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2011
Amyloid-β annular protofibrils evade fibrillar fate in Alzheimer disease brain
Lasagna-Reeves, C. A., Glabe, C. G. & Kayed, R., Jun 24 2011, In: Journal of Biological Chemistry. 286, 25, p. 22122-22130 9 p.Research output: Contribution to journal › Article › peer-review
100 Scopus citations -
ApoE4-driven accumulation of intraneuronal oligomerized Aß42 following activation of the amyloid cascade in vivo is mediated by a gain of function
Zepa, L., Frenkel, M., Belinson, H., Kariv-Inbal, Z., Kayed, R., Masliah, E. & Michaelson, D. M., 2011, In: International Journal of Alzheimer's Disease. 792070.Research output: Contribution to journal › Article › peer-review
21 Scopus citations -
Astrocytes contain amyloid-β annular protofibrils in Alzheimer's disease brains
Lasagna-Reeves, C. A. & Kayed, R., Oct 3 2011, In: FEBS Letters. 585, 19, p. 3052-3057 6 p.Research output: Contribution to journal › Article › peer-review
28 Scopus citations -
Formation of immunoglobulin light chain amyloid oligomers in primary cutaneous nodular amyloidosis
Clos, A. L., Lasagna-Reeves, C. A., Castillo-Carranza, D. L., Sengupta, U., Jackson, G. R., Kelly, B., Beachkofsky, T. M. & Kayed, R., Dec 1 2011, In: British Journal of Dermatology. 165, 6, p. 1349-1354 6 p.Research output: Contribution to journal › Article › peer-review
12 Scopus citations -
Role of oligomers in the amyloidogenesis of primary cutaneous amyloidosis
Clos, A. L., Lasagna-Reeves, C. A., Kelly, B., Wagner, R., Wilkerson, M., Jackson, G. R. & Kayed, R., Nov 1 2011, In: Journal of the American Academy of Dermatology. 65, 5, p. 1023-1031 9 p.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
Tau oligomers as potential targets for immunotherapy for alzheimer's disease and tauopathies
Lasagna-Reeves, C. A., Castillo-Carranza, D. L., Jackson, G. R. & Kayed, R., Sep 1 2011, In: Current Alzheimer Research. 8, 6, p. 659-665 7 p.Research output: Contribution to journal › Article › peer-review
57 Scopus citations -
Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice
Lasagna-Reeves, C. A., Castillo-Carranza, D. L., Sengupta, U., Clos, A. L., Jackson, G. R. & Kayed, R., 2011, In: Molecular Neurodegeneration. 6, 1, 39.Research output: Contribution to journal › Article › peer-review
270 Scopus citations -
2012
Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau
Lasagna-Reeves, C. A., Castillo-Carranza, D. L., Sengupta, U., Guerrero-Munoz, M. J., Kiritoshi, T., Neugebauer, V., Jackson, G. R. & Kayed, R., 2012, In: Scientific reports. 2, 700.Research output: Contribution to journal › Article › peer-review
256 Scopus citations -
Association of skin with the pathogenesis and treatment of neurodegenerative amyloidosis
Clos, A. L., Kayed, R. & Lasagna-Reeves, C. A., 2012, In: Frontiers in Neurology. JAN, Article 5.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
Differential activation of the ER stress factor XBP1 by oligomeric assemblies
Castillo-Carranza, D. L., Zhang, Y., Guerrero-Muñoz, M. J., Kayed, R., Rincon-Limas, D. E. & Fernandez-Funez, P., Aug 2012, In: Neurochemical Research. 37, 8, p. 1707-1717 11 p.Research output: Contribution to journal › Article › peer-review
25 Scopus citations -
Identification of oligomers at early stages of tau aggregation in Alzheimer's disease
Lasagna-Reeves, C. A., Castillo-Carranza, D. L., Sengupta, U., Sarmiento, J., Troncoso, J., Jackson, G. R. & Kayed, R., May 2012, In: FASEB Journal. 26, 5, p. 1946-1959 14 p.Research output: Contribution to journal › Article › peer-review
236 Scopus citations -
Molecular mechanisms of amyloid oligomers toxicity
Kayed, R. & Lasagna-Reeves, C. A., Dec 1 2012, Alzheimer'S Disease: Advances For A New Century. Perry, G., Zhu, X., Smith, M., Sorensen, A. & Avila, J. (eds.). p. 67-78 12 p. (Advances in Alzheimer's Disease; vol. 3).Research output: Chapter in Book/Report/Conference proceeding › Chapter
17 Scopus citations -
Tau protein: Function and pathology
Rosenmann, H., Blum, D., Kayed, R. & Ittner, L. M., 2012, In: International Journal of Alzheimer's Disease. 707482.Research output: Contribution to journal › Editorial › peer-review
6 Scopus citations -
Vaccination with a non-human random sequence amyloid oligomer mimic results in improved cognitive function and reduced plaque deposition and micro hemorrhage in Tg2576 mice
Rasool, S., Albay, R., Martinez-Coria, H., Breydo, L., Wu, J., Milton, S., Misra, S., Tran, A., Pensalfini, A., Laferla, F., Kayed, R. & Glabe, C. G., 2012, In: Molecular Neurodegeneration. 7, 1, 37.Research output: Contribution to journal › Article › peer-review
29 Scopus citations -
α-Synuclein oligomers oppose long-term potentiation and impair memory through a calcineurin-dependent mechanism: Relevance to human synucleopathic diseases
Martin, Z. S., Neugebauer, V., Dineley, K. T., Kayed, R., Zhang, W., Reese, L. C. & Taglialatela, G., Feb 2012, In: Journal of neurochemistry. 120, 3, p. 440-452 13 p.Research output: Contribution to journal › Article › peer-review
63 Scopus citations -
2016
Advances in tau immunotherapy
Gerson, J. & Kayed, R., Jan 1 2016, Research Progress in Alzheimer’s Disease and Dementia. Volume 6. Nova Science Publishers, Inc., p. 99-114 16 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter
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Aβ Amyloid Pathology Affects the Hearts of Patients With Alzheimer's Disease: Mind the Heart
Troncone, L., Luciani, M., Coggins, M., Wilker, E. H., Ho, C. Y., Codispoti, K. E., Frosch, M. P., Kayed, R. & del Monte, F., Dec 6 2016, In: Journal of the American College of Cardiology. 68, 22, p. 2395-2407 13 p.Research output: Contribution to journal › Article › peer-review
58 Scopus citations -
Caspase-cleaved tau exhibits rapid memory impairment associated with tau oligomers in a transgenic mouse model
Kim, Y., Choi, H., Lee, W., Park, H., Kam, T. I., Hong, S. H., Nah, J., Jung, S., Shin, B., Lee, H., Choi, T. Y., Choo, H., Kim, K. K., Choi, S. Y., Kayed, R. & Jung, Y. K., Mar 1 2016, In: Neurobiology of Disease. 87, p. 19-28 10 p.Research output: Contribution to journal › Article › peer-review
32 Scopus citations -
Oligomer Formation and Cross-Seeding: The New Frontier
Farmer, K., Gerson, J. E. & Kayed, R., 2016, (Accepted/In press) In: Israel Journal of Chemistry.Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
Potential mechanisms and implications for the formation of tau oligomeric strains
Gerson, J. E., Mudher, A. & Kayed, R., Nov 1 2016, In: Critical Reviews in Biochemistry and Molecular Biology. 51, 6, p. 482-496 15 p.Research output: Contribution to journal › Review article › peer-review
25 Scopus citations -
Pre-amyloid oligomers budding: A metastatic mechanism of proteotoxicity
Bernini, F., Malferrari, D., Pignataro, M., Bortolotti, C. A., Di Rocco, G., Lancellotti, L., Brigatti, M. F., Kayed, R., Borsari, M., Del Monte, F. & Castellini, E., Oct 24 2016, In: Scientific reports. 6, 35865.Research output: Contribution to journal › Article › peer-review
8 Scopus citations -
Tau Oligomers Derived from Traumatic Brain Injury Cause Cognitive Impairment and Accelerate Onset of Pathology in Htau Mice
Gerson, J., Castillo-Carranza, D. L., Sengupta, U., Bodani, R., Prough, D. S., DeWitt, D. S., Hawkins, B. E. & Kayed, R., Nov 15 2016, In: Journal of neurotrauma. 33, 22, p. 2034-2043 10 p.Research output: Contribution to journal › Article › peer-review
39 Scopus citations -
Therapeutic approaches targeting pathological tau aggregates
Gerson, J. & Kayed, R., Jul 1 2016, In: Current Pharmaceutical Design. 22, 26, p. 4028-4039 12 p.Research output: Contribution to journal › Review article › peer-review
9 Scopus citations -
The Role of Amyloid-β Oligomers in Toxicity, Propagation, and Immunotherapy
Sengupta, U., Nilson, A. N. & Kayed, R., Apr 1 2016, In: EBioMedicine. 6, p. 42-49 8 p.Research output: Contribution to journal › Review article › peer-review
252 Scopus citations -
2017
Cerebral microvascular accumulation of tau oligomers in Alzheimer's disease and related tauopathies
Castillo-Carranza, D. L., Nilson, A. N., Van Skike, C. E., Jahrling, J. B., Patel, K., Garach, P., Gerson, J. E., Sengupta, U., Abisambra, J., Nelson, P., Troncoso, J., Ungvari, Z., Galvan, V. & Kayed, R., 2017, In: Aging and Disease. 8, 3, p. 257-266 10 p.Research output: Contribution to journal › Article › peer-review
31 Scopus citations -
Corrigendum: Pre-amyloid oligomers budding:a metastatic mechanism of proteotoxicity
Bernini, F., Malferrari, D., Pignataro, M., Bortolotti, C. A., Di Rocco, G., Lancellotti, L., Brigatti, M. F., Kayed, R., Borsari, M., Del Monte, F. & Castellini, E., Jan 19 2017, In: Scientific reports. 7, 1 p.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
Critical Role of the CXCL10/C-X-C Chemokine Receptor 3 Axis in Promoting Leukocyte Recruitment and Neuronal Injury during Traumatic Optic Neuropathy Induced by Optic Nerve Crush
Ha, Y., Liu, H., Zhu, S., Yi, P., Liu, W., Nathanson, J., Kayed, R., Loucas, B., Sun, J., Frishman, L. J., Motamedi, M. & Zhang, W., Feb 1 2017, In: American Journal of Pathology. 187, 2, p. 352-365 14 p.Research output: Contribution to journal › Article › peer-review
17 Scopus citations -
Evaluating Tau Oligomers Passive Immunotherapy using Aged Transgenic Animals of Tauopathy
Al Lahham, R., Bittar, A., Carretero Murillo, M., McAllen, S., Bhatt, N., Ellsworth, A. & Kayed, R., Dec 2017, (Unpublished).Research output: Contribution to conference › Poster
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iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases
Abud, E. M., Ramirez, R. N., Martinez, E. S., Healy, L. M., Nguyen, C. H. H., Newman, S. A., Yeromin, A. V., Scarfone, V. M., Marsh, S. E., Fimbres, C., Caraway, C. A., Fote, G. M., Madany, A. M., Agrawal, A., Kayed, R., Gylys, K. H., Cahalan, M. D., Cummings, B. J., Antel, J. P., Mortazavi, A. & 3 others, , Apr 19 2017, In: Neuron. 94, 2, p. 278-293.e9Research output: Contribution to journal › Article › peer-review
248 Scopus citations -
Oligomeric tau-targeted immunotherapy in Tg4510 mice
Schroeder, S., Joly-Amado, A., Soliman, A., Sengupta, U., Kayed, R., Gordon, M. N. & Morgan, D., Jun 27 2017, In: Alzheimer's Research and Therapy. 9, 1, 46.Research output: Contribution to journal › Article › peer-review
7 Scopus citations -
Selective lowering of synapsins induced by oligomeric α-synuclein exacerbates memory deficits
Larson, M. E., Greimel, S. J., Amar, F., LaCroix, M., Boyle, G., Sherman, M. A., Schley, H., Miel, C., Schneider, J. A., Kayed, R., Benfenati, F., Lee, M. K., Bennett, D. A. & Lesné, S. E., Jun 6 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 23, p. E4648-E4657Research output: Contribution to journal › Article › peer-review
24 Scopus citations -
Tau oligomers as pathogenic seeds: Preparation and propagation in vitro and in vivo
Gerson, J. E., Sengupta, U. & Kayed, R., 2017, Methods in Molecular Biology. Humana Press Inc., Vol. 1523. p. 141-157 17 p. (Methods in Molecular Biology; vol. 1523).Research output: Chapter in Book/Report/Conference proceeding › Chapter
15 Scopus citations -
Tau oligomers associate with inflammation in the brain and retina of tauopathy mice and in neurodegenerative diseases
Nilson, A. N., English, K. C., Gerson, J. E., Barton Whittle, T., Nicolas Crain, C., Xue, J., Sengupta, U., Castillo-Carranza, D. L., Zhang, W., Gupta, P. & Kayed, R., 2017, In: Journal of Alzheimer's Disease. 55, 3, p. 1083-1099 17 p.Research output: Contribution to journal › Article › peer-review
45 Scopus citations -
Tau Oligomers in Sera of Patients with Alzheimer's Disease and Aged Controls
Kolarova, M., Sengupta, U., Bartos, A., Ricny, J. & Kayed, R., 2017, In: Journal of Alzheimer's Disease. 58, 2, p. 471-478 8 p.Research output: Contribution to journal › Article › peer-review
11 Scopus citations -
The Potential of Small Molecules in Preventing Tau Oligomer Formation and Toxicity
Gerson, J. E., Lo Cascio, F. & Kayed, R., Jan 20 2017, Neuroprotection in Alzheimer's Disease. Elsevier Inc., p. 97-121 25 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter
1 Scopus citations -
2019
Amyloid oligomer interactions and polymorphisms: disease-relevant distinct assembly of α-synuclein and tau
Sengupta, U. & Kayed, R., Jan 1 2019, In: Neuropsychopharmacology. 44, 1, p. 222-223 2 p.Research output: Contribution to journal › Comment/debate › peer-review
1 Scopus citations -
Near Infrared Light Treatment Reduces Synaptic Levels of Toxic Tau Oligomers in Two Transgenic Mouse Models of Human Tauopathies
Comerota, M. M., Tumurbaatar, B., Krishnan, B., Kayed, R. & Taglialatela, G., May 1 2019, In: Molecular Neurobiology. 56, 5, p. 3341-3355 15 p.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
NLRP3 inflammasome activation drives tau pathology
Ising, C., Venegas, C., Zhang, S., Scheiblich, H., Schmidt, S. V., Vieira-Saecker, A., Schwartz, S., Albasset, S., McManus, R. M., Tejera, D., Griep, A., Santarelli, F., Brosseron, F., Opitz, S., Stunden, J., Merten, M., Kayed, R., Golenbock, D. T., Blum, D., Latz, E. & 2 others, , Nov 28 2019, In: Nature. 575, 7784, p. 669-673 5 p.Research output: Contribution to journal › Article › peer-review
109 Scopus citations -
Tau Interacts with the C-Terminal Region of α-Synuclein, Promoting Formation of Toxic Aggregates with Distinct Molecular Conformations
Dasari, A. K. R., Kayed, R., Wi, S. & Lim, K. H., Jun 25 2019, In: Biochemistry. 58, 25, p. 2814-2821 8 p.Research output: Contribution to journal › Article › peer-review
6 Scopus citations -
Tau oligomers mediate aggregation of RNA-binding proteins Musashi1 and Musashi2 inducing Lamin alteration
Montalbano, M., McAllen, S., Sengupta, U., Puangmalai, N., Bhatt, N., Ellsworth, A. & Kayed, R., Dec 1 2019, In: Aging cell. 18, 6, e13035.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Toxic Tau Oligomers Modulated by Novel Curcumin Derivatives
Lo Cascio, F., Puangmalai, N., Ellsworth, A., Bucchieri, F., Pace, A., Palumbo Piccionello, A. & Kayed, R., Dec 1 2019, In: Scientific reports. 9, 1, 19011.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
2020
Advances and considerations in AD tau-targeted immunotherapy
Bittar, A., Bhatt, N. & Kayed, R., Feb 2020, In: Neurobiology of Disease. 134, 104707.Research output: Contribution to journal › Review article › peer-review
Open Access14 Scopus citations -
Functional Integrity of Synapses in the Central Nervous System of Cognitively Intact Individuals with High Alzheimer's Disease Neuropathology Is Associated with Absence of Synaptic Tau Oligomers
Singh, A., Allen, D., Fracassi, A., Tumurbaatar, B., Natarajan, C., Scaduto, P., Woltjer, R., Kayed, R., Limon, A., Krishnan, B., Taglialatela, G. & Abisambra, J., 2020, In: Journal of Alzheimer's Disease. 78, 4, p. 1661-1678 18 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Internalization mechanisms of brain-derived tau oligomers from patients with Alzheimer’s disease, progressive supranuclear palsy and dementia with Lewy bodies
Puangmalai, N., Bhatt, N., Montalbano, M., Sengupta, U., Gaikwad, S., Ventura, F., McAllen, S., Ellsworth, A., Garcia, S. & Kayed, R., May 1 2020, In: Cell Death and Disease. 11, 5, 314.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
Modulating disease-relevant tau oligomeric strains by small molecules
Cascio, F. L., Garcia, S., Montalbano, M., Puangmalai, N., McAllen, S., Pace, A., Piccionello, A. P. & Kayed, R., Oct 30 2020, In: Journal of Biological Chemistry. 295, 44, p. 14807-14825 19 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
P53 aggregation, interactions with tau, and impaired DNA damage response in Alzheimer's disease
Farmer, K. M., Ghag, G., Puangmalai, N., Montalbano, M., Bhatt, N. & Kayed, R., Aug 10 2020, In: Acta Neuropathologica Communications. 8, 1, 132.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Polymorphic α-Synuclein Strains Modified by Dopamine and Docosahexaenoic Acid Interact Differentially with Tau Protein
Sengupta, U., Puangmalai, N., Bhatt, N., Garcia, S., Zhao, Y. & Kayed, R., Jun 1 2020, In: Molecular Neurobiology. 57, 6, p. 2741-2765 25 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Revisiting the intersection of amyloid, pathologically modified tau and iron in Alzheimer's disease from a ferroptosis perspective
Derry, P. J., Hegde, M. L., Jackson, G. R., Kayed, R., Tour, J. M., Tsai, A. L. & Kent, T. A., Jan 2020, In: Progress in Neurobiology. 184, 101716.Research output: Contribution to journal › Review article › peer-review
Open Access11 Scopus citations -
RNA-binding proteins Musashi and tau soluble aggregates initiate nuclear dysfunction
Montalbano, M., McAllen, S., Puangmalai, N., Sengupta, U., Bhatt, N., Johnson, O. D., Kharas, M. G. & Kayed, R., Dec 1 2020, In: Nature communications. 11, 1, 4305.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Soluble endogenous oligomeric α-synuclein species in neurodegenerative diseases: Expression, spreading, and cross-talk
Kayed, R., Dettmer, U. & Lesné, S. E., 2020, In: Journal of Parkinson's Disease. 10, 3, p. 791-818 28 p.Research output: Contribution to journal › Review article › peer-review
Open Access1 Scopus citations