: Contribution to journal › Comment/debate › peer-review
  1 Scopus citations

• Near Infrared Light Treatment Reduces Synaptic Levels of Toxic Tau Oligomers in Two Transgenic Mouse Models of Human Tauopathies

  Comerota, M. M., Tumurbaatar, B., Krishnan, B., Kayed, R. & Taglialatela, G., May 1 2019, In: Molecular Neurobiology. 56, 5, p. 3341-3355 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Tauopathies
  • Transgenic Mice
  • Poisons
  • Light
  • Synaptosomes
  5 Scopus citations

• NLRP3 inflammasome activation drives tau pathology

  Ising, C., Venegas, C., Zhang, S., Scheiblich, H., Schmidt, S. V., Vieira-Saecker, A., Schwartz, S., Albasset, S., McManus, R. M., Tejera, D., Griep, A., Santarelli, F., Brosseron, F., Opitz, S., Stunden, J., Merten, M., Kayed, R., Golenbock, D. T., Blum, D., Latz, E. & 2 others, Buée, L. & Heneka, M. T., Nov 28 2019, In: Nature. 575, 7784, p. 669-673 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Inflammasomes
  • Drive
  • Amyloid
  • Pathology
  • Neurofibrillary Tangles
  125 Scopus citations

• Tau Interacts with the C-Terminal Region of α-Synuclein, Promoting Formation of Toxic Aggregates with Distinct Molecular Conformations

  Dasari, A. K. R., Kayed, R., Wi, S. & Lim, K. H., Jun 25 2019, In: Biochemistry. 58, 25, p. 2814-2821 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Molecular Conformation
  • Synucleins
  • Conformations
  • Poisons
  • Agglomeration
  9 Scopus citations

• Tau oligomers mediate aggregation of RNA-binding proteins Musashi1 and Musashi2 inducing Lamin alteration

  Montalbano, M., McAllen, S., Sengupta, U., Puangmalai, N., Bhatt, N., Ellsworth, A. & Kayed, R., Dec 1 2019, In: Aging cell. 18, 6, e13035.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Lamins
  • Tauopathies
  • RNA-Binding Proteins
  • Alzheimer Disease
  • Poisons
  8 Scopus citations

• Toxic Tau Oligomers Modulated by Novel Curcumin Derivatives

  Lo Cascio, F., Puangmalai, N., Ellsworth, A., Bucchieri, F., Pace, A., Palumbo Piccionello, A. & Kayed, R., Dec 1 2019, In: Scientific reports. 9, 1, 19011.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Curcumin
  • Neurodegenerative Diseases
  • Poisons
  • Tauopathies
  • Microtubule-Associated Proteins
  12 Scopus citations