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2012
Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau
Lasagna-Reeves, C. A., Castillo-Carranza, D. L., Sengupta, U., Guerrero-Munoz, M. J., Kiritoshi, T., Neugebauer, V., Jackson, G. R. & Kayed, R., 2012, In: Scientific reports. 2, 700.Research output: Contribution to journal › Article › peer-review
256 Scopus citations -
Association of skin with the pathogenesis and treatment of neurodegenerative amyloidosis
Clos, A. L., Kayed, R. & Lasagna-Reeves, C. A., 2012, In: Frontiers in Neurology. JAN, Article 5.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
Differential activation of the ER stress factor XBP1 by oligomeric assemblies
Castillo-Carranza, D. L., Zhang, Y., Guerrero-Muñoz, M. J., Kayed, R., Rincon-Limas, D. E. & Fernandez-Funez, P., Aug 2012, In: Neurochemical Research. 37, 8, p. 1707-1717 11 p.Research output: Contribution to journal › Article › peer-review
25 Scopus citations -
Identification of oligomers at early stages of tau aggregation in Alzheimer's disease
Lasagna-Reeves, C. A., Castillo-Carranza, D. L., Sengupta, U., Sarmiento, J., Troncoso, J., Jackson, G. R. & Kayed, R., May 2012, In: FASEB Journal. 26, 5, p. 1946-1959 14 p.Research output: Contribution to journal › Article › peer-review
236 Scopus citations -
Molecular mechanisms of amyloid oligomers toxicity
Kayed, R. & Lasagna-Reeves, C. A., Dec 1 2012, Alzheimer'S Disease: Advances For A New Century. Perry, G., Zhu, X., Smith, M., Sorensen, A. & Avila, J. (eds.). p. 67-78 12 p. (Advances in Alzheimer's Disease; vol. 3).Research output: Chapter in Book/Report/Conference proceeding › Chapter
17 Scopus citations -
Tau protein: Function and pathology
Rosenmann, H., Blum, D., Kayed, R. & Ittner, L. M., 2012, In: International Journal of Alzheimer's Disease. 707482.Research output: Contribution to journal › Editorial › peer-review
6 Scopus citations -
Vaccination with a non-human random sequence amyloid oligomer mimic results in improved cognitive function and reduced plaque deposition and micro hemorrhage in Tg2576 mice
Rasool, S., Albay, R., Martinez-Coria, H., Breydo, L., Wu, J., Milton, S., Misra, S., Tran, A., Pensalfini, A., Laferla, F., Kayed, R. & Glabe, C. G., 2012, In: Molecular Neurodegeneration. 7, 1, 37.Research output: Contribution to journal › Article › peer-review
29 Scopus citations -
α-Synuclein oligomers oppose long-term potentiation and impair memory through a calcineurin-dependent mechanism: Relevance to human synucleopathic diseases
Martin, Z. S., Neugebauer, V., Dineley, K. T., Kayed, R., Zhang, W., Reese, L. C. & Taglialatela, G., Feb 2012, In: Journal of neurochemistry. 120, 3, p. 440-452 13 p.Research output: Contribution to journal › Article › peer-review
63 Scopus citations -
2013
Accelerated neurodegeneration through chaperone-mediated oligomerization of tau
Blair, L. J., Nordhues, B. A., Hill, S. E., Scaglione, K. M., O'Leary, J. C., Fontaine, S. N., Breydo, L., Zhang, B., Li, P., Wang, L., Cotman, C., Paulson, H. L., Muschol, M., Uversky, V. N., Klengel, T., Binder, E. B., Kayed, R., Golde, T. E., Berchtold, N. & Dickey, C. A., Oct 1 2013, In: Journal of Clinical Investigation. 123, 10, p. 4158-4169 12 p.Research output: Contribution to journal › Article › peer-review
128 Scopus citations -
Design of metastable β-sheet oligomers from natively unstructured peptide
Guerrero-Muñoz, M. J., Castillo-Carranza, D. L., Sengupta, U., White, M. A. & Kayed, R., Dec 18 2013, In: ACS chemical neuroscience. 4, 12, p. 1520-1523 4 p.Research output: Contribution to journal › Article › peer-review
9 Scopus citations -
Dual role of p53 amyloid formation in cancer; loss of function and gain of toxicity
Lasagna-Reeves, C. A., Clos, A. L., Castillo-Carranza, D., Sengupta, U., Guerrero-Muñoz, M., Kelly, B., Wagner, R. & Kayed, R., Jan 18 2013, In: Biochemical and Biophysical Research Communications. 430, 3, p. 963-968 6 p.Research output: Contribution to journal › Article › peer-review
48 Scopus citations -
Formation and propagation of tau oligomeric seeds
Gerson, J. E. & Kayed, R., Sep 11 2013, In: Frontiers in Neurology. 4 JUL, Article 93.Research output: Contribution to journal › Review article › peer-review
66 Scopus citations -
Molecular mechanisms of amyloid oligomers toxicity
Kayed, R. & Lasagna-Reeves, C. A., 2013, In: Journal of Alzheimer's Disease. 33, SUPPL. 1, p. S67-S78Research output: Contribution to journal › Review article › peer-review
210 Scopus citations -
Molecular mechanisms of amyloid oligomers toxicity
Kayed, R. & Lasagna-Reeves, C. A., Feb 15 2013, Alzheimer's Disease: Advances for a New Century. IOS Press, p. 67-78 12 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter
2 Scopus citations -
Rapid accumulation of endogenous Tau oligomers in a rat model of traumatic brain injury: Possible link between traumatic brain injury and sporadic tauopathies
Hawkins, B. E., Krishnamurthy, S., Castillo-Carranza, D. L., Sengupta, U., Prough, D. S., Jackson, G. R., DeWitt, D. S. & Kayed, R., Jun 7 2013, In: Journal of Biological Chemistry. 288, 23, p. 17042-17050 9 p.Research output: Contribution to journal › Article › peer-review
90 Scopus citations -
Small misfolded tau species are internalized via bulk endocytosis and anterogradely and retrogradely transported in neurons
Wu, J. W., Herman, M., Liu, L., Simoes, S., Acker, C. M., Figueroa, H., Steinberg, J. I., Margittai, M., Kayed, R., Zurzolo, C., Di Paolo, G. & Duff, K. E., Jan 18 2013, In: Journal of Biological Chemistry. 288, 3, p. 1856-1870 15 p.Research output: Contribution to journal › Article › peer-review
273 Scopus citations -
Tau aggregates as immunotherapeutic targets
Castillo-Carranza, D. L., Lasagna-Reeves, C. A. & Kayed, R., Jan 1 2013, In: Frontiers in Bioscience - Scholar. 5 S, 2, p. 426-438 13 p.Research output: Contribution to journal › Article › peer-review
30 Scopus citations -
2017
Cerebral microvascular accumulation of tau oligomers in Alzheimer's disease and related tauopathies
Castillo-Carranza, D. L., Nilson, A. N., Van Skike, C. E., Jahrling, J. B., Patel, K., Garach, P., Gerson, J. E., Sengupta, U., Abisambra, J., Nelson, P., Troncoso, J., Ungvari, Z., Galvan, V. & Kayed, R., 2017, In: Aging and Disease. 8, 3, p. 257-266 10 p.Research output: Contribution to journal › Article › peer-review
31 Scopus citations -
Corrigendum: Pre-amyloid oligomers budding:a metastatic mechanism of proteotoxicity
Bernini, F., Malferrari, D., Pignataro, M., Bortolotti, C. A., Di Rocco, G., Lancellotti, L., Brigatti, M. F., Kayed, R., Borsari, M., Del Monte, F. & Castellini, E., Jan 19 2017, In: Scientific reports. 7, 1 p.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
Critical Role of the CXCL10/C-X-C Chemokine Receptor 3 Axis in Promoting Leukocyte Recruitment and Neuronal Injury during Traumatic Optic Neuropathy Induced by Optic Nerve Crush
Ha, Y., Liu, H., Zhu, S., Yi, P., Liu, W., Nathanson, J., Kayed, R., Loucas, B., Sun, J., Frishman, L. J., Motamedi, M. & Zhang, W., Feb 1 2017, In: American Journal of Pathology. 187, 2, p. 352-365 14 p.Research output: Contribution to journal › Article › peer-review
17 Scopus citations -
Evaluating Tau Oligomers Passive Immunotherapy using Aged Transgenic Animals of Tauopathy
Al Lahham, R., Bittar, A., Carretero Murillo, M., McAllen, S., Bhatt, N., Ellsworth, A. & Kayed, R., Dec 2017, (Unpublished).Research output: Contribution to conference › Poster
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iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases
Abud, E. M., Ramirez, R. N., Martinez, E. S., Healy, L. M., Nguyen, C. H. H., Newman, S. A., Yeromin, A. V., Scarfone, V. M., Marsh, S. E., Fimbres, C., Caraway, C. A., Fote, G. M., Madany, A. M., Agrawal, A., Kayed, R., Gylys, K. H., Cahalan, M. D., Cummings, B. J., Antel, J. P., Mortazavi, A. & 3 others, , Apr 19 2017, In: Neuron. 94, 2, p. 278-293.e9Research output: Contribution to journal › Article › peer-review
248 Scopus citations -
Oligomeric tau-targeted immunotherapy in Tg4510 mice
Schroeder, S., Joly-Amado, A., Soliman, A., Sengupta, U., Kayed, R., Gordon, M. N. & Morgan, D., Jun 27 2017, In: Alzheimer's Research and Therapy. 9, 1, 46.Research output: Contribution to journal › Article › peer-review
7 Scopus citations -
Selective lowering of synapsins induced by oligomeric α-synuclein exacerbates memory deficits
Larson, M. E., Greimel, S. J., Amar, F., LaCroix, M., Boyle, G., Sherman, M. A., Schley, H., Miel, C., Schneider, J. A., Kayed, R., Benfenati, F., Lee, M. K., Bennett, D. A. & Lesné, S. E., Jun 6 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 23, p. E4648-E4657Research output: Contribution to journal › Article › peer-review
24 Scopus citations -
Tau oligomers as pathogenic seeds: Preparation and propagation in vitro and in vivo
Gerson, J. E., Sengupta, U. & Kayed, R., 2017, Methods in Molecular Biology. Humana Press Inc., Vol. 1523. p. 141-157 17 p. (Methods in Molecular Biology; vol. 1523).Research output: Chapter in Book/Report/Conference proceeding › Chapter
15 Scopus citations -
Tau oligomers associate with inflammation in the brain and retina of tauopathy mice and in neurodegenerative diseases
Nilson, A. N., English, K. C., Gerson, J. E., Barton Whittle, T., Nicolas Crain, C., Xue, J., Sengupta, U., Castillo-Carranza, D. L., Zhang, W., Gupta, P. & Kayed, R., 2017, In: Journal of Alzheimer's Disease. 55, 3, p. 1083-1099 17 p.Research output: Contribution to journal › Article › peer-review
45 Scopus citations -
Tau Oligomers in Sera of Patients with Alzheimer's Disease and Aged Controls
Kolarova, M., Sengupta, U., Bartos, A., Ricny, J. & Kayed, R., 2017, In: Journal of Alzheimer's Disease. 58, 2, p. 471-478 8 p.Research output: Contribution to journal › Article › peer-review
11 Scopus citations -
The Potential of Small Molecules in Preventing Tau Oligomer Formation and Toxicity
Gerson, J. E., Lo Cascio, F. & Kayed, R., Jan 20 2017, Neuroprotection in Alzheimer's Disease. Elsevier Inc., p. 97-121 25 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter
1 Scopus citations -
2018
AAV2-mediated GRP78 transfer alleviates retinal neuronal injury by downregulating ER stress and Tau oligomer formation
Ha, Y., Liu, W., Liu, H., Zhu, S., Xia, F., Gerson, J. E., Azhar, N. A., Tilton, R. G., Motamedi, M., Kayed, R. & Zhang, W., Sep 2018, In: Investigative Ophthalmology and Visual Science. 59, 11, p. 4670-4682 13 p.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
Azure C Targets and Modulates Toxic Tau Oligomers
Lo Cascio, F. & Kayed, R., Jun 20 2018, In: ACS Chemical Neuroscience. 9, 6, p. 1317-1326 10 p.Research output: Contribution to journal › Article › peer-review
17 Scopus citations -
Binding and neurotoxicity mitigation of toxic tau oligomers by synthetic heparin like oligosaccharides
Wang, P., Lo Cascio, F., Gao, J., Kayed, R. & Huang, X., 2018, In: Chemical Communications. 54, 72, p. 10120-10123 4 p.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
Elevated phospholipase D isoform 1 in Alzheimer's disease patients’ hippocampus: Relevance to synaptic dysfunction and memory deficits
Krishnan, B., Kayed, R. & Taglialatela, G., 2018, In: Alzheimer's and Dementia: Translational Research and Clinical Interventions. 4, p. 89-102 14 p.Research output: Contribution to journal › Article › peer-review
12 Scopus citations -
Evaluating Passive Immunotherapy using Aged Transgenic Animals of Tauopathy
Al Lahham, R., Bittar, A., Montalbano, M., Carretero Murillo, M., McAllen, S., Bhatt, N., Ellsworth, A. & Kayed, R., Apr 2018, (Unpublished).Research output: Contribution to conference › Poster › peer-review
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Evaluating Tau Oligomers Passive Immunotherapy using Aged Transgenic Animals of Tauopathy
Al Lahham, R., Bittar, A., Montalbano, M., Carretero Murillo, M., McAllen, S., Bhatt, N., Ellsworth, A. & Kayed, R., Jul 2018, In: Alzheimer's and Dementia. 14, 7, p. 1657Research output: Contribution to journal › Meeting Abstract › peer-review
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Formation of Toxic Oligomeric Assemblies of RNA-binding Protein: Musashi in Alzheimer's disease
Sengupta, U., Montalbano, M., McAllen, S., Minuesa, G., Kharas, M. & Kayed, R., Oct 26 2018, In: Acta Neuropathologica Communications. 6, 1, p. 113 1 p.Research output: Contribution to journal › Article › peer-review
8 Scopus citations -
Immunotherapy Targeting Tau Oligomeric Strains in Aged Transgenic Animals of Tauopathy
Al Lahham, R., Bittar, A., Carretero Murillo, M., McAllen, S., Bhatt, N., Ellsworth, A. & Kayed, R., Oct 2018, p. S64.Research output: Contribution to conference › Abstract › peer-review
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Preparation and characterization of tau oligomer strains
Sengupta, U., Carretero-Murillo, M. & Kayed, R., Jan 1 2018, Methods in Molecular Biology. Humana Press Inc., p. 113-146 34 p. (Methods in Molecular Biology; vol. 1779).Research output: Chapter in Book/Report/Conference proceeding › Chapter
6 Scopus citations -
Prospects for strain-specific immunotherapy in Alzheimer's disease and tauopathies
Bittar, A., Sengupta, U. & Kayed, R., Dec 1 2018, In: npj Vaccines. 3, 1, 9.Research output: Contribution to journal › Article › peer-review
24 Scopus citations -
Soluble tau aggregates, not large fibrils, are the toxic species that display seeding and cross-seeding behavior
Ghag, G., Bhatt, N., Cantu, D. V., Guerrero-Munoz, M. J., Ellsworth, A., Sengupta, U. & Kayed, R., Nov 2018, In: Protein Science. 27, 11, p. 1901-1909 9 p.Research output: Contribution to journal › Article › peer-review
21 Scopus citations -
Tau Immunotherapy for Alpha-Synucleinopathy
Aguilar, C., Al Lahham, R., Sengupta, U., Carretero Murillo, M., Kayed, R. & Dineley, K., Jul 2018, In: Alzheimer's and Dementia. 14, 7, p. 1412Research output: Contribution to journal › Article › peer-review
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Tau Immunotherapy for Alpha-Synucleinopathy
Aguilar, C., Al Lahham, R., Sengupta, U., Carretero Murillo, M., Kayed, R. & Dineley, K., Jul 2018, In: Alzheimer's and Dementia. 14, 7, p. 1442Research output: Contribution to journal › Meeting Abstract › peer-review
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Tau oligomers mediate α-synuclein toxicity and can be targeted by immunotherapy
Gerson, J. E., Farmer, K. M., Henson, N., Castillo-Carranza, D. L., Carretero Murillo, M., Sengupta, U., Barrett, A. & Kayed, R., Mar 15 2018, In: Molecular Neurodegeneration. 13, 1, 13.Research output: Contribution to journal › Article › peer-review
21 Scopus citations -
α-Synuclein Oligomers Induce a Unique Toxic Tau Strain
Castillo-Carranza, D. L., Guerrero-Muñoz, M. J., Sengupta, U., Gerson, J. E. & Kayed, R., Oct 1 2018, In: Biological Psychiatry. 84, 7, p. 499-508 10 p.Research output: Contribution to journal › Article › peer-review
28 Scopus citations -
2019
Amyloid oligomer interactions and polymorphisms: disease-relevant distinct assembly of α-synuclein and tau
Sengupta, U. & Kayed, R., Jan 1 2019, In: Neuropsychopharmacology. 44, 1, p. 222-223 2 p.Research output: Contribution to journal › Comment/debate › peer-review
1 Scopus citations -
Near Infrared Light Treatment Reduces Synaptic Levels of Toxic Tau Oligomers in Two Transgenic Mouse Models of Human Tauopathies
Comerota, M. M., Tumurbaatar, B., Krishnan, B., Kayed, R. & Taglialatela, G., May 1 2019, In: Molecular Neurobiology. 56, 5, p. 3341-3355 15 p.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
NLRP3 inflammasome activation drives tau pathology
Ising, C., Venegas, C., Zhang, S., Scheiblich, H., Schmidt, S. V., Vieira-Saecker, A., Schwartz, S., Albasset, S., McManus, R. M., Tejera, D., Griep, A., Santarelli, F., Brosseron, F., Opitz, S., Stunden, J., Merten, M., Kayed, R., Golenbock, D. T., Blum, D., Latz, E. & 2 others, , Nov 28 2019, In: Nature. 575, 7784, p. 669-673 5 p.Research output: Contribution to journal › Article › peer-review
109 Scopus citations -
Tau Interacts with the C-Terminal Region of α-Synuclein, Promoting Formation of Toxic Aggregates with Distinct Molecular Conformations
Dasari, A. K. R., Kayed, R., Wi, S. & Lim, K. H., Jun 25 2019, In: Biochemistry. 58, 25, p. 2814-2821 8 p.Research output: Contribution to journal › Article › peer-review
6 Scopus citations -
Tau oligomers mediate aggregation of RNA-binding proteins Musashi1 and Musashi2 inducing Lamin alteration
Montalbano, M., McAllen, S., Sengupta, U., Puangmalai, N., Bhatt, N., Ellsworth, A. & Kayed, R., Dec 1 2019, In: Aging cell. 18, 6, e13035.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Toxic Tau Oligomers Modulated by Novel Curcumin Derivatives
Lo Cascio, F., Puangmalai, N., Ellsworth, A., Bucchieri, F., Pace, A., Palumbo Piccionello, A. & Kayed, R., Dec 1 2019, In: Scientific reports. 9, 1, 19011.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
2020
Advances and considerations in AD tau-targeted immunotherapy
Bittar, A., Bhatt, N. & Kayed, R., Feb 2020, In: Neurobiology of Disease. 134, 104707.Research output: Contribution to journal › Review article › peer-review
Open Access14 Scopus citations