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• 2019

  Amyloid oligomer interactions and polymorphisms: disease-relevant distinct assembly of α-synuclein and tau

  Sengupta, U. & Kayed, R., Jan 1 2019, In: Neuropsychopharmacology. 44, 1, p. 222-223 2 p.

  Research output: Contribution to journal › Comment/debate › peer-review
  1 Scopus citations

• Near Infrared Light Treatment Reduces Synaptic Levels of Toxic Tau Oligomers in Two Transgenic Mouse Models of Human Tauopathies

  Comerota, M. M., Tumurbaatar, B., Krishnan, B., Kayed, R. & Taglialatela, G., May 1 2019, In: Molecular Neurobiology. 56, 5, p. 3341-3355 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Tauopathies
  • Transgenic Mice
  • Poisons
  • Light
  • Synaptosomes
  5 Scopus citations

• NLRP3 inflammasome activation drives tau pathology

  Ising, C., Venegas, C., Zhang, S., Scheiblich, H., Schmidt, S. V., Vieira-Saecker, A., Schwartz, S., Albasset, S., McManus, R. M., Tejera, D., Griep, A., Santarelli, F., Brosseron, F., Opitz, S., Stunden, J., Merten, M., Kayed, R., Golenbock, D. T., Blum, D., Latz, E. & 2 others, Buée, L. & Heneka, M. T., Nov 28 2019, In: Nature. 575, 7784, p. 669-673 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Inflammasomes
  • Drive
  • Amyloid
  • Pathology
  • Neurofibrillary Tangles
  109 Scopus citations

• Tau Interacts with the C-Terminal Region of α-Synuclein, Promoting Formation of Toxic Aggregates with Distinct Molecular Conformations

  Dasari, A. K. R., Kayed, R., Wi, S. & Lim, K. H., Jun 25 2019, In: Biochemistry. 58, 25, p. 2814-2821 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Molecular Conformation
  • Synucleins
  • Conformations
  • Poisons
  • Agglomeration
  6 Scopus citations

• Tau oligomers mediate aggregation of RNA-binding proteins Musashi1 and Musashi2 inducing Lamin alteration

  Montalbano, M., McAllen, S., Sengupta, U., Puangmalai, N., Bhatt, N., Ellsworth, A. & Kayed, R., Dec 1 2019, In: Aging cell. 18, 6, e13035.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Lamins
  • Tauopathies
  • RNA-Binding Proteins
  • Alzheimer Disease
  • Poisons
  7 Scopus citations

• Toxic Tau Oligomers Modulated by Novel Curcumin Derivatives

  Lo Cascio, F., Puangmalai, N., Ellsworth, A., Bucchieri, F., Pace, A., Palumbo Piccionello, A. & Kayed, R., Dec 1 2019, In: Scientific reports. 9, 1, 19011.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Curcumin
  • Neurodegenerative Diseases
  • Poisons
  • Tauopathies
  • Microtubule-Associated Proteins
  12 Scopus citations
• 2020

  Advances and considerations in AD tau-targeted immunotherapy

  Bittar, A., Bhatt, N. & Kayed, R., Feb 2020, In: Neurobiology of Disease. 134, 104707.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Immunotherapy
  • Alzheimer Disease
  • tau Proteins
  • Amyloid
  • Direction compound
  14 Scopus citations

• Functional Integrity of Synapses in the Central Nervous System of Cognitively Intact Individuals with High Alzheimer's Disease Neuropathology Is Associated with Absence of Synaptic Tau Oligomers

  Singh, A., Allen, D., Fracassi, A., Tumurbaatar, B., Natarajan, C., Scaduto, P., Woltjer, R., Kayed, R., Limon, A., Krishnan, B., Taglialatela, G. & Abisambra, J., 2020, In: Journal of Alzheimer's Disease. 78, 4, p. 1661-1678 18 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Neuropathology
  • Synapses
  • Alzheimer Disease
  • Central Nervous System
  • Cognitive Dysfunction

• Internalization mechanisms of brain-derived tau oligomers from patients with Alzheimer’s disease, progressive supranuclear palsy and dementia with Lewy bodies

  Puangmalai, N., Bhatt, N., Montalbano, M., Sengupta, U., Gaikwad, S., Ventura, F., McAllen, S., Ellsworth, A., Garcia, S. & Kayed, R., May 1 2020, In: Cell Death and Disease. 11, 5, 314.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Progressive Supranuclear Palsy
  • Lewy Body Disease
  • Heparan Sulfate Proteoglycans
  • Alzheimer Disease
  • Brain
  12 Scopus citations

• Modulating disease-relevant tau oligomeric strains by small molecules

  Cascio, F. L., Garcia, S., Montalbano, M., Puangmalai, N., McAllen, S., Pace, A., Piccionello, A. P. & Kayed, R., Oct 30 2020, In: Journal of Biological Chemistry. 295, 44, p. 14807-14825 19 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Oligomers
  • Tauopathies
  • Molecules
  • Brain
  • Agglomeration
  1 Scopus citations

• P53 aggregation, interactions with tau, and impaired DNA damage response in Alzheimer's disease

  Farmer, K. M., Ghag, G., Puangmalai, N., Montalbano, M., Bhatt, N. & Kayed, R., Aug 10 2020, In: Acta Neuropathologica Communications. 8, 1, 132.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • DNA Damage
  • Alzheimer Disease
  • Brain
  • Neurodegenerative Diseases
  • Transcription Factors
  3 Scopus citations

• Polymorphic α-Synuclein Strains Modified by Dopamine and Docosahexaenoic Acid Interact Differentially with Tau Protein

  Sengupta, U., Puangmalai, N., Bhatt, N., Garcia, S., Zhao, Y. & Kayed, R., Jun 1 2020, In: Molecular Neurobiology. 57, 6, p. 2741-2765 25 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Synucleins
  • tau Proteins
  • Docosahexaenoic Acids
  • Parkinson Disease
  • Dopamine
  2 Scopus citations

• Revisiting the intersection of amyloid, pathologically modified tau and iron in Alzheimer's disease from a ferroptosis perspective

  Derry, P. J., Hegde, M. L., Jackson, G. R., Kayed, R., Tour, J. M., Tsai, A. L. & Kent, T. A., Jan 2020, In: Progress in Neurobiology. 184, 101716.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Amyloid
  • Iron
  • Alzheimer Disease
  • Metals
  • Oxidative Stress
  11 Scopus citations

• RNA-binding proteins Musashi and tau soluble aggregates initiate nuclear dysfunction

  Montalbano, M., McAllen, S., Puangmalai, N., Sengupta, U., Bhatt, N., Johnson, O. D., Kharas, M. G. & Kayed, R., Dec 1 2020, In: Nature communications. 11, 1, 4305.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • RNA-Binding Proteins
  • proteins
  • Alzheimer Disease
  • Frontotemporal Dementia With Motor Neuron Disease
  • Neurodegenerative diseases
  2 Scopus citations

• Soluble endogenous oligomeric α-synuclein species in neurodegenerative diseases: Expression, spreading, and cross-talk

  Kayed, R., Dettmer, U. & Lesné, S. E., 2020, In: Journal of Parkinson's Disease. 10, 3, p. 791-818 28 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Synucleins
  • Neurodegenerative Diseases
  • Amyloidogenic Proteins
  • Multiple System Atrophy
  • Lewy Body Disease
  1 Scopus citations

• TDP-43 and Tau Oligomers in Alzheimer's Disease, Amyotrophic Lateral Sclerosis, and Frontotemporal Dementia

  Montalbano, M., McAllen, S., Cascio, F. L., Sengupta, U., Garcia, S., Bhatt, N., Ellsworth, A., Heidelman, E. A., Johnson, O. D., Doskocil, S. & Kayed, R., Dec 2020, In: Neurobiology of Disease. 146, 105130.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Frontotemporal Dementia With Motor Neuron Disease
  • DNA-Binding Proteins
  • Alzheimer Disease
  • Inclusion Bodies
  • Neurodegenerative Diseases